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17I. ХИМИЯ И ХИМИЧЕСКАЯ ТЕХНОЛОГИЯ Неорганическая и физическая химия
УДК 541.11/.118
Глушнев Г.А.1,Канбар Аят1, Федченко М.Г.1, Кескинов В.А.1, Чарыков Н.А.1,2, Семенов К.Н.14,6, Шаймарданов Ж.К.3, Шаймарданова Б.К.3, Куленова Н.А.3, Летенко Д.Г.5, Закиров Б.С.7
РАСТВОРИМОСТЬ В
тройной системе с
УЧАСТИЕМ ОКТО-АДДУКТА ЛЕГКОГО ФУЛЛЕРЕНА С АРГИНИНОМ И СОЛИ ЛЮТЕЦИЯ:
LuCl3-C60(C6H14N4O2)8(H)8-H2O
при 25 °C
1Санкт-Петербургский государственный технологический институт (технический университет), Московский пр., 26 Санкт-Петербург, 190013, Россия 2Санкт-Петербургский электротехнический университет "ЛЭТИ", ул. Проф. Попова, 5, 197376 Санкт-Петербург, Россия
3Восточно-Казахстанский государственный технический университет им. Д. Серикбаева, ул. А. К. Протозанова, 69, г. Усть-Каменогорск, 070004, Республика Казахстан 4Институт химии. Санкт-Петербургский государственный университет, Университетский пр., 26., Санкт-Петербург, Петергоф 198504, Россия 5Санкт-Петербургский государственный архитектурно-строительный университет, 2-я Красноармейская ул., 4, 190005 Санкт-Петербург, Россия 6Первый Санкт-Петербургский государственный медицинский университет им. И.П. Павлова, ул. Льва Толстого, 6-8, Санкт-Петербург, 195176, Россия 7Институт общей и неорганической химии АН Узбекистана, ул. Мирзо Улугбека, 77а, Ташкент, 100170, Республика Узбекистан. e-mail: keskinov@mail.ru
В работе нами использовался LuCl3, синтезированный из оксида Lu2O3 марки ЛУОЕ обработкой"ч.д.а." HCl с последующей вакуумной сушкой. Окто-аддукт фуллере-на - C60(C6H14N4O2)s(H)s синтезировали гетерогенно-каталитическим синтезом C60, растворенного в о-ксилоле с аминокислотой аргинином - C6H14N4O2, растворенным в воде, в присутствии межфазного катализатора [n-(C4H9)4N]OH с последующим осаждением и очисткой продукта. Диаграмму растворимости исследовали методом насыщения в ампулах при 25±0,020 °С в течение 4 часов. Концентрацию LuCl3 определяли ком-плексометрическим титрованием, концентрацию C60(C6H14N4O2)s(H)s определяли с помощью абсорбционной электронной спектроскопии, по оптической плотности на длине волны/ А = 330 нм, плотность растворов определяли с помощью кварцевых пикнометров с рабочим объемом V ~ 5 см. Диаграмма растворимости в тройной системе LuCl3-C60(С6H14N4O2)s(H)s-H2O при 25 °C оказалась простой эвтонической, состоящей из двух ветвей, отвечающих кристаллизации кристаллогидратов: LuCl36H2O и C^^H^NO^^HS "15H2O. Диаграмма
Georgy A.Glushnev1, Ayat Kanbar1, Maxim G. Fedchenko1, Victor A. Keskinov1, Nikolay A. Charykov1,2, Konstantin N. Semenov1,4,6, Zhasulan K. Shaimardanov 3, Botagoz K. Shaimardanova 3, Natalie A. Kulenova3, Dmitrii.G. Letenko5, Bakhtiyar S. Zakirov7
SOLUBILITY PHASE EQUILIBRIUM IN TERNARY SYSTEMS WITH OCTO-ADDUCT OF LIGHT FULLERENE WITH ARGININE AND LUTETIUM SALT:
LuCl3-C60(C6H14N4O2)8(H)8-H2O
at 25 °C
1St Petersburg State Institute of Technology (Technical University), 26, Moskovsky Pr., St Petersburg, 190013, Russia
2S-Petersburg Electrotechnical University «LETI», St. Petersburg, 197376, ul. Professora Popova, 5 3D. Serikbayev East Kazakhstan state technical university, Ust-Kamenogorsk city, 070004, A.K. Protozanov Street, 69, The Republic of Kazakhstan
4St. Petersburg State University,7/9 Universitetskaya emb., Saint Petersburg, 199034, Russia 5St.Petersburg State University of Architecture and Civil Engineering (SPSUACE), 2-nd Krasnoarmeiskaya St. 4, 190005 St. Petersburg, Russia
6Pavlov First St.Petrsburg State Medical University,. L. Tolstoy st. 6-8, St Petersburg, 195176, Russia 7Institute of General and Inorganic Chemistry Academy of Science Uzbekistan Republic, Mirzo Ulugbek st., 77 a, Tashkent, 100170, Uzbekistan Republic e-mail: keskinov@mail.ru
In the presented study, we used LuCl3 chloride synthesized from LUOEgrade Lu2O3 oxide by treatment with HCl "purely for analysis" followed by vacuum drying.Octo-adduct of fullerene Ceo - Ceo(CeH14N4O2)s(H)s was synthesized by heterogeneous - catalyst synthesis of Ceo dissolved in o-xylene amino-acid arginine - CeH14N4O2, dissolved in water, with interphase catalyst [n-(C4H9)4N]OH with subsequent precipitation and purification of the product. Solubility diagram was investigated by the method of saturation in ampules at 25±0.02 °C for 4 hours. The concentration of LuCl3 was determined by complexometric titration, the concentration of Ceo(CeH14N4O2)(H)s was determined with the help of absorption electronic spectroscopy, according to optical density at wavelength A = 330 nm, density of the solutions were determined with the help of quartz picnometers with operating volume V ~ 5 cm3. Diagram of solubility in ternary system LuCl3-Ceo(CeH14N4O2)s(H)s-H2O at 25 °C occures to be simple eutonics, consist of two branches, corresponds to crystallization of crystal-hydrates: LuCl36H2O and Ceo(CeH14N4O2)8(H)s-15H2O. Diagram contains one non-variant point each - eutonics, which
содержит одну нонвариантную точку - эвтонику, которая соответствует насыщению парой кристаллогидратов одновременно. Диаграмма также содержит очень короткую ветвь кристаллизации ШС136Н2О и длинную ветвь С60(С6Н14М4О2)е(Н)8,15Н2О, где отчетливо наблюдается эффект высаливания окто-аддукта
Ключевые слова: фуллерен С60, окто-аддукт, хлорид лютеция, диаграмма растворимости, тройная система, простая эвтоника.
corresponds to saturation with pair of crystal-hydrates simultaneously. Diagram also contains very short branch of LuCl3-6H2O crystallization, and long branch of C60(C6H14N4O2)8(H)815H2O, where the effect of octo-adduct salt-out is observed distinctly
Key words: fullerene C50, arginine, octo-adduct, lutetium chloride, solubility diagram, ternary system, simple euton-ic.
DOI 10.36807/1998-9849-2020-53-79-3-8
Дата поступления - 27 декабря 2019 года
Introduction
This article continue the cycle of publications, concerning the synthesis, identification and physical-chemical, physical, bio-chemical, biological properties investigation of the adducts of light fullerenes and amino-acids [1-31], herewith some publications [1-7] were devoted to the investigation of octo-adduct of light fullerene C50 with L-arginine, namely. This article is devoted to the investigation of the diagram of solubility in the systems, containing simultaneously water soluble fullerene nano-cluster, inorganic salt, including rare earth metals and actinoids, and water, as a solvent [32-39]. In all last articles it was shown, that water soluble fullerene nano-clusters (adducts with amino-acids, poly-hydroxylated forms - fullerenols, complex eithers with carbon acids) have a very strong salting-out effect at addition of inorganic salts or it's crystal-hydrates, and the salting-out effect is most strongly manifested for salts of 4-f and 5-f elements, somewhat weaker for the salts of d-elements, and even weaker for the salts of p- and s-elements. So, such 4-f elements salts (as LuCl3) may be effectively used for the sedimentation (by salting-out effect) fullerene nano-clusters (as C50(C5Hi4N4O2)8(H)8) and maybe it's separation from the matrix solution and purification virtually without losses of nanoclusters. Now separation from the matrix solution and purification of fullerenes nanoclusters is carried out, as a rule, by multistage (often triple) methanol (or methyl-acetate, or ethanol)-water recrystalli-zation, which leads to the following:
-considerable losses of nanoclusters, because solubility of last ones in methanole with water impurities solutions is more or less considerable;
-nanoclusters for the same reasons contain a significant amount of impurities;
-recrystallization process itself is laborious. So, the main practical goal of the presented investigation is elaboration of a convenient and economical method of allocation of water soluble fullerene derivatives from water solutions without losses by salt-out effect with the help of rare earth metals salts (in our case LuCl3). Theoretical basis of such salt-out process is namely solubility diagrams in our ternary system.
Reagents
In presented investigation we used rare earth chloride LuCl3, synthesized from the "chemical pure" oxide Lu2O3 by treatment of "pure for the analysis" HCl with following vacuum drying. Octo-adduct C50(C5Hi4N4O2)8(H)8 was synthesized by heterogeneous - catalyst reaction of C50, with amino-acid arginine - C5Hi4N4O2, with interphase catalyst [n-(C4H9)4N]OH [1,5,5]. So, LuCl3 and
C50(C5Hi4N4O2)8(H)8 with purity ~ 99.0 and 97.3 mas. %, correspondingly, were synthesized.
Experimental method
Solubility diagrams were investigated by the method of saturation in ampules at 25±0.02 °C for 4 hours in the conditions of shaker-thermostate with shaking friequence ~ 2 Hz. For the prevention of Lu3+ in the form Lu(OH)3 sedimentation some drops oh HCl was added to the heterogeneous systems, to approximate fixation of pH ~ 2 a.u.
The concentration of LuCl3 were determined by complexometric titration with trilon-B (disodium salt of ethylene-diamine-tetraacetic acid - EDTA), titration conditions were the following: acetic buffer, indicator - 2-3 drops of 1-% Xylenol orange solution, color transition from violet to lemon-yellow [40-43].
Concentration of C50(C5H14N4O2)8(H)8 was determined with the help of absorption electronic spectroscopy according to optical density at wavelength A = 330 nm - D330 (Ultraviolet-Visible Electronic Specto-photometer Shimadzu, wavelength 200 nm < A < 900 nm). Typical spectrum for C50(C5H14N4O2)8(H)8 water solution is represented in Fig.1.
Fig.1. Electronic spectrum of C60(C6H14N4O2)s(H)s water solution (concentration of C60(C6H14N4O2)s(H)s C = 0.34 g/dm3).
One can see, that, althought spectrum has no any expressed absorption peaks, we can calculate C50(C5Hi4N4O2)8(H)8 concentration in g/dm3, from optical density at wavelength A = 330 nm, according to Booger-Lambert-Behr law by the formule:
C(g/dm3) = 0.609'D330 (at l = 1cm)
(1)
Density of the solutions were determined with the help of quartz picnometers with operating volume
V~ 5 cm3. Errors in the deteremination of LuCl3 concentration was 5 ~ 3 relative %, Cec(CeHi4N4O2)8(H)8 5 ~ 5 relative % , density 5 ~ 0.1 relative %.
Experimental data discussion
Solubility diagram in the ternary system LuCh-q^QHnN.AHHy^O at 25 °C is represented in the Fig.2 and Table. Diagram is represented in bilogarithm form, because concentration of both components in the long branch of crystallization changes very quiskly and very strongly. In Fig. 3. the dependence of the densities of saturated solutions in ternary system
LuCl3 - C60(C6HmN4O2)8(H)8 represented. P
H2O at 25 °C is
Lg|Concentration octo-adduct] IgC^^^y^ (gdm )
Fig. 2. Solubility in ternary system LuC/з - C6o(С6HмN4O2)s(H)s - H2O at 25 °C
Fig.3. Density of saturated solutions in ternary system LuCh - QoCQHNOOzMHJs - H2O at 25C
Table. Solubility in ternary system LuCh - C60(C6HmNO2)s(H)s - H2O at 25 °C
Num Density Optical density Concentration Concentration Solid Phase
P (g/cm3) D (a.u.) C60(C6H14N402)s(H)s (g/dm3) LuCIs (g/dm3)
1. 1.013 27.73399 16.9 0.00 C60(C6H14N402)s(H)s'15H20
2. 1.018 2.348112 1.43 1.08 C60(C6H14N402)s(H)s'15H20
3. 1.032 2.298851 1.40 1.91 C60(C6H14N402)s(H)s'15H20
4. 1.053 1.674877 1.02 2.64 C60(C6H14N402)s(H)s'15H20
5. 1.075 1.543514 0.69 4.78 C60(C6H14N402)s(H)s'15H20
6. 1.189 0.279146 0.17 33.3 C60(C6H14N402)s(H)s'15H20
7. 1.290 0.116585 0.071 137 C60(C6H14N402)s(H)s'15H20
8. 1.508 0.060755 0.037 379 C60(C6H14N402)s(H)s'15H20
9. 1.837 0.034483 0.021 941 C60(C6H 14N402)s(H)s '15H20+LuCl3 -6H20
10. 1.851 - 0.000 944 LuCl3'6H20
Diagram of solubility in ternary system LuCh-q^QHMNiO^HyH^D at 25 °C occures to be simple eutonics [44-46], consist of two branches corresponds to crystallization of crystal-hydrates: LuCl3'6H2O and q^QHnN.AHHy^HA Diagrams contains one non-variant point - eutonics [7, s], which corresponds to saturation the pair of crystal-hydrates simultaneously. Diagram contains very short branch of LuCl3-6H2O and long branche of Q^QHHN.tO^Hy^^O crystallization, where effect of octo-adduct salt-out is observed distinctly.
Conclusions
So, diagram of solubility in ternary system LuCh-q^QHnN.AKHy^O at 25CC occures to be simple eutonics, with non-variant point, laying very close to figurative point of LuCl3 (in eutonics relation between LuCl3 and Q^QsHh^O^H^ concentrations is nearly 1/3CCCC). This fact determines high perspectivity of LuCl3 use for C^QsHh^O^H^ precipitation from the solutions, practically wuthout any losses and impurities.
Acknowledgements
This work was supported by Russian Foundation for Basic Research (RFBR) (Projects Nos. 18-08-00143 A, 19-015-00469A, and 19-016-00003A).
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Сведения об авторах:
Глушнев Георгий Александрович, студент; Georgiy A. Glushnev, student
Канбар Аят аспирант; Ayat Kanbar, Graduate student
Федченко Максим Георгиевич магистр; Maxim G. Fedchenko, Master student
Кескинов Виктор Анатольевич, канд хим. наук, доцент; Victor A. Keskinov, Ph.D (Chem.), Associate Professor Чарыков ННиколай Александрович, д-р хим. наук, профессор; Nikolay A. Charykov Dr Sc, (Chem.), Professor, e-mail: ncharykov@yandex.ru
Семенов Константин Николаевич, д-р хим. наук, профессор, Konstantin N. Semenov, Dr Sc, (Chem.), Professor, e-mail: semenov1986@yandex.ru
Шаймарданов Жасулан Кудайбергенович, д-р биол. наук, профессор; Zhasulan K Shaimardanov, Dr Sc,, (Biol.),
Professor
Шаймарданова Ботагоз Каы/мовна д-р биол. наук, профессор, Bоtagoz K Shaimаrdanova, Dr Sc,, (Biol.), professor Куленова Наталья Анатольевна, канд. хим. наук; Natalie A. Kulenova, e-mail: NKulenova@ektu.kz
Летенко: Дмитрий Георгиевич, канд. физ.-мат. наук, доцент, Dmitrii G. Letenko Ph.D (Phys.-Math.), Associate Professor, e-mail: dletenko@mail.ru
Закиров Бахтияр Сабиржанович д-р хим. наук, проф., директор института; Bakhtiyar S. Zakirov, Dr Sci (Chem.), Professor, Director of the Institute
