Фундаментальная медицина список научных статей
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Оценка изменения активности карбоксипептидаз под действием пептидов продуктов пчеловодства при хроническом стрессе
Аннотация. За последние несколько лет резко выросла частота заболеваемости тревожными и депрессивным расстройствами, поэтому исследование анксиолитической активности пептидов различного происхождения является актуальной проблемой. Цель данной статьи — изучить влияние пептидов маточного молочка,...
2023 / Сергей Викторович Клыченков, Анастасия Дмитриевна Кручинина, Сергей Сергеевич Гамзин, Ольга Анатольевна ЛевашоваВАК -
Эколого-видовые особенности ретикулоцитоза у животных (Bos taurus taurus, Alces alces, Rangifer tarandus) на ранних стадиях онтогенеза
Представлен материал, характеризующий процесс последовательного обновления клеток красной крови новорожденных и взрослых животных. Показано, что особенности приспособления исследуемых видов к природным условиям обитания формируются на ранних стадиях онтогенеза. У се-верного оленя, адаптированного к ...
2023 / Николай Петрович Монгалёв, Лев Исакович Иржак -
Исследование стресс-протекторного эффекта экдистероид-содержащей субстанции «Серпистен» у человека
Проведено исследование влияния экдистероидсодержащей субстанции «Серпистен» на агглютинабельность, адренореактивность эритроцитов, некоторые показатели сердечнососудистой системы человека в покое и после физической нагрузки (в качестве стрессового фактора). Двухнедельный прием ЭС Серпистена...
2023 / Наталья Борисовна Петрова -
ГРИБКОВОЕ ВОСПАЛЕНИЕ НЕБНЫХ МИНДАЛИН У БЕРЕМЕННЫХ
Ткань миндалин при гистопатологических обследованиях обычно имеет признаки воспаления. Поэтому миндалины, в рамках своей задачи, физиологически находятся в длительном воспалительном процессе, который достигает клинической значимости только тогда, когда к этому физиологическому локальному воспалению ...
2023 / Мирхонов Жавохир Жахонгир Угли -
GUT MICROBIOTA ALTERATIONS IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS
Currently, the issue of the relationship between gut microbiota and juvenile idiopathic arthritis (JIA) is still relevant. The study was aimed to assess alterations in the gut microbiota taxonomic composition and estimate the relationship between these alterations and cortisol, melatonin, and TNFα...
2022 / Porosyuk M.V., Klementiev D.D., Hodov N.A., Gumenyuk L.N., Esatova E.S., Sereda E.V., Chetveruhina-Malova K.S., Sarchuk E.V., Ivanov S.V. -
THE RS17713054 AND RS1800629 POLYMORPHISMS OF GENES LZTFL1 AND TNF ARE ASSOCIATED WITH COVID-19 SEVERITY
Both genetic and non-genetic factors are responsible for high interindividual variability in response to SARS-CoV-2. Despite the fact that multiple genetic polymorphisms have been identified as risk factors of severe COVID-19, such polymorphisms are still insufficiently studied in the Russian...
2022 / Traspov A.A., Minashkin M.M., Poyarkov S.V., Komarov A.G., Shtinova I.A., Speshilov G.I., Karbyshev I.A., Pozdnyakova N.V., Godkov M.A. -
PECULIARITIES OF AMINO ACID PROFILE IN MONOCYTES IN BREAST CANCER
Monocytes are large circulating white blood cells that are the main precursors of tissue macrophages as well as tumor-associated macrophages in the adult body. Different types of monocytes have multidirectional effects on the growth and metastatic spread of cancer cells, both activating and...
2022 / Novoselova А.V., Yushina M.N., Patysheva M.R., Prostakishina E.A., Bragina О.D., Garbukov E.Y., Kzhyshkowska J.G. -
CORRELATION OF MICROEMBOLISM RISK FACTORS WITH AGE IN THE ISCHEMIC STROKE RECOVERY PERIOD
Identification of the age-related features of interaction between the risk factors of microembolism can improve understanding of the mechanisms underlying the development of ischemic stroke (IS). The study was aimed to assess the effects of age and other risk factors of stroke on the biophysical...
2022 / Orlova E.V., Berlin A.B., Lelyuk V.G. -
AMICOUMACIN-BASED PRODRUG DEVELOPMENT APPROACH
Coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, is highly contagious and has a severe morbidity. Providing care to patients with COVID-19 requires the development of new types of antiviral drugs. The aim of this work is to develop a prodrug for the treatment of coronavirus disease...
2022 / Shmygarev V.I., Prokopenko Yu.A., Terekhov S.S., Zakharova M.Yu., Dubinnyi M.A., Smirnov I.V., Yampolsky I.V., Tsarkova A.S. -
EFFICACY OF FAVIPIRAVIR AND MOLNUPIRAVIR AGAINST NOVEL SARS-COV-2 VARIANTS IN VITRO AND IN VIVO
The COVID-19 disease pandemic remains a significant global problem, resulting in hundreds of millions of cases and millions of deaths. The search for specific inhibitors of SARS-CoV-2 for the treatment of this infection remains relevant. Drugs such as Favipiravir and Molnupiravir, which exhibit...
2022 / Siniavin A.E., Russu L.I., Vasina D.V., Shidlovskaya E.V., Kuznetsova N.A., Gushchin V.A., Gintsburg A.L. -
EFFECTS OF VARIOUS MRNA-LNP VACCINE DOSES ON NEUROINFLAMMATION IN BALB/C MICE
It has been proven that mRNA vaccines are highly effective against the COVID-19 outbreak, and low prevalence of side effects has been shown. However, there are still many gaps in our understanding of the biology and biosafety of nucleic acids as components of lipid nanoparticles (LNPs) most often...
2022 / Kirshina A.S., Kazakova A.A., Кolosova E.S., Imasheva E.A., Vasileva О.О., Zaborova О.V., Terenin I.M., Muslimov A.R., Reshetnikov V.V. -
DRUG DESIGN STRATEGIES FOR THE TREATMENT OF CORONAVIRUS INFECTION
The increasing size and density of the human population is leading to an increasing risk of infectious diseases that threaten to spread yet another pandemics. The widespread use of vaccination has reduced morbidity and mortality associated with viral infections and in some cases eradicated the...
2022 / Terekhov S.S., Shmygarev V.I., Purtov K.V., Smirnov I.V., Yampolsky I.V., Tsarkova A.S. -
THE APPROACH TO PATIENT CLUSTERING BASED ON THE MICROCHIP DATA CONFINED TO DISTINCT LOCI USING THE COMBINATIONS OF VARIANTS
Fuchs' endothelial corneal dystrophy is a socially significant hereditary disease. More than a half of cases in the European population are caused by the increased number of trinucleotude repeats in the TCF4 gene. The study was aimed to develop and test the approach of dividing patients into groups ...
2023 / Iulmetova L.N., Kulemin N.A., Sharova E.I. -
ADIPOKINES AND MYOKINES AS INDICATORS OF OBESE PHENOTYPES AND THEIR ASSOCIATION WITH THE GUT MICROBIOME DIVERSITY INDICES
Today, metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) are distinguished. Adipose and muscle tissues can determine the obese phenotype due to adipokine and myokine production. Gut microbial community is also involved in MHO. The study was aimed to reveal the features...
2023 / Shestopalova A.V., Ganenko L.A., Grigoryeva T.V., Luikov A.V., Vasilyev I.Yu., Kolesnikova I.M., Naboka Yu.L., Volkova N.I., Roumiantsev S.A. -
METABOLIC ENGINEERING IS A PROMISING WAY TO GENERATE HIGHLY EFFECTIVE PRODUCERS OF BIOACTIVE SUBSTANCES
Medicines play an indisputable role in life extension and improvement of the quality of life. To obtain medicinal compounds, researchers traditionally rely on natural sources and chemical synthesis, however, currently developing biotechnological methods allow one to introduce the group of genes...
2023 / Blokhina A.E., Palkina K.A., Shakhova E.S., Malyshevskaya A.K., Osipova Z.M., Myshkina N.M. -
APOPTOSIS OF GRANULOSA CELLS IN WOMEN WITH IMPAIRED REPRODUCTIVE FUNCTION AND EXTRAGENITAL PATHOLOGY
Granulosa cells feed the oocyte during its maturation and protect it. Aberrant apoptosis in these cells is known to ultimately impair oogenesis. The current knowledge of how extragenital inflammation affects apoptosis in granulosa cells is incomprehensive, which is the root of an urgent problem...
2023 / Rogova L.N., Lipov D.S., Perfilova V.N., Kustova M.V., Mukhina A.V., Churzin D.A. -
GUT MICROBIOTA ALTERATIONS AND THEIR ASSOCIATION WITH IL6, IL8 AND TNFα LEVELS IN PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS
Today, the association of gut microbiota with external genital endometriosis (EGE) is of special scientific interest. The study was aimed to assess alterations of the gut microbiota taxonomic composition and explore their correlations with plasma levels of IL6, IL8 and TNFα at the species level in...
2023 / Gumenyuk L.N., Zemlyanaya I.A., Rami Almasoud, Badula E.S., Ismailov A.R., Seroshtanov N.A., Kokareva S.S., Cheremisova A.A., Kupreichyuk Yu.R. -
IMMUNOGENICITY OF FULL-LENGTH AND MULTI-EPITOPE MRNA VACCINES FOR M. TUBERCULOSIS AS DEMONSTRATED BY THE INTENSITY OF T-CELL RESPONSE: A COMPARATIVE STUDY IN MICE
Development of the new tuberculosis vaccines that would be effective in adults is an urgent task: worldwide, the annual death toll of this disease exceeds 1.5 million. In the recent decades, the matter has been addressed in numerous studies, but none has yielded an effective vaccine so far. There...
2023 / Vasileva O.O., Tereschenko V.P., Krapivin B.N., Muslimov A.R., Kukushkin I.S., Pateev I.I., Rybtsov S.A., Ivanov R.A., Reshetnikov V.V. -
MORPHOLOGICAL PECULIARITIES OF REGENERATION OF ORAL MUCOSA ASSOCIATED WITH USE OF POLYMERIC PIEZOELECTRIC MEMBRANES
Wound defects of the oral mucosa are a common pathology the treatment of which often involves synthetic membranes. Development of varieties of such membranes is an ongoing process. This study aimed to register morphological features of the oral mucosa regeneration process in the presence of one of...
2023 / Konyayeva A.D., Varakuta E.Yu., Leiman A.E., Review D.O., Bolbasov E.N., Stankevich K.S. -
TRYPTOPHAN CATABOLITES AND PREDICTED GUT FLORA ENZYME-ENCODING GENE
The signaling role of tryptophan and its catabolites is well known. However, their effects on the potential microbiota metabolic activity is still poorly understood. The study was aimed to assess concordance between changes in the predicted gut microbiome enzyme-encoding gene abundance and the...
2023 / Shadow O.P., Gaponov A.M., Grigoryeva T.V., Vasiliev I.Yu., Stoletova L.S., Makarov V.V., Yudin S.M., Roumiantsev S.A., Shestopalov A.V.