Фундаментальная медицина список научных статей
-
METABOLIC ENGINEERING IS A PROMISING WAY TO GENERATE HIGHLY EFFECTIVE PRODUCERS OF BIOACTIVE SUBSTANCES
Medicines play an indisputable role in life extension and improvement of the quality of life. To obtain medicinal compounds, researchers traditionally rely on natural sources and chemical synthesis, however, currently developing biotechnological methods allow one to introduce the group of genes...
2023 / Blokhina A.E., Palkina K.A., Shakhova E.S., Malyshevskaya A.K., Osipova Z.M., Myshkina N.M. -
APOPTOSIS OF GRANULOSA CELLS IN WOMEN WITH IMPAIRED REPRODUCTIVE FUNCTION AND EXTRAGENITAL PATHOLOGY
Granulosa cells feed the oocyte during its maturation and protect it. Aberrant apoptosis in these cells is known to ultimately impair oogenesis. The current knowledge of how extragenital inflammation affects apoptosis in granulosa cells is incomprehensive, which is the root of an urgent problem...
2023 / Rogova L.N., Lipov D.S., Perfilova V.N., Kustova M.V., Mukhina A.V., Churzin D.A. -
GUT MICROBIOTA ALTERATIONS AND THEIR ASSOCIATION WITH IL6, IL8 AND TNFα LEVELS IN PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS
Today, the association of gut microbiota with external genital endometriosis (EGE) is of special scientific interest. The study was aimed to assess alterations of the gut microbiota taxonomic composition and explore their correlations with plasma levels of IL6, IL8 and TNFα at the species level in...
2023 / Gumenyuk L.N., Zemlyanaya I.A., Rami Almasoud, Badula E.S., Ismailov A.R., Seroshtanov N.A., Kokareva S.S., Cheremisova A.A., Kupreichyuk Yu.R. -
IMMUNOGENICITY OF FULL-LENGTH AND MULTI-EPITOPE MRNA VACCINES FOR M. TUBERCULOSIS AS DEMONSTRATED BY THE INTENSITY OF T-CELL RESPONSE: A COMPARATIVE STUDY IN MICE
Development of the new tuberculosis vaccines that would be effective in adults is an urgent task: worldwide, the annual death toll of this disease exceeds 1.5 million. In the recent decades, the matter has been addressed in numerous studies, but none has yielded an effective vaccine so far. There...
2023 / Vasileva O.O., Tereschenko V.P., Krapivin B.N., Muslimov A.R., Kukushkin I.S., Pateev I.I., Rybtsov S.A., Ivanov R.A., Reshetnikov V.V. -
MORPHOLOGICAL PECULIARITIES OF REGENERATION OF ORAL MUCOSA ASSOCIATED WITH USE OF POLYMERIC PIEZOELECTRIC MEMBRANES
Wound defects of the oral mucosa are a common pathology the treatment of which often involves synthetic membranes. Development of varieties of such membranes is an ongoing process. This study aimed to register morphological features of the oral mucosa regeneration process in the presence of one of...
2023 / Konyayeva A.D., Varakuta E.Yu., Leiman A.E., Review D.O., Bolbasov E.N., Stankevich K.S. -
TRYPTOPHAN CATABOLITES AND PREDICTED GUT FLORA ENZYME-ENCODING GENE
The signaling role of tryptophan and its catabolites is well known. However, their effects on the potential microbiota metabolic activity is still poorly understood. The study was aimed to assess concordance between changes in the predicted gut microbiome enzyme-encoding gene abundance and the...
2023 / Shadow O.P., Gaponov A.M., Grigoryeva T.V., Vasiliev I.Yu., Stoletova L.S., Makarov V.V., Yudin S.M., Roumiantsev S.A., Shestopalov A.V. -
CLINICAL SIGNIFICANCE OF CYTOKINE COUNTING IN PATIENTS WITH MULTIPLE SCLEROSIS AND ITS RELATIONSHIP WITH HERPES INFECTION
There are persistent infections that contribute to the emergence and development of multiple sclerosis (MS) exacerbations; they are triggered by the Epstein–Barr, herpes type 6, herpes simplex types 1 and 2, varicella-zoster viruses. Cytokines are crucial to arresting the spread of a herpes...
2023 / Baranova N.S., Grist M.S., Baranov A.A., Aspirin N.N., Artyukhov A.S., Shakirova K.M., Nasonov E.L. -
PROMISING BIOCEMICAL MARKERS OF PARKINSON'S DISEASE
Parkinson's disease (PD) is a chronic neurodegenerative disease associated with specific neurological deficits in patients, it mainly affects dopaminergic neurons in the substantia nigra causing accumulation of the neurotoxic amounts of aggregated α-synuclein protein in the neuronal cell bodies....
2023 / Gusyakova O.A., Smirnov S.V., Kuznetsova O.Yu., Apergenova A.R., Albikova A.R. -
ANTIBACTERIAL, ANTI-ADHESIVE AND ANTI-BIOFILM-FORMING ACTIVITY OF PLANT COMPLEXES AGAINST PERIODONTOPATHOGENIC BACTERIA IN VITRO
Periodontitis is a problem urgent in Russia and throughout the world in general. Because of the dynamically changing flora causing this diseases, the treatment methods designed against it should be adapted on a regular basis. The classic approach to arresting development of the acute process relies ...
2023 / Nosov M.A., Latif I.I., Kraeva L.A., Khamdulaeva G.N., Sharov A.N., Kopetsky I.S., Eremin D.A., Postnikova E.V., M.A Postnikov -
FEATURES OF CD163+ AND HLA-DR+ EXPRESSION ON BLOOD MONOCYTES ASSOCIATED WITH BREAST CANCER
Circulating monocytes are important actors of the tumor growth pathogenesis. It has been shown that some features of the monocyte populations expressing endocytosis receptors or the major histocompatibility complex components are observed in blood of patients with breast cancer. The study was aimed ...
2023 / Patysheva M.R., Stakheyeva M.N., Grigoryeva E.S., Tarabanovskaya N.A., Bragina O.D., Kzhyshkowska J.G., Cherdyntseva N.V. -
CYP2D6*3, *4, *6 GENOTYPES AND ENDOMETRIAL THICKNESS IN PATIENTS WITH BREAST CANCER DURING TAMOXIFEN THERAPY
Tamoxifen therapy results in endometrial thickening in some patients with hormone-sensitive breast cancer (HSBC). The data on the impact of polymorphic variants of the CYP2D6 gene encoding the CYP2D6 enzyme of the cytochrome P450 family on the efficacy and safety of treatment with tamoxifen are...
2023 / Goryainova A.Yu., Usman N.Yu., Rubanovich A.V., Borinskaya S.A., Meshcheryakov A.A. -
Оценка уровня психоэмоционального стресса у обучающихся с использованием биохимического анализа слюны
Проблема и цель. На начальной стадии профессионализации будущих педагогов особое значение имеет оценка нервно-психической устойчивости. Наиболее подвержены стрессу студенты 1 курса, так как устойчивость психики (нравственная, личностная, эмоциональная) находится в процессе становления, поэтому...
2023 / Сарф Елена Александровна, Бельская Людмила Владимировна -
STUDYING THE PROBLEMS OF INCREASING THE REPUTATION OF UZBEKISTAN IN THE FIELD OF MEDICINE IN THE INTERNATIONAL COMMUNITY (IN THE EXAMPLE OF FERGANA VALLEY, IN 1950-1980)
This article covers the issues of providing the population with medical staff, their qualifications, the state of modern medical equipment and equipment, vaccination of the population against diseases during the Soviet government period in the Fergana Valley.
2023 / Qodirjon Najmiddinov -
CONSIDERATION OF SYSTEMS FOR ORGANIZING THE PROVISION OF EMERGENCY MEDICAL CARE IN VARIOUS COUNTRIES
This article provides a brief description of existing emergency medical care (EMS) systems using the example of several countries. Also ways to improve the possibility of digitalizing the system of recording and recording data on patients in need of emergency medical care.
2023 / Akhmedova Dilafruz Tashpulat Qizi -
International students’ adjustment to the educational environment of the Russian university: medical and psychological aspect of socio-cultural integration
Introduction. The increase in the number of academic exchange programmes for students contributes to a significant growth in the number of international students in Russian universities who often experience a sense of dislocation and have to adjust to new academic and cultural environments. The key ...
2023 / Anna Mikhailovna Markus, Inna Nickolaevna Dmitrusenko, Igor Andreevich Tishevskoy -
РАЗВИТИЕ СОВРЕМЕННОЙ ХИМИЧЕСКОЙ ПРОМЫШЛЕННОСТИ В МИРЕ
Данная работа посвящена раскрытию темы развития технологий в химической отрасли и их особенностей. Проведен перекрестный и сравнительный анализ развития технологий в работе химической систем. Даны рекомендации по внедрению разработок в отрасль.
2023 / Гурбанмяммедова Ширинай Баймухаммедовна, Мамедов Довран, Аннабердиев Аннаберди -
Контрабанда метамфетамина из Афганистана: состояние и перспективы
После введенного талибами запрета на выращивание опиумного мака в Афганистане внимание производителей наркотиков в этой стране переключилось на изготовления метамфетамина преимущественно из растительного сырья – травы эфедры, широко произрастающей в Афганистане и не попадающей под запреты...
2023 / Афонин Дмитрий Николаевич -
CROSS ETHNIC EXAMINATION OF PSYCHOPATHIC TRAITS AMONG PAKISTANI INDIVIDUALS
As a forensic concept, psychopathy has received the greatest attention in the present century. Crime, hostility, violence, and personality traits are just a few of the areas that researchers have found psychopathy to be associated with. The purpose of the current research was to examine the link...
2022 / Sher DilScopusВАК -
EFFECT OF PEER SUPPORT AND PSYCHOLOGICAL CAPITAL ON STATISTICAL ANXIETY IN UNIVERSITY STUDENTS
Statistical anxiety (SA) is a major problem faced by university graduates majoring in almost all the disciplines. Researchers have been investigating the factors that may reduce its intensity. This study aimed to investigate the effect of peer support (PS) and psychological capital (PC) on...
2023 / Shumaila Shahzad, Nida Khalid, Bushra Naoreen, Umair Ayub, Hina GullScopusВАК -
"BALANCING LIFE AND DEATH: UNRAVELING THE IMPACT OF WORK ENVIRONMENT ON DEATH ANXIETY, RESILIENCE, AND SPIRITUAL WELLBEING AMONG HEALTH PROFESSIONALS IN INTENSIVE CARE AND NON INTENSIVE CARE UNITS"
The current study aimed to investigate the im pact of work environment on healthcare professionals, particularly in intensive care and non intensive care settings. The emotional experiences of health professionals were explored through the assessment of death anxiety, resilience, and spiritual...
2023 / Abida Khalil, Roomana Zeb, Saima Arzeen, Siraj Ul HaqScopusВАК