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A.M. ZHYKEMBAEYVA, K.K. ALIMBETOVA, A.TALGATKIZI, S.O.ABDRAZAKOV, A.K.AMREKYLOVA, ZH.C.ANASOVA, R.A.MYKAI, M.ZH. SARSENOVA, A.N.TLEYBERGENOV, K.B.BEISEMBEKOV, A.E. SADIRBAEVA, B. SYLTAN, B.C. TASHODZHAEV, S.M. TELENCHIEVA
S.D. Asfendiyarov Kazakh National Medical University The Republic of Kazakhstan, Almaty
ACUTE RESPIRATORY VIRAL INFECTION IN PRACTICE PEDIATRICIAN: QUESTIONS RATIONAL THERAPY
Resume: Acute respiratory infections (ARI) - a group of acute infectious respiratory diseases, which differ in etiology (cause various respiratory viruses), but have similar epidemiological, pathogenetic and clinical characteristics. Keywords: acute respiratory infections, epidemiological, pathogenetic
UDK 616.211/232-022-092:616.23-002
R.K. MUSABEKOVA, M.K. AKIMZHAN, G.N. MAEMGENOVA, A.M. TAZHIMBETOVA
Kazakh National Medical University. S.D. Asfendiyarov Clinnical Children's Hospital, № 2, Almaty city
THE SIGNIFICANCE OF BRONCHIAL OBSTRUCTION SYNDROME IN ACUTE RESPIRATORY INFECTIONS
In early ages of children to the development of bronchial obstruction of respiratory infections the frequently reason is premorbid background, modifying factors, which have no direct connection with pneumonia or pathogen, but can significantly worsen the course of disease and adversely can affect to the outcome.
Keywords: bronchial obstruction, acute respiratory infections
Introduction. Respiratory diseases remain one of the most important topics of Pediatrics, which is due not only to its widespread among children of all ages, but also high death-rates at an early age, despite of using the latest diagnostic methods and the use of broad-spectrum antimicrobial agents. Obstructive syndrome is the one that mostly occurs among respiratory diseases . The swelling of the bronchial mucosa is the main predictor of the genesis of bronchial obstruction, its inflammatory infiltration, hypersecretion of mucus viscous, thereby it faces the derangement of mucociliary clearance and obstruction of the bronchial tubes [1].
The most important are the age characteristics of the respiratory system of the child. Bronchus of children have a smaller diameter than an adults'. Tracheal mucosa and bronchial edema immediately reacts by hypersecretion of mucus as response to the progression of a viral infection. The narrowness of the bronchial tubes and the whole respiratory system significantly increases aerodynamic resistance. Thus, edema of the bronchial mucosa in 1 mm can cause in resistance more than 50% of air flow in the trachea [2].
Compliance cartilage of bronchial tract specific to early age children, when insufficient rigidity of the bone structure of the thorax, freely reacting indrawing of compliant places to increase airway resistance, as well as a number of features of the structure and position of the diaphragm can be observed. Definite influence on functional disorders of the respiratory system of a child affect by factors as prolonged sleep, frequent crying, continuous position lying on his back in the first months of life. [3]
Respiratory viral infection is the main cause of the occurrence of bronchial obstruction. To the viruses that most frequently causes a bronchial obstruction are included respiratory syncytial virus (about 50%), parainfluenza virus, mycoplasma pneumonia, at least - flu viruses and adenoviruses. [4].
Among the environmental factors that may lead the development of obstructive syndrome, particularly influenced by passive smoking at home. Tobacco smoke causes hypertrophy of bronchial mucous glands, impaired mucociliary clearance, slowing advancement of the mucus. Passive smoking triggers destruction of bronchial epithelium. Especially vulnerable in the first years of the child. [5].
Materials and methods. Another important harmful factor is the pollution of the atmosphere by industrial gases, as well as organic and inorganic dust.
Most researchers recognize the influence of factors on the development of premorbid background of the bronhoobstructive syndrome. They are - pregnant toxicosis, obstructed labor, hypoxia during labor, premature birth, assertive allergic history, bronchial hyperreactivity, rickets, degeneration, hyperplasia of the thymus, perinatal encephalopathy, early feeding, transferred respiratory disease at the age of 6-12 months. Results and discussion. Numerous studies in our country and abroad have shown that outcomes of obstructive bronchitis generally positive. 54% of children with recurrent episodes of obstructive bronchitis quit be ailing after four years, and other 37% - at older age; thereby, over 90% of patients recovers. Furthermore, the presence of obstructive syndrome at the first three years of life can not be considered as a factor, predisposing to asthma hereinafter. That is, discovered that the mechanism for the development of wheezing in young children other than those of older children, and the main role is played not by hyperreactivity of the bronchial mucosa and muscle spasm, but the tone of the bronchial wall and swelling of the bronchial mucosa. This reflects the fact that "wheezing" of infants is due to various reasons, including abnormalities of the respiratory system and other inflammatory etiology. [5]. The aim of the research was to determine the significance of bronchial obstruction in clinical symptoms of acute respiratory infections of the respiratory tract.
Examination of patients with pneumonia and obstructive bronchitis was conducted on the basis of the pulmonary department of the clinical children hospital № 2. Complex examination was conducted 112 patients aged from 1 month to 1 year, most of children were boys - 61.9%, 38.1% were girls. Diagnosis of pneumonia, obstructive bronchitis installed on the basis of medical history, clinical and radiographic signs of hematological parameters. To identify premorbid background persistent intracellular pathogens carried immunosorbent assay (ELISA) for the presence of antibodies to the membrane and intracellular pathogens such as Mycoplasma hominis, Mycoplasma pneumoniae, Chlamidiae pneumoniae and cytomegalovirus. As a result of this survey, we found that in children often determined by IgM-antibodies to M. pneumoniae, M. hominis and Chi. Pneumoniae, and IgG antibodies to CMV-diagnostic titers. Thus significant differences in the presence the mixed or mono infection not observed.
In the history of the surveyed patients found that 7 children were born prematurely, the mothers checked out obstetric and somatic pathology in the form of gestosis, the threat of
pregnancy, acute pyelonephritis, viral infections, in the most children to the disease so far have been repeatedly respiratorno-acute viral infection and bronchitis, 12% of the patients had pneumonia. Mostly all children with pneumonia had an unfavorable premorbid background. And the majority of children has been a combination of several different factors: anemia had 19 (45%) children had rickets in 4 (9%) children paratrofiya in 7 (14%) children. PEM suffered 2 (8%), allergic dermatitis in 10 (33%) diagnosed Thymomegalia in 7 (17%) of children. The clinical picture in most children observed symptoms prevalence of respiratory failure due to moderate, but persistent bronchical obstruction. Persistent symptoms were paroxysmal unproductive cough. The physical changes in the lungs characterized in 16% of the children persistent local finely wheezing, 73% noted a combination wet and wheezes of all sizes scattered, dry rales auditioned in 11% of children. There was a correlation between clinical and radiological data. When X-ray research of logic in all patients was determined by the presence of increased pulmonary pattern, of bronchial obstruction syndrome in combination with focal-infiltrative
shadows in both lungs. It should be noted that a persistent bronchial obstruction observed in preterm infants. In 5 (11%) children had a place segmental pneumonia different localization, physical changes have been meager, so for 7-8 days appeared auscultation changes in the form of wet finely wheezing on the side of the process. Hemodynamic disorders were stopped on day 8 of the disease.
All patients received etiopathogenetic therapy, which included, along with antibiotics and mukolytics, nebulized bronchodilators (Ventolin or berodual) Choice dependent on the nature and severity of bronchial obstruction inflammation. Conclusions. The results give grounds to speak about the impact of the maturity of the child (prematurity, intrauterine infection, background pathology, neurological diseases) to the nature and course of the disease, in which the presence and duration of bronchial obstruction may occur and largely determine the clinical symptoms of the disease. In young children, the presence of airflow obstruction is due to various reasons, including abnormalities of the respiratory system and acute inflammatory processes.
REFERENCES
1 Kotlukov V.K., B.M. Blokhin, A.G. Rumyantsev "Syndrome of bronchial obstruction in infants with respiratory infections of different etiology": Specialty of clinical manifestations and immune response // Pediatrics. - M.: 2006. - № 3. - P. 14-21.
2 V.G. Maydannik Clinical Recommendations of diagnosis, treatment and prevention of diseases of the upper respiratory tract in children. -K .: Vidavnitstvo "Aspect Poligraf", 2003.-177p.
3 Akhmedova D.I. Bronchial obstruction in young children and the principles of its treatment. - M.: 2004 - 218 p.
4 Samsygina G.A. and others." Nosocomial pneumonia in children: etiology and clinical-morphological features // Pediatriya. - 2001. - №1. - P. 5-8.
5 G.A.Samsygina, T.A.Dudina, A.G Talalaev, M.A Kornyushin Ssevere community-acquired pneumonia in children // Pediatrics. - 2005. -№4. - P. 5-6.
Р.К. МУСАБЕКОВА, МД. ЭК1МЖАН, Г.Н. МАЕМГЕНОВА, А.М. ТАЖИМБЕТОВА
СЖАсфендияров атындагы К,азац ¥лттъщ Медицина университетi №2 %алалы% клиникалыц балалар ауруханасы, Алматы цаласы
ЖЕДЕЛ РЕСПИРАТОРЛЫ ИНФЕКЦИЯЛАРДА БРОНХООБСТРУКТИВТ1 СИНДРОМНЫН, МАН.ЫЗЫ
tywh: Ерте жастагы балалар респираторлы инфекциялармен ауырганда бронхиалды обструкция дамуы ушш нау;астыц фонды; жагдайларыныц, ынталандырушы факторлардыц улей аз емес, олардыц пневмонияга жэне оныц к;оздыргыштарына тшелей ;атысы болмаса да, б1ра; аурудыц агымын ;иындатады жэне оныц нэтижейне жагымсыз эсер етедт TYffiH^ сездер:бронхообструктивт синдром, жедел респираторлы инфекция
Р.К. МУСАБЕКОВА, МД ЭЮМЖАН, Г.Н. МАЕМГЕНОВА, А.М ТАЖИМБЕТОВА
Казахский Национальный медицинский университет им. С.Д.Асфендиярова. Городская детская клиническая больница, № 2 г. Алматы
ЗНАЧЕНИЕ БРОНХООБСТРУКТИВНОГО СИНДРОМА ПРИ ОСТРЫХ РЕСПИРАТОРНЫХ ИНФЕКЦИЯХ
Резюме: У детей первых лет жизни развитию бронхиальной обструкции при респираторных инфекциях немало важное значение имеет преморбидный фон, модифицирующие факторы, которые не имеют непосредственной связи с пневмонией или ее возбудителем, но способны значительно усугубить течение заболевания и неблагоприятно воздействовать на исход. Ключевые слова: бронхообструктивный синдром, острые респираторные инфекции
