CC BY
2The 30th International Conference on Advanced Laser Technologies B-I-31
ALT'23
Multimodal collaborative tumor precision therapy based on phototherapy
Siwen Li1,Yueqing Gu2
1,2 State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, No. 639 Longmian Avenue, Jiangning District,
Nanjing 211198, China.
Corresponding author e-mail address: [email protected]
Abstract: Chemotherapy, radiotherapy and surgery are the main treatments in the field of tumor therapy, but they all have their own limitations. Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), which relies on the conversion of light energy into chemical and thermal energy by photo-therapeutic moieties to kill tumors, has been widely used in clinic as a non-invasive oncologic therapeutic modality. Besides, the biological effects in vivo of phototherapy can be combined with other strategies to achieve the purpose of synergistic treatment. In this study, we constructed a nanobiomaterial drug carrying system for multimodal combined precision treatment of solid tumor, which combined immunotherapy, gene therapy, chemotherapy and phototherapy to make each treatment cooperative and enhance tumor treatment including effective inhibition of tumor development, metastasis and recurrence. In vitro and in vivo experiments have shown that these tactics may provide a promising and pragmatic platform for clinical applications.
[1]Yuewen Zhai, Xiaorong He, Ying Li , Ran Han , Yuying Ma1, Peng Gao , Zhiyu Qian , Yueqing Gu*, Siwen Li*. A splenic-targeted versatile antigen courier: iPSC wrapped in coalescent erythrocyte-liposome as tumor nanovaccine. Science Advances, 2021, 7(35).
[2] Tian Xu, Yuying Ma, Qinling Yuan, Huixin Hu, Xinkai Hu, Zhiyu Qian, Rolle Janiqua Kyiesha, Yueqing Gu*, Siwen Li*. Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy. ACS Nano, 2020, 14(3): 3414-3425.
[3] Yuying Ma, Jinnan Zhang, Yalan Rui, Rolle Janiqua, Tian Xu, Zhiyu Qian , Yueqing Gu*, Siwen Li*. Depletion of glioma stem cells by synergistic inhibition of mTOR and c-Myc with a biological camouflaged cascade brain-targeting nanosystem. Biomaterials, 2020, 268, 120564.
[4] Yuying Ma, Yanqin Zhang, Ran Han, Ying Li, Yuewen Zhai, Zhiyu Qian , Yueqing Gu*, Siwen Li*. A cascade synergetic strategy induced by photothermal effect based on platelet exosome nanoparticles for tumor therapy. Biomaterials. 2022, 282: 121384.
[5] Ran Han, Luting Yu, Chenxuan Zhao, Ying Li, Yuying Ma, Yuewen Zhai, Zhiyu Qian , Yueqing Gu*, Siwen Li*. Inhibition of SerpinB9 to enhance granzyme B-based tumor therapy by using a modified biomimetic nanoplatform with a cascade strategy. Biomaterials. 2022, 288 : 121723.
[6] Ying Li, Chunjiao Wu, Yuewen Zhai, Ran Han, Ruoyu Gu, Yuying Ma, Peng Gao, Zhiyu Qian, Yueqing Gu*, Siwen Li*. Palliating the escalated post-PDT tumor hypoxia with a dual cascade oxygenation nanocomplex. Applied Materials Today. 2022, 26:101287.
