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8MULTI-MODE COOPERATIVE PRECISION THERAPY OF TUMOR BASED ON PHOTOTHERAPY
SIWEN LI1*, YUEQING GU
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory ofDrug Screening, Department ofBiomedical Engineering,
School of Engineering, China Pharmaceutical University, China.
lsw@cpu.edu.cn
ABSTRACT
Cancer remains one of the deadliest diseases and causes millions of deaths every year. Nowadays, chemotherapy and radiotherapy and surgery are the major clinical treatments, all of which frequently cause adverse effects and pose a risk of recurrence. In contrast, phototherapy, a rising platform with specific spatiotemporal selectivity and minimal invasiveness, has become an emerging solution for cancer therapy. Phototherapy, including photodynamic therapy and photothermal therapy, relies on the conversion of light energy into chemical and thermal energy by phototherapeutic moieties to kill tumors, and the in vivo biological effects induced can be combined with other therapeutic modalities to achieve synergistic treatment. In the meantime, the development of nanomedicine has ushered new frontiers in cancer therapy, holding great promise for improving the therapeutic index and reducing side effects. We always focused on the construction of a multi-functional nano-drug delivery system for phototherapy combined with other treatments for multimodal synergistic therapy of tumors. Centering on the above concept, we utilized targeted cascade delivery [1], tumor oxygenation enhanced photodynamic therapy [2], photothermal therapy combined with immunotherapy and other strategies which through liposomes, micelles, biofilm fusion liposomes, biological vesicles to make each treatment cooperative and enhance cancer treatment. In vitro and in vivo experiments have shown that these tactics may provide a promising and pragmatic platform for clinical applications.
REFERENCES
[1] Ma Y, Zhang J, Rui Y, Rolle J, Xu T, Qian Z, Gu Y, Li S. Depletion of glioma stem cells by synergistic inhibition of mTOR and c-Myc with a biological camouflaged cascade brain-targeting nanosystem. Biomaterials.268:120564. 2021.
[2] Xu T, Ma Y, Yuan Q, Hu H, Hu X, Qian Z, Rolle JK, Gu Y, Li S. Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy. ACS Nano.14(3):3414-3425. 2020.
