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13HIGH-PERFORMANCE BIOMEDICAL PHOTOACOUSTIC TOMOGRAPHY
CHAO TIAN
1School of Engineering Science, University of Science and Technology of China, China 2Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, China
ctian@ustc.edu.cn
ABSTRACT
Based on the energy conversion of light into sound, photoacoustic imaging is an emerging noninvasive biomedical imaging technique and has experienced explosive developments in the past two decades. As a hybrid imaging technique, photoacoustic imaging possesses distinguished optical absorption contrast as in optical imaging and superb spatial resolution as in ultrasound imaging. It can visualize biological samples at scales from organelles, cells, tissues, organs to small-animal whole body and has found unique applications in a range of biomedical fields. In this presentation, I will present our most recent progress in photoacoustic imaging, including photoacoustic tomography and photoacoustic microscopy. In photoacoustic tomography, I will present our efforts in the development of a high-performance, real-time photoacoustic scanner and its applications in the sentinel lymph node identification in vivo. Results reveal that the detector view angle, element number, center frequency, bandwidth, aperture size, focusing, orientation error, and scan step angle error all have significant impacts on the imaging performance of the scanner. The developed scanner can be used in practical scenarios and produce real-time high-performance imaging. In photoacoustic microscopy, I will report our work in single cell and single vessel imaging. Results show that optical-resolution photoacoustic microscopy can not only achieve high-resolution, high-sensitivity single cell imaging but also can visualize blood vessels architecture of the retina and choroid in living rabbits without any labeling. The work advances both the technology and applications of photoacoustic imaging in biomedicine.
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Figure: Impact of detector bandwidth on image quality. First row: imaging results of a blood vessel phantom using detectors with different bandwidths. Second row: imaging results of the multidisk phantom using detectors with different bandwidths. First to fourth columns, detector bandwidths of B = 50%, 100%, 150%, and full, respectively. Detectors with broader bandwidths suppress ringing artifacts and produce sharper images.
REFERENCES
[1] L. V. Wang and S. Hu, "Photoacoustic tomography: in vivo imaging from organelles to organs," science 335, 1458-1462 (2012).
[2] Y. Zhao, C. Zhang, S. Liu, and C. Tian, "Ultrasound-guided adaptive photoacoustic tomography," Optics Letters 47, 15 (2022).
[3] C. Tian, C. Zhang, H. Zhang, D. Xie and Y. Jin, "Spatial Resolution in Photoacoustic Computed Tomography," Reports on Progress in Physics, (2021).
[4] C. Tian, M. Pei, K. Shen, S. Liu, Z. Hu, and T. Feng, "Impact of System Factors on the Performance of Photoacoustic Tomography Scanners," Physical Review Applied 13, 014001 (2020).
[5] S. Liu, H. Wang, C. Zhang, J. Dong, S. Liu, R. Xu, and C. Tian, "In Vivo Photoacoustic Sentinel Lymph Nodes Imaging Using Clinically-Approved Carbon Nanoparticles," IEEE Transactions on Biomedical Engineering, (2020).
