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35
BHopagHKa^w u ÁHTHOKCHgaHTbi 2018 TOM 5, №3
97
FACIAL BIOSTIMULATION WITH PRP ACTIVATED WITH OZONE RESOUND ON CELLULAR REDOX BALANCE AND IMPROVES LIPOATROPHY IN HIV PATIENTS
L. Gil-del Valle1, M.A. Acosta2, C.L. Rabeiro-Martinez2, R. Gravier-Hemández1, M.C. Hernández González-Abreu1, Y. Bermúdez-Alfonso1, M. Rosa Font2, D. Hernández-Requejo2
Pharmacological Research Department, Institute "Pedro Kourí" (IPK), La Habana, Cuba
Medical Department, Hospital, Institute "Pedro Kourí" (IPK), La Habana, Cuba
Introduction
Infection by both human immunodeficiency virus (HIV) generates sustained inflammation with increased reactive oxygen species production. Pathogenic impact of high-grade local and systemic oxidative stress indexes in antiretroviral treated patients are higher and recognized to influencing in lipodystrophy which is proposed can be ameliorate with platelet rich plasma (PRP). The aim of this quasi-experimental study was to determine the effect and safety of facial bioestimulation of PRP activated with ozone and calcium in lipoatrophy -aids Cuban individuals.
Methods
Blood samples were drawn from 30 individuals. Total peroxide (HPO), malondialdehyde and advanced oxidation protein products (AOPP) as damage indexes and antioxidant responses (glutathione, peroxidation potential, superoxide dismutase and catalase) were assessed. Also haematological and hemochemical indexes and progression markers (viral load, T CD4+ lymphocyte absolute count) were determined and also quality of life questionnaires. Different statistical analyses were done comparing baseline respect final values of variables after 5 interventions during a year.
Results
Reductions of lipoatrophy lesion at 75% of patients and significant differences in global indexes of damage and antioxidant status of 80% of patients at the end of the study was demonstrated (p< 0,05). The comparison revealed a significantly smaller damage (HPO, AOPP) and lower antioxidant status (SOD, CAT) compared to baseline values (p<0,05). Non-significant modifications was observed in hematological and hemohemical indexes (p>0,05) with 75% improves of two dimension in quality of life. Non adverse reactions were observed during study period.
Conclusions
These results corroborate that beneficial reductions of oxidative stress occurs in lipoatrophy aids patients during safety PRP-ozone facial bioestimulation with high perception of health improve by patients. Redox indexes diagnosis should be considering in early diagnostics, prevention and treatment with PRP, which would be worthwhile to conduct a more comprehensive study and manage of lipoatrophy. Key words: facial bioestimulation, ozone, PRP
