Diagnosis and treatment children with acute scrotal pain. Twenty years single Centre experience Текст научной статьи по специальности «Клиническая медицина»

медицинский вестник северного кавказа MEDicAL NEws of NoRTH cAucAsus

2015. Т. 10. № 2 2015. Vоl. 10. iss. 2

© Minaev S. V., Bolotov lu. N., 2015 UDC 616.672-053.2/.5-089

DOI - http://dx.doi.org/10.14300/mnnc.2015.10026 ISSN - 2073-8137

DIAGNOSIS AND TREATMENT CHILDREN WITH ACUTE SCROTAL PAIN. TWENTY YEARS SINGLE CENTRE EXPERIENCE

Minaev S. V., Bolotov Iu. N.

Stavropol State Medical University, Stavropol, Russian Federation

ДВАДЦАТИЛЕТНИЙ ОПЫТ ДИАГНОСТИКИ И ЛЕЧЕНИЯ ДЕТЕЙ С СИНДРОМОМ «ОСТРОЙ МОШОНКИ»

С. В. Минаев, Ю. Н. Болотов

Ставропольский государственный медицинский университет, Ставрополь, Российская Федерация

The aim of study was to determine the value of Doppler ultrasonography in the diagnosis of acute scrotal pain in the different stages of acute scrotum.

The case notes of 344 boys with an acute scrotum aged from 1st day of life to 17 years old were reviewed in the Department of Pediatric Surgery of StSMU (Russia). The size and ultrasonography structure of the testis and its epididymis, as well as the testicular blood flow, were assessed.

The sensitivity of ultrasonography findings for testicular torsion without scrotal edema was relatively low (50%), but with scrotal edema - increased to 83.3%. The specificity of sonography for testicular torsion in the presence or absence of edema of the scrotum did not change significantly (83.2%). The characteristic ultrasonography evidence of torsion of a testicular appendage was an increase in size of the epididymis and its heterogeneous echostructure. The sensitivity of these signs was high (83.3%) in all boys. The sonography signs of acute epididymitis are an enlarged epididymis and its homogeneity. The sensitivity (83.3%) and specificity (87.5%) of the findings did not depend on the presence or absence of scrotal edema. Operative exploration was performed on 240 patients. Surgical findings were: testicular torsion -61, torsion of a testicular appendage - 164, acute epididymitis - 20.

Thus, the sensitivity and specificity of physical examination signs of the acute scrotum in the absence of scrotal edema in children are higher than the ultrasonography findings, but significantly drops after the onset of scrotal edema.

Key words: scrotal pain, testicular torsion, diagnosis management, children

Цель исследования - определить диагностические возможности допплеровского ультразвукового исследования при острых заболеваниях яичка у детей в разные периоды заболевания.

Было обследовано 344 мальчика в возрасте от 1 дня жизни до 17 лет с синдромом «острой мошонки». При ультразвуковой допплерографии оценивали размер и эхоструктуру яичка и его придатка, а также показатели внутриорганного кровотока.

Чувствительность ультразвуковых симптомов перекрута яичка в отсутствие отека и гиперемии мошонки была достаточно низкой (50%), однако значительно возрастала при присоединении воспалительных явлений со стороны мошонки (до 83,3%). Специфичность ультразвуковых симптомов перекрута яичка от стадии заболевания не зависела и составляла 83,2%. Характерными ультразвуковыми симптомами перекрута гидатиды были увеличение размеров придатка и гетерогенность его структуры. Чувствительность этих признаков была достаточно высокой (83,3%). Ультразвуковыми симптомами острого эпидидимита являлись: незначительное увеличение придатка яичка при сохранении его гомогенности. Чувствительность и специфичность этих признаков были высокими (83,3 и 87,5% соответственно) и не зависели от наличия или отсутствия отека и гиперермии мошонки. Всего было прооперировано 240 детей, из них: с перекрутом яичка - 61, с перекрутом гидатиды - 164 и с острым эпидидимитом - 20.

Таким образом, чувствительность и специфичность клинических симптомов при острых заболеваниях яичка при отсутствии отека и гиперемии мошонки превышает таковые показатели ультразвуковых симптомов. С появлением отека и гиперемии мошонки ультразвуковые симптомы становятся достоверно чувствительнее клинических данных.

Ключевые слова: острая боль, мошонка, перекрут яичка, диагностика, дети

оригинальные исследования

Хирургия

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Surgery

The acute painful scrotum is one of the most challenging urological emergencies [1, 2, 3]. Making the correct diagnosis of testicular torsion, torsion of a testicular appendage, or acute epididymitis can be difficult because pathognomonic findings are infrequently present [4, 5]. Delayed diagnosis and treatment can potentially lead to irreversible parenchymal damage and loss of a testis. The introduction of color Doppler sonography has reduced the number of diagnostic explorations. Doppler ultrasonography (US) for the diagnosis of testicular torsion had a 94% sensitivity, 96% specificity, 95.5% accuracy, an 89.4% positive predictive value, and a 98% negative predictive value in one study [6]. In another study, US yielded a sensitivity of 69.2%, specificity of 100%, positive predictive value of l0o% and negative predictive value of 97.5% for torsion [7]. In 84% of children with acute scrotal pain, the DUS was able to differentiate between a surgical emergency and other etiologies [8]. However, the color Doppler sonography of scrotum at times can show significant false-negative results [9, 10, 11]. If clinical suspicion of testicular torsion persists after US, the patient should still undergo scrotal exploration [12]. Also, some pediatric surgeons believe that any boy with acute scrotal pain and suspicion of testicular torsion on physical examination should undergo scrotal exploration [13]. Therefore a number of clinicians do not perform additional examination of children with «acute scrotum» and proceed directly to operative intervention [14].

Our hypothesis is that the accuracy of clinical examination and US for acute scrotal pain in childhood varies during different stages of the disease. The aim of this study was to determine the value of US in the diagnosis of acute scrotal pain in the different stages of the disease.

Material and Methods. The case notes of 344 boys with an acute scrotum aged from 1st day of life to 17 years old were reviewed in the Department of Pediatric Surgery of Stavropol State Medical University at the Regional Pediatric Hospital of Stavropol (Russia) from 1991 to 2010. The study included all males diagnosed or admitted with an acute scrotum. Physical findings reviewed were position, size and mobility of the testis, location of testicular tenderness, the presence of a palpable nodule at the superior aspect of the testicle (blue-dot sign), and scrotal edema. All patients had blood and urine tests.

Patients underwent testicular US with Color Doppler by GE Pro series LOGIQ 500 and SonoAce PICO 7.5 MHz transducer. The size and echo structure of the testis and its epididymis, as well as the testicular blood flow, were assessed and documented.

Based on the results from the clinical findings and US examination, further management and treatment was planned. For both the physical examination signs and US findings, sensitivity (Se) and specificity (Sp) were determined.

Results. Torsion of a testicular appendage was diagnosed in 205 children (59.6%), acute epididymitis in 78 (22.7%), and testicular torsion in 61

(17.7%). Based on these results, we have calculated the sensitivity and specificity for clinical and US signs of testicular torsion, torsion of a testicular appendage, and epididymitis.

The sensitivity of the physical examination signs for testicular torsion (elevation of the testis, transverse lie, and diffuse tenderness of the tes-tis) in the absence of scrotal edema was very high (Se - 98.5%). However, in boys with scrotal edema, the sensitivity of these signs of testicular torsion was dramatically reduced (Se - 8.3%). The specificity of the signs remains high (Sp - 95.8%), both in the presence and absence of scrotal edema.

Physical examination signs of torsion of a testicular appendage (a blue-dot sign or palpable tender nodule at the superior aspect of the testis) showed high sensitivity in patients without scrotal edema (Se - 97.3%). If scrotal edema is present, the sensitivity of the listed signs declined considerably (Se - 25.5%). However, the specificity of physical examination signs for torsion of a testicular appendage in boys without scrotal edema was high (Sp - 68.5%), and increased with the development of edema in 96%. Characteristic local symptoms of acute epididymitis were identified (Table 1).

Table 1

General data of the physical examination of acute scrotum in children

Index Testicular torsion n=61 Torsion of testicular appendage n = 205 Acute epididymitis n = 78

scrotal edema scrotal edema scrotal edema

yes (n=55) no (n=6) yes (n=164) no (n=41) yes (n=54) no (n=24)

Elevation of the testis 7 (12.7%) 6 (100%) 20 (12.2%) 7 (17.1%) 6 (11.1%) -

Transverse lie of the testis 3 (5.5%) 6 (100%) - - - -

Diffuse tenderness Tenderness is localized to the upper pole of the testis 53 (96.4%) 2 (3.6%) 6 (100%) 103 (62.8%) 61 (37.2%) 41 (100%) 51 (94.5%) 3 (5.5%) 12 (50%) 12 (50%)

Parates-ticular nodule at the superior aspect of the testicle 2 (3.3%) - 21 (12.8%) 41 (100%) 3 (5.5%) 9 (37.5%)

With regards to US, the sensitivity of US findings for testicular torsion (increase in size of testis and its epididymis in conjunction with the heterogeneity of its echostructure) in boys without scrotal edema was relatively low (50%). When scrotal edema was present, the sensitivity of US increased to 83.3%. The specificity of US for testicular torsion in the presence or absence of edema of the scrotum did not change significantly, and was 83.2% on average.

медицинский вестник северного кавказа MEDICAL NEWS of NORTH CAUCASUS

2015. Т. 10. № 2 2015. Vоl. 10. Iss. 2

The characteristic US evidence of torsion of a testicular appendage was an increase in size of the epididymis and its heterogeneous echostructure. The sensitivity of these signs was high (83.3%), and was not different in boys with or without scrotal edema. These US findings showed high specificity in infants without scrotal edema (77.5%) and increased to 90% with scrotal edema.

The US signs of acute epididymitis are an enlarged epididymis and its homogeneity. The sensitivity and specificity of the findings (Table 2) did not depend on the presence or absence of scrotal edema (Se - 83.3%, Sp - 87.5%).

Table 2

General data of the ultrasound examination of acute scrotum in children

Index Testicular torsion n = 61 Torsion of testicular appendage n = 205 Acute epididymitis n=78

scrotal edema scrotal edema scrotal edema

yes (n = 55) no (n=6) yes (n = 164) no (n=41) yes (n = 54) no (n = 24)

Testicular size - large - normal 47 (85.5%) 8 (14.5%) 6 (100%) 164 (100%) 41 (100%) 54 (100%) 24 (100%)

Epididymis size - large - normal 47 (85.5%) 8 (14.5%) 6 (100%) 164 (100%) 34 (82.9%) 7 (17.1%) 12 (22.2%) 41 (77.8%) 24 (100%)

Testicular structure - heterogenous - homogenous 55 (100%) 6 (100%) 164 (100%) 41 (100%) 54 (100%) 24 (100%)

Epididymis structure - heterogenous - homogenous 55 (100%) 6 (100%) 164 (140%) 41 (100%) 54 (100%) 24 (100%)

Blood tests in children with an acute scrotum sho wed leukocytosis, lymphocytosis neutrophilia, eosi-nophilia and an accelerated sedimentation rate. Leukocytosis was observed more frequently with testicular torsion (29.5%) and less often in epididymitis (23.1%) and torsion of testicular appendage (9.8%), (p<0.05). Lymphocytosis was typical for epididymitis (50%), but not for testicular torsion (33.2%) or testicular appendage torsion (14.8%), (p<0.05). Other indicators of blood tests showed no significant differences (p>0.05).

Urine tests in children with an acute scrotum showed proteinuria, hematuria and

pyuria. Proteinuria was observed more of- ,_

ten in boys with torsion of the testis (16.6%) than with epididymitis or torsion of testicular appendage (3.9% and 2.9%, respectively) (p<0.05). Pyuria was characteristic of epididymitis (20.5%). In boys with testicular torsion, pyuria was rare (8.2%), and was not found for testicular torsion appendage (p<0.05). Hematuria occurred equally often with testicular torsion (24.4%), torsion of the testicular appendage (22.9%), and epididymitis (12.8%), (p>0.05).

Operative exploration was performed on 240 patients with an acute scrotum. Surgical findings were: testicular torsion -61, torsion of testicular appendage - 164, acute epididymitis - 20. In the 61 boys with testicular torsion, the testis was removed in 16, but was salvaged in 45.

Discussion. From our data, the sensitivity of physical examination for testicular torsion and torsion of a testicular appendage in boys without scrotal edema was very high, but dropped significantly when

scrotal edema was present. The sensitivity of US findings for an acute scrotum was low in the early stages of disease and increased with the development of scrotal edema.

Scrotal edema significantly impedes palpation of the testis and epididymis. At the same time, edema of scrotum is not an obstacle for US beams. Based on this study, a diagnostic and treatment algorithm has been developed for boys with an acute scrotum (Figure).

Acute scrotal pain

Scrotal edema

Block #1 Physical examination Equivocal findings

I

Л-J

Elevation of the testis

Transverse lie of the testis

Anterior rotation of epididymis

Diffuse tenderness

A blue-aot sign

Paratesticular nodule at the superior aspect of the testicle

Vertical orientation

Tenderness Is localized to the upper pole of the testis

Testicular torsion

Torsion of testicular

Epididymitis suspect

Block#2

History and clinical presentation X

Age 0-3 year, 12-16year

Acute onset

Severe pain

Nausea, vomiting

Onset of pain less 6 hours

Previos trauma and/or pain attacks

Emergency surgery

Block #3

ultrasonography

Epididymis structure is homogenous

Epididymis size is normal Testicular size is normal

Epididymisstructureis heterogenous

Testicularstructure is homogenous Epididymis size more than 20% Testicular size is normal

3 elements or 2 elements

more or less

Epididymis structure is heterogenous Testicularstructure is heterogenous Epididymis size more than 20% Testicular size more than 20% I

Epididymitis

Testicular torsion highly probable

Л

Impossible

Conservative detorsión

Surgery required

Conservative treatment

Testicular torsion or Epididymo-orchlt

Testicular torsion

ш

Doppler ultrasonography

nz

Normal or increased blood flow

Absent or

blood flow

Epldidymo-orchit

Testicular torsion

Fig. Algorithm for the diagnosis and 3 management of the acute scrotum in children

оригинальные исследования

Хирургия ^щ

oRiGiNAL research

Surgery

The proposed algorithm relies on three principles: diagnostic value of US significantly exceeds the clinical

1. Testicular torsion should be highly considered examination when scrotal edema has developed. in males with acute scrotal pain until confidently Conclusions. In summary, the Doppler US is a highly excluded. sensitive preoperative diagnostic tool for scrotal pain.

2. Scrotal US should be used in cases where The sensitivity and specificity of physical examination spermatic cord torsion is suspected clinically. signs of the acute scrotum in the absence of scrotal

3. In the absence of scrotal edema, the diagnostic edema in children are higher than the US findings, but value of clinical findings is higher than with US. The significantly drops after the onset of scrotal edema.

References

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2. Minaev S. V, Bolotov lu. N., Pavliuk N. N. The use of ultrasonography in the acute scrotum edema in children. Khirurgiia (Mosk) 2008; (4): 55-58.

3. Minaev S. V., Bolotov lu. N., Albert A. E., Prislegina D. A., Butko M. V. The torsion of testis in 1 year old infant. Medi-tsinskii Vestnik Severnogo Kavkaza. - Medical News of North Caucasus. 2011; 3(23): 112-114.

4. Jaison A., Mitra B., Cameron P. and Sengupta S. Use of ultrasound and surgery in adults with acute scrotal pain. ANZ Journal of Surgery. 2011; 81: 366-370. doi: 10.1111/j.1445-2197.2010.05535.x

5. Tiemstra J. D., Kapoor S. Evaluation of scrotal masses. Am Fam Physician. 2008; 78(10): 1165-1170.

6. Yagil Y., Naroditsky I., Milhem J. et al. Role of Doppler ultrasonography in the triage of acute scrotum in the emergency department. J Ultrasound Med. 2010; 29: 11-21.

7. Kalisvaart J. F., Broecker B., Cerwinka W. H., Cuda S., Elmore J., Kaye J. et al. Pediatric chronic orchalgia. J Pediatr Urol. 2012 Aug;8(4):421-425. doi: 10.1016/j. jpurol.2011.09.002. Epub 2011 Nov 4

About authors:

8. Schalamon J., Ainoedhofer H., Schleef .J et al. Management of acute scrotum in children the impact of Doppler ultrasound. J Pediatr Surg. 2006; 41: 1377-1380.

9. Kalfa N., Veyrac C., Lopez M. et al. Multicenter assessment of ultrasound of the spermatic cord in children with acute scrotum. J Urol. 2007; 177(1): 297-301

10. Frauscher F., Klauser A., Radmayr C. Ultrasonographic assessment of the scrotum. Lancet. 2001; 3; 357(9257): 721-722

11. Varga J., Zivkovic D., Grebeldinger S. et al. Acute scrotal pain in children-ten years' experience. Urol Int. 2007; 78(1): 73-77.

12. Sorensen M. D., Galansky S. H., Striegl A. M. et al. Perinatal extravaginal torsion of the testis in the first month of life is a salvageable event. Urology. 2003; 62(1): 132134.

13. Murphy F. L., Fletcher L., Pease P. Early scrotal exploration in all cases is the investigation and intervention of choice in the acute paediatric scrotum. Pediatr Surg Int. 2006; 22(5): 413-416. Epub 2006 Apr 7

14. Kraft K. H., Lambert S. M., Snyder H. M. 3rd, Canning D. A. Pyocele of the scrotum in the pediatric patient. J Pediatr Urol. 2012; Oct;8(5): 504-508. doi: 10.1016/j. jpurol.2011.10.005. Epub 2011 Nov 22

Minaev Sergey Victorovich, Professor, MD, PhD (corresponding author) Head of Department of Pediatric Surgery, Stavropol State Medical University, Russia; tel.: +79624507653; e-mail: [email protected]

Bolotov Iuriy Nikolaevich, Assistant of Professor, MD; Department of Pediatric Surgery, Stavropol State Medical University, Russia; tel.: +79187838354; e-mail: [email protected]

© Group of authors, 2015 UDC 616.125.127.8-009.3

DOI - http://dx.doi.org/10.14300/mnnc.2015.10027 ISSN - 2073-8137

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1 Stavropol State Medical University, Stavropol, Russian Federation

2 Stavropol Regional Clinical Hospital, Stavropol, Russian Federation

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1 Ставропольский государственный медицинский университет, Ставрополь, Российская Федерация

2 Краевая клиническая больница, Ставрополь, Российская Федерация

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