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Clinical and biochemical justification of prevention of basal seat tissues atrophy in the maxilla
Table 6. - Continuous of illness
No Antecedent anamnesis Men Women
Number Abc % Number Abc %
1 1-15 days 14 14,4±3,6 25 14,6±2,7
2 1-3 month 10 10,3±3,1 21 12,3±2,5
3 1 year 16 16,5±3,8 30 17,5±2,9
4 Several years. 57 58,8±5,0 94 55,0±3,8
Analyses of the number of attacks of neuralgia of trigeminal for men and women. what given in the table 7. nerve during a day showed that it achieves more than 10 times both
Table 7. - Number of attacks of neuralgia of trigeminal nerve during a day
No Times of attack for a day Men Women
Number Abc % Number Abc %
1 1-2 times 10 10,3±3,1 17 9,9±2,3
2 4-5 times 30 30,9±4,7 56 32,7±3,6
3 10 times 39 40,2±5,0 64 37,4±3,7
4 10 more than times 18 18,6±3,9 35 20,5±3,1
As a conclusion, we can say that idiopathic neuralgia is the most spreaded type of trigeminal neuralgia. Men have more cases of catching this illness than women. At men this disease will occur as losing of taste. Disease-producing factors of neuralgia at men:
shaving, toothbrushing, draught; at women: toothbrushing, laughter, draught. A neuralgia attack both at men and women often occurs during summer time. Dependence of duration of illness from gender is not defined.
References:
1. Grechko. V.E. Diagnostics of neuralgia of trigeminal nerve//Mag. Neuropathologist and Psychiatrist - 1985; 7: 1053-1055.
2. Grachev Y. V., Klimov B. A., Molodetskix V. A. Prosopalgia and Mental disorder//Mag. Neuropathologist and Psychiatrist. - 2002. -№ 4. - C. 13-16.
3. Kridjanovskiy G. N. Central mechanics of Pathological ache//Mag. Neuropathologist and Psychiatrist. Korsakov S. S. - 1999 - № 12 -C. 4-8.
4. Melnikova O. N. "Neuralgia of Trigeminal Nerve"//Mag. "Head |Ache", - № 7, - 2004.
5. Pavlenko C. C. Epidemiology of ache//Neurologic magazine. - 1999 - № 1 - C. 41-46.
6. Stepanchenko A. V. "Neuralgia of Trigeminal Nerve"//Russian medical magazine. - 2003. - 11, - № 25. - C. 381-1384.
7. Jundelson Ya. B., Gribova N. P. Face hyperkineses Facial hyperkinesis and dystonia. Smolensk - 1997, - C. 36-44.
8. Troyan V. V., Savchenko A. Yu., Glebov M. A., Layda Yu. I., Nevelskiy I. V. Cryosurgical effects of trigeminal neuralgia//The Second Congress of Neurosurgeons of the Russian Federation/under edition of Ph. D. V. N. Kondakov. - St. Petersburg: edition of RSCI named after A. L. Polenova, - 1998. - P. 206.
DOI: http://dx.doi.org/10.20534/ESR-16-9.10-85-87
Ziyadullaeva Nigora Saidullaevna, PhD Tashkent state dental Institute, Uzbekistan, Department of faculty prosthetic dentistry E-mail: nigorazstom@yandex.ru
Clinical and biochemical justification of prevention of basal seat tissues atrophy in the maxilla
Abstract: Complete removable dentures have a negative effect on the tissues of basal seat resulting in atrophy of edentulous jaws. It needs correction of the microcirculation of basal seat tissues.
Keywords: removable dentures, complete dentures, edentulous ridge/jaw, basal seat, oral mucose membrane, negative effect of removable dentures.
Most of all, a removable denture is inevitable need for replacing both the complete edentulous arch and the partial teeth loss. Despite achievements in manufacturing techniques ofthe complete removable dentures, a question ofimprovement oftheir stability need its decision.
Among all manufactured dentures the removable complete dentures are the most non-physiological. Removable dentures and the materials, which from they have made, can have a negative effect on the oral mucous membrane, which condition is balanced.
Stability of the complete removable dentures depends on a condition of buffer zones of a basal seat, which, in turn, closely depend on microcirculation of the last one.
There is compression syndrome during complete removable dentures is used, resulting in endothelial damage of blood vessels, which disrupts capillary permeability, decreases the tone of blood vessels, slows blood flow, deposits fibrin on the vascular wall, stimulates collagen activity, increases aggregation and adhesion of
Sectiom 6. Medical science
platelets (T. M. Milenkaya, E. G. Bessmertnaya). It will undoubtedly lead to restriction ofblood flow in the terminal parts of the vascular bed, which is will resulting in a fUrther deterioration of the organ and the systemic circulation. As a result, disturbance of a metabolism will increase atrophy of the edentulous ridge (Tereshina T. P., Labunets V. A., Diyeva T. V., 2006).
The purpose of the research. The research objective was the evaluation of the complex treatment effectiveness directed to prevention of basal seat's tissues atrophy in the maxilla in edentulous individuals using of the antiplatelet medicine dipyridamolum and carrying the course of darsonvalisation.
Material and methods. There was prosthetic survey of 91 individuals with edentulous maxilla at the age of 50 years and more and 10 individuals with intact dentition (the control group). The 53 individuals received traditional prosthetic treatment. The main group consisted of 38 patients with decreased microcirculation and increased coagulation properties of blood. They had divided into 2 subgroups by the method of random selection. The patients of both subgroups took dipyridamolum in average therapeutic dose of 50 mg 3 times a day for 20 days. Patients of the second subgroup additionally have receiving a darsonvalization on prosthetic bed's tissues, session duration 3 minutes, every other day, for a course of 6 sessions.
There were applied the following methods to evaluate the effectiveness of the suggested therapy:
— clinical stomatoscopy examination;
— quantitative analysis of saliva and determining ofpH of saliva;
— LDF examination ofthe basal seat's oral mucous in the maxilla;
— biochemical analysis of the blood.
The hemodynamic of a basal seat tissues was studied by LDF (laser Doppler flowmetry) method. Examination of each patient was carried out after stabilization of a hemodynamic during 1015 minute in the reclining position in the room with the soft irradiating lighting, at a temperature of 18-25 0 C. The sensor of the device was installed in the area of a palatal distal third, controlling the pressure upon a mucosa was not excessive (to exclude pressure to microvessels) and too weak. Register time is 2 min for each side.
For diagnostics of a basal seat changes in edentulous maxilla we studied an indicator of microcirculation (IM), the index of microcirculation effectiveness (IEM) and vibration amplitudes of the LDF-signal (Kv, LF, HF, CF) reflecting rhythmic processes in system of microcirculation.
The obtained results and their discussion.
Biochemical blood results showed that respondents of the main group while using complete removable dentures have a significant increase in the content of Willebrand factor, indicating the in-
creasing of thrombogenic potential of the vascular wall. It was equal to 151,2 ± 3.2% in contrast to 100,6 ± 6.3% in the controle grope. Damaging of the vascular wall resulting to the violation of the integrity of the endothelial lining of microvessels, which in turn increased the content of circulating endothelial cells. They average content in the blood is equal to 24,2 ± 2,01104/l in contrast to 8,19 ± 0,24-•104/l in the individuals with intact dentures.
One of the acute phase protein is fibrinogen, the contents of which significantly increased 1.5 times and amounts of 4.97 ± ± 0,54 g/l in the surveyed individuals, but 3.2 ± 0,21 g/l in the control group.
Damaging of the vascular wall and the marked increasing in hemostatic activity of platelets of respondents due to launch the coagulation cascade and increase the number of microaggregates in the bloodstream. Uncontrolled coagulation in the blood and the disbalance of protrombogenic and antithrombogenic factors contribute to the consumption of the natural anticoagulant — antithrombin III and decrease its concentration by 11%.
All patients of the main group had taken dipyridamolum in average therapeutic dose of 50 mg 3 times a day for 20 days.
Clinical stomatoscopy examination of patients of the first group showed improvement in the basal bed's oral mucous color on day 10. A survey of patients felt discomfort while using dentures, revealed that even at 6-8 day of the treatment with dipyridamolum discomfort like a burning sensation and phantom pain significantly decreased or passed at all.
Analysis of saliva in patients of the first group showed that on day 3 of treatment with dipyridamolum the amount of saliva increased to 3.1 ml, on the 7th day — 4.3 ml, on day 10 to 4.5 ml, subsequently the amount of saliva remained relatively stable. Knowing that the dipyridamolum has interferon-inducing properties, we can assume the increase in the level of interferon in the mixed saliva. It increases resistance of the oral cavity to viral infections, which is especially important for our age group of the patients.
Analysis of LDF-grams, executed on the 10th day of treatment showed that the level of tissue blood flow increased by 44%, although the intensity had still reduced by 12%. Vasomotor activity of blood vessels had also reduced by 26% while it was close to the norm. Analysis of amplitude-frequency spectrum of LDF-grams revealed a slight increase in the active modulation of blood flow by 8-10% and reduction of the pulse flaxmotions by 8%, indicating that the reduction of stagnation of the tissues under the complete denture basis. On the 20th day of treatment in our patients recorded a slight decrease in MI (10%) of the original level, however, the lower level of the CF-waves at 13% testified to further reduce venous stagnation in the tissues of the basal seat.
10 d 20 d
Figure 1. Analysis of LDF-grams
Interrelation of personal characteristics and affective disorders of patients with breast cancer
Biochemical analysis of blood showed a tendency to decrease platelet aggregation in 88% of the surveyed persons, with a more pronounced effect had observed on day 20 ofthe research. The content of fibrinogen amounted to an average of 2.83 ± 0,31 g/l, which is 44% below the baseline. The using of dipyridamolum treatment significantly reduced the number of endothelial cells and content of Willebrand factor in the blood respectively for 41% and 22%.
Performances of the saliva analysis and biochemical blood tests of patients of the second subgroup did not have significant differences from those patients of the first subgroup.
Clinical stomatoscopy examination of the second subgroup ofpa-tients showed improvement of the oral mucous color of the prosthetic bed is already on the 6-7-th day of treatment. Subjective complaints of the patients decreased by 5-6-th day of complex treatment.
The results of the LDF-grams on the 10 th day of treatment testified the increased blood flow and its intensity respectively for 53% and 4%, while the vasomotor activity of microvessels had reduced by 27%. The analysis of the dynamics of amplitude-frequency characteristics of tissue blood flow held on the 10th day of combined
treatment found an increasing level of high-frequency vasomotions and flaxmotions respectively for 11% and 18%, indicating increased blood flow in the arterial and venular parts of the microvasculature. The decreasing level of the pulse flaxmotions by 9% showed an improvement of the venous outflow in the microvasculature of the basal seat tissues.
Examination of the patients on the 20th day of combined treatment the level of tissue blood flow exceeded initial values by 58% and the intensity of the microcirculation increased by 10%.
Conclusions. Our data shows that dipyridamolum reduces the aggregation properties of blood, improves microcirculation, reduces stagnant processes in the basal seat tissues and enhances the protective functions of saliva by stimulating the interferon production. The application of darsonvalization to the tissues of the basal seat had improved outcomes. In this case, it is possible to recommend the using of dipyridamolum in combination with darsonvalization on basal seat tissues to prevent atrophy of edentulous jaw, thrombotic complications, and to improve blood rheology of persons using complete dentures.
References:
1. Irsaliev H. I., Khodjimetov A. A., Ziyadullaeva N. S., Mukhamedova N. H. Clinical and biochemical justification of prevention of basal seat tissues atrophy in the maxilla using antiplatelet teurapia Dentist. - 2007. - № 1 (5). - P. 143-146.
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DOI: http://dx.doi.org/10.20534/ESR-16-9.10-87-88
Sattarov Timur Farkhadovich, Senior Researcher
Tashkent Medical Academy, Department of Neurology E-mail: Timurs1987@gmail.com
Interrelation of personal characteristics and affective disorders of patients with breast cancer
Abstract: In order to study psychoemotional state of breast cancer carriers at various stages of therapy 70 patients were tested using Hospital Anxiety and Depression Scale (HADS) and Eysenck personality inventory (EPI) subject to undergo various stages of supervision.
Keywords: breast cancer, temperament, anxiety, depression, neuroticism.
Relevance: Breast cancer (BC) is the most common disease among women in oncology practice. According to WHO data (2014), the incidence rate among women with breast cancer is 43.3 per 100 000 population.
Anxiety and depressive disorders are the major mental disorders in case of Breast Cancer [5; 7]. Depression is one of the most common mental illnesses among patients who have cancer. Diagnosis of depressive disorders in case of patients ill with cancer is still impeded because
of the fact that many symptoms of major depressive disorders (loss of appetite, weight loss, insomnia, loss of interests, cognitive impairment, fatigue and increased fatigability) are similar to signs of cancer. This causes additional challenges upon search for solutions of timely use of psychotherapeutic measures to eliminate depressive symptoms among oncologic patients. Taking into account a great risk of depression among oncologic patients it is suggested to conduct an early and timely psychological intervention to eliminate symptoms of depression [1; 2].
