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Interrelation of personal characteristics and affective disorders of patients with breast cancer
Biochemical analysis of blood showed a tendency to decrease platelet aggregation in 88% of the surveyed persons, with a more pronounced effect had observed on day 20 ofthe research. The content of fibrinogen amounted to an average of 2.83 ± 0,31 g/l, which is 44% below the baseline. The using of dipyridamolum treatment significantly reduced the number of endothelial cells and content of Willebrand factor in the blood respectively for 41% and 22%.
Performances of the saliva analysis and biochemical blood tests of patients of the second subgroup did not have significant differences from those patients of the first subgroup.
Clinical stomatoscopy examination of the second subgroup ofpa-tients showed improvement of the oral mucous color of the prosthetic bed is already on the 6-7-th day of treatment. Subjective complaints of the patients decreased by 5-6-th day of complex treatment.
The results of the LDF-grams on the 10 th day of treatment testified the increased blood flow and its intensity respectively for 53% and 4%, while the vasomotor activity of microvessels had reduced by 27%. The analysis of the dynamics of amplitude-frequency characteristics of tissue blood flow held on the 10th day of combined
treatment found an increasing level of high-frequency vasomotions and flaxmotions respectively for 11% and 18%, indicating increased blood flow in the arterial and venular parts of the microvasculature. The decreasing level of the pulse flaxmotions by 9% showed an improvement of the venous outflow in the microvasculature of the basal seat tissues.
Examination of the patients on the 20th day of combined treatment the level of tissue blood flow exceeded initial values by 58% and the intensity of the microcirculation increased by 10%.
Conclusions. Our data shows that dipyridamolum reduces the aggregation properties of blood, improves microcirculation, reduces stagnant processes in the basal seat tissues and enhances the protective functions of saliva by stimulating the interferon production. The application of darsonvalization to the tissues of the basal seat had improved outcomes. In this case, it is possible to recommend the using of dipyridamolum in combination with darsonvalization on basal seat tissues to prevent atrophy of edentulous jaw, thrombotic complications, and to improve blood rheology of persons using complete dentures.
References:
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3. Alan B. Carr, Glen P. McGivney, David T. Brown. McCracken's Removable partial prosthodontics.URL: http://dentalbooks-drbassam. blogspot.com/
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DOI: http://dx.doi.org/10.20534/ESR-16-9.10-87-88
Sattarov Timur Farkhadovich, Senior Researcher
Tashkent Medical Academy, Department of Neurology E-mail: Timurs1987@gmail.com
Interrelation of personal characteristics and affective disorders of patients with breast cancer
Abstract: In order to study psychoemotional state of breast cancer carriers at various stages of therapy 70 patients were tested using Hospital Anxiety and Depression Scale (HADS) and Eysenck personality inventory (EPI) subject to undergo various stages of supervision.
Keywords: breast cancer, temperament, anxiety, depression, neuroticism.
Relevance: Breast cancer (BC) is the most common disease among women in oncology practice. According to WHO data (2014), the incidence rate among women with breast cancer is 43.3 per 100 000 population.
Anxiety and depressive disorders are the major mental disorders in case of Breast Cancer [5; 7]. Depression is one of the most common mental illnesses among patients who have cancer. Diagnosis of depressive disorders in case of patients ill with cancer is still impeded because
of the fact that many symptoms of major depressive disorders (loss of appetite, weight loss, insomnia, loss of interests, cognitive impairment, fatigue and increased fatigability) are similar to signs of cancer. This causes additional challenges upon search for solutions of timely use of psychotherapeutic measures to eliminate depressive symptoms among oncologic patients. Taking into account a great risk of depression among oncologic patients it is suggested to conduct an early and timely psychological intervention to eliminate symptoms of depression [1; 2].
Sectiom 6. Medical science
Some therapies of cancer themselves may result in development of psychological disorders. Malaise and nausea is often accompanied by the radiation therapy. Complications caused by chemotherapy are nausea, vomiting, general weakness and emotional distress. Some patients become feel sick even in advance before the repeated course and can be so extremely intense that further treatment is impossible. In such cases the positive effects are often provided using measures aimed to eliminate anxiety as well as other psychotherapeutic methods [3; 4].
Introduction to the integrated treatment of psychological care on the basis of personal characteristics and emotional status is an important task to improve the patients' life quality ill with Breast Cancer.
Research objective: Study of interrelation of the level of anxiety and depression with temperament type of breast cancer patients.
Materials and research methods: 70 patients with breast cancer I-III stages were studied on the basis of Tashkent Regional Oncology Dispensary. The average age is 39.5 ± 12.5 years. All patients gave their voluntary consent to participate in the research. Patients suspected to have mental pathology and with apparent accentuations of personality traits have not been admitted to be enrolled. All patients have been received a combined treatment: surgery, radiation or drug therapy. The study was conducted during the period of drug therapy. The psychometric methods have been used as follows:
1) Hospital Anxiety and Depression Scale (HADS) developed by A. S. Zigmond and R. P. Snaith in 1983 to identify and evaluate the severity of anxiety and depression in general medical conditions [8];
2) Personal Inventory by D. Eysenck (EPI);
The received data was processed by statistical method.
Results: According to clinical and psychological studies the following results have been obtained. Melancholic amounted to 33%, choleric — 25%, phlegmatic — 23%, sanguine — 19%, level of neuroticism was high at 59%, average — 23% and low — 18%. Introverts amounted to 57%, extroverts — 43%. False responses were not found.
According to the Hospital Anxiety and Depression Scale (HADS) anxiodepressive state was detected among 25.7% pa-
tients. Increased anxiety was revealed among all patients, without exception. Clinical manifestation of anxiety was characterized by the prevalence of stress, confusion, emotional instability and irritation.
A quarter of patients were found to have depression (24.9%). A clinical presentation of depressive symptoms and signs was dominated with melancholy, low mood, anxiety, apathy and tearfulness.
Based on the received data it was found that a predominant type of temperament was melancholic, moreover introverts were greater than extroverts in number, and whether it is caused by psycho-emotional condition during disease as some authors suppose that introversion is a risk factor in the development of breast cancer [6], remains not investigated until last.
Comparative data analysis shows that anxious and depressive disorders are more manifested in case of introverts than extroverts.
Also worth noting is that according to the type of temperament and level of anxiety and depression the differences have been revealed. A level of anxiety and depression was higher in case of melancholic and choleric types whereas phlegmatic and sanguine indicators were lower.
Therefore the level of anxiety among women ill with breast cancer is interdependent with depression level and type of temperament. Based on the retrieved data it is possible to suggest that patients with breast cancer are characterized with single anxiety-depressive syndrome manifestation ofwhich depends on the severity of emotional state.
Anxiety is a significant factor in the patients' life quality for which reason an early psychological diagnostics of emotional peculiarities will allow to anticipate possible variations of personal emotionally colored reactions within the system of personality relations in progress of illness and arrange respectively a psycho prophylactic intervention.
Conclusion: Research on personality traits and manifestation degree of affective disorders in case of patients ill with breast cancer is an important component to choose treatment modalities and achieve adherence to the therapy. Therefore identified psychological peculiarities during research will be required while definition of the strategy ofpsychological counseling for patients with breast cancer.
References:
1. Avdeev, D. A. Depression - a passion and as a disease/AD Avdeev. - Moscow: Mir, - 2009. - 195.
2. Alexander, F. Psychosomatic Medicine/FM Alexander. - M.: Gerrus, - 2011. - 350 p.
3. Aseev A. V. Psychological problems associated with breast cancer//Clinical medicine. - 1993-3 - C. 30-34.
4. Demin, E.V, Chulkova, Blinov N. N. Quality of life of cancer patients: Methods of studying the physical, social and psychological adaptation of women with breast cancer and endometrial cancer//Questions of oncology. - 1990-36. - P. 360-364.
5. Depression and anxiety levels in woman under follow-up for breast cancer: relationship to coping with cancer and quality oflife/O. Kara-koyun-Celik [et al.]//Med. Oncol. - 2010. - Vol. 27 (1). - P. 108-13.
6. Jensen A. B. Psychosocial factors and breast cancer: areview/A. B. Jensen//Ugeskr.Laeger. - 1992. - Vol. 154, - N51. - P. 3666-3670.
7. Lim C. C. Anxiety in women with breast cancer undergoing treatment: a systematic review/C. C. Lim, M. K. Devi, E. Ang//Int. J. Evid. Based Healthc. - 2011. - Vol. 9 (3). - P. 215-35.
8. Zigmond A. S., Snaith R. P. The hospital anxiety and depression scale. Acta Psychiatr Scand - 1983;67 (6): 361-70.
