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Abstracts. PHYTOPHARM 2017
many of them. Considering the phrases used to describe the impact of these drugs, it seems some of them have temporary and some have lasting effects. Most of remedies have been advised to use with honey or yolk for increasing their effects. More studies would be necessary for evaluation of safety and efficacy of these herbs.
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VIOLA SYRUP AS AN ANTITUMOR FORMULA IN PERSIAN TRADITIONAL MEDICINE: IN-VITRO STUDY
© Parvin Pasalar1, Narjes Gorji2, Reihaneh Moeini2, Maliheh Paknejad1,Javad Hashemi1, Hossein Rezaeizadeh1, Mohammad Kamalinejad3, Siamak Salami3, Esmail Nazem 1
1 Tehran University of Medical Sciences, Tehran, Iran;
2 Traditional Medicine and History of Medical Sciences Research Center, Babol University of Medical Sciences Babol, Iran;
3 Shahid Beheshti University of Medical Sciences, Tehran, Iran
Complementary and Alternative Medicine (CAM), such as Persian medicine (PM) is a precious source of methods in the management of cancer. In this study one of the prescriptions of Persian Medicine was tested on a breast adenocarcinoma cell line (MDA- MB-468).
V. odorata L. was prepared as syrup and its anticancer properties was studied using flow-cytometry and MTT assay in compared to aqueous extract and sucrose alone. Two different cell lines were used in this study: breast cancer cell line (MDA-MB-468) and normal fibroblast cell (AGO-1522).
MTT and flow-cytometry assays showed a dose-dependent cytotoxic activity of V. odorata L.on MDA-MB-468, regardless of the preparation method. In the MTT assay; crude extract of v. odorata L., with or without
sucrose, had potent cytotoxic effect (IC50:1.36 mg/ ml and 0.23 mg/ml respectively) and no efficacy on the normal cells in these concentrations (P > 0.05). In flow-cytometry assay 2 mg/ml of viola syrup was the lowest concentration that significantly increased the cell apoptosis compared with negative control. The percentage of cell apoptosis was higher when cells were treated with 4 mg/nl of viola syrup compared to the positive H2O2 control (57.1% vs. 51%).
This study revealed that the cytotoxic activity of V. odorata L. was lower in the presence of sucrose. To better understand the potential benefits of this PM recommendation, more studies on the different two forms are required in gastric absorption, side effects and patient compliance.
ANTI-TUMOR ACTIVITIES OF PANAX QUINQUEFOLIUS SAPONINS AND POTENTIAL DIAGNOSTIC MARKERS IN PROSTATE CANCER
© Shan He, Fangqiao Lyu, Lixia Lou, Lu Liu, Songlin Li, Tianchi Jiang, Johannes Jakowitsch, Yan Ma
Division of Comparative Immunology and Oncology, Department of Pathophysiology and Allergy Research, Vienna General Hospital, Medical University of Vienna, Austria
Prostate carcinoma is one of the most commonly diagnosed types of cancer and the second most common cause of cancer mortality among men in the USA and in Europe. We aimed to define and explore new therapeutic approaches and novel biomarkers for diagnosis and treatment of prostate cancer.
The Chinese medicinal herb Panax quinquefolius has been tested for its tumor selectivity and cytotoxic efficacy. P. quinquefolius saponins (PQS) have been shown to have anti-tumor effects in vivo and in vitro. In this study human prostate cancer cells DU145 and immortalized normal prostate epithelial cells PNT2 were
Obzory po kliniceskoj farmacologii i lekarstvennoj terapii [Reviews of clinical pharmacology and drug therapy]
vol. 15/2017/suppLeMEnT 1
