МАШИНОСТРОЕНИЕ И МАШИНОВЕДЕНИЕ MACHINE BUILDING AND MACHINE SCIENCE
УДК 678.549 10.23947/1992-5980-2017-17-2-46-55
The safest point method as an efficient tool for reliability-based design optimization applied to free vibrated composite structures*.
G. Kharmanda .
Lund University, Lund, Sweden
Точечный метод как самый безопасный и эффективный инструмент для оптимизации на основе надежности
***
применительно к свободным вибрированным композитным структурам . Г. Харманда
Лундский университет, г. Лунд, Швеция
Introduction. Reliability-Based Design Optimization (RBDO) model reduces the structural weight in uncritical regions; it provides not only an improved design but also a higher level of confidence in the design.
Materials and Methods. The classical RBDO approach can be carried out in two separate spaces: the physical space and the normalized space. Since lots of repeated researches are needed in the above two spaces, the computational time for such an optimization is a big problem. Fortunately, an efficient method called the Hybrid Method (HM) has been elaborated by which the optimization process is carried out in a Hybrid Design Space (HDS). When designing free vibrated structures, the HM can be used with a big implementation complexity, and that leads to high computing time. An efficient method called Safest Point (SP) method is developed to overcome this drawback.
Research Results. A numerical application on the composite aircraft wing under free vibrations shows the efficiency of the proposed method relative to the HM. The SP method can reduce efficiently the computing time relative to the HM. Discussion and Conclusions. The simplified implementation framework of the SP strategy consists of decoupling the RBDO problem into a number of simple problems. That provides designers with efficient solutions that should be economically justified for a required reliability level for dynamic cases (modal studies).
Введение. Модель на основе оптимизации надежности (RBDO) снижает структурный вес в некритических регионах, обеспечивает не только улучшенный дизайн, но и более высокий уровень уверенности в конструкции. Материалы и методы. Классический подход RBDO может быть выполнен в двух отдельных пространствах: физическом и нормализованном. Так как в этих двух пространствах требуется очень много повторных исследований, решающее время для такой оптимизации - большая проблема. К счастью, был разработан эффективный метод, называемый гибридным методом (HM), посредством которого процесс оптимизации завершается в гибридном пространстве проектирования (HDS). При проектировании свободных вибрирующих структур HM может использоваться с большой сложностью реализации и приводит к большому времени вычислений. Для преодоления этого недостатка разработан эффективный метод под названием Safest Point (SP).
Результаты исследования. Численное приложение на крыле самолета при свободных колебаниях показывает эффективность предложенного метода относительно НМ. Метод SP может эффективно сократить время вычислений относительно HM.
Обсуждение и заключения. Упрощенная структура реализации стратегии SP состоит в разделении проблемы RBDO на ряд простых проблемах. Это обеспечивает конструкторам эффективные решения, которые должны быть экономически оправдывающими необходимый уровень надежности для динамических случаев (модальные исследования).
Keywords: Reliability-Based Design Optimization, structural Ключевые слова: оптимизация на основе надежности, струк-reliability, safety factors. турная надежность, факторы безопасности.
Introduction
The objective of the RBDO model is to design structures which should be both economic and reliable where the solution reduces the structural weight in uncritical regions. It does not only provide an improved design but also a higher level of confidence in the design. The classical approach can be carried out in two separate spaces: the physical space and the normalized space. Since very many repeated researches are needed in the above two spaces, the computational time for such an opti-
* Работа выполнено в рамках инициативной НИР.
** E-mail: [email protected]
. The research is done within the frame of independent R&D.
mization is a big problem [1,2]. The major difficulty lies in the evaluation of the probabilistic constraints, which is prohibitively expensive and even diverges with many applications. However, an efficient method called the Hybrid Method (HM) has been elaborated [3] where the optimization process is carried out in a Hybrid Design Space (HDS). This method has been shown to verify the optimality conditions relative to the classical RBDO method [3]. The advantage of the hybrid method allows us to satisfy a required reliability level for different cases (static, dynamic, ...), but the vector of variables here contains both deterministic and random variables. Next, an OSF (Optimum Safety Factor) methodology has been proposed to simplify the optimization problem (reduction of number of variables) and aims to find at least a local optimum solution because it is based on the optimality conditions [4,5,6]. However, the OSF method cannot be used in some dynamic cases of free vibrated structures. So there is a strong motivation to develop a new technique that can overcome both drawbacks. In this paper, an efficient method, called Safest Point (SP) method is developed to give the reliability-based optimum solutions. A numerical application on a free vibrated composite aircraft wing is presented to show the efficiency of the SP method relative to the HM.
Reliability Analysis
Structural reliability analysis is a tool that assists the design engineer to take into account all possible uncertainties during the design and construction phases and the lifetime of a structure in order to estimate the probabilities of failure. The evaluation of the probability of failure is carried out using numerical integrals. However, Hasofer and Lind [7] proposed to evaluate a reliability index instead of the numerical integral calculation. The reliability index can be found by solving the following constrained optimization:
P = min ^uru = min ^¿m2 j s.t. H (u)< 0 (1)
where H (u) is the limit state function in the normalized space (Figure 1). For more details about reliability index and probability of failure, the interested reader can see [8].
X2' \ Failure domain y)=0
0 V Physical space
U2 * у Failure domain Д H(x,u)<0 H(x,u)=0 ла *
0 > ul Normalized space
Fig. 1: The transformation between the physical space and normalized one Рис. 1: Преобразование между физическим и нормированным пространством Deterministic Design Optimization
In Deterministic Design Optimization (DDO), the system safety may be taken into account by assigning safety factors to certain structural parameters. Using these safety factors, the optimization problem which is carried out in the physical space (Fig. 1a), consists in minimizing an objective function (cost, volume of material,...) subject to geometrical, physical or functional constraints in the form
min : f (x) s.t. gk (x)< 0 , k = 1,...,K (2)
where x designates the vector of deterministic design variables. Over the last 20 years there has been an increasing trend in analyzing structures using probabilistic information on loads, geometry, material properties, and boundary conditions. Using Deterministic Design Optimization (DDO), we can distinguish between two cases:
Case 1: High reliability level: when choosing high values of safety factors for certain parameters, the structural cost (or weight) will be significantly increased because the reliability level becomes much higher than the required level for the structure. So, the design is safe but very expensive.
Case 2: Low reliability level: when choosing small values of safety factors or bad distribution of these factors, the structural reliability level may be too low to be appropriate. For example, Grandhi and Wang [9] found that the resulting reliability index of the optimum deterministic design of a gas turbine blade is p = 0.0053 under some uncertainties. This result indicated that the reliability at the deterministic optimum is quite low and needs to be improved by reliability-based design optimization.
Reliability-Based Design Optimization
Classical Method (CM)
Traditionally, for the reliability-based optimization procedure we use two spaces: the physical space and the normalized space (Figure 1). Therefore, the reliability- based optimization is performed by nesting the two following problems:
1 Optimization problem:
mm : f (x) s.t. : gk{ x )< 0and p( x,u) > p, (3)
where fx) is the objective function, gk(x) < 0 are the associated constraints, P(x,u) is the reliability index of the structure, and pt is the target reliability.
2 Reliability analysis:
The reliability index P(x,u) is determined by solving the minimization problem:
P = min d(us.t.:H(x,u)<0
(4)
where d(u) is the distance in the normalized random space and H(x,u) is the performance function (or limit state function) in the normalized space. Since a very large number of repeated searches are needed in the above two spaces, the computational time for such an optimization is a big problem. To reduce the effects of this difficulty, a hybrid method (HM) based on simultaneous solution of the reliability and the optimization problem has been elaborated [3].
Hybrid Method (HM)
The hybrid approach consists in minimizing a multiplicative form of the objective function F(x,y) subject to a limit state and to deterministic as well as to reliability constraints, as:
min: F (x,y ) = f (x). dp( x,y) s.t. : G(x,y) < 0
: gk (x)< 0
and : dp (x,y) > p,
Here, dp(x,y) is the distance in the hybrid space between the optimum and the design point, dp(x,y) = d(u). The minimization of the function F(x,y) is carried out in the Hybrid Design Space (HDS) of deterministic variables x and random variables y. An example of this HDS is given in figure 2, containing design and random variables, where the reliability levels dp
can be represented by ellipses in case of normal distribution, the objective function levels are given by solid curves and the limit state function is represented by dashed level lines except for G(x,y)=0. We can see two important points: the optimal solution P* and the reliability solution P* (i.e. the design point found on the curves G(x,y)=0 and dp = p).
(5)
Fig. 2: Hybrid Design Space for normal distribution Рис. 2: Гибридный дизайн пространства для нормального распределения
The hybrid approach leads to a high computing time especially when considering the dynamic cases. So we develop an efficient technique called Safest Point method (SP).
Safest Point Method (SP)
Let consider a given interval [f,f,]. For the first shape mode, to get the reliability-based optimum solution for a given interval, we consider the equality of the reliability indices (Pa = P) with
P =
and p
i = 1,...,n
(6)
Here, we distinguish between two cases.
Case 1: Non-symmetric: u" uf or |m°| ^ |wf |
The reliability-based optimum structure under free vibrations for a given interval of eign-frequency is found at the safest position of this interval where the safest point has the same reliability index relative to both sides of the interval (Figure 3). A simple method has been proposed here to meet the safest point requirements relative to a given frequency interval. The basic principle is to decompose the RBDO problem into three simple optimization problems. Problem 1:
- The first problem consists of minimizing the objective function of the first structure subject to the frequency fa constraint as follows
min : f (yo) s.t. : freqa (yo)- f < 0 (7)
Problem 2:
- The second problem consists in minimizing the objective function of the second structure subject to the frequency fb constraint as follows
min : fb (yb) s.t. : freqb (yb)- f < 0 (8)
Problem 3:
- The third is to minimize the objective function of the third model subject to the equality reliability constraints and the boundary frequency interval as follows:
min: f (x)
s.t. : Pa -Pb = 0 (9)
and : fa < freq (x )< f
Fig. 3: The safest point at frequency fn Рис. 3: Самая безопасная точка на частоте fn
Case 2: Symmetric: u"t = - u. or |uf| = |u. | Problem 1:
- The first problem consists in minimizing the objective function of the first structure subject to the frequency fa constraint as
follows
min : f (ya) s.t. : freq° (ya)-fa < 0 (10)
Problem 2:
- The second problem consists in minimizing the objective function of the second structure subject to the frequency fb constraint as follows
min : fb (y. ) s.t. : freqb (y. )- fb < 0 (11)
To verify the equality (16), we propose the equality of each term. So we have:
ua = — ubt , i = 1,..., n (12)
According to the normal distribution law, the normalized variable u is given by (12), we get:
ya — m yb — m ya — x. yb — x.
y-L =—y-^ , or y-^ =—y-^ , i = 1,...,n (13)
CTi CTi CTi CTi
To obtain equality between the reliability indices (see equation 16), the mean value of variable corresponds to the
structure atfn. So the mean values of safest solution are located in the middle of the variable interval [ y°,yb ] as follows:
ya + yb
m = x = -—— , i = 1,...,n (14)
' ' 2
In the next section, we demonstrate the efficiency of the proposed method on a numerical application of a composite aircraft wing under free vibrations for both cases (equality and inequality).
Numerical application on composite aircraft wing
The wing is uniform along its length with cross sectional area as illustrated in Figure 8a. It is firmly attached to the body of the airplane at one end. The chord of the airfoil has dimensions and orientation as shown in Figure 5. The wing is made of two different low density polyethylenes with the following properties:
Table 1 Таблица 1
Input parameters Входные параметры
Parameters Mat 1 Mat 2
Young's modulus (psi) 18.000 38.000
Poisson's ratio 0.3 0.3
Density (1bf-sec2/in4) 8.3E-5 8.3E-5
Effective thickness (m) 0.025 0.025
Assume the side of the wing connected to the plane is completely fixed in all degrees of freedom. The wing is solid and material properties are constant and isotropic.
Fig. 4: Aircraft wing section and materials Рис. 4: Сечение крыла самолета и материалы The objective is to find the Eigen-frequency for a given interval [16,18] Hz, that is located on the safest position of this interval. So the first structure corresponds to the first frequency value of the given interval fa=16 Hz, and the third structure corresponds to the last frequency value of the given interval f=18 Hz. However, the second structure corresponds to the unknown frequency valuef=? Hz, which must verify the equality of reliability indices: Pa = P4 (see Figure 5).
Fig. 5: Aircraft wing optimization models Рис. 5: Модели оптимизации крыла самолета
Figure 6 shows the first shape mode of each structure, where the maximum values of displacements are located on the free wing side and the minimum values (zeros) of displacement is located at the fixed side.
Structure fa
Structure fb
Structure fn
Fig. 6: Shape modes Рис. 6: Режимы формы
Here, we can deal with two reliability-based design optimization methods: hybrid and safest point methods. The hybrid method (HM) simultaneously optimizes the three structures but the safest point method consists in optimizing three simple problems. So we distinguish two cases: u° ф - u] and u° = - u] : as follows:
Case 1: Non-symmetric: u° ф- u] or |u°| ф |uf|
1- HM procedure: We minimize the multiplicative form of the objective function subject to the different frequencies constraint
and the reliability one as follows:
min : Voln (mAmD(AaDa,mAmD).dh (Ab,...,Db,mA,...,mD)
s.t. : Pa (Aa,...,Da ,mA,...,mD)-Pb (Ab,...,Db ,mA,...,mD) = 0 (15)
and fa < freq" (mA, mB, mc, mD ) < fb
2- SP procedure: We have three simple optimization problems:
- The first is to minimize the objective function of the first model subject to the frequency fa constraint as follows:
min
in : Vola (A, Ba, C,, Da ) s.t. : freqa (Aa, Ba, Ca, Da ) - fa < 0
(16)
- The second is to minimize the objective function of the second model subject to the frequency fb constraint as follows:
min : Volf (Af, Bb, C„, Db) s.t. : freqb (A, Bb, C„, Db) - f < 0 (17)
- The third is to minimize the objective function of the third model subject to the equality reliability constraints and the boundary frequency interval as follows:
min : voin ( m, m, m, m )
s.t. : Pa (Aa,...,Da,Ma,...,Md)-p4 (Ab,...,Db,Ma,...,Md) = 0
and fa < freq" (ma , Mb , mc , Md ) < fb
Table 2 Таблица 2
Results of the aircraft wing for the first case Результаты применения методов для первого случая
Variables Initial design Optimum design with SP Optimum design with HM
A 0.04 0.03948 0.03960
FN B 0.05 0.04138 0.04758
C 1.00 0.98826 0.98815
D 0.425 0.47733 0.41764
A1 0.02 0.02730 0.02944
FA B1 0.02 0.02004 0.02531
C1 0.9 0.90021 0.91867
D1 0.5 0.49983 0.48806
A2 0.06 0.05346 0.05688
FB B2 0.08 0.06088 0.06386
C2 1.1 1.0002 1.0581
D2 0.35 0.42485 0.37862
FA 15.60 16.001 16.100
FB 18.55 17.999 17.903
FN 16.91 16.814 16.796
DIF = ß1-ß2 0 -0.00578 -0.09884
volume 0.334 0.280 0.310
Time(S) - 280 1920
Table 2 shows the results of the hybrid and SP methods for the first case when considering a given interval [16,18] Hz. The value offn presents the equality of reliability indices. The SP method reduces the computing time by 85% relative to the hybrid method. The advantage of the SP method is simple to be implemented on the machine and to define the eigen-frequency of a given interval and provides the designer with reliability-based optimum solution with a small tolerance relative to the hybrid method. So this method can be also a conjoint of the OSF method. Case 2: Symmetric: uf = - ub or |u°| = |uf|
1- HM procedure: We minimize the multiplicative form of the objective function subject to the different frequencies constraint
and the reliability one as follows:
mm : Voln (mA,...,mD ). (Aa,...,Da,mA,...,mD). {Ab,...,Db,mA,...,mD)
St : dp a (AaDa , mA ,..., mD )-dPb (Ab ,..., Db , mA ,..., mD )= 0
: UA (Aa , mA ) + UA (Ab , mA ) = 0
: UB (Ba , mB ) + K (Bb , mB ) = 0 (19)
: uac (Ca, mc ) + ubc (Cb,mc) = 0
: uD (Da , mD ) + uD (Db, mD) = 0
: freqa (Aa , Ba , Ca , Da ) - fa < 0
: freqb (Ab, Bb, Cb, Db) - fa < 0
2- SP procedure: We have two simple optimization problems and a model evaluation:
- The first is to minimize the objective function of the first model subject to the frequency fa constraint as follows:
min : Vola (Ac , Ba, Ca, Da) s.t. : freqa (Ac , Ba, Ca, Da) - fa < 0 (20)
- The second is to minimize the objective function of the second model subject to the frequency fb constraint as follows:
min : Volb (Ac , Bb, Cb, Db) s.t. : freqb (Ab, Bb, Cb, Db) - fb < 0 (21)
- The model evaluation leads to analytically compute the mean values corresponding to the frequency fn
A + Ah
" ' (22)
B + B (23)
(24)
(25)
2
Cq +C
2
Da + Db
D 2
That leads to Voln (mA, mB, mc, mD) and f < freqn (mA, mB, mc, mD) < f •
Table 3 shows the results of the hybrid and SP methods for the second case when considering a given interval [16,18] Hz. The value of fn presents the equality of reliability indices and the equality case uQ = - ubt . The SP method reduces the computing time by 91% relative to the hybrid method. In the hybrid problem (19), we need a high computing time because of the big number of optimization variables and of constraints relative to hybrid problem (15). The advantage of the SP method is simple to be implemented on the machine and to define the eigen-frequency of a given interval and provides the designer with reliability-based optimum solution with a small tolerance relative to the hybrid method. So this method can be also a conjoint of the OSF method.
Table 3 Таблица 3
Results of the aircraft wing for the second case Результаты применения методов для второго случая
mB =
mc =
Variables Initial design Optimum design with SP Optimum design with HM
A 0.04 0.04028 0.04204
FN B 0.05 0.04046 0.04664
C 1 0.95020 0.9979
D 0.425 0.46234 0.42683
A1 0.02 0.02730 0.02639
FA B1 0.02 0.02004 0.02615
C1 0.9 0.90021 0.90971
D1 0.5 0.49983 0.49124
A2 0.06 0.05346 0.05739
FB B2 0.08 0.06088 0.06669
C2 1.1 1.0002 1.0921
D2 0.35 0.42485 0.36206
FA 15.60 16.001 16.100
FB 18.55 17.999 17.908
FN 16.91 16.920 16.874
DIF = P1-P2 0 -0.00578 0.10125
surface 0.334 0.279 0.320
Time(S) - 230 2700
Conclusion
A RBDO solution that reduces the structural weight in uncritical regions both provides an improved design and a higher level of confidence in the design. The classical RBDO approach can be carried out in two separate spaces: the physical space and the normalized space. Since very many repeated searches are needed in the above two spaces, the computational time for such an optimization is a big problem. The structural engineers do not consider the RBDO as a practical tool for design optimization. Fortunately, an efficient method called the Hybrid Method (HM) has been elaborated where the optimization process is carried out in a Hybrid Design Space (HDS). However, the vector of variables here contains both deterministic and random variables. The RBDO problem by HM is thus more complex than that of deterministic design. The major difficulty lies in the evaluation of the structural reliability, which is carried out by a special optimization procedure. The use of HM necessitates a high computing time and a complex implementation. The SP method is proposed to overcome this drawback. As it is shown in the numerical application on a composite aircraft wing under free vibrations, the SP method can reduce efficiently the computing time relative to the HM.
References
1. Feng Y.S., Moses , F. A method of structural optimization based on structural system re-liability. J. Struct. Mech., 1986, no.14, pp.437-453.
2. TU J, Choi, K.K., Park, Y.H. A new study on reliability-based design optimization. Journal of Mechanical Design, ASME, 1999, no. 121(4), pp. 557-564.
3. Kharmanda, G., Mohamed, A., Lemaire, M. Efficient reliability-based design optimization using hybrid space with application to finite element analysis. Structural and Multidisciplinary Optimization, 2002, no. 24, pp.233-245.
4. Kharmanda, G., Antypas, I.R. Reliability-Based Design Optimization Strategy for Soil Tillage Equipment Considering Soil Parameter Uncertainty.]Vestnik of DSTU, 2016, vol. 16, no. 2 (85), pp. 136-147.
5. Kharmanda, G., Antypas, I.R. Integration of reliability and optimization concepts into composite yarns. Sostoyanie i perspektivy razvitiya sel'skokhozyaystvennogo mashinostroeniya Sbornik statey 10-y Mezhdunarodnoy yubileynoy nauchno-prakticheskoy konferentsii v ramkakh 20-y Mezhdunarodnoy agropro-myshlennoy vystavki "Interagromash-2017". [State and prospects of agricultural engineering development: Proc. 10th Int. Sci.-Pract. Conf. within framework of 20th Int. Agroindustrial Exhibition "Interagromash-2017".] Rostov-on-Don: DSTU Publ. Centre, 2017, pp. 174-176.
6. Kharmanda, G., Antypas, I.R. System reliability-based design optimization using optimum safety factor with application to multi failure fatigue analysis. Sostoyanie i perspektivy razvitiya sel'skokhozyaystvennogo mashinostroeniya Sbornik statey 10-y Mezhdunarodnoy yubileynoy nauchno-prakticheskoy konferentsii v ramkakh 20-y Mezhdunarodnoy ag-ropro-myshlennoy vystavki "Interagromash-2017". [State and prospects of agricultural engineering development: Proc. 10th Int. Sci.-Pract. Conf. within framework of 20th Int. Agroindustrial Exhibition "Interagromash-2017".] Rostov-on-Don: DSTU Publ. Centre, 2017, pp. 177-179.
7. Hasofer, A.M., Lind, N.C. An exact and invariant first order reliability format. J. Eng. Mech, ASCE, EM1, 1974, iss. 100, pp. 111-121.
8. Kharmanda, G., Antypas, I.R. Integration of Reliability Concept into Soil Tillage Machine Design. Vestnik of DSTU, 2015, vol. 15, no. 2 (81), pp. 22-31.
9. Grandhi, R.V., Wang, L. Reliability-based structural optimization using improved two-point adaptive nonlinear approximations. Finite Elements in Analysis and Design, 1998, no. 29, pp. 35-48.
Библиографический список
1. Feng Y.S. A method of structural optimization based on structural system reliability/ Y.S.Feng, F. Moses // J. Struct. Mech. - 1986 -14, P.437-453.
2. TU J. A new study on reliability-based design optimization / TU J., K.K. Choi., Y.H. Park //Journal of Mechanical Design, ASME - 1999 -121(4), 557-564
3. Kharmanda G. Efficient reliability-based design optimization using hybrid space with application to finite element analysis/ G. Kharmanda, A. Mohamed, M. Lemaire // Structural and Multidisciplinary Optimization- 2002- 24, P.233-245.
4. Kharmanda G. Reliability-Based Design Optimization Strategy for Soil Tillage Equipment Considering Soil Parameter Uncertainty / G. Kharmanda, I.R. Antypas // Vestnik of DSTU, vol. 16 (2), pp 136-147, 2015. ISSN 1992-5980.
5. Kharmanda G.: Integration of reliability and optimization concepts into composite yarns / G. Kharmanda, I. Antypas //10-th International Scientific-Practical Conference of Current Status and Prospects of Agricultural Engineering, "IN-TERAGROMASH-2017". 1-3 March, 2017, Rostov-on-Don, Russia, DSTU Publ. Centre, pp. 174-176.
6. Kharmanda G. System reliability-based design optimization using optimum safety factor with application to multi failure fatigue analysis / G. Kharmanda, I. Antypas // 10-th International Scientific-Practical Conference of Current Status and Prospects of Agricultural Engineering, "INTERAGROMASH-2017", 1-3 March, 2017, Rostov-on-Don, Russia, DSTU Publ. Centre, pp. 174-176.
7. Hasofer A.M. An exact and invariant first order reliability format / A.M. Hasofer, N.C. Lind // J. Eng. Mech, ASCE, EM1- 1974 - 100, P.111-121.
8. Kharmanda G. Integration of Reliability Concept into Soil Tillage Machine Design / G. Kharmanda, I. Antypas // Vestnik of DSTU - 2015 - vol. 15 (2), P. 22-31, 2015. ISSN 1992-5980.
9. Grandhi R.V. Reliability-based structural optimization using improved two-point adaptive nonlinear approximations /R.V. Grandhi, L. Wang // Finite Elements in Analysis and Design - 1998 -29, P.35-48.
Поступила в редакцию 24.03.2017 Сдана в редакцию 24.03.2017 Запланирована в номер 05.04.2017
Об авторе: Гиас Харманда,
приглашенный научный сотрудник кафедры биомедицинской инженерии Лундского университета (Ole Rômersvâg 1, Box 118, 221 00 Lund, Sweden), ORCID: http://orcid.org/0000-0002-8344-9270 [email protected]
Received 24.03.2017 Submitted 24.03.2017 Scheduled in the issue 05.04.2017
Author:
Ghias Kharmanda,
guest researcher of the Department of Biomedical Engineering, Lund University (Ole Römersväg 1, Box 118, 221 00 Lund, Sweden),
ORCID: http://orcid.org/0000-0002-8344-9270 [email protected]