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ПРЕДСТАВЛЕНИЕ НАУЧНОЙ РАБОТЫ
SELECTION OF BASES FOR SUPPOSITORIES OF KOGLUMET
Kozimjonova Nasiba Saminjon qizi, Umarova Firuza Alisherovna, Tashkent Pharmaceutical Institute, Tashkent, Uzbekistan
E-mail: [email protected]
Abstract. Based on the study of the technological properties of the substance of coglumet, as well as the study of various lipophilic characters on the quality indicators of suppositories, a scientifically based technology of suppositories was selected. The optimal parameters of the technological process of obtaining suppository mass. The technology for producing suppositories of Coglumet of 0.21 g was tested in Biocom LLC.
Key words: substance "Koglumet", test, immunomodulatory effects.
The purpose of the research. The purpose of the work was the development of technology and the assessment of the quality of dosage forms in the form of suppositories of coglumet with antiviral and immunomodulatory effects.
Research methods. The objects of research were the substance "Koglumet" (FS 42 Uz 1304-2011) with immunomodulatory and antiviral properties, as well as a number of lipophilic bases permitted for medical use. Koglumet was first synthesized at AV-Biocom LLC, which is an amorphous brownish brown powder with a specific smell, sour-salty taste, slightly hygroscopic, soluble in water, practically insoluble in chloroform and ether.
The drug has officially passed clinical trials at the Research Institute of Dermatology and Venereology of the Ministry of Health of the Republic of Uzbekistan and the City Center for the Rehabilitation of Chronic and Infectious-Somatic Pathologies (protocol No. 1 of December 31, 2006) [1; 3; 4].
Main results. When developing suppositories on the basis of the substance Koglumet based on the recommendations of pharmacologists and toxicologists adhered to an optimal concentration of 5%. The determining factor in determining the effective action of the suppository medicinal substance is the choice of the base. In order to select the optimal suppository formulations that provide the maximum speed
ВЕСТНИК НАУКИ И ТВОРЧЕСТВА
and completeness of the release of the active substances, suppositories were prepared as models on lipophilic and hydrophobic bases. Supporin-M (Supporinum-M) VFS 42-173-98, which consists of 95% of hydrogenated cottonseed oil (GOST 28414-89) and 5% T-2 emulsifier, was used as the lipophilic base. Supporin-M is a mass of light yellow color with a slight specific smell, uniform color, solid at room temperature. The base is easily melted and completely releases the medicinal substance, mixes well with medicinal substances with different physicochemical properties, is easily formed and does not irritate the rectal mucosa. Melting point 34-36.80 C, freezing point -23.20 ° C, full deformation time 6-8 minutes.
Conclusions. Based on the above, it can be concluded that to create suppositories based on the drug substance Koglumet, which has an immunomodulatory and antiviral effect, we used lipophilic bases for suppositories of local origin called Supporin-M and "Enzifob".
Suppositories were obtained by pouring. Ready suppositories were evaluated by ND. During the experiment, it was found that both lipophilic bases can be used to obtain suppositories of coglumet.
References:
1. Akbarov A.B., Makhmudjanova K.S., Umarova F.A. Temporary pharmacopoeial monograph on tablets "Coglumet 0,21 g" VFS. 42 Uz-1304-2011.
2. Yemshanova S.V. Quality assurance of domestic medicines. Abstract of Dissertation of Doctor of Pharmaceutical sciences. - 2007. - p. 48.
3.Tsh 42-01: 2002 "Standards for the quality of medicines". The main provisions.
