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ПРЕДСТАВЛЕНИЕ НАУЧНОЙ РАБОТЫ
DEVELOPMENT OF MEDICINAL POLYMER
Umarova Firuza Alisherovna, Ramazonova Shahzoda Shoyim qizi, Kozimjonova Nasiba Saminjonqizi, Normatov Sanjar, Tashkent Pharmaceutical Institute, Tashkent, Uzbekistan
E-mail: [email protected]
Abstract. The composition and technology of medicinal polymer films for dentistry containing aqueous extraction of medicinal sage and chlorhexidine have been developed. As the film-forming base, sodium carboxymethyl cellulose, polyvinylpyrrolidone gelatin and water were used. The physicochemical properties of the finished polymer films are given.
Key words: medicinal polymer films, sage, sodium carboxymethyl cellulose (Na-RMC), polyvinylpyrrolidone (PVP), gelatin, chlorhexidine, physicochemical properties.
Introduction. Currently, in the treatment of inflammatory diseases of the oral mucosa, namely the periodontium, traditional dosage forms, such as rinses, pastes, gels and aerosols, are most often used. However, the use of many of them leads to a number of complications, which significantly reduces their healing properties. Although the oral cavity, teeth and gums are isolated areas, the continuous moistening of their saliva causes a rapid leaching of the drug into the lower parts of the oral cavity, which requires repeated administration of the drug. In this regard, the creation of prolonged dosage forms, in particular dental films with anti-inflammatory effects, wound healing and antibacterial activity, is of great importance for use in dentistry.
One of the most promising areas of drug technology is the development of periodontal dental films based on polymers. This dosage form, compared with traditional ones, has a number of advantages: pronounced bioavailability, prolonged action, accuracy of dosing of the active substance, significantly reduces treatment time, is better tolerated by patients and reduces the number of procedures. In modern dentistry, the following tasks are solved: strengthening and improving the protective properties of the gums, reducing inflammatory diseases of the oral mucosa and reducing tooth decay. Antioxidants are often used in dentistry to solve these problems.
ВЕСТНИК НАУКИ И ТВОРЧЕСТВА
Currently, a promising antioxidant is sage. In official medicine, sage is best known for its anti-inflammatory and antimicrobial properties, which make rinsing the mouth and throat effective for treating inflammation, ulcers, etc. In scientific works, I.N. Zilfikarova et al. Provide information that sage extracts due to rosmarinic and salvianolic acids have pronounced antioxidant properties. In addition to antioxidant activity, sage also has wound healing and anti-inflammatory properties. This is explained by the fact that carnosol and karnic acid of sage inhibit the formation of prostaglandin E2, which explains its anti-inflammatory properties, which are necessary in the treatment of the above diseases [1,8,9].
The aim of this work was to develop the composition of medicinal films for the treatment of inflammatory periodontal diseases with wound healing and antimicrobial effects.
Material and methodology. The objects of research were selected aqueous extraction of sage Salvia officinalis L., which is widely used in dental practice, has an antioxidant and anti-inflammatory effect, helps cleanse wounds from necrotic tissues, stimulates their healing. Chlorhexidine, a drug with antiseptic and disinfectant properties, which has been successfully used in dentistry for traumatic injuries of the oral cavity, was also chosen to prevent inflammation after tooth extraction and other dental operations. In addition, the introduction of chlorhexidine in the composition of the films guarantees an extension of the shelf life, and also prevents the development of undesirable microflora of the film surface during its storage [4].
At the first stage of the research, the selection of polymers for drug matrix carriers was carried out. As the basis of the drug, we used high molecular weight compounds: sodium carboxymethyl cellulose (Na-KMC), polyvinylpyrrolidone (PVP), gelatin and their combinations with each other.
As a result of studying the performance of experimental samples of films, it was found that the most optimal is the following composition of the medicinal film shown in table-1. To prepare the film mass, the required amount of gelatin was placed in a vessel, water extraction of sage was added, and left to swell for 40-60 minutes. Next, the temperature was raised to 60° C and stirred for 30-40 minutes until completely dissolved. At the same time, a Na-KMC solution was prepared in the same way. The obtained gel-forming solutions were filtered into a vessel, the required amount of chlorhexidine was added and mixed until a homogeneous mass was obtained for 3040 minutes. The prepared film mass was defended for 1 hour at a temperature of about 40° C until the complete removal of air bubbles. After that, the film mass was poured in a warm form onto glass substrates and then naturally dried at room temperature. Finished films were removed from the substrate and weighed. In appearance, the films were flexible elastic plates of light brown color with a specific smell and taste characteristic of the organoleptic properties of sage. The obtained organoleptic properties of the films made it possible to dispense with the introduction of flavoring agents into them. The resulting films were well separated from the glass surface, were homogeneous.
ВЕСТНИК НАУКИ И ТВОРЧЕСТВА
One of the main requirements for medical films is humidity. Since humidity is one of the criteria for the stability of films during storage. As shown in the literature, the optimum moisture content of the films should be in the range of 6-12%. If the moisture value in the film is less than normal, then the film will be brittle, and vice versa with a larger value it becomes sticky. Since the humidity of the films obtained by us was about 35%, drying was used in the drying oven at a temperature recommended by the literature for t = 45 ± 2 ° C [5,6,7]. This allowed to reduce the moisture content of the films up to 14%. The data obtained are shown in table-1.
Table 1
Physico-chemical characteristics of the obtained films
№ Film composition Appearance Humid-it, % Thickness, mm Dissolution time, min pH
1 Na-KMC - 2.0; Gelatin - 2.0; PVP - 2.0; Chlorhexidine - 0.01 Water purified - 100 Flexible elastic plates of light brown color with a specific smell and taste characteristic of sage 16,03± 0,12 0,54± 0,03 15,0± 0, 56 6,14 ± 0,03
2 Na-KMC- 2.0; Gelatin - 2.0; PVP - 2.0; Water purified - 100 Flexible elastic plates of light brown color with a specific smell and taste characteristic of sage 13,08± 0,15 0,60± 0,07 20,0± 0,70 6,14 ± 0,03
Another criterion for films is the dissolution time, which characterizes the ability of the films to completely absorb in the oral cavity and depends on the duration of the active substance. To prolong resorption and reduce solubility, films of various thicknesses were obtained. During the study, it was found that the films also differed in the presence of chlorhexidine in their composition. Films in the composition of which chlorhexidine was not introduced having similar moisture indicators, with an increase in their thickness, had a lower solubility, but generally met the requirements for medicinal films.
Medicinal films, in which chlorhexidine was introduced, with an increase in their thickness, had a higher humidity. To reduce to normalized indicators, it is necessary to develop a drying method for such dosage forms. The drug film with a thickness of 0.54 mm met the requirements of the films.
Conclusions. As a result of experimental studies on the creation of medicinal dental films based on products of natural origin, it was possible to develop optimal compositions of therapeutic and prophylactic agents. The obtained dental films allow us to recommend not only for treatment, but also for the prevention of oral mucous membranes, in particular periodontitis.
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ВЕСТНИК НАУКИ И ТВОРЧЕСТВА
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