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1РАСТЕНИЯ С АДАПТОГЕННОИ И АНТИГИПОКСАНТНОИ АКТИВНОСТЬЮ
(Обзор литературы)
Абдиназаров Иброхим Туйчиевич
Институт химии растительных веществ АНРУз Саноев Зафар Исомиддинович
Институт химии растительных веществ АНРУз Ташкентский государственный стоматологический институт
В обзорной статье представлены данные о распространенности, химическом составе, общей фармакологической активности, а также специфической адаптогенной и антигипоксической активности лекарственных растений, широко используемых в практике, на основе статей, опубликованных в отечественных и зарубежных журналах за последние годы. Описаны компоненты, биологически активные вещества этих растений, а также особенности их применения в медицинской практике.
Ключевые слова: женьшень, радиола, адаптоген, антигипоксант, фармакологическая активность, применение.
ADAPTOGEN VA ANTIGIPOKSANTFAOLLIKKA EGA BO'LGAN O'SIMLIKLAR
(Adabiyotlar sharxi)
Tahliliy maqolada so'nggi yillarda mahalliy va xorijiy jurnallarda chop etilgan maqolalar asosida amaliyotda keng qo'llaniladigan dorivor o'simliklarning tarqalishi, kimyoviy tarkibi, umumiy farmakologik faolliklari hamda spetsifik adaptogen va gipoksiyaga qarshi faolliklari to'g'risida ma'lumotlar keltirilgan. Ushbu o'simliklarning tarkibiy qismlari, biologik faol moddalari hamda ularning tibbiyot amaliyotida qo'llanilishining o'ziga xos xususiyatlari bayon etilgan.
Kalit so'zlar: jenshen, radiola, adaptogen, antigipoksant, farmakologik faollik, qo'llanilishi.
PLANTS WITHADAPTOGENICAND ANTIHYPOXANTACTIVITY
(Literature review)
The review article presents data on the prevalence, chemical composition, general pharmacological activity, as well as specific adaptogenic and antihypoxic activity of medicinal plants widely used in practice, based on articles published in domestic and foreign journals in recent years. The components, biologically active substances of these plants, as well as the features of their use in medical practice are described.
Keywords: ginseng, radiola, adaptogen, antihypoxant, pharmacological activity, application.
Kirish. Adaptogenlarning faol moddalari inson tanasining mudofaasini uyg'un tarzda safarbar qiladi, to'qima almashinuviga ta'sir qiladi, ekstremal tashqi ta'sirlarni keltirib chiqaradigan, jismoniy va aqliy faoliyatini normallashtiragan yoki oshiradigan kasalliklarning rivojlanishini oldini oladi. Adaptogenlar - stimulyatorlar va tonusni oshiradigan dorilar o'rtasidagi asosiy farq barqaror dinamik muvozanatni tiklash, ishlashni yaxshilash va samaradorlikni oshirish, bu ularni qabul qilish boshlanishidan oldingi dastlabki darajaga qaytmaydi. Antigipoksant faollikdagi preparatlar esa organizmni kislorodga bo'lgan ehtiyojini kamaytirib, og'ir kasalliklarda va yuklamalarda chidamlilikni oshirishga sababchi bo'ladi. O'simlik asosida olinadigan preparatlar tibbiy xususiyatlarga ega bo'lgan yoki dorivor xossaga ega turli o'simliklarning barglari, ildizlari, urug'lari, po'stlog'i, mevalari, poyalari yoki gullaridan ishlab chiqariladi. O'simlik dori-darmonlari FDA tomonidan farmatsevtika sanoatida tartibga solinmaganligi sababli, ular sotilishidan oldin
retsept bo'yicha dori-darmonlarni qabul qiladigan keng ko'lamli sinovlardan o'tishlari shart emas [1]. O'simliklar tarkibining asosiy qismlari uglevodlar, oqsillar, lipidlar va nuklein kislotalar hamda ikkilamchi metabolitlari terpenoidlar, flovanoidlar, alkaloidlar va fenol birikmalari muhim ahaniyat kasb etadi. Bular antiaterogen, gepatoprotektor, mikroblarga qarshi, virusga qarshi, antibakterial, o'smaga qarshi, allergiyaga qarshi, trombolitik, kardioprotektor va vazodilatator kabi biologik faolliklari uchun keng qadrlanadi [2]. Bu biologik xususiyatlar bilan bir qatorda antioksidant va oksidlanish-qaytarilish xususiyatlari bilan ajralib turadi va ular erkin radikallarni zararsizlantirishda hal qiluvchi rol o'ynaydi [3]. Organizm darajasida adaptogenlarning ta'sir qilish tartibi ba'zan yengil deb ataladi. Buni tekshiruvlarda kortikosteronning pastroq chiqishi bilan kuzatish mumkin adaptogenni olgan sub'ektlarda eksperimental ravishda qo'zg'atilgan stress sharoitlari taqqoslandi ushbu stressga qarshi vosita berilmaganlarni nazorat qilish uchun [4]. Bundan tashqari, o'simlik moddalari turli xil farmakologik ta'sirga, shu jumladan yallig'lanishga qarshi faolliklni namoyon qiladi. Eleutherococcus senticosus, Rhodiola rosea ekstraktlari izolyatsiya qilingan miya hujayralarida yallig'lanish yuzaga keltiradigan leykotriyenlar hujayra biosintezini boshqaradigan asosiy genlarning faolligini kamaytiradi [5]. Bundan tashqari, ko'plab tadqiqotlar taniqli adaptogen, Panax ginsengning yallig'lanishga qarshi salohiyatini mavjudligini isbotlaydi [6]. Shuningdek uning faolligi molekulyar darajada, in vitro modellarida ham tasdiqlandi. Hozirgacha ma'lum bo'lganidek, molekulyar darajada faol adaptogenlarning birikmalari antioksidant fermentlarni, neyropeptidlarni (masalan, NPY), o'sishni qo'zg'atadigan va apoptozni ingibirlovchi omillar (masalan, BDNF) hamda signalizatsiya yo'llari asoslantirilgan [7]. Ushbu faollik neyrodegenerativ kasalliklarni davolashda muhim rol o'ynaydi [8]. Texnik uzum navlari asosida olingan ekstrakt eksperimental tajribalar asosida isbotlangan gipoksiyaga qarshi faollikni namoyon qilganligini ko'rish mumkin [9]. Tribulus Terrestris L. ekstrakti turli dozalarda laboratoriya hayvonlarida o'tkazilgan tajribalarda gipoksiyaga qarshi faollikni namoyon qilgan [10]. Bir guruh olimlar tomonidan [11-20] o'tkazilgan tajribalarda o'simlik tarkibidan va yarim sintez yo'li bilan ajratib olingan alkoloidlar turli xil psixofarmakologik faolliklarni, jumladan, depressiyaga qarshi, tutqanoqqa qarshi, neyroleptik, psixostimullovchi va boshqa markaziy nerv tizimiga ta'sir ko'rsatuvchi faolliklari haqida ma'lumotlar keltirilgan.
Quyida yuqori adaptogen faolliklarni namoyon qiluvchi o'simliklar haqida ma'lumotlarni keltirib o'tamiz.
Panax Ginseng
Panax ginseng (Panax ginseng C. A. Mey.) o'simligini 2000 yildan ortiq vaqt davomida foydalanib kelishmoqda [21]. Ilgari ginsengning poyalari, barglari va asosan ildizlari ishlatilgan. Ekstraktlar inson tanasida gomeostazni ta'minlash, charchoq va zaiflikni davolash, immunitetni oshirish va gipertenziya, diabetning 2 turi va erektil disfunktsiyani davolash uchun tayyorlangan va ishlatilgan [21-24]. Xitoy an'anaviy tibbiyotida ginseng ekstraktlari nootrop moddalar va tonusni oshiruvchi vosita sifatida ishlatilgan [22-24]. Panax ginsengining adaptogen ta'sirining aniq mexanizmi noma'lum, ammo u gipotalamus-gipofiz-buyrak usti bezi o'qiga ta'sir qiladi va antioksidant faollikni ham namoyon qiladi [25-27]. Panax ginseng ekstraktini qabul qilish plazma lipid profilining yaxshilanishi va qon glyukoza darajasi bilan bog'liq. Panax ginseng ekstraktlari yurak-qon tomir kasalliklari, giperlipidemiya va diabet bilan og'rigan bemorlarning ratsioniga kiritilishi mumkin. O'simlikdan olingan ekstraktlar nafaqat kognitiv funktsiyani va xotira funktsiyalarini oshiradi, balki uyqu va charchoqni yaxshilaydi. Panax ginseng ekstrakti jiddiy nojo'ya ta'sirlarga ega emas [28-37]. Ekstraktning xavfsizligi e'tiborga olinadigan yana bir foyda.
Eleutherococcus Senticosus
Sibir ginseng (Eleutherococcus senticosus ((Rupr. va Maksim.) Maksim.) birinchi 19-asrda Porfiry Kirilov tomonidan tasvirlangan edi [38]. Uning adaptogen ta'siri Rossiyada 1960-1970 yillarda keng o'rganilgan [39]. Sportchilarda o'simlik ekstraktlaridan foydalanish bo'yicha birinchi
ma'lumotlar Rossiyadan xabar qilingan. Bugungi kunda o'simlik ekstraktlari nafaqat butun dunyo sportchilari, balki sport bilan faol shug'ullanmaydigan boshqa ko'plab iste'molchilar tomonidan ham qo'llaniladi.
Fitokimyoviy tarkibi fenilpropanoid-syringindan iborat; lignanlar—sesamin; saponinlar— daucosterol; kumarinlar, terpenoidlar, flavonoidlar, organik kislotalar va vitaminlar [40,41]. Eleutherococcus senticosus ildizining ekstraktlari olinadi, immunitet tizimini rag'batlantiradi, tashqi omillarga moslashishga ta'sir qiladi, aqliy va jismoniy, xotira funktsiyalarini yaxshilaydi, gipoglikemik va yallig'lanishga qarshi ta'sirga ega [40,41]. Eleutherococcus senticosus gipotalamus-gipofiz-adrenal o'qiga ta'sir qilish orqali uning adaptogen faollikni namoyon qiladi deb o'ylashadi [40].
Rhaponticum Carthamoides
Rhaponticum carthamoides (Rhaponticum carthamoides IIjin.) Rossiya, Xitoy va Mo'g'ulistonda asrlar davomida ishlatilgan ko'p yillik o't [42]. O'simlik Leuzea sifatida ham tanilgan. O'simlikning ekstraktlari zaiflik [42,43], o'pka kasalliklari, buyrak kasalliklari, isitma va angina [44] ni davolash uchun ishlatilgan.
1969 yilda Brexman va Dardimov bu o'simlikni adaptogen sifatida tasnifladilar [42]. So'nggi o'n yilliklarda Rhaponticum carthamoides ildizi ekstrakti bo'lgan mahsulotlardan foydalanish oshdi. Ekstrakt odamlarga juda ko'p foydali ta'sir ko'rsatadi: yuqori jismoniy chidamlilik, anabolik ta'sir, gipoxolesterinemik ta'sir, neyroprotektiv ta'sir, diabetga qarshi xususiyatlar, oksidlanishga qarshi va immunitetning oshishi [42]. Ekdisteroidlar tufayli yuzaga keladigan mexanizm steroid va estrogen retseptorlari bilan emas, balki signal uzatish yo'llari bilan bog'lanadi [45].
Rhodiola rosea
An'anaviy tibbiyotda (Rhodiola rosea L.) jismoniy chidamlilikni oshiradigan, charchoq, depressiya va asab tizimining buzilishlariga ta'sir qiluvchi adaptiv vosita sifatida tavsiflanadi. Ilgari Osiyoda gripp va sovuqni davolash uchun ishlatilgan va sil kasalligida foydalanish haqida xabar berilgan. Yevropaning Skandinaviya qismida o'simlik ekstraktlari jismoniy chidamlilikni oshirish uchun ishlatilgan [46].
O'simlikning fitokimyoviy tarkibida oltita birikma guruhi ustunlik qiladi: fenilpropanoidlar, feniletanol hosilalari, flavonoidlar, fenolik kislotalar va mono - va triterpen [47]. Asosiy feniletanol hosilalari salidrosid (rhodioloside), para-tirozol va fenilpropanoid-rosavin. Ular Rhodiola rosea [46,48] ning adaptogen va ergogen ta'siri uchun ham javobgardir. Rhodiola roseaning adaptogen ta'siri norepinefrin va serotonin darajasini oshirish orqali miya yarim sharining faollashishi bilan bog'liq. Bundan tashqari, u kortikotropin-ozod gormonlar, kortikotropin, kortizol va epinefrin [46, 49] darajasini kamaytirish, gipotalamus-gipofiz-buyrak usti o'qi tizimiga ta'sir qiladi.
Shisandra chinensis
Schisandra chinensis (Schisandra chinensis (Turcz.) Garov) birinchi marta 200 yil oldin kitobda Shennong BenCao Jing tasvirlangan, yo'tal va astma uchun chora sifatida ishlatilgan [50]. Ilgari Schisandra chinensis mevalari va urug'lari tungi ko'rishni yaxshilash, ochlik, chanqoqlik va charchoqni kamaytirish uchun ishlatilgan. 1960 yilda Rossiyada o'simlikning adaptogen xususiyatlari isbotlangan [51]. Schisandra chinensis mevalari bugungi kunda [50-53] ishlatiladi. Barcha fitokimyoviy moddalar sitotoksik, antioksidant, neyroprotektiv, gepatoprotektiv, jismoniy kuchning oshishi, stressdan himoya qiluvchi, yallig'lanishga qarshi [51, 54] kabi foydali ta'sirlarni namoyon qiladi. Schisandra chinensisning adaptogen ta'siri va antioksidant ta'siri kortikotropinni chiqaradigan gormon darajasini pasaytirish orqali gipotalamus-gipofiz-buyrak usti o'qi tizimiga ta'siri bilan bog'liq.
Xulosalar. Tabiiy adaptogenlar organizmning turli xil stress omillari ta'sirida stress o'zgarishiga chidamliligini oshirish qobiliyatiga ega. Sintetik adaptogenlardan farqli o'laroq, tabiiy
juda boy fitokimyoviy tarkibga ega ekstraktlardir. Ularning adaptogen xususiyatlari bitta molekulaga emas, balki turli moddalarning birikmasiga bog'liq. Odamlar tomonidan tabiiy adaptogenlardan foydalanish boy tarixga ega-ular kasallikdan, jismoniy zaiflikdan, aqliy funktsiyaning buzilishidan va boshqa holatlardan tiklanishda ishlatilgan. Taxminan 50 yil davomida o'simlik adaptogenlari organizmning chidamliligini oshirish va jismoniy chidamliligini oshirishi yuqori salohiyati tufayli professional sportchilar tomonidan qo'llanilgan. Hozirgi kunda eng ko'p ishlatiladigan o'simlik adaptogenlari Panax ginseng, Eleutherococcus senticosus va Rhaponticum carthamoides hisoblanadi. 2020 yildan beri Leuzea ekstraktiga boy ecdysterone VADA monitoring dasturiga kiritilgan va taqiqlangan ro'yxatga kiritish istiqbollari mavjud. Rhodiola rosea, Eleutherococcus senticosus, Panax ginseng, Schisandra chinensis va Rhaponticum carthamoides ekstraktlaridan foydalanishning afzalliklarini o'rganadigan tadqiqotlar soni cheklangan. Shu bilan birga, ushbu o'simliklarning ekstraktlarini surunkali charchoqni, kognitiv buzilishlarni davolashga, shuningdek immunitetni kuchaytirishga qaratilgan dorivor mahsulotlarga kiritish uchun imkoniyatlar mavjud. Ko'p bosqichli tadqiqotlar yurak-qon tomir kasalliklari bilan og'rigan bemorlarda, immuniteti zaif bemorlarda va surunkali charchoq bilan og'rigan bemorlarda ekstraktlardan foydalanishni juda samarali natijalar olingan.
ADABIYOTLAR
1. Herbal Drugs." Drugs and Controlled Substances: Information for Students. Retrieved January 17, 2023 from Encyclopedia.com: https://www.encyclopedia.com/science/applied- and- social-sciences- magazines/herbal- drugs.
2. Ksouri R., Megdiche W., Debez A., Falleh H., Grignon C., Abdelly C. Salinity effects on polyphenol content and antioxidant activities in leaves of the halophyte Cakile maritima, Plant Physiol. Biochem. 45 (3-4) (2007) 244-249, doi:10.1016/j.plaphy. 2007.02.001
3. Sellami M., Slimeni O., Pokrywka A., Kuvacic G., Hayes L. D., Milic M., Padulo J. Herbal medicine for sports: a review, J. Int. Soc. Sports Nutr. 15 (1) (2018) 14, doi:10.1186/s12970- 0180218- y.
4. Panossian, A.; Wikman, G. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—Protective activity. Pharmaceuticals 2010, 3, 188-224.
5. Panossian, A.; Seo, E.J.; Efferth, T. Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells. Phytomedicine 2019, 60, 152881.
6. Kim, J.H.; Yi, Y.S.; Kim, M.Y.; Cho, J.Y. Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. J. Ginseng Res. 2017, 41, 435-443.
7. Panossian, A. Understanding adaptogenic activity: Specificity of the pharmacological action of adaptogens and other phytochemicals. Ann. N. Y. Acad. Sci. 2017, 1401, 49-64.
8. Wrobel-Biedrawa, D.; Podolak, I. Anti-Neuroinflammatory Effects of Adaptogens: A MiniReview. Molecules 2024, 29, 866. https://doi.org/10.3390/ molecules29040866
9. Sanoev Z.I., Abdinazarov I.T., Sanoev A.I., Khamroev T.T., Rakhimboev S.D., & Rashidov S.Z. (2022). Study of antihypoxic activity of dry grape seed extract under normal conditions. Oriental Journal of Medicine and Pharmacology, 2(03), 6-13. https://doi.org/10.37547/supsci-ojmp-02-03-02
10. Abdinazarov I. T., Sanoev Z. I., Khamroev T. T., Khazhibaev T. A., Rashidov S. Z., & Rakhimboev S. D. (2023). Antihypoxic Activity of Tribulus Terrestris L. Extract in Experimental Animals. Central Asian Journal of Medical and Natural Science, 4(6), 1320-1325. https://doi.org/10.17605/cajmns.v4i6.2230
11. Sanoev Z.I., Mirzayev Yu.R. Pharmacological Activity Of The Possessing New Atypical Neuroleptics 1-Phenyltetrahydroiso-quinoline Structure. The American Journal of Medical Sciences
and Pharmaceutical Research Published: August 11, 2020 | Pages: 18-26 Doi:https://doi.org/10.37547/TAJMSPR/Volume02Issue08-03
12. Sanoev Z.I., Mirzayev Yu.R. Research of a new atypical neuroleptic 1-(3,4,-methylenedioxyphenyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline on the central nervous system. Annals of the Romanian Society for Cell Biology, 2021,25(2), 2363-2369
13. Khamroev, T. T., Sanoev Z.I., Rakhimboev, S. D., Abdinazarov, I. T., Rashidov, S. Z. Effect of antiarrhythmic substance N -dezacetyllapoconitin on the central nervous system. ISJ Theoretical & Applied Science, 07 (99), 153-157. Soi:http://soi.org/1.1/TAS-07-99-31Doi:https://dx.doi.org/10.15863
14. Zafar I. Sanoev. (2022).Study of acute toxicity and psychopharmacological activity of 1-(2-hydroxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline.Oriental Journal of Medicine and Pharmacology,2(02), 65-71.https://doi.org/10.37547/supsci-ojmp-02-02-08
15. Sanoev Z.I., Mirzayev Yu.R. Influence of donaxine on physical and psychoemotional state of white mice at single and prolonged administration. «European Journal of Biomedical and Life Sciences» No4, 2016, с. 45-49
16. Мирзаев Ю.Р., Турсунова Н.В., Расулова Х.А., Саноев З.И. Особенности психофармакологической активности суммы фуранохинолиновых алкалоидов из Haplophyllun perforatum. XL Международная научно-практическая конференция «Современная медицина: Актуальные вопросы. 2015, с.103-110
17. Sanoev Z.I. Skimmianine -a promising antidepressant among furanoquinoline alkaloids. Journal of Biomedicine and Practice 2020, Special issue -2, pp.751-757
18. Sanoev Z.I., Mirzaev Yu.R. (2018). On comparative stimulating action on the cns of furanoquinoline alkaloids of skimmianine and amitriptyline //European science review № 5-6, May-June, Vienna, p.189-192
19. Rashidov S.Z., Rakhimboev S.D., Sanoev Z.I., Abdinazarov I.T., Khamroev T.T., Ismailova D.S., & Elmuradov B.J.(2022). Study of psychoactive activity potassium salt 5-(o-aminophenyl)-1,3,4-oxadiazole-2-thion (d-361). International Journal of Medical Sciences and Clinical Research, 2(09), 1-5. https://doi.org/10.37547/ijmscr/Volume02Issue09-01
20. Sanoev Z.I., Khamroev T.T., Abdinazarov I.T., Sadikov A.Z., Rakhimboev S.D., Rashidov S.Z. Study of N-deacetylappaconitine (N-DAL) anticonvulsant action. Oriental Journal of Medicine and Pharmacology. 2022, Vol 2, p. 29-37
21. Baeg I.-H., So S.-H. The world ginseng market and the ginseng (Korea) J. Ginseng Res. 2013;37:1-7. doi: 10.5142/jgr.2013.37.1.
22. Kiefer D.S., Pantuso T. Panax ginseng. Am. Fam. Physician. 2003;68:1539-1542. [
23. Patel S., Rauf A. Adaptogenic herb ginseng (Panax) as medical food: Status quo and future prospects. Biomed. Pharmacother. 2016;85:120-127. doi: 10.1016/j.biopha.2016.11.112.
24. Shergis J., Zhang A.L., Zhou W., Xue C.C. Panax ginseng in randomised controlled trials: A systematic review. Phytother. Res. 2012;27:949-965. doi: 10.1002/ptr.4832.
25. Nocerino E., Amato M., Izzo A. The aphrodisiac and adaptogenic properties of ginseng. Fitoterapia. 2000;71:S1-S5. doi: 10.1016/S0367-326X(00)00170-2.
26. Mahady G.B., Gyllenhaal C., Fong H.H., Farnsworth N.R. Ginsengs: A review of safety and efficacy. Nutr. Clin. Care. 2000;3:90-101. doi: 10.1046/j.1523-5408.2000.00020.x.
27. Wilson L. Review of adaptogenic mechanisms: Eleuthrococcus senticosus, panax ginseng, rhodiola rosea, schisandra chinensis and withania somnifera. Aust. J. Med. Herbal. 2007;19:126-138. doi: 10.3316/informit.406522201744304.
28. Kim S.H., Park K.S. Effects of panax ginseng extract on lipid metabolism in humans. Pharmacol. Res. 2003;48:511-513. doi: 10.1016/S1043-6618(03)00189-0.
29. Bhattacharjee I., Bandyopadhyay A. Effects of acute supplementation of panax ginseng on endurance performance in healthy adult males of Kolkata, India. Int. J. Clin. Exp. Physiol. 2020;7:63-68. doi: 10.5530/ijcep.2020.7.2.16.
30. Etemadifar M., Sayahi F., Abtahi S.-H., Shemshaki H., Dorooshi G.-A., Goodarzi M., Akbari M., Fereidan-Esfahani M. Ginseng in the treatment of fatigue in multiple sclerosis: A randomized, placebo-controlled, double-blind pilot study. Int. J. Neurosci. 2013;123:480-486. doi: 10.3109/00207454.2013.764499.
31. Engels H.-J., Said J.M., Wirth J.C. Failure of chronic ginseng supplementation to affect work performance and energy metabolism in healthy adult females. Nutr. Res. 1996;16:1295-1305. doi: 10.1016/0271-5317(96)00138-8.
32. Perazzo F.F., Fonseca F.L., Souza G.H.B., Maistro E.L., Rodrigues M., Carvalho J.C. Doubleblind clinical study of a multivitamin and polymineral complex associated with panax ginseng extract (Gerovital®) Open Complement. Med. J. 2010;2:100-104.
33. Ziemba A.W. The effect of ginseng supplementation on psychomotor performance, indices of physical capacity and plasma concentration of some hormones in young well fit men; Proceedings of the Ginseng Society Conference; Seoul, Korea. 1 October 2002; pp. 145-158.
34. Zarabi L., Arazi H., Izadi M. The effects of panax ginseng supplementation on growth hormone, cortisol and lactate response to high-intensity resistance exercise. Biomed. Hum. Kinet. 2018;10:8-14. doi: 10.1515/bhk-2018-0002.
35. Lee S.A., Kang S.G., Lee H.J., Jung K.Y., Kim L. Effect of Korean red ginseng on sleep: A randomized, placebo-controlled Trial. Sleep Med. Psychophysiol. 2010;17:85-90.
36. Kim H.-G., Cho J.-H., Yoo S.-R., Lee J.-S., Han J.-M., Lee N.-H., Ahn Y.-C., Son C.-G. Antifatigue Effects of Panax ginseng CA Meyer: A randomised, double-blind, placebo-controlled trial. PLoS ONE. 2013;8:e61271. doi: 10.1371/journal.pone.0061271.
37. Ping F.W.C., Keong C.C., Bandyopadhyay A. Effects of acute supplementation of Panax ginseng on endurance running in a hot & humid environment. Indian J. Med. Res. 2011;133:96-102.
38. Davydov M., Krikorian A. Eleutherococcus senticosus (Rupr. & Maxim.) maxim. (Araliaceae) as an adaptogen: A closer look. J. Ethnopharmacol. 2000;72:345-393. doi: 10.1016/s0378-8741(00)00181-1.
39. World Health Organization . WHO Monographs on Selected Medicinal Plants. Volume 2 World Health Organization; Geneva, Switzerland: 2002.
40. Bleakney T.L. Deconstructing an adaptogen: Eleutherococcus Senticosus. Holist. Nurs. Pract. 2008;22:220-224. doi: 10.1097/01.HNP.0000326005.65310.7c.
41. Jia A., Zhang Y., Gao H., Zhang Z., Zhang Y., Wang Z., Zhang J., Deng B., Qiu Z., Fu C. A review of Acanthopanax senticosus (Rupr and Maxim.) harms: From ethnopharmacological use to modern application. J. Ethnopharmacol. 2020;268:113586. doi: 10.1016/j.jep.2020.113586.
42. Kokoska L., Janovska D. Chemistry and pharmacology of Rhaponticum carthamoides: A review. Phytochemistry. 2009;70:842-855. doi: 10.1016/j.phytochem.2009.04.008.
43. Budesinsky M., Vokac K., Harmatha J., Cvacka J. Additional minor ecdysteroid components of Leuzea carthamoides. Steroids. 2008;73:502-514. doi: 10.1016/j.steroids.2007.12.021.
44. Timofeev N.P. Leuzea Carthamoides DC: Application prospects as pharmpreparations and biologically active components. In: Martirosyan D.M., editor. Functional Foods for Chronic Diseases. Richardson; Texas, TX, USA: 2006. pp. 105-120.
45. Bathori M., Toth N., Hunyadi A., Marki A., Zador E. Phytoecdysteroids and anabolic-androgenic steroids—Structure and effects on humans. Curr. Med. Chem. 2008;15:75-91. doi: 10.2174/092986708783330674.
46. Brown R.P., Gerbarg P.L., Ramazanov Z. Rhodiola rosea: A phytomedicinal overview. Herbal. Gram. 2002;56:40-52.
47. Pu W.-L., Zhang M.-Y., Bai R.-Y., Sun L.-K., Li W.-H., Yu Y.-L., Zhang Y., Song L., Wang Z.-X., Peng Y.-F., et al. Anti-inflammatory effects of Rhodiola rosea L.: A review. Biomed. Pharmacother. 2020;121:109552. doi: 10.1016/j.biopha.2019.109552.
48. Khanum F., Bawa A.S., Singh B. Rhodiola rosea: A versatile adaptogen. Compr. Rev. Food Sci. Food Saf. 2005;4:55-62. doi: 10.1111/j.1541-4337.2005.tb00073.x.
49. Panossian A., Seo E.-J., Efferth T. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine. 2018;50:257-284. doi: 10.1016/j.phymed.2018.09.204.
50. Hancke J., Burgos R., Ahumada F. Schisandra chinensis (Turcz.) Baill. Fitoterapia. 1999;70:451-471. doi: 10.1016/S0367-326X(99)00102-1.
51. Lu Y., Chen D.-F. Analysis of Schisandra chinensis and Schisandra sphenanthera. J. Chromatogr. A. 2009;1216:1980-1990. doi: 10.1016/j.chroma.2008.09.070.
52. Panossian A., Wikman G. Pharmacology of Schisandra chinensis bail.: An overview of Russian research and uses in medicine. J. Ethnopharmacol. 2008;118:183-212. doi: 10.1016/j.jep.2008.04.020.
53. Slanina J., Tâborskâ E., Lojkovâ L. Lignans in the seeds and fruits of Schisandra chinensis cultured in Europe. Planta Med. 1997;63:277-280. doi: 10.1055/s-2006-957676.
54. Yang B.-Y., Guo J.-T., Li Z.-Y., Wang C.-F., Wang Z.-B., Wang Q.-H., Kuang H.-X. New Thymoquinol Glycosides and Neuroprotective Dibenzocyclooctane Lignans from the Rattan Stems of Schisandra chinensis. Chem. Biodivers. 2016;13:1118-1125. doi: 10.1002/cbdv.201500311.
