CC BY
14УДК: 615.322
ПРИМЕНЕНИЕ РОЗМАРИНА ПРИ ЗАБОЛЕВАНИЯХ НЕРВНОЙ СИСТЕМЫ (ОБЗОР ЛИТЕРАТУРЫ) doi: 10.24412/cl-34438-2024-1-211-243.
КАРОМАТОВ ИНОМДЖОН ДЖУРАЕВИЧ
руководитель медицинского центра «Магия здоровья», ассистент кафедры народной медицины и профессиональных болезней Бухарского государственного медицинского института. Город Бухара. Республика Узбекистан. ORCID ID 0000-0002-2162-9823 БАЙМУРАДОВ РАДЖАБ САЙФИТДИНОВИЧ доцент кафедры спортивной деятельности Бухарского государственного Университета. Город Бухара.
Республика Узбекистан. ORCID ID 0000-0002-2650-7921
САФАРОВА МАСТУРА ТУЛКИНОВНА студентка Бухарского государственного университета. Город Бухара Республики Узбекистан.
ORCID ID 0009-0008-7863-0340 АННОТАЦИЯ
Как и все приправы, экстракты розмарина обладают выраженными антиоксидантными свойствами. Эксперименты на животных выявили антистрессовый эффект экстракта листьев розмарина. Сырой экстракт розмарина проявлял противовоспалительную активность, ингибируя лейкоциты и уменьшая экссудацию. Эти эффекты были связаны со снижением провоспали-тельных параметров (миелопероксидаза, аденозиндезаминаза, нитрит/нитрат и интерлейкин 17A) и увеличением противовоспалительного цитокина (интерлейкин 10). Ароматические растения, шалфей (Salvia officinalis), лаванда (Lavandula angustifolia) и розмарин (Salvia Rosmarinus) обладают анксиолитическими,
противовоспалительными, антиоксидантными и нейропротек-торными свойствами, перспективны в лечении распространенных неврологических расстройств, включая болезнь Альцгеймера, болезнь Паркинсона, мигрень и когнитивные расстройства. Экспериментальные исследования показали, что экстракт розмарина, благодаря антиоксидантным свойствам предупреждает поражение мозга, нервную ткань и развитие эпилептических припадков под воздействием пентилентетразола. Экстракты розмарина обладают антидепрессант- и анксиолитической активностью посредством модуляции окситоцинергической системы в мозге мышей. Рандомизированные, контролируемые клинические исследования показали, что ингаляционная ароматерапия маслом розмарина, музыкальная терапия и комбинированная аромате-рапия и музыкальная терапия являются эффективными подходами для снижения тревожности у хирургических пациентов.
Ключевые слова: розмарин, Rosmarinus officinalis, специи, приправы, ароматерапия, растительные антидепрессанты, фитотерапия, фитотерапия дегенеративных заболеваний нервной системы.
ROSEMARY IN NERVOUS SYSTEM DISEASES (LITERATURE REVIEW)
KAROMATOVINOMJON DZHURAEVICH
Head of the Medical Center "Health Magic, " Assistant of the Department of Folk Medicine and Professional Diseases of the Bukhara State Medical Institute. City of Bukhara. Republic of
Uzbekistan. ORCID ID 0000-0002-2162-9823. BAYMURADOVRAJAB SAYFITDINOVICH Associate Professor of the Department of Sports Activities, Bukhara State University. City of Bukhara. Republic of
Uzbekistan. ORCID ID 0000-0002-2650-7921 SAFAROVA MASTURA TULKNOVNA
student of Bukhara State University. City of Bukhara of the Republic of Uzbekistan. ORCID ID 0009-0008-7863-0340
ABSTRACT
Like all seasonings, rosemary extracts have pronounced antioxidant properties. Animal experiments revealed the anti-stress effect of rosemary leaf extract. The crude rosemary extract exhibited anti-inflammatory activity, inhibiting white blood cells and reducing exudation. These effects were associated with decreased pro-inflammatory parameters (myeloperoxidase, adenosine deaminase, nitrite/nitrate, and interleukin 17A) and increased anti-inflammatory cytokine (interleukin 10). Aromatic plants, sage (Salvia officinalis), lavender (Lavandula angustifolia) and rosemary (Salvia Rosmarinus) have anxiolytic, anti-inflammatory, antioxidant and neuroprotective properties, promising in the treatment of common neurological disorders, including Alzheimer's disease, Parkinson's disease, migraine and cognitive disorders. Experimental studies have shown that rosemary extract, thanks to antioxidant properties, prevents brain damage, nerve tissue and the development of epileptic seizures under the influence of pentylene tetrazole. Rosemary extracts have antidepressant and anxiolytic activity through modulation of the oxytocinergic system in mouse brains. Randomized, controlled clinical trials have shown that inhaled rosemary oil aromatherapy, music therapy, and combination aromatherapy and music therapy are effective approaches to reduce anxiety in surgical patients.
Keywords: rosemary, Rosmarinus officinalis, spices, aromatherapy, herbal antidepressants, phytotherapy, phytotherapy of degenerative diseases of nervous system.
РОЗМАРИННИНГ АСАБ ТИЗИМИ КАСАЛЛИКЛАРИДА КУЛЛАНИЛИШИ (АДАБИЁТЛАР ШАР^И)
КАРОМАТОВ ИНОМДЖОН ДЖУРАЕВИЧ
«Магия здоровья» тиббий маркази бошлиги, халц табобати ва касб касалликлари кафедраси ассистенти, Бухоро давлат тиббиёт институти, Бухоро ш., Узбекистон
Республикаси ORCID ID 0000-0002-2162-9823 БАЙМУРАДОВ РАДЖАБ САЙФИТДИНОВИЧ Спорт фаолияти кафедраси доценти, Бухоро давлат университети. Бухоро ш., Узбекистон Республикаси
ORCID ID 0000-0002-2650-7921 САФАРОВА МАСТУРА ТУЛКИНОВНА Талаба, Бухоро давлат университети, Бухоро ш., Узбекистон Республикаси ORCID ID 0009-0008-7863-0340
АННОТАЦИЯ
Барча зираворлар сингари розмарин экстракти яццол анти-оксидант таъсирга эга. Хайвонларда утказилган тадцицотлар розмарин барглари экстрактининг стрессга царши хусусият-ларини аницлади. Розмарин экстракти лейкоцитларни ингибирлаш ва экссудацияни камайтириш орцали яллигланишга царши таъсир курсатади. Бу таъсирлар яллигланишни цуллаб цувватловчи курсаткичларнинг (миелопероксидаза, аденозиндезаминаза, нитрит / нитрат ва интерлейкин 17A) камайиши ва яллигланишга царши цитокиннинг (интерлейкин 10) ошиши билан боглиц. Ароматик усимликлар, мармарак (Salvia officinalis), лаванда (Lavandula angustifolia) ва розмарин (Salvia Rosmarinus) анксиолитик, яллигланишга царши, антиоксидант ва нейропротектив таъсир-ларга эга, тарцалган асаб бузилишларини, шу жумладан Альцгеймер касаллиги, Паркинсон касаллиги, мигрень ва когнитив бузилишларни даволашда истицболли цисобланади. Эксперимен-
тал тадцицотлар курсатишича, розмарин экстракти анти-оксидант хусусиятлари туфайли мия, асаб туцимаси зарарланиши ва пентилентетразол таъсирида ривожланадиган тутцаноцлар ривожланишини олдини олади. Розмарин экстракти сичцонлар миясида окситоцинергик тизимнинг модуляцияси орцали антидепрессант ва анксиолитик таъсир курсатади. Рандомизирланган, назорат цилинадиган клиник тадцицотлар курсатишича, розмарин мойи билан ингаляцион ароматерапия, мусицали терапия ва комбинирланган ароматерапия хирургик беморларда хавотирни енгишга ёрдам беради.
Калит сузлар: розмарин, Rosmarinus officinalis, зираворлар, ароматерапия, антидепрессант усимликлар, фитотерапия, асаб тизими дегенератив касалликлари фитотерапияси
Rosmarinus officinalis - -
(Rosmarinus
Lamiaceae).
[3].
фММаШФЯЩЯ
216
Химический состав.
-37,7%), 1,8- -29,3%), (+) - -16,9%), (-)
-6,9%), (-) - -
-4,4%) [101; 105; 76; 123; 102; 61; 119; 13].
[1].
[6; 127].
[88].
[5].
[142; 139; 16; 134; 47;
[111].
[68].
Rosmarinus officinalis L
[99; 48; 24].
SH-SY5Y
Nrf2/HO-
NF- [23; 33].
[63; 49].
[117].
A
[138; 132; 74; 31].
NF-kB
iNOS COX-
[141].
TNF- , IL- IL-6),
[107; 110; 30; 25; 79; 27;
53; 57].
[59].
aromaticum Rosmarinus officinalis
Syzygium
[36].
COX COX
[42].
[86].
COX-
Rosmarinus officinalis
KCl [136].
[89].
NF-kappaB STAT PI3K/Akt MAPK
iNOS
[75].
[86].
[114].
[80].
[54].
PPAR
[131].
Salvia officinalis (Lavandula angustifolia Salvia Rosmarinus
[71; 133; 44; 116].
R. officinalis
[50].
[32].
[126].
РС
[41].
[118].
А1С13 Н2О2
[70; 51; 103].
[18].
[69; 96].
SAMP [45].
[12; 104]. R. officinalis
[19; 62].
[94].
SRM- (Salvia officinalis L., Rosmarinus officinalis L Melissa officinalis L
[109].
Rosmarinus officinalis [67].
[10].
[130].
[98].
т vitro
[100].
N -D-
[
[95; 58; 22; 91].
Rosmarinus officinalis
- BACE
R. officinalis
[90].
Rosmarinus officinalis L
[85].
1-42-
Crocus
sativus L
[60].
PI3K/Akt/Nrf
Nrf2 [35]. R. officinalis H 2O2
[106].
[52].
SARS-CoV-
[122].
- [78;
140; 34].
Васора топтеп
[113].
с6 [72]. NGF [73].
[66].
[129].
АМ
[21].
[128].
[20]. BDNF
[46; 11].
[81; 120].
(50-
[9].
[26; 121].
R. officinalis [82; 83].
BV-[56].
[40].
D D (2) [84]. Rosmarinus officinalis Curcuma longa
DD
[43]. -
[29].
[77].
[135].
[115].
[37].
[2].
[124].
[64].
[87].
[137].
[97].
[4].
[7; 8].
[28].
Список литературы:
1.
(Rosmarinus officinalis L
2018. -204. DOI
10.25684/NBG.scbook.146.2018.32. EDN XRCBNZ. 2.
2016. S4.
61-66. EDN YHSIJN.
3.
Rosmarinun Officinalis L Life Sciences and Agriculture. 2020. 111. DOI 10.24411/2181-0761/2020-10059. EDN VBPBMQ.
4.
2012. 104.
5.
Rosmarinus officinalis L.),
2015. -15. -3332. EDN TSNLTJ.
6.
Rosmarinus officinalis L
2018. -207.
DOI 10.14258/jcprm.2018033733. EDN YABUXZ. 7.
2022. 2 (56) Special Issue. -177.
2023. 2S. -234.
9. Abdelhalim A., Karim N., Chebib M., Aburjai T., Khan I., Johnston G.A., Hanrahan J. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. //J. Pharm. Pharm. Sci. 2015; 18(4): 448-459. doi: 10.18433/j3pw38.
10. Abdelrazik E., Hassan H.M., Hamza E., Ezz Elregal F.M., Elnagdy M.H., Abdulhai E.A. Beneficial role of rosemary extract on oxidative stress-mediated neuronal apoptosis in rotenone-induced attention deficit hyperactivity disease in juvenile rat model. //Acta Biomed. 2023 Jun 14; 94(3): e2023104. doi: 10.23750/abm.v94i3.14260.
11. Achour M., Ben Salem I., Ferdousi F., Nouira M., Ben Fredj M., Mtiraoui A., Isoda H., Saguem S. Rosemary Tea Consumption Alters Peripheral Anxiety and Depression Biomarkers: A Pilot Study in Limited Healthy Volunteers. //J. Am. Nutr. Assoc. 2022 Mar-Apr; 41(3): 240-249. doi: 10.1080/07315724.2021. 1873871.
12.
plants used in Danish folk medicine to treat memory dysfunction for acetylcholinesterase inhibitory activity. //J. Ethnopharmacol. 2006 Apr 6; 104(3): 418-422. doi: 10.1016/j.jep.2005.09.032.
13. Alibeili Kh., Sadygov T., Abbasov Ja. Use of Essential Oil Rosmarinus officinalis L. in Industry // Bulletin of Science and Practice. 2023. Vol. 9, No. 3. P. 59-62. DOI 10.33619/2414-2948/88/05. EDN KZBWVJ.
14. Alrashdi J., Albasher G., Alanazi M.M., Al-Qahtani W.S., Alanezi A.A., Alasmari F. Effects of Rosmarinus officinalis L. Extract on Neurobehavioral and Neurobiological Changes in Male Rats with Pentylenetetrazol-Induced Epilepsy. //Toxics. 2023 Sep 30; 11(10): 826. doi: 10.3390/toxics11100826.
15. Al-Tawarah N.M., Al-Dmour R.H., Abu Hajleh M.N., Khleifat K.M., Alqaraleh M., Al-Saraireh Y.M., Jaradat A.Q., Al-Dujaili E.A.S. Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition. //Nutrients. 2023 Mar 22; 15(6): 1547. doi: 10.3390/nu15061547.
16. Amaral G.P., Mizdal C.R., Stefanello S.T., Mendez A.S.L., Puntel R.L., de Campos M.M.A., Soares F.A.A., Fachinetto R. Antibacterial and antioxidant effects of Rosmarinus officinalis L. extract and its fractions. //J. Tradit. Complement. Med. 2018 Oct 9; 9(4): 383-392. doi: 10.1016/j.jtcme.2017.10.006.
17. Aponso M., Patti A., Hearn M.T.W., Bennett L.E. Anxiolytic effects of essential oils may involve anti-oxidant regulation of the pro-
oxidant effects of ascorbate in the brain. //Neurochem. Int. 2021 Nov; 150: 105153. doi: 10.1016/j.neuint.2021.105153.
18. Araki R., Sasaki K., Onda H., Nakamura S., Kassai M., Kaneko T., Isoda H., Hashimoto K. Effects of Continuous Intake of Rosemary Extracts on Mental Health in Working Generation Healthy Japanese Men: Post-Hoc Testing of a Randomized Controlled Trial. //Nutrients. 2020 Nov 20; 12(11): 3551. doi: 10.3390/nu12113551.
19. Ayaz M., Sadiq A., Junaid M., Ullah F., Subhan F., Ahmed J. Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants. //Front Aging Neurosci. 2017 May 30; 9: 168. doi: 10.3389/fnagi.2017.00168.
20. Azizi S., Mohamadi N., Sharififar F., Dehghannoudeh G., Jahanbakhsh F., Dabaghzadeh F. Rosemary as an adjunctive treatment in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. //Complement. Ther. Clin. Pract. 2022 Nov; 49: 101685. doi: 10.1016/j.ctcp.2022.101685.
21. Baron D.C., Marko D.M., Tsiani E., MacPherson R.E.K. Rosemary extract increases neuronal cell glucose uptake and activates AMPK. //Appl. Physiol. Nutr. Metab. 2021 Feb; 46(2): 141-147. doi: 10.1139/apnm-2020-0014.
22. Benny A., Thomas J. Essential Oils as Treatment Strategy for Alzheimer's Disease: Current and Future Perspectives. //Planta Med. 2019 Feb; 85(3): 239-248. doi: 10.1055/a-0758-0188.
23. P., Pierre F.X., Bily A.C., Roller M. Carnosic acid. //Phytochemistry. 2015 Jul; 115: 9-19. doi: 10.1016/j.phytochem.2014.12.026.
24. Borges R.S., Lima E.S., Keita H., Ferreira I.M., Fernandes C.P.,
-Moyado J., Ortiz B.L.S., Castro A.N., Ferreira J.V., da Silva Hage-Melim L.I., Carvalho J.C.T. Anti-inflammatory and antialgic actions of a nanoemulsion of Rosmarinus officinalis L. essential oil and a molecular docking study of its major chemical constituents. //Inflammopharmacology. 2018 Feb; 26(1): 183-195. doi: 10.1007/s10787-017-0374-8.
25. Borges R.S., Ortiz B.L.S., Pereira A.C.M., Keita H., Carvalho J.C.T. Rosmarinus officinalis essential oil: A review of its phytochemistry, anti-inflammatory activity, and mechanisms of action involved. //J. Ethnopharmacol. 2019 Jan 30; 229: 29-45. doi: 10.1016/j.jep.2018.09.038.
26. Boumendjel M., Boucheker A., Feknous S., Taibi F., Rekioua N., Bouzeraa N., Chibi A., Feknous N., Baraoui A., N'har S., Toubal A., Taguida A., Zaidi H., Sekiou O., Bouziane I., Metai A., Bouaziz M., Benselhoub A., Boumendjel A., Messarah M. Adaptogenic activity of
Rosmarinus officinalis essential oil used in North-African folk medicine.
//Cell Mol. Biol (Noisy-le-grand). 2021 Aug 31; 67(2): 83-88. doi: 10.14715/cmb/2021.67.2.12.
27. Brindisi M., Bouzidi C., Frattaruolo L., Loizzo M.R., Tundis R., Dugay A., Deguin B., Cappello A.R., Cappello M.S. Chemical Profile, Antioxidant, Anti-Inflammatory, and Anti-Cancer Effects of Italian Salvia rosmarinus Spenn. Methanol Leaves Extracts. //Antioxidants (Basel). 2020 Sep 3; 9(9): 826. doi: 10.3390/antiox9090826.
28. Capatina L., Boiangiu R.S., Dumitru G., Napoli E.M., Ruberto G., Hritcu L., Todirascu-Ciornea E. Rosmarinus officinalis Essential Oil Improves Scopolamine-lnduced Neurobehavioral Changes via Restoration of Cholinergic Function and Brain Antioxidant Status in Zebrafish (Danio rerio). //Antioxidants (Basel). 2020 Jan 10; 9(1): 62. doi: 10.3390/antiox9010062.
29. Choukairi Z., Hazzaz T., Lkhider M., Ferrandez J.M., Fechtali T. Effect of Salvia Officinalis L. and Rosmarinus Officinalis L. leaves extracts on anxiety and neural activity. //Bioinformation. 2019 Mar 15; 15(3): 172-178. doi: 10.6026/97320630015172.
30. Colica C., Di Renzo L., Aiello V., De Lorenzo A., Abenavoli L. RosmarinicAcid as Potential Anti-Inflammatory Agent. //Rev. Recent. Clin. Trials. 2018; 13(4): 240-242. doi: 10.2174/157488711304180911095818.
31. da Rosa J.S., Facchin B.M., Bastos J., Siqueira M.A., Micke
of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy. //Planta Med. 2013 Nov; 79(17): 1605-614. doi: 10.1055/S-0033-1351018.
32. de Oliveira M.R. The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View. //Mol. Neurobiol. 2016 Nov; 53(9): 6155-6168. doi: 10.1007/s12035-015-9519-1.
33.
Acid Induces Anti-Inflammatory Effects in Paraquat-Treated SH-SY5Y Cells Through a Mechanism Involving a Crosstalk Between the Nrf2/HO-1 Axis and NF- -897. doi:
10.1007/S12035-017-0389-6.
34. de Oliveira M.R., Ferreira G.C., Schuck P.F. Protective effect of carnosic acid against paraquat-induced redox impairment and mitochondrial dysfunction in SH-SY5Y cells: Role for PI3K/Akt/Nrf2 pathway. //Toxicol. In Vitro. 2016 Apr; 32: 41-54. doi: 10.1016/j.tiv.2015.12.005.
35. de Oliveira M.R., Ferreira G.C., Schuck P.F., Dal Bosco S.M. Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells. //Chem. Biol. Interact. 2015 Dec 5; 242: 396-406. doi: 10.1016/j.cbi.2015.11.003.
36. - -Villalobos K.L., Aguilar-Mariscal
Synergistic Herb-Herb Interaction of the Antinociceptive and Anti-Inflammatory Effects of Syzygium aromaticum and Rosmarinus officinalis Combination. //Evid. Based Complement. Alternat. Med. 2021 Nov 11; 2021:8916618. doi: 10.1155/2021/8916618.
37. Dehghan N., Azizzadeh Forouzi M., Etminan A., Roy C., Dehghan M. The effects of lavender, rosemary and orange essential oils on memory problems and medication adherence among patients undergoing hemodialysis: A parallel randomized controlled trial. //Explore (NY). 2022 Sep-Oct; 18(5): 559-566. doi: 10.1016/j.explore.2021.10.004.
38. Di Cesare Mannelli L., Micheli L., Maresca M., Cravotto G., Bellumori M., Innocenti M., Mulinacci N., Ghelardini C. Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: relevance of nicotinic receptors. //Sci. Rep. 2016 Oct 7; 6: 34832. doi: 10.1038/srep34832.
39. E L Omri A., Han J., Ben Abdrabbah M., Isoda H. Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells. //Cytotechnology. 2012 May; 64(3): 231-240. doi: 10.1007/s10616-011-9352-y.
40. El Alaoui C., Chemin J., Fechtali T., Lory P. Modulation of T-type Ca2+ channels by Lavender and Rosemary extracts. //PLoS One. 2017 Oct 26; 12(10): e0186864. doi: 10.1371/journal.pone.0186864.
41. El Omri A., Han J., Yamada P., Kawada K., Ben Abdrabbah M., Isoda H. Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2. //J. Ethnopharmacol. 2010 Sep 15; 131(2): 451-458. doi: 10.1016/j.jep.2010.07.006.
42. Emami F., Ali-Beig H., Farahbakhsh S., Mojabi N., Rastegar-Moghadam B., Arbabian S., Kazemi M., Tekieh E., Golmanesh L., Ranjbaran M., Jalili C., Noroozzadeh A., Sahraei H. Hydroalcoholic extract of Rosemary (Rosmarinus officinalis L.) and its constituent carnosol inhibit formalin-induced pain and inflammation in mice. //Pak. J. Biol. Sci. 2013 Apr 1; 16(7): 309-316. doi: 10.3923/pjbs.2013.309.316.
43. Farahani M.S., Bahramsoltani R., Farzaei M.H., Abdollahi M., Rahimi R. Plant-derived natural medicines for the management of depression: an overview of mechanisms of action. //Rev. Neurosci. 2015; 26(3): 305-321. doi: 10.1515/revneuro-2014-0058.
44. Faridzadeh A., Salimi Y., Ghasemirad H., Kargar M., Rashtchian A., Mahmoudvand G., Karimi M.A., Zerangian N., Jahani N., Masoudi A., Sadeghian Dastjerdi B., Salavatizadeh M., Sadeghsalehi H., Deravi N. Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender. //Front Neurosci. 2022 Jun 28; 16: 909833. doi: 10.3389/fnins.2022.909833.
45. Farr S.A., Niehoff M.L., Ceddia M.A., Herrlinger K.A., Lewis B.J., Feng S., Welleford A., Butterfield D.A., Morley J.E. Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice. //Physiol. Behav. 2016 Oct 15; 165: 328-338. doi: 10.1016/j.physbeh.2016.08.013.
46. FerlemiA.V., Katsikoudi A., Kontogianni V.G., Kellici T.F., latrou G., Lamari F.N., Tzakos A.G., Margarity M. Rosemary tea consumption results to anxiolytic- and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity; phytochemical investigation and in silico studies. //Chem. Biol. Interact. 2015 Jul 25; 237: 47-57. doi: 10.1016/j.cbi.2015.04.013.
47. Francolino R., Martino M., Caputo L., Amato G., Chianese G., Gargiulo E., Formisano C., Romano B., Ercolano G., lanaro A., De Martino L., Feo V. Phytochemical Constituents and Biological Activity of Wild and Cultivated Rosmarinus officinalis Hydroalcoholic Extracts. //Antioxidants (Basel). 2023 Aug 18; 12(8): 1633. doi: 10.3390/antioxl2081633.
48. Ghasemian M., Owlia S., Owlia M.B. Review of Anti-Inflammatory Herbal Medicines. //Adv. Pharmacol. Sci. 2016; 2016:9130979. doi: 10.1155/2016/9130979.
49. Ghasemzadeh M.R., Amin B., Mehri S., Mirnajafi-Zadeh S.J., Hosseinzadeh H. Effect of alcoholic extract of aerial parts of Rosmarinus officinalis L. on pain, inflammation and apoptosis induced by chronic constriction injury (CCI) model of neuropathic pain in rats. //J. Ethnopharmacol. 2016 Dec 24; 194: 117-130. doi: 10.1016/j.jep.2016.08.043.
50. Ghasemzadeh Rahbardar M., Amin B., Mehri S., Mirnajafi-Zadeh S.J., Hosseinzadeh H. Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. //Biomed. Pharmacother. 2017 Feb; 86: 441-449. doi: 10.1016/j.biopha.2016.12.049.
51. Ghasemzadeh Rahbardar M., Hosseinzadeh H. Effects of rosmarinic acid on nervous system disorders: an updated review. //Naunyn. Schmiedebergs Arch. Pharmacol. 2020 Oct; 393(10): 1779-1795. doi: 10.1007/S00210-020-01935-w.
52. Ghasemzadeh Rahbardar M., Hosseinzadeh H. Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. //Iran J. Basic. Med. Sci. 2020 Sep; 23(9): 1100-1112. doi: 10.22038/ijbms.2020.45269.10541.
53.
Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation. //Molecules. 2022 Jan 18; 27(3): 609. doi: 10.3390/molecules27030609.
54.
Guevara-
the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. //J. Ethnopharmacol. 2007 May 22; 111(3): 476-482. doi: 10.1016/j.jep.2006.12.011.
55. -Souza L.F.L., Lopes R.M., Arini G.S., Feitosa L.G.P., Silva R.R., Nantes I.L., Damasceno D.C., Lopes N.P., Rodrigues T. Rosemary (Rosmarinus officinalis L.) Glycolic Extract Protects Liver Mitochondria from Oxidative Damage and Prevents Acetaminophen-lnduced Hepatotoxicity. //Antioxidants (Basel). 2023 Mar 3; 12(3): 628. doi: 10.3390/antioxl2030628.
56. Guo Y., Xie J., Li X., Yuan Y., Zhang L., Hu W., Luo H., Yu H., Zhang R. Antidepressant Effects of Rosemary Extracts Associate With Anti-inflammatory Effect and Rebalance of Gut Microbiota. //Front. Pharmacol. 2018 Oct 2; 9: 1126. doi: 10.3389/fphar.2018.01126.
57. Habtemariam S. Anti-Inflammatory Therapeutic Mechanisms of Natural Products: Insight from Rosemary Diterpenes, Carnosic Acid and Carnosol. //Biomedicines. 2023 Feb 13; 11(2): 545. doi: 10.3390/biomedicines11020545.
58. Habtemariam S. The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer's Disease. //Evid. Based Complement. Alternat. Med. 2016; 2016:2680409. doi: 10.1155/2016/2680409.
59. Hajhashemi V., Salimian M., Hajihashemi O. Involvement of the NO/cGMP/K ATP pathway in the antinociceptive effect of rosemary (Rosmarinus officinalis) essential oil in mice. //Behav. Pharmacol. 2023 Feb 1; 34(1): 37-44. doi: 10.1097/FBP.0000000000000709.
60. Hassan M., Ismail H., Hammam O., Elsayed A., Othman O., Aly Hassan S. Natural inhibitors for acetylcholinesterase and autophagy
-amyloid in Alzheimer's rat model. //Biomarkers. 2023 May; 28(3): 273-288. doi: 10.1080/1354750X.2022.2164617.
61. Hussain A.I., Anwar F., Chatha S.A., Jabbar A., Mahboob S., Nigam P.S. Rosmarinus officinalis essential oil: antiproliferative, antioxidant and antibacterial activities. //Braz. J. Microbiol. 2010 Oct; 41(4): 1070-1078. doi: 10.1590/S1517-838220100004000027.
62. Hussain S.M., Syeda A.F., Alshammari M., Alnasser S., Alenzi N.D., Alanazi S.T., Nandakumar K. Cognition enhancing effect of rosemary (Rosmarinus officinalis L.) in lab animal studies: a systematic review and meta-analysis. //Braz. J. Med. Biol. Res. 2022 Feb 9; 55: e11593. doi: 10.1590/1414-431X2021e11593.
63. Inoue K., Takano H., Shiga A., Fujita Y., Makino H., Yanagisawa R., Ichinose T., Kato Y., Yamada T., Yoshikawa T. Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice. //Int. J. Mol. Med. 2005 Aug; 16(2): 315-319.
64. Jimbo D., Kimura Y., Taniguchi M., Inoue M., Urakami K. Effect of aromatherapy on patients with Alzheimer's disease. //Psychogeriatrics. 2009 Dec; 9(4): 173-179. doi: 10.1111/j.1479-8301,2009.00299.x.
65. Kamli M.R., Sharaf A.A.M., Sabir J.S.M., Rather I.A. Phytochemical Screening of Rosmarinus officinalis L. as a Potential Anticholinesterase and Antioxidant-Medicinal Plant for Cognitive Decline Disorders. //Plants (Basel). 2022 Feb 14; 11(4): 514. doi: 10.3390/plantsl 1040514.
66. Karagianni K., Pettas S., Kanata E., Lioulia E., Thune K., Schmitz M., Tsamesidis I., Lymperaki E., Xanthopoulos K., Sklaviadis T., Dafou D. Carnosic Acid and Carnosol Display Antioxidant and Anti-Prion Properties in In Vitro and Cell-Free Models of Prion Diseases. //Antioxidants (Basel). 2022 Apr 6; 11(4): 726. doi: 10.3390/antioxl 1040726.
67. Karim N., Khan I., Abdelhalim A., Abdel-Halim H., Hanrahan J.R. Molecular docking and antiamnesic effects of nepitrin isolated from Rosmarinus officinalis on scopolamine-induced memory impairment in mice. //Biomed. Pharmacother. 2017 Dec; 96: 700-709. doi: 10.1016/j.biopha.2017.09.121.
68. Kayashima T., Nagao K., Umino M., Kaikiri H., Shibata S., Matsubara K. Anti-stress effects of rosemary (Rosmarinus officinalis L.) leaf extract on intestinal goblet cells and immobility of forced-swimming test in BALB/c mice. //Biosci. Biotechnol. Biochem. 2020 Nov; 84(11): 2385-2389. doi: 10.1080/09168451.2020.1800445.
69. Kennedy D.O., Scholey A.B. The psychopharmacology of European herbs with cognition-enhancing properties. //Curr. Pharm. Des. 2006; 12(35): 4613-4623. doi: 10.2174/138161206779010387.
70. Khalid A., Abbasi U.A., Amber S., Sumera, Mirza F.J., Asif M., Javed A., Zahid S. Methylphenidate and Rosmarinus officinalis improves cognition and regulates inflammation and synaptic gene expression in AlCh-induced neurotoxicity mouse model. //Mol. Biol. Rep. 2020 Oct; 47(10): 7861-7870. doi: 10.1007/s11033-020-05864-y.
71. Kim S.J., Kim J.S., Cho H.S., Lee H.J., Kim S.Y., Kim S., Lee S.Y., Chun H.S. Carnosol, a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells. //Neuroreport. 2006 Nov 6; 17(16): 1729-1733. doi: 10.1097/01 .wnr.0000239951.14954.10.
72. Kim S.Y., Park E., Park J.A., Choi B.S., Kim S., Jeong G., Kim C.S., Kim D.K., Kim S.J., Chun H.S. The plant phenolic diterpene carnosol suppresses sodium nitroprusside-induced toxicity in c6 glial cells. //J. Agric. Food Chem. 2010 Feb 10; 58(3): 1543-1550. doi: 10.1021/jf903294x.
73. Kosaka K., Yokoi T. Carnosic acid, a component of rosemary (Rosmarinus officinalis L.), promotes synthesis of nerve growth factor in
T98G human glioblastoma cells. //Biol. Pharm. Bull. 2003 Nov; 26(11): 1620-1622. doi: 10.1248/bpb.26.1620.
74. Kuo C.F., Su J.D., Chiu C.H., Peng C.C., Chang C.H., Sung T.Y., Huang S.H., Lee W.C., Chyau C.C. Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves. //J. Agric. Food Chem. 2011 Apr 27; 59(8): 3674-3685. doi: 10.1021/jf104837w.
75. Lai C.S., Lee J.H., Ho C.T., Liu C.B., Wang J.M., Wang Y.J., Pan M.H. Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways. //J. Agric. Food Chem. 2009 Nov 25; 57(22): 10990-10998. doi: 10.1021/jf9025713.
76.
variations in the composition of the essential oils of rosemary (Rosmarinus officinalis, Lamiaceae). //Nat. Prod. Commun. 2013 Jan; 8(1): 131-134.
77. Li T., Wang W., Guo Q., Li J., Tang T., Wang Y., Liu D., Yang K., Li J., Deng K., Wang F., Li H., Wu Z., Guo J., Guo D., Shi Y., Zou J., Sun J., Zhang X., Yang M. Rosemary (Rosmarinus officinalis L.) hydrosol based on serotonergic synapse for insomnia. //J. Ethnopharmacol. 2024 Jan 10; 318(Pt B): 116984. doi: 10.1016/j.jep.2023.116984.
78. Lin C.Y., Chen J.H., Fu R.H., Tsai C.W. Induction of Pi form of glutathione S-transferase by carnosic acid is mediated through PI3K/Akt/NF-
Toxicol. 2014 Nov 17; 27(11): 1958-1966. doi: 10.1021/tx5003063.
79. Lorenzo- -Malo A., Bach H. Antimicrobial, Cytotoxic, and Anti-Inflammatory Activities of Pimenta dioica and Rosmarinus officinalis Essential Oils. //Biomed. Res. Int. 2019 May 7; 2019:1639726. doi: 10.1155/2019/1639726.
80. Lucarini R., Bernardes W.A., Ferreira D.S., Tozatti M.G.,
W.R. In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative. //Pharm. Biol. 2013 Sep; 51(9): 1087-1090. doi: 10.3109/13880209.2013.776613.
81. Machado D.G., Bettio L.E., Cunha M.P., Capra J.C., Dalmarco J.B., Pizzolatti M.G., Rodrigues A.L. Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system. //Prog. Neuropsychopharmacol. Biol. Psychiatry. 2009 Jun 15; 33(4): 642-650. doi: 10.1016/j.pnpbp.2009.03.004.
82. Machado D.G., Cunha M.P., Neis V.B., Balen G.O., Colla A., Bettio L.E., Oliveira A., Pazini F.L., Dalmarco J.B., Simionatto E.L., Pizzolatti M.G., Rodrigues A.L. Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus
officinalis L. //Food Chem. 2013 Jan 15; 136(2): 999-1005. doi: 10.1016/j.foodchem.2012.09.028.
83. Machado D.G., Cunha M.P., Neis V.B., Balen G.O., Colla A.R., Grando J., Brocardo P.S., Bettio L.E., Dalmarco J.В., Rial D., Prediger R.D., Pizzolatti M.G., Rodrigues A.L. Rosmarinus officinalis L. hydroalcoholic extract, similar to fluoxetine, reverses depressive-like behavior without altering learning deficit in olfactory bulbectomized mice. //J. Ethnopharmacol. 2012 Aug 30; 143(1): 158-169. doi: 10.1016/j.jep.2012.06.017.
84. Machado D.G., Neis V.B., Balen G.O., Colla A., Cunha M.P., Dalmarco J.В., Pizzolatti M.G., Prediger R.D., Rodrigues A.L. Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: evidence for the involvement of the dopaminergic system. //Pharmacol. Biochem. Behav. 2012 Dec; 103(2): 204-211. doi: 10.1016/j.pbb.2012.08.016.
85. Malik N., Amber S., Zahid S .Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCh-lnduced Mouse Model of Alzheimer's Disease. //Front Pharmacol. 2022 Aug 12; 13: 943163. doi: 10.3389/fphar.2022.943163.
86.
Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception. //J. Ethnopharmacol. 2012 Jun 26; 142(1): 28-34. doi: 10.1016/j.jep.2012.03.052.
87. McCaffrey R., Thomas D.J., Kinzelman A.O. The effects of lavender and rosemary essential oils on test-taking anxiety among graduate nursing students. //Holist. Nurs. Pract. 2009 Mar-Apr; 23(2): 88-93. doi: 10.1097/HNP.0b013e3181a110aa.
88. Mena P., Cirlini M., Tassotti M., Herrlinger K.A., Dall'Asta C., Del Rio D. Phytochemical Profiling of Flavonoids, Phenolic Acids, Terpenoids, and Volatile Fraction of a Rosemary (Rosmarinus officinalis L.) Extract. //Molecules. 2016 Nov 19; 21(11): 1576. doi: 10.3390/molecules21111576.
89. Mengoni E.S., Vichera G., Rigano L.A., Rodriguez-Puebla M.L., Galliano S.R., Cafferata E.E., Pivetta O.H., Moreno S., Vojnov A.A. Suppression of COX-2, IL-
infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L. //Fitoterapia. 2011 Apr; 82(3): 414-421. doi: 10.1016/j.fitote.2010.11.023.
90. Mirza F.J., Amber S., Sumera, Hassan D., Ahmed Т., Zahid S. Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic
1-42-induced
mouse model of Alzheimer's disease. //Phytomedicine. 2021 Mar; 83: 153490. doi: 10.1016/j.phymed.2021.153490.
91. Mirza F.J., Zahid S. Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer's disease. //Front. Pharmacol. 2022 Dec 22; 13: 1058358. doi: 10.3389/fphar.2022.1058358.
92. Mirza F.J., Zahid S., AmberS., Sumera, Jabeen H., Asim N., AN Shah S.A. Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer's Disease. //Molecules. 2022 Oct 25; 27(21): 7241. doi: 10.3390/molecules27217241.
93. Mirza F.J., Zahid S., Holsinger R.M.D. Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action. //Molecules. 2023 Mar 2; 28(5): 2306. doi: 10.3390/molecules28052306.
94. Moss M., Smith E., Milner M., McCready J. Acute ingestion of rosemary water: Evidence of cognitive and cerebrovascular effects in healthy adults. //J. Psychopharmacol. 2018 Dec; 32(12): 1319-1329. doi: 10.1177/0269881118798339.
95. Nabavi S.F., Tenore G.C., Daglia M., Tundis R., Loizzo M.R., Nabavi S.M. The cellular protective effects of rosmarinic acid: from bench to bedside. //Curr. Neurovasc. Res. 2015; 12(1): 98-105. doi: 10.2174/1567202612666150109113638.
96. Naderali E., Nikbakht F., Ofogh S.N., Rasoolijazi H. The role of rosemary extract in degeneration of hippocampal neurons induced by kainicacid in the rat: A behavioral and histochemical approach. //J. Integr. Neurosci. 2018; 17(1): 19-25. doi: 10.31083/JIN-170035.
97. Nasiri A., Boroomand M.M. The effect of rosemary essential oil inhalation on sleepiness and alertness of shift-working nurses: A randomized, controlled field trial. //Complement. Ther. Clin. Pract. 2021 May; 43: 101326. doi: 10.1016/j.ctcp.2021.101326.
98. Nematolahi P., Mehrabani M., Karami-Mohajeri S., Dabaghzadeh F. Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students: A randomized clinical trial. //Complement. Ther. Clin. Pract. 2018 Feb; 30: 24-28. doi: 10.1016/j.ctcp.2017.11.004.
99. Nogueira de Melo G.A., Grespan R., Fonseca J.P., Farinha T.O., Silva E.L., Romero A.L., Bersani-Amado C.A., Cuman R.K. Rosmarinus officinalis L. essential oil inhibits in vivo and in vitro leukocyte migration. //J. Med. Food. 2011 Sep; 14(9): 944-946. doi: 10.1089/jmf.2010.0159.
100. Noori Ahmad AbadiM., Mortazavi M., Kalani N., Marzouni H.Z., Kooti W., Ali-Akbari S. Effect of Hydroalcoholic Extract of Rosmarinus officinalis L. Leaf on Anxiety in Mice. //J. Evid. Based Complementary Altern. Med. 2016 Oct; 21(4): NP85-90. doi: 10.1177/2156587216642101.
101.0kamura N., Haraguchi H., Hashimoto K., Yagi A. Flavonoids in Rosmarinus officinalis leaves. //Phytochemistry. 1994 Nov; 37(5): 1463-1466. doi: 10.1016/S0031-9422(00)90434-5.
102.0lah N.K., Benedec D., Socaci S., Toma C.C., Filip L., Morgovan C., Hanganu D. Terpenic profile of different Rosmarinus officinalis extracts. //Pak. J. Pharm. Sci. 2017 Jul; 30(4(Suppl.)): 1439-1443.
103.0resanya I.O., Orhan I.E. Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies. //Curr. Drug Targets. 2024 Jan 22. doi: 10.2174/0113894501255093240117092328.
104.0zarowski M., Mikolajczak P.L., Bogacz A., Gryszczynska A., KujawskaM., Jodynis-Liebert J., PiaseckaA., Napieczynska H., SzulcM., Kujawski R., Bartkowiak-Wieczorek J., Cichocka J., Bobkiewicz-Kozlowska T., Czerny B., Mrozikiewicz P.M. Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. //Fitoterapia. 2013 Dec; 91: 261-271. doi: 10.1016/j.fitote.2013.09.012.
105.0zcan M.M., Chalchat J.C. Chemical composition and antifungal activity of rosemary (Rosmarinus officinalis L.) oil from Turkey. //Int. J. Food Sci. Nutr. 2008 Nov-Dec; 59(7-8): 691-698. doi: 10.1080/09637480701777944.
106. Park S.E., Kim S., Sapkota K., Kim S.J. Neuroprotective effect of Rosmarinus officinalis extract on human dopaminergic cell line, SH-SY5Y. //Cell. Mol. Neurobiol. 2010 Jul; 30(5): 759-767. doi: 10.1007/S10571-010-9502-3.
107.Peng C.H., Su J.D., Chyau C.C., Sung T.Y., Ho S.S., Peng C.C., Peng R.Y. Supercritical fluid extracts of rosemary leaves exhibit potent anti-inflammation and anti-tumor effects. //Biosci. Biotechnol. Biochem. 2007 Sep; 71(9): 2223-2232. doi: 10.1271/bbb.70199.
108. Pengelly A., Snow J., Mills S.Y., ScholeyA., Wesnes K., Butler L.R. Short-term study on the effects of rosemary on cognitive function in an elderly population. //J. Med. Food. 2012 Jan; 15(1): 10-17. doi: 10.1089/jmf.2011.0005.
109.Perry N.S.L., Menzies R., Hodgson F., Wedgewood P., Howes M.R., Brooker H.J., Wesnes K.A., Perry E.K. A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age. //Phytomedicine. 2018 Jan 15; 39: 42-48. doi: 10.1016/j.phymed.2017.08.015.
HO.Poeckel
C., Steinhilber D., Schubert-Zsilavecz M., Werz O. Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress proinflammatory responses of stimulated human polymorphonuclear
leukocytes. //Biochem. Pharmacol. 2008 Jul 1; 76(1): 91-97. doi: 10.1016/j.bcp.2008.04.013.
111.
B., Reglero G., De Miguel E. Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged rats. //Exp. Gerontol. 2009 Jun-Jul; 44(6-7): 383-389. doi: 10.1016/j.exger.2009.02.015.
112. Presti-Silva S.M., Herlinger A.L., Martins-Silva C., Pires R.G.W. Biochemical and behavioral effects of rosmarinic acid treatment in an animal model of Parkinson's disease induced by MPTP. //Behav. Brain Res. 2023 Feb 25; 440: 114257. doi: 10.1016/j.bbr.2022.114257.
113.Ramachandran C., Quirin K.W., Escalon E., Melnick S.J. Improved neuroprotective effects by combining Bacopa monnieri and Rosmarinus officinalis supercritical C02 extracts. //J. Evid. Based Complementary Altern. Med. 2014 Apr; 19(2): 119-127. doi: 10.1177/2156587214524577.
114.Raskovic A., Milanovic I., Pavlovic N., Milijasevic B., Ubavic M., Mikov M. Analgesic effects of rosemary essential oil and its interactions with codeine and paracetamol in mice. //Eur. Rev. Med. Pharmacol. Sci. 2015 Jan; 19(1): 165-172.
115.Rezaie T., McKercher S.R., Kosaka K., Seki M., Wheeler L., Viswanath V., Chun T., Joshi R., Valencia M., Sasaki S., Tozawa T., Satoh T., Lipton S.A. Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration. //Invest. Ophthalmol. Vis. Sci. 2012 Nov 27; 53(12): 7847-7854. doi: 10.1167/iovs. 12-10793.
116.Rezk S., Lashen S., El-Adl M., Elshopakey G.E., Elghareeb M.M., Hendam B.M., Caceci T., Cenciarelli C., Marei H.E. Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Alzheimer model) in rat. //Metab. Brain Dis. 2022 Apr; 37(4): 973-988. doi: 10.1007/sl 1011-021-00890-6.
117.Rocha J., Eduardo-Figueira M., Barateiro A., Fernandes A., Brites D., Bronze R., Duarte C.M., Serra A.T., Pinto R., Freitas M., Fernandes E., Silva-Lima B., Mota-Filipe H., Sepodes B. Antiinflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation. //Basic. Clin. Pharmacol. Toxicol. 2015 May; 116(5): 398-413. doi: 10.1111/bcpt. 12335.
118.Samarghandian S., Azimi-Nezhad M., Borji A., Samini M., Farkhondeh T. Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats. //BMC Complement. Altern. Med. 2017 May 4; 17(1): 249. doi: 10.1186/s12906-017-1753-9.
119.Santos Rodrigues A.P., Faria E. Souza B.S., Alves BarrosA.S., de Oliveira Carvalho H., Lobato Duarte J., Leticia Elizandra Boettger M.,
Barbosa R., Maciel Ferreira A., Maciel Ferreira I., Fernandes C.P., Cesar Matias Pereira A., Tavares Carvalho J.C. The effects of Rosmarinus officinalis L. essential oil and its nanoemulsion on dyslipidemic Wistar rats. //J. Appl. Biomed. 2020 Dec; 18(4): 126-135. doi: 10.32725/jab.2020.016.
120.Sasaki K., El Omri A., Kondo S., Han J., Isoda H. Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergicand cholinergic functions modulation. //Behav. Brain. Res. 2013 Feb 1; 238: 86-94. doi: 10.1016/j.bbr.2012.10.010.
121.Sasaki K., Ferdousi F., Fukumitsu S., Kuwata H., Isoda H. Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models: Involvement of oxytocinergic system. //Biomed. Pharmacother. 2021 Dec; 144: 112291. doi: 10.1016/j.biopha.2021.112291.
122.Satoh T., Trudler D., Oh C.K., Lipton S.A. Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome. //Antioxidants (Basel). 2022 Jan 6; 11(1): 124. doi: 10.3390/antiox11010124.
123.Satyal P., Jones T.H., Lopez E.M., McFeeters R.L., AN N.A., Mansi I., Al-Kaf A.G., Setzer W.N. Chemotypic Characterization and Biological Activity of Rosmarinus officinalis. //Foods. 2017 Mar 5; 6(3): 20. doi: 10.3390/foods6030020.
124.Sayadi Mank-Halati M., Rezaei M., Farzaei M.H., Khatony A. Comparing the effects of rosemary aromatherapy and music therapy on anxiety levels in patients undergoing general surgery: A randomized controlled clinical trial. //Explore (NY). 2024 Jan 9: S1550-8307(24)00002-8. doi: 10.1016/j.explore.2024.01.002.
125.Seibel R., Schneider R.H., Gottlieb M.G.V. Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease. //Curr. Alzheimer Res. 2021; 18(4): 347-357. doi: 10.2174/1567205018666210716122034.
126.Seyedemadi P., Rahnema M., Bigdeli M.R., Oryan S., Rafati H. The Neuroprotective Effect of Rosemary (Rosmarinus officinalis L.) Hydro-alcoholic Extract on Cerebral Ischemic Tolerance in Experimental Stroke. //Iran. J. Pharm. Res. 2016 Fall; 15(4): 875-883.
127.Shen X., Zhou M., Zhu X., Zhang J., Xu J., Jiang W. Chemical composition and antioxidant activity of petroleum ether fraction of Rosmarinus officinalis. //Heliyon. 2023 Oct 20; 9(11): e21316. doi: 10.1016/j.heliyon.2023.e21316.
128.Shimojo Y., Kosaka K., Noda Y., Shimizu T., Shirasawa T. Effect of rosmarinic acid in motor dysfunction and life span in a mouse model of familial amyotrophic lateral sclerosis. //J. Neurosci. Res. 2010 Mar; 88(4): 896-904. doi: 10.1002/jnr.22242.
129.Solhi H., Salehi B., Alimoradian A., Pazouki S., Taghizadeh M., Saleh A.M., Kazemifar A.M. Beneficial Effects of Rosmarinus Officinalis for Treatment of Opium Withdrawal Syndrome during Addiction Treatment Programs: A Clinical Trial. //Addict. Health. 2013 Summer-Autumn; 5(3-4): 90-94.
130.Song H., Xu L., Zhang R., Cao Z., Zhang H., Yang L., Guo Z., Qu Y., Yu J. Rosemary extract improves cognitive deficits in a rats model of repetitive mild traumatic brain injury associated with reduction of astrocytosis and neuronal degeneration in hippocampus. //Neurosci. Lett.
2016 May 27; 622: 95-101. doi: 10.1016/j.neulet.2016.04.048.
131.Takahashi A., Dohi H., Egashira Y., Hirai S. Erucic acid derived from rosemary regulates differentiation of mesenchymal stem cells into osteoblasts/adipocytes via suppression of peroxisome proliferator-
ther. Res. 2020 Jun;
34(6): 1358-1366. doi: 10.1002/ptr.6607.
132.Takaki I., Bersani-Amado L.E., Vendruscolo A., Sartoretto S.M., Diniz S.P., Bersani-Amado C.A., Cuman R.K. Anti-inflammatory and antinociceptive effects of Rosmarinus officinalis L. essential oil in experimental animal models. //J. Med. Food. 2008 Dec; 11(4): 741-746. doi: 10.1089/jmf.2007.0524.
133.Tamaki Y., Tabuchi T., Takahashi T., Kosaka K., Satoh T. Activated glutathione metabolism participates in protective effects of carnosic acid against oxidative stress in neuronal HT22 cells. //Planta Med. 2010 May; 76(7): 683-688. doi: 10.1055/S-0029-1240622.
134.Ulewicz-Magulska B., Wesolowski M. Antioxidant Activity of Medicinal Herbs and Spices from Plants of the Lamiaceae, Apiaceae and Asteraceae Families: Chemometric Interpretation of the Data. //Antioxidants (Basel). 2023 Nov 24; 12(12): 2039. doi: 10.3390/antioxl 2122039.
135.Vagedes J., Henes J., Deckers B., Vagedes K., Kuderer S., Helmert E., von Schoen-Angerer T. Topical Rosmarinus officinalis L. in Systemic Sclerosis-Related Raynaud's Phenomenon: An Open-Label Pilot Study. //Complement. Med. Res. 2022; 29(3): 242-248. doi: 10.1159/000522507.
136.Ventura-
Trujano M.E. Spasmolytic activity of Rosmarinus officinalis L. involves calcium channels in the guinea pig ileum. //J. Ethnopharmacol. 2011 Oct 11; 137(3): 1528-1532. doi: 10.1016/j.jep.2011.08.047.
137. Villareal M.O., Ikeya A., Sasaki K., Arfa A.B., Neffati M., Isoda H. Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil. //BMC Complement. Altern. Med.
2017 Dec 22; 17(1): 549. doi: 10.1186/s12906-017-2060-1.
138.Wang W., Wu N., Zu Y.G., Fu Y.J. Antioxidative activity of Rosmarinus officinalis L. essential oil compared to its main components.
//Food Chem. 2008 Jun 1; 108(3): 1019-1022. doi: 10.1016/j.foodchem.2007.11.046.
139.Wijeratne S.S., Cuppett S.L. Potential of rosemary (Rosemarinus officinalis L.) diterpenes in preventing lipid hydroperoxide-mediated oxidative stress in Caco-2 cells. //J. Agric. Food Chem. 2007 Feb 21; 55(4): 1193-1199. doi: 10.1021/jf063089m.
140.Wu C.R., Tsai C.W., Chang S.W., Lin C.Y., Huang L.C., Tsai C.W. Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson's disease: involvement of antioxidative enzymes induction. //Chem. Biol. Interact. 2015 Jan 5; 225: 40-46. doi: 10.1016/j.cbi.2014.11.011.
141. Yu M.H., Choi J.H., Chae I.G., Im H.G., Yang S.A., More K., Lee I.S., Lee J. Suppression of LPS-induced inflammatory activities by Rosmarinus officinalis L. //Food Chem. 2013 Jan 15; 136(2): 1047-1054. doi: 10.1016/j.foodchem.2012.08.085.
142.Zeng H.H., Tu P.F., Zhou K., Wang H., Wang B.H., Lu J.F. Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis. //Acta Pharmacol. Sin. 2001 Dec; 22(12): 1094-1098.
143.Zhou P., Wang X., Zhao Y., She X., Jia Y., Wang W., Li J., Luo X. Evaluation of the Mechanism of Action of Rosemary Volatile Oil in the Treatment of Alzheimer's Disease Using Gas Chromatography -mass Spectrometry Analysis and Network Pharmacology. //Comb. Chem. High Throughput. Screen. 2023; 26(13): 2321-2332. doi: 10.2174/1386207325666220930091758.
