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ПРИМЕНЕНИЕ РОЗМАРИНА ПРИ ЗАБОЛЕВАНИЯХ НЕРВНОЙ СИСТЕМЫ (ОБЗОР ЛИТЕРАТУРЫ) doi: 10.24412/cl-34438-2024-1-211-243.
КАРОМАТОВ ИНОМДЖОН ДЖУРАЕВИЧ
руководитель медицинского центра «Магия здоровья», ассистент кафедры народной медицины и профессиональных болезней Бухарского государственного медицинского института. Город Бухара. Республика Узбекистан. ORCID ID 0000-0002-2162-9823 БАЙМУРАДОВ РАДЖАБ САЙФИТДИНОВИЧ доцент кафедры спортивной деятельности Бухарского государственного Университета. Город Бухара.
Республика Узбекистан. ORCID ID 0000-0002-2650-7921
САФАРОВА МАСТУРА ТУЛКИНОВНА студентка Бухарского государственного университета. Город Бухара Республики Узбекистан.
ORCID ID 0009-0008-7863-0340 АННОТАЦИЯ
Как и все приправы, экстракты розмарина обладают выраженными антиоксидантными свойствами. Эксперименты на животных выявили антистрессовый эффект экстракта листьев розмарина. Сырой экстракт розмарина проявлял противовоспалительную активность, ингибируя лейкоциты и уменьшая экссудацию. Эти эффекты были связаны со снижением провоспали-тельных параметров (миелопероксидаза, аденозиндезаминаза, нитрит/нитрат и интерлейкин 17A) и увеличением противовоспалительного цитокина (интерлейкин 10). Ароматические растения, шалфей (Salvia officinalis), лаванда (Lavandula angustifolia) и розмарин (Salvia Rosmarinus) обладают анксиолитическими,
противовоспалительными, антиоксидантными и нейропротек-торными свойствами, перспективны в лечении распространенных неврологических расстройств, включая болезнь Альцгеймера, болезнь Паркинсона, мигрень и когнитивные расстройства. Экспериментальные исследования показали, что экстракт розмарина, благодаря антиоксидантным свойствам предупреждает поражение мозга, нервную ткань и развитие эпилептических припадков под воздействием пентилентетразола. Экстракты розмарина обладают антидепрессант- и анксиолитической активностью посредством модуляции окситоцинергической системы в мозге мышей. Рандомизированные, контролируемые клинические исследования показали, что ингаляционная ароматерапия маслом розмарина, музыкальная терапия и комбинированная аромате-рапия и музыкальная терапия являются эффективными подходами для снижения тревожности у хирургических пациентов.
Ключевые слова: розмарин, Rosmarinus officinalis, специи, приправы, ароматерапия, растительные антидепрессанты, фитотерапия, фитотерапия дегенеративных заболеваний нервной системы.
ROSEMARY IN NERVOUS SYSTEM DISEASES (LITERATURE REVIEW)
KAROMATOVINOMJON DZHURAEVICH
Head of the Medical Center "Health Magic, " Assistant of the Department of Folk Medicine and Professional Diseases of the Bukhara State Medical Institute. City of Bukhara. Republic of
Uzbekistan. ORCID ID 0000-0002-2162-9823. BAYMURADOVRAJAB SAYFITDINOVICH Associate Professor of the Department of Sports Activities, Bukhara State University. City of Bukhara. Republic of
Uzbekistan. ORCID ID 0000-0002-2650-7921 SAFAROVA MASTURA TULKNOVNA
student of Bukhara State University. City of Bukhara of the Republic of Uzbekistan. ORCID ID 0009-0008-7863-0340
ABSTRACT
Like all seasonings, rosemary extracts have pronounced antioxidant properties. Animal experiments revealed the anti-stress effect of rosemary leaf extract. The crude rosemary extract exhibited anti-inflammatory activity, inhibiting white blood cells and reducing exudation. These effects were associated with decreased pro-inflammatory parameters (myeloperoxidase, adenosine deaminase, nitrite/nitrate, and interleukin 17A) and increased anti-inflammatory cytokine (interleukin 10). Aromatic plants, sage (Salvia officinalis), lavender (Lavandula angustifolia) and rosemary (Salvia Rosmarinus) have anxiolytic, anti-inflammatory, antioxidant and neuroprotective properties, promising in the treatment of common neurological disorders, including Alzheimer's disease, Parkinson's disease, migraine and cognitive disorders. Experimental studies have shown that rosemary extract, thanks to antioxidant properties, prevents brain damage, nerve tissue and the development of epileptic seizures under the influence of pentylene tetrazole. Rosemary extracts have antidepressant and anxiolytic activity through modulation of the oxytocinergic system in mouse brains. Randomized, controlled clinical trials have shown that inhaled rosemary oil aromatherapy, music therapy, and combination aromatherapy and music therapy are effective approaches to reduce anxiety in surgical patients.
Keywords: rosemary, Rosmarinus officinalis, spices, aromatherapy, herbal antidepressants, phytotherapy, phytotherapy of degenerative diseases of nervous system.
РОЗМАРИННИНГ АСАБ ТИЗИМИ КАСАЛЛИКЛАРИДА КУЛЛАНИЛИШИ (АДАБИЁТЛАР ШАР^И)
КАРОМАТОВ ИНОМДЖОН ДЖУРАЕВИЧ
«Магия здоровья» тиббий маркази бошлиги, халц табобати ва касб касалликлари кафедраси ассистенти, Бухоро давлат тиббиёт институти, Бухоро ш., Узбекистон
Республикаси ORCID ID 0000-0002-2162-9823 БАЙМУРАДОВ РАДЖАБ САЙФИТДИНОВИЧ Спорт фаолияти кафедраси доценти, Бухоро давлат университети. Бухоро ш., Узбекистон Республикаси
ORCID ID 0000-0002-2650-7921 САФАРОВА МАСТУРА ТУЛКИНОВНА Талаба, Бухоро давлат университети, Бухоро ш., Узбекистон Республикаси ORCID ID 0009-0008-7863-0340
АННОТАЦИЯ
Барча зираворлар сингари розмарин экстракти яццол анти-оксидант таъсирга эга. Хайвонларда утказилган тадцицотлар розмарин барглари экстрактининг стрессга царши хусусият-ларини аницлади. Розмарин экстракти лейкоцитларни ингибирлаш ва экссудацияни камайтириш орцали яллигланишга царши таъсир курсатади. Бу таъсирлар яллигланишни цуллаб цувватловчи курсаткичларнинг (миелопероксидаза, аденозиндезаминаза, нитрит / нитрат ва интерлейкин 17A) камайиши ва яллигланишга царши цитокиннинг (интерлейкин 10) ошиши билан боглиц. Ароматик усимликлар, мармарак (Salvia officinalis), лаванда (Lavandula angustifolia) ва розмарин (Salvia Rosmarinus) анксиолитик, яллигланишга царши, антиоксидант ва нейропротектив таъсир-ларга эга, тарцалган асаб бузилишларини, шу жумладан Альцгеймер касаллиги, Паркинсон касаллиги, мигрень ва когнитив бузилишларни даволашда истицболли цисобланади. Эксперимен-
тал тадцицотлар курсатишича, розмарин экстракти анти-оксидант хусусиятлари туфайли мия, асаб туцимаси зарарланиши ва пентилентетразол таъсирида ривожланадиган тутцаноцлар ривожланишини олдини олади. Розмарин экстракти сичцонлар миясида окситоцинергик тизимнинг модуляцияси орцали антидепрессант ва анксиолитик таъсир курсатади. Рандомизирланган, назорат цилинадиган клиник тадцицотлар курсатишича, розмарин мойи билан ингаляцион ароматерапия, мусицали терапия ва комбинирланган ароматерапия хирургик беморларда хавотирни енгишга ёрдам беради.
Калит сузлар: розмарин, Rosmarinus officinalis, зираворлар, ароматерапия, антидепрессант усимликлар, фитотерапия, асаб тизими дегенератив касалликлари фитотерапияси
Rosmarinus officinalis - -
(Rosmarinus
Lamiaceae).
[3].
фММаШФЯЩЯ
216
Химический состав.
-37,7%), 1,8- -29,3%), (+) - -16,9%), (-)
-6,9%), (-) - -
-4,4%) [101; 105; 76; 123; 102; 61; 119; 13].
[1].
[6; 127].
[88].
[5].
[142; 139; 16; 134; 47;
[111].
[68].
Rosmarinus officinalis L
[99; 48; 24].
SH-SY5Y
Nrf2/HO-
NF- [23; 33].
[63; 49].
[117].
A
[138; 132; 74; 31].
NF-kB
iNOS COX-
[141].
TNF- , IL- IL-6),
[107; 110; 30; 25; 79; 27;
53; 57].
[59].
aromaticum Rosmarinus officinalis
Syzygium
[36].
COX COX
[42].
[86].
COX-
Rosmarinus officinalis
KCl [136].
[89].
NF-kappaB STAT PI3K/Akt MAPK
iNOS
[75].
[86].
[114].
[80].
[54].
PPAR
[131].
Salvia officinalis (Lavandula angustifolia Salvia Rosmarinus
[71; 133; 44; 116].
R. officinalis
[50].
[32].
[126].
РС
[41].
[118].
А1С13 Н2О2
[70; 51; 103].
[18].
[69; 96].
SAMP [45].
[12; 104]. R. officinalis
[19; 62].
[94].
SRM- (Salvia officinalis L., Rosmarinus officinalis L Melissa officinalis L
[109].
Rosmarinus officinalis [67].
[10].
[130].
[98].
т vitro
[100].
N -D-
[
[95; 58; 22; 91].
Rosmarinus officinalis
- BACE
R. officinalis
[90].
Rosmarinus officinalis L
[85].
1-42-
Crocus
sativus L
[60].
PI3K/Akt/Nrf
Nrf2 [35]. R. officinalis H 2O2
[106].
[52].
SARS-CoV-
[122].
- [78;
140; 34].
Васора топтеп
[113].
с6 [72]. NGF [73].
[66].
[129].
АМ
[21].
[128].
[20]. BDNF
[46; 11].
[81; 120].
(50-
[9].
[26; 121].
R. officinalis [82; 83].
BV-[56].
[40].
D D (2) [84]. Rosmarinus officinalis Curcuma longa
DD
[43]. -
[29].
[77].
[135].
[115].
[37].
[2].
[124].
[64].
[87].
[137].
[97].
[4].
[7; 8].
[28].
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