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55Бюллетень науки и практики / Bulletin of Science and Practice Т. 6. №9. 2020
https://www.bulletennauki.com https://doi.org/10.33619/2414-2948/58
появления каждого из исследуемых веществ и лекарственного сырья. Автор указывает на их безопасные свойства и возможные недостатки применения, а также побочные эффекты.
Keywords: sweetener, diabetes mellitus, diet, nutritionist, healthy lifestyle.
Ключевые слова: подсластитель, сахарный диабет, диета, нутрициолог, здоровый образ жизни.
Introduction
Sweeteners are becoming more and more popular in the world nowadays both among those who lead a healthy lifestyle and ordinary people. Any attempts to restrict or even give up using sugar in meals make human beings feel ill at ease. Hence, nutritionists worldwide are puzzled how, on the one hand, to preserve the customary taste in foods and drinks we consume, and, on the other hand, cause no harm to human health. As for diabetes mellitus (DM), how can one choose a sugar substitute that makes a full-fledged substitute for sugar and, at the same time, be safe? Are all sweeteners dangerous or is it another myth that requires debunking? Let us have a go at handling these issues.
Saccharin history as food additive The first sugar substitute was accidentally invented by the Russian chemist Konstantin Falberg. He paid attention to the sweet taste of bread he was eating during lunch. It appeared that it was not flour that was sweet in taste but the chemist's fingers. Thus, sulphobenzoic acid was discovered. A little later, Falberg synthesized saccharin (E954) from it which he successfully patented in 1884. Saccharin is eliminated from the body in its original form with urine.
A few studies held in 1960s in the US proved saccharin was a carcinogen causing urinary bladder cancer in rats. The latter were fed with high dosages of saccharin which exceeded their weight. In 1977 the US Food and Drug Administration (FDA), Canada and the USSR banned saccharin in the food industry. However, later it was established and confirmed that the permissible daily dosage of 5 mg per 1 kg of human weight is completely harmless. In 1991 FDA re-established saccharin as safe sweetener. Still the product packaging inscriptions with warnings of possible health consequences of saccharin were maintained in 1981-2000. Nowadays the use of saccharin is authorized in more than 90 countries, including Russia.
Saccharin is used in the food industry as a sweetener and flavoring. It is zero-calorie, from 300 to 500 times sweeter than sugar. In the production of beverages, it is used as one of the components of sweeteners, because when used alone, foods acquire an unpleasant metallic taste. But now its use in the food industry is significantly reduced.
The most popular sugar substitutes among diabetics are fructose, sorbitol, xylitol and stevia.
Fructose impact on glycemic control Fructose is the sweetest of all-natural sugars. It is present in all sweet fruits, honey, some vegetables, while it is less calorie than sugar and not so harmful to the teeth. Unlike other carbohydrates, fructose is involved in intracellular metabolism without insulin. It is removed from the blood in a short period of time, as a result, blood sugar rises less than after glucose. The daily
Бюллетень науки и практики / Bulletin of Science and Practice Т. 6. №9. 2020
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allowed intake of fructose is about 35 grams. Fructose is allowed in the diabetic diet. Due to its high sweetness, it helps to reduce the consumption of sugar. Its nutritional value is 368 kcal per 100 grams of dry powder.
Cozma's et al. (2012) meta-analysis inquired into the effect of fructose on glycemic control in DM. The research proved that isocaloric exchange of fructose for other carbohydrate improves long-term glycemic control, as assessed by glycated blood proteins, without affecting insulin in people with diabetes. DM changes the macronutrients metabolism. Hence, the role of diabetic diet and the quality of carbohydrates consumed are of considerable interest [1].
Gomez-Samano et al. (2018) investigated the complications which may be cause by fructose intake. Their research was dedicated to possible links between albuminuria and fructose consumption in people with T2MD. As many as 136 volunteers participated in a single centre cross-sectional study and were assessed. The research proved a significant positive link between fructose intake and albuminuria in people with T2DM. The scientists reported gender differences in albuminuria progress. Despite the fact that fructose intake equalled in male and female participants, albuminuria was higher in males then in females. In addition, a high fructose intake (>25 g a day) was reported to aggravate oxidative stress and increase uric acid, triglycerides, hence, leading to kidney damage (diabetic nephropathy) [2].
Sorbitol use: pros and cons
Sorbitol (E420) is one of the most popular sugar substitutes on the Russian domestic consumer market. The import of sorbitol (mostly from France) totalled 32m USD in 2018 [3]. Sorbitol is widely used in the food industry as a natural sweetener and an ingredient with a wide range of technological and functional properties. Sorbitol is a colorless sweet crystals, soluble in water and alcohol. It is also used in pharmaceuticals, cosmetics and some other areas. Sorbitol's nutritional value is 3.5 kcal/g only. The sweetness of the sugar substitute is 40 per cent lower than sugar. At the same time, when consumed, it almost does not lead to a hike of glucose in blood because of its poor absorption. Sorbitol glycemic index is equal to 4. As much as 98 per cent of sorbitol consumed is absorbed by the human body. It is non-toxic and harmless for human health.
Sorbitol is widely used in the production of sugar-free confectionery since it adds mass and increases structural stability in foodstuffs. The sweetener regulates the moisture content, hence, increasing the foods shelf life. Sorbitol absorbs environmental moisture, thereby maintaining moisture and extending the shelf life of foodstuffs. For instance, candies, jelly, marshmallow and some other products dry out rapidly, their quality deteriorating. Therefore, for better preservation, from 5 to 10 per cent of sorbitol is added to them.
In cosmetics, sorbitol acts as a moisturizer, making human skin velvety and soft. Sorbitol is also used as an emulsifier, it gives a certain consistency to the products — it is used in the production of margarine, sauces, egg and fatty products. In addition, sorbitol is a free-flow agent, it tends to prevent the dry foods caking (e.g. in concentrates, jelly, puddings, and other powdered products). Sorbitol is also used in food production as a complex former and color stabilizer.
Sorbitol was first extracted from ash-berries in 1868. Its highest concentrations are found in ash-berries, blackthorn, cornel, apricots and haws. In subjects diagnosed for as T2DM it is absorbed better than glucose and does not require insulin. In addition, sorbitol has an antiketogenic effect which is important for patients with ketoacidosis episodes in medical history. Sorbitol affects the
Бюллетень науки и практики / Bulletin of Science and Practice Т. 6. №9. 2020
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activity of the gastrointestinal tract, stimulates the secretion of gastric juice, has a cholagogue effect and can be prescribed for hypotonic biliary dyskinesia. However, patients with T2DM are advised to make one-month intervals after each 3 months of continuous sorbitol consumption. Fermentation of sorbitol in the large intestine can create gastrointestinal discomfort including bloating, gas and diarrhea, dehydration, nausea and vomiting. But these effects are not the same for everyone. The FDA found sorbitol safe overall and approved its daily dosage of <50 g a day. Its use has not been studied well enough in pregnant women to determine whether it's safe for the fetus.
Medical use of xylitol
Xylitol (E967) was first synthesized in 1891 by Bertrand and Fisher by reducing D-, and L-xylose with sodium amalgam. Cotton husk, wood raw material (birch), sunflower husk, and other agricultural waste served as raw materials for the production of xylitol. The most important advantage was the cost-effectiveness of manufacturing these products, because the raw materials used for other purposes have almost never used before. Xylitol is absorbed more slowly than glucose: its absorption rate is 20 per cent lower than that of glucose. Thus, the sugar substitute can be recommended to patients with T2DM. In 2011, the European Food Safety Authority (EFSA) approved a marketing claim that foods or beverages containing xylitol or similar artificial sweeteners cause lower blood glucose and lower insulin responses compared to sugar-containing foods or drinks. Therefore, high dosages of xylitol may cause diarrhea due to its water retention effect through accumulation in the intestine. A 40-gramme daily intake of xylitol increases blood sugar by 1.1 mmol/l only. Xylitol is reported to enhance oxygen absorption and inhibits the formation of acetoacetic acid in liver. The sweetener is allowed for use in patients with DM, although it can be prescribed as cholekinetic which forces the gall bladder to contract without any side effects observed. Some reports say xylitol can be an allergen, so it should be taken with care by highly allergic individuals.
Stevia in T2DM
Stevia is a natural sweetener. Its main component, steviol glycosides, lacks calories and 300 times sweeter than sugar. Regular consumption of stevia in the permitted dosage (max. 2 mg/kg of body weight per day) is beneficial to the whole body.
FDA approved high-purity steviol glycosides as a safe food additive in the USA in 2008, although stevia leaf and crude stevia extracts are not considered safe and do not have FDA approval for use in food [4].
As to stevia consumption by T2DM patients, stevia lowers blood sugar levels, whereas it does not change normal sugar. Stevia also has the ability to stimulate insulin secretion in pancreas. That's why in some countries, medicines, which have stevia as an ingredient and tea with stevia, are included in the mandatory treatment programme for DM. Stevioside helps to restore the sensitivity of the body's cells to insulin and increase the penetration of glucose. Contra-indications to the use of stevia are idiosyncrasy, hypotension, allergy.
Бюллетень науки и практики / Bulletin of Science and Practice Т. 6. №9. 2020
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Conclusion
Thus, of the four sweeteners reviewed in the article, only stevia can be considered today as a safe alternative to sugar in DM, since it has a minimum of side effects and contraindications. It is less toxic than synthetic sugar additives, well-tolerated, has a good taste, and is affordable in price.
References:
1. Cozma, A. I., Sievenpiper, J. L., De Souza, R. J., Chiavaroli, L., Ha, V., Wang, D. D., ... & Jenkins, A. L. (2012). Effect of fructose on glycemic control in diabetes: a systematic review and meta-analysis of controlled feeding trials. Diabetes care, 35(7), 1611-1620. https://doi.org/10.2337/dc12-0073
2. Gómez-Sámano, M. Á., Almeda-Valdes, P., Cuevas-Ramos, D., Navarro-Flores, M. F., Espinosa-Salazar, H. D., Martínez-Saavedra, M., ... & Rivera-González, L. A. (2018). A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus. International journal of nephrology. https://doi.org/10.1155/2018/5459439
3. Sadiku, M. N., Musa, S. M., & Ashaolu, T. J. (2019). Food Industry: An Introduction. International Journal of Trend in Scientific Research and Development, 3(4). https://doi.org/10.31142/ijtsrd23638
4. (2018). US Food and Drug Administration. Has Stevia been approved by FDA to be used as a sweetener.
Список литературы:
1. Cozma A. I., Sievenpiper J. L., De Souza R. J., Chiavaroli L., Ha V., Wang D. D., ... Jenkins A. L. Effect of fructose on glycemic control in diabetes: a systematic review and metaanalysis of controlled feeding trials // Diabetes care. 2012. V. 35. №7. P. 1611-1620. https://doi.org/10.2337/dc12-0073
2. Gómez-Sámano M. Á., Almeda-Valdes P., Cuevas-Ramos D., Navarro-Flores M. F., Espinosa-Salazar H. D., Martínez-Saavedra M., ... Rivera-González L. A. A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus // International journal of nephrology. 2018. V. 2018. https://doi.org/10.1155/2018/5459439
3. Sadiku M. N. O., Musa S. M., Ashaolu T. J. Food Industry: An Introduction // International Journal of Trend in Scientific Research and Development. 2019. V. 3. №4. https://doi.org/10.31142/ijtsrd23638
4. US Food and Drug Administration. Stevia been approved by FDA to be used as a sweetener.
Работа поступила Принята к публикации
в редакцию 12.06.2020 г. 17.06.2020 г.
Бюллетень науки и практики / Bulletin of Science and Practice Т. 6. №9. 2020
https://www.bulletennauki.com https://doi.org/10.33619/2414-2948/58
Ссылка для цитирования:
Evseev A. Sweeteners in Diabetes Mellitus Diet // Бюллетень науки и практики. 2020. Т. 6. №9. С. 192-197. https://doi.org/10.33619/2414-2948/58/18
Cite as (APA):
Evseev, A. (2020). Sweeteners in Diabetes Mellitus Diet. Bulletin of Science and Practice, 6(9), 192-197. https://doi.org/10.33619/2414-2948/58/18
Бюллетень науки и практики / Bulletin of Science and Practice Т. 6. №9. 2020
https://www.bulletennauki.com https://doi.org/10.33619/2414-2948/58
ТЕХНИЧЕСКИЕ НА УКИ / TECHNICAL SCIENCES
УДК 66.023.2 https://doi.org/10.33619/2414-2948/58/19
МОДЕРНИЗИРОВАННАЯ ЭКСПЕРИМЕНТАЛЬНАЯ УСТАНОВКА ДЛЯ РЕГИСТРАЦИИ И ИССЛЕДОВАНИЯ МНОГОЗАРЯДНЫХ ИОНОВ ЛАЗЕРНОЙ ПЛАЗМЫ
©Матназаров А. Р., канд. физ.-мат. наук, Ургенчский государственный университет, г. Ургенч, Узбекистан, [email protected] ©Давлетов И. Ю., д-р физ.-мат. наук, Ургенчский государственный университет, г. Ургенч,
Узбекистан, [email protected] ©Жапаков А. И., Ургенчский государственный университет, г. Ургенч, Узбекистан,
UPGRADED EXPERIMENTAL APPARATUS FOR THE DETECTION AND INVESTIGATION OF MULTIPLY CHARGED IONS OF A LASER PLASMA
©Matnazarov A., Ph.D., Urgench State University, Urgench, Uzbekistan, [email protected] ©Davletov I., Sc.D., Urgench State University, Urgench, Uzbekistan, [email protected] ©Japakov A., Urgench State University, Urgench, Uzbekistan. [email protected]
Аннотация. В статье приведены данные по модернизированной экспериментальной установке для исследования взаимодействия излучения лазера с твердыми телами при различных углах падения. Для регистрации и исследования спектра ядер исследуемых элементов был использован твердотельный неодимовый лазер, работающий в моноимпульсном режиме.
Abstract. The article analyses about the usage of a modernized experimental setup for studying the interaction of laser radiation with solids at different angles of incidence. To register and investigation the spectrum of the nuclei in the elements under study, a solid-state neodymium laser operating was used in a mono-pulse mode.
Ключевые слова: лазер, масс-спектрометр, атом, ядро, спектр, параметр, плазма, заряд, мишень, легких элементов, рекомбинация, излучения, многозарядные ионы.
Keywords: laser, mass-spectrometry, atom, nucleus, spectrum, parameter, plasma, charge, target, radiation, recombination, multiply charged ions.
Модернизация экспериментальной установки для исследования взаимодействия скользящего излучения лазера с поверхностью твердых тел, проведено сравнительное исследование процессов образования масс-зарядовых, энергетических и других характеристик лазерной плазмы, получаемой при углах падения излучения лазера а=18° и 85°. Идентифицированы масс-зарядовые спектры ионов лазерной плазмы, получаемые в зависимости от плотности мощности и углов падения излучения лазера. Установка позволяла получать и изучать особенности формирования спектра многозарядных ионов лазерной плазмы, образованных при скользящем падении излучения лазера. Также разработанная
