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DOI 10.24412/cl-37136-2023-1-129-130
PHOTOACOUSTIC MOLECULAR IMAGING TECHNOLOGY AND APPLICATIONS
CHENGBO LIU
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China
cb.liu@siat.ac.cn
ABSTRACT
Photoacoustic molecular imaging possesses the merits of both high optical contrast and large acoustic penetration. It is expected to play a more and more important role in both fundamental research and clinical applications, and has the potential to revolutionize the playground of tumor and cardiovascular disease management and treatment. In this talk, I will focus on how we improve the speed of photoacoustic molecular imaging. I will start with conventional photoacoustic microscopy using point-by-point mechanical scanning. Then I will move on to fast optical scanning based on MEMS and polygon mirror devices. After that, I will introduce single pixel imaging method without the need of scanning. Combined with sparse sampling, the imaging speed can be improved by 20 times. Besides photoacoustic microscopy, we also built photoacoustic computed tomography system which uses an array of ultrasound transducers to sense the signals. Due to simultaneous acquisition of photoacoustic signals, PACT can acquire 100 frames of two-dimensional images in one second. We applied our technology and instrumentation to study tumor microenvironment and evolution of tumor, as well as to investigate the mechanism of neurovascular coupling in the brain. We also intraoperatively guided a biopsy needle with photoacoustic imaging to extract tissue samples from sentinel lymph node to monitor tumor metastasis status. Our technology has also been successfully translated to human imaging to diagnose vascular plaques and image periphery blood vessels, aiming at better management of diseases such as diabetic foot or varicosity.
