CC BY
11B-I-11
BIOMEDICAL PHOTONICS
OCE-assisted monitoring and quantification of osmotically-induced strain in
biological tissues
Yu.M. Alexandrovskaya1, O.I. Baum1, A.A. Sovetsvky2, A.L. Matveyev2, L.A. Matveev2, V.Y. Zaitsev2
1 Institute of Photon Technologies, Federal Scientific Research Centre 'Crystallography and Photonics' of Russian
Academy of Sciences, Troitsk, 108840 Moscow, Russia 2 Institute of Applied Physics of the Russian Academy of Sciences, 603950 Nizhny Novgorod, Russia
The work shows that diffusion of the non-isotonic solutions through biological tissues is accompanied by non-uniform strain, for which its sign and amplitude depend on the solution type and concentration. Such strain often occurs when various optical clearing and/or contrast agents are applied in order to improve the quality of MRI, CT or optical diagnostics. Osmotic strains may affect the tissue integrity, as well as influence the results of diagnostic procedures. Besides, in some cases it may provide additional diagnostically relevant information concerning the tissue hydration and permeability. In the present work the recently developed technique, optical coherence elastography, is used to enable monitoring of spatial distribution and dynamics of osmotically-induced strain within porous biological tissues [1,2]. The effect of different types and concentrations of optical clearing and osmotically active agents, such as polyhydric alcohols, PEGs, saccharides and polyelectrolytes, on the dynamic of osmotically-induced strain within porous biological tissues is discussed in comparative manner. The general regularities of the tissue response to concentration gradients are revealed and described.
The study was supported by the Russian Science Foundation grant No. 22-12-00295
References
[1] Alexandrovskaya, Y.; Baum, O.; Sovetsky, A.; Matveyev, A.; Matveev, L.; Sobol, E.; Zaitsev, V. Optical Coherence Elastography as a Tool for Studying Deformations in Biomaterials: Spatially-Resolved Osmotic Strain Dynamics in Cartilaginous Samples. Materials 2022, 15, 904. https://doi.org/10.3390/ma15030904
[2] Yu. Alexandrovskaya, O. Baum, V. Zaitsev, A. Sovetsky, A. Matveyev, L. Matveev, K. Larin, E. Sobol, V. Tuchin, Optical and mechanical properties of the cartilage during optical clearing, In book Tissue optical clearing: new prospects in optical imaging, CRC Press (Dan Zhu, Elina Genina, and Valery Tuchin Eds.), 2021, Boca Raton, Florida, United States
ALT'22
