CC BY
14ALT'22
BIOMEDICAL PHOTONICS
B-P-15
Monitoring of the ice ball formation during tissue cryosurgery using
sapphire shaped crystals
A.K. Zotov1*, I.N. Dolganova12, K.I. Zaytsev2-3, I.A. Shikunova1, L.P. Safonova2 and V.N. Kurlov12
1- Institute of Solid State Physics of the Russian Academy of Sciences, Chernogolovka, Russia 2- Bauman Moscow State Technical University, Moscow, Russia 3- Prokhorov General Physics Institute, Moscow, Russia *E-mail: akzotov@hotmail.com
Cryoablation is the procedure of living tissue damaging by their freezing. This method has several advantages; among them are relative painlessness, hemostatic effect, minimal damage to healthy tissues, and shorter patient rehabilitation [1]. This method of tissue removal implies special cryoprobes, which must possess a number of features for effective performance, such as biocompatibility, chemical inertness and high thermal conductivity for achieving rather high cooling rate that is essential for tissue cryonecrosis. It is also necessary to be able to control the process of cryode-struction, which may cause risks of damage of surrounding healthy tissues, as well as incomplete cell death. To increase the effectiveness of cryosurgical treatment, it is important to control the tissue freezing depth [1-3].
The sapphire cryoprobes, which are characterized by high transparency in a wide spectral range, chemical resistance and high thermal conductivity at cryogenic temperatures, provide a favorable material platform for cryosurgical instruments [4-8]. To monitor the cryoablation process, the sapphire probe is combined with diffuse reflectance spectroscopy for non-invasive control of tissue freezing [7]. In this work, we demonstrate the developed sapphire cryoprobe and experimentally confirm the possibility to monitoring of the ice ball formation in tissues during their freezing. In addition, we compare the performance of the most commonly used metal probes with the sapphire one. The results reveal the benefits of sapphire for cryosurgical applications.
The work was supported by the Russian Science Foundation Project No. 19-79-10212.
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[7] E.N. Dubyanskaya, et al. "A concept of cryoapplicator based on sapphire shaped crystal enabling control of the ice ball formation using spatially resolved elastic backscattering of light," Proc. SPIE, 10685, 1068529, (2018)
[8] A.K. Zotov, et al., "In situ terahertz monitoring of an ice ball formation during tissue cryosurgery: a feasibility test, " J. Biomed. Opt. 26(4), 043003, (2021)
