CC BY
10B-O-8
Sapphire shaped crystals as a prospcective material platform for novel modalities of medical diagnosis and therapy
I. Dolganova1,2, G. Katyba1,3, I. Shikunova1, I. Reshetov4, M. Schcedrina4, K. Zaytsev2,3, V. Tuchin56, V. Kurlov1
institute of Solid State Physics of the Russian Academy of Sciencies, Laboratory of Shaped Crystals, Chernogolovka, Russian Federation
2Bauman Moscow State Technical University, Laboratory of Terahertz Technology, Moscow, Russian Federation
3Prokhorov General Physics Institute of the Russian Academy of Sciences, Laboratory of Submillimeter-Wave Dielectric Spectroscopy, Moscow, Russian Federation 4Sechenov First Moscow State Medical University, Department of Oncology-Radiotherapy and Plastic Surgery, Moscow, Russian Federation
5Saratov State University, Chair of Optics and Biomedical Physics, Saratov, Russian Federation 6Institute of Precision Mechanics and Control of the Russian Academy of Sciences, Laboratory of laser diagnostics of technical and living systems, Saratov, Russian Federation
Sapphire shaped crystals feature a beneficial combination of physical properties, which makes them rather prospective for the development and fabrication of medical instruments for diagnosis, therapy, and surgery [1]. They are nonmagnetic, biocompatible, enable operation in a harsh environment, including biological tissues and liquids, provide exceptional waveguiding properties for electromagnetic radiation of different frequencies delivering to the object, and possess high mechanical strength, thermal conductivity, and high melting point [2]. Applying the unique technology of shaped crystal growth [3], it is possible to manufacture sapphire crystals with internal capillary channels, allowing for combination of several functions in a single medical instrument. Most of the additional functions are optically-based. Thus, sapphire scalpel with internal channels can be used for tissue resection, fluorescent diagnostics, and coagulation [4]; capillary needles can be applied for photodynamic therapy and laser interstitial thermal therapy due to placing of quartz fibres inside them and forming of the needle tips of complex form, which determine a desirable radiation distribution [5]; sapphire neuroprobes enable intraoperative diagnosis, brain tissue aspiration, and coagulation of blood vessels [6]; sapphire applicators for cryosurgery can include quartz fibres in order to optically control the freezing process [7,8]. We demonstrate recent developments and experimental study of such instruments, which open novel horizons in medical approaches for treatment, surgery, and diagnosis.
This work was funded by the Russian Foundation for Basic Research (RFBR), according to the research project # 18-38-20140.
References
[1] G.M. Katyba et al., Progress in Crystal Growth and Characterization of Materials 64, 133-151 (2018).
[2] V.N. Kurlov. Reference Module in Materials Science and Materials Engineering. Ed. by Saleem Hashmi. Oxford: Elsevier, 2016.
[3] P.I. Antonov, V.N. Kurlov, Progress in Crystal Growth and Characterization of Materials 44, 63-122 (2002).
[4] V.N. Kurlov et al., Bulletin of the Russian Academy of Sciences: Physics 73, 1341-1344 (2009).
[5] I.A. Shikunova et al., Proceedings of SPIE 10716, 1071605 (2018).
[6] I.A. Shikunova et al., Optics and Spectroscopy 126, 545-553 (2019).
[7] I.A. Shikunova et al., Proceedings ofSPIE 10716, 1071605 (2018).
[8] E.N. Dubyanskaya et al., Proceedings of SPIE 10685, 1068529 (2018).
