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0Laser-induced thermo-mechanical effect in regenerative medicine
O.I. Baum
Institute of Photon Technologies of the Kurchatov Complex of Crystallography and Photonics, National Research Center "Kurchatov Institute"
baumolga@gmail.com
Our scientific group is developing new laser technologies for structure modification, shape correction and tissue reconstruction in otolaryngology, orthopedics and ophthalmology. The thermo-mechanical effect can be useful in correction of refraction [1,2], treatment of glaucoma [3,4] and laser reshaping of rib cartilage for larynx stenosis surgery [5,6].
Based on our previous research, we have recently focused on studying laser effects in regenerative medicine. It has been shown that laser-induced thermo-mechanical effect can be used to trigger targeted cellular regeneration in avascular biological tissues.
[1] O. Baum, A. Yuzhakov, A. Bolshunov, et al, New laser technologies in ophthalmology for normalisation of intraocular pressure and correction of refraction, Quantum electronics, 47(9), p.860, 2017.
[2] O.I. Baum, A.I. Omelchenko, E.M. Kasianenko, V.Ya. Panchenko, R.V. Skidanov, N.L. Kazanskiy, E.N. Sobol', A.V. Bolshunov, S.E. Avetisov, Control of laser-beam spatial distribution for correcting the shape and refraction of eye cornea, Quantum Electronics, 2020, Vol. 50, № 1, pp.87-93.
[3] O. Baum, S. Wachsmann-Hogiu, T. Milner, E. Sobol, Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure, Laser Physics Letters, 14 (6), p.065601, 2017.
[4] O.I. Baum, V.Y. Zaitsev, A.V. Yuzhakov, A.P. Sviridov, M.L. Novikova, A.L. Matveyev, L.A. Matveev, A.A. Sovetsky, E.N. Sobol, Interplay of temperature, thermal-stresses and strains in laser-assisted modification of collagenous tissues: Speckle-contrast and OCT-based studies, J Biophotonics, 2019.
[5] O. Baum, Y. Soshnikova, E. Sobol, Laser reshaping of costal cartilage for transplantation, Lasers in surgery and medicine, 43 (6), pp.511515 (2011).
[6] O.I. Baum, Yu.M. Alexandrovskaya, V.M. Svistushkin, S.V. Starostina, E.N. Sobol, New clinical application of laser correction of cartilage shape for implantation in otolaryngology, 2019, Laser Phys. Lett., 16, 035603.
