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1Laser-induced thermo-mechanical effect in regenerative medicine
O.I. Baum
Institute of Photon Technologies of the Kurchatov Complex of Crystallography and Photonics, National Research Center "Kurchatov Institute"
Our scientific group is developing new laser technologies for structure modification, shape correction and tissue reconstruction in otolaryngology, orthopedics and ophthalmology. The thermo-mechanical effect can be useful in correction of refraction [1,2], treatment of glaucoma [3,4] and laser reshaping of rib cartilage for larynx stenosis surgery [5,6].
Based on our previous research, we have recently focused on studying laser effects in regenerative medicine. It has been shown that laser-induced thermo-mechanical effect can be used to trigger targeted cellular regeneration in avascular biological tissues.
[1] O. Baum, A. Yuzhakov, A. Bolshunov, et al, New laser technologies in ophthalmology for normalisation of intraocular pressure and correction of refraction, Quantum electronics, 47(9), p.860, 2017.
[2] O.I. Baum, A.I. Omelchenko, E.M. Kasianenko, V.Ya. Panchenko, R.V. Skidanov, N.L. Kazanskiy, E.N. Sobol', A.V. Bolshunov, S.E. Avetisov, Control of laser-beam spatial distribution for correcting the shape and refraction of eye cornea, Quantum Electronics, 2020, Vol. 50, № 1, pp.87-93.
[3] O. Baum, S. Wachsmann-Hogiu, T. Milner, E. Sobol, Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure, Laser Physics Letters, 14 (6), p.065601, 2017.
[4] O.I. Baum, V.Y. Zaitsev, A.V. Yuzhakov, A.P. Sviridov, M.L. Novikova, A.L. Matveyev, L.A. Matveev, A.A. Sovetsky, E.N. Sobol, Interplay of temperature, thermal-stresses and strains in laser-assisted modification of collagenous tissues: Speckle-contrast and OCT-based studies, J Biophotonics, 2019.
[5] O. Baum, Y. Soshnikova, E. Sobol, Laser reshaping of costal cartilage for transplantation, Lasers in surgery and medicine, 43 (6), pp.511515 (2011).
[6] O.I. Baum, Yu.M. Alexandrovskaya, V.M. Svistushkin, S.V. Starostina, E.N. Sobol, New clinical application of laser correction of cartilage shape for implantation in otolaryngology, 2019, Laser Phys. Lett., 16, 035603.
