Научная статья на тему 'Laser functionalization of titanium surface for medical applications'

Laser functionalization of titanium surface for medical applications Текст научной статьи по специальности «Биотехнологии в медицине»

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Текст научной работы на тему «Laser functionalization of titanium surface for medical applications»

ALT'22

LM-I-12

LASER-MATTER INTERACTION

Laser functionalization of titanium surface for medical applications

G. Odintsova, V. Veiko, Yu. Karlagina

ITMO University, Kronverksky Pr. 49, bldg. A, St. Petersburg, 197101, Russia Main author email address: gvodintsova@itmo.ru

The past year has convincingly shown how important healthcare is in modern society. Improving the quality of medical services, development of new medicines, medical equipment and instruments is a critical condition for maintaining the health, ability to work, longevity and quality of life of the population of our country. One of the well-known examples is dental implantology. The installation of dental implants can not only fully restore all the functions of the teeth like mechanical processing and retention of food, participation in the formation of speech sounds and aesthetic function, but also prevent bone tissue atrophy.

As science and technology develop, new areas of application are revealed and new materials and methods of their processing appear, which states a new problem as how to the control of surface properties (at micro- and nano-level). With the advent of laser technologies, it has become possible to locally control the surface geometry and partly its chemical composition (during processing in various media) in order to impart certain properties to it.

In this work, we propose to give the following properties to implants and other medical metal products: improvement of biocompatibility (implants for various purposes); increase in bacterial resistance (medical instruments, orthopedic components: abutments, screws, membranes, etc.); product identification (medical instruments, orthopedic components: abutments, screws, membranes, etc.).

As an example, we present an ideal implant consisting of three functional zones (Fig. 1). The first zone is an implant screw in contact with a trabecular bone, which we treated with a "Groove" type structure with a cell size comparable to one of the bone tissue. The second zone is a collar of the implant in contact with the compact bone, on which we recreated the biomimetic structure of the bone tissue - "Osteon".

The first two zones showed improved cell proliferation, differentiation, and migration.

The third zone is an abutment in contact with an epithelium tissue, on which we created an oxide film exhibit high photoactivity when irradiated with UV light, which leads to the formation of hydroxyl radicals, which gradually destroy bacterial membranes, which leads to their death.

Authors acknowledge the support of the Ministry of Science and Higher Education of the Russian Federation research agreement No. 075-11-2021-045 of24.06.2021, project title "Development of high-tech production of equipment and technologies for laser functionalization of the surface of medical products" (within the framework of decree of the Government of the Russian Federation No. 218 of09.04.2010).

1 - abstinent / epithelium tissue CONCEPT OF -------------------------------

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Fig. 1. Concept of ideal dental implant

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