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abstracts. phytopharm 2o12
GENOME WIDE EXPRESSION ANALYSIS OF THE EFFECT OF BANHAHOOBAK-TANG EXTRACT (BHTE), A TRADITIONAL KOREAN HERBAL FORMULA, ON PSYCHOLOGICAL STRESS IN MICE
© Lim CY1, Lim SH2, Cho SI3
1Department of Medicine, College of Medicine, Dongguk University, 410-773, Republic of Korea 2Department of Nursing, School of Public Health, Far East University, 369-700, Republic of Korea 3Division of Pharmacology, School of Korean Medicine, Pusan National University, 626-770, Republic of Korea
Banhahoobak-tang (Table) has been used to treat symptoms caused by repeated emotional stress (1). Stress triggers important adaptive responses that enable an organism to cope with a changing environment. However, when prolonged or repeated, stress can be extremely harmful (2). in present report, anti-psychological effects of Banhahoobak-tang extract (BHTe) were observed. BHTe decreased serum level of corticosterone compared with control group. Genes up-regulated by psychological stress and restored by BHTe were involved in different pathways compared with that of genes down-regulated by psychological stress and restored by BHTe. Pathways
Herbal Name Scientific Name Weight (g>
Pinelliae Rhizoma Pinellia ternata 6
Magnoliae Cortex Magnolia officinalis 6
Hoelen Poria tocos 9
Zingiberis Rhizoma Crudus Zingiber officinale 2
Perillae Herba Perilla frutescens 6
Total Amount 29
significantly enriched in genes up-regulated (A) and down-regulated (B) by psychological stress and restored by BHTe were analyzed via the SPiA program in the brain of mice (Figure). The horizontal axis shows the over-representation of a pathway (PNDE) and the vertical axis, the perturbation of a pathway (PPERT). Pathway analysis shows that genes up-regulated by psychological stress and restored by BHTe were involved in different pathways compared with that of genes down-regulated by psychological stress and restored by BHTe.
References: (1) Lee, GK (1994) Gumgyeyoryak from Aulos publishing company 600-1. (2) Esther LS and Richard K (2001) TRENDS in Neurosciences 24 (2):91-98.
Table. Prescription of Banhahoobak-tang
Figure. Pathway analysis of genes
ANGELICAEGIGANTIS RADIX AMELIORATES GENE EXPRESSION IN OVARIAN TISSUE ON POLYCYSTIC OVARY SYNDROME IN RATS
© Lim CY1, Lim SH2, Cho SI-3
1Department of Medicine, College of Medicine, Dongguk University, 410-773, Republic of Korea 2Department of Nursing, School of Public Health, Far East University, 369-700, Republic of Korea 3Division of Pharmacology, School of Korean Medicine, Pusan National University, 626-770, Republic of Korea
Angelicae gigantis Radix (AGR) is one of the most useful herbal-drug to treat patients with Polycystic Ovary Syndrome (PCOS) in Korean Traditional Medicine (1, 2). The present authors investigated the effects of AGR on gene expression of ovary tissue re-
sected from PCOS induced rats using single injection of beta-Estradiol 17-Valerate (EV). Total 2,812 genes were up-regulated or down-regulated, and expression levels of 1,442 genes were restored to those of naïve animals by administration of AGR (A and B in left
ТОМ 10/2012/2 Obzory po kliniceskoj farmacologii i lekarstvennoj terapii [Reviews of clinical pharmacology and drug therapy] И 41
