CC BY
104. Babenko V.N., Babenko R.O., Gamieldien G., Markel A.L. FTO haplotyping underlines high obesity risk for European populations. BMC Medical Genomics. 2019;12(2):46. DOI: 10.1186/s12920-019-0491-x
5. Chen J.J., Li Y.M., Zou W.Y., Fu J.L. Relationships between CETP genetic polymorphisms and Alzheimer's disease risk: a meta-analysis. DNA Cell Biol. 2014;33(11):807-815. DOI: 10.1089/dna.2013.2265.
6. Park S.L., Cheng I., Pendergrass S.A., Kucharska-Newton A.M., Lim U., Ambite J.L., Caberto C.P., Monroe K.R., Schumacher F., Hindorff L.A., Oetjens M.T., Wilson S., Goodloe R.J., Love S.A., Henderson B.E., Kolonel L.N., Haiman C.A., Crawford D.C., North K.E., Heiss G., Ritchie M.D., Wilkens L.R., Le Marchand L. Association of the FTO Obesity Risk Variant rs8050136With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations. American Journal of Epidemiology. 2013;178(5):780-790. DOI: 10.1093/aje/kwt028.
7. Суплотова Л. А, Вахромеева К. А., Бельчикова Л. Н., Носиков В. В. Поиск ассоциаций полиморфных генетических маркеров с сахарным диабетом 2 типа в русской популяции // Медицинская наука и образование Урала. - 2014. - №4. - С. 51-57.
8. Yang Y., Liu B., Xia W., Yan J., Liu H.Y., Hu L., Liu S.M. FTO Genotype and Type 2 Diabetes Mellitus: Spatial Analysis and Meta-Analysis of 62 Case-Control Studies from Different Regions. Genes. 2017;8(70). DOI:10.3390/genes8020070.
9. The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012;491(7422):56-65. DOI: 10.1038/nature11632.
10. Табиханова Л.Э., Осипова Л.П., Чуркина Т.В., Воронина Е.Н., Филипенко М.Л. Полиморфизм генов CYP1A1 и CYP2D6 в популяциях бурят, телеутов и у русских Восточной Сибири // Вавиловский журнал генетики и селекции. - 2018. -№22. Т.2. - С. 205-211. DOI: 10.18699/VJ18.348 ИФ- 0,510(2016)
Bibliograficheskij spisok
1. Hallmark B., Karafet T.M., Hsieh P.H., Osipova L.P., Watkins J.C. Hammer M.F. Genomic Evidence of Local Adaptation to Climate and Diet in Indigenous Siberians. Molecular Biology and Evolution. 2018;36(2):315-327. DOI: 10.1093/molbev/msy211.
2. Hsieh P.H., Hallmark B., Watkins J.C., Karafet T.M., Osipova L.P., Gutenkunst R.N., Hammer M.F. Exome Sequencing Provides Evidence of Polygenic Adaptation to a Fat-Rich Animal Diet in Indigenous Siberian Populations. Mol Biol Evol.;34(11):2913-2926. DOI: 10.1093/molbev/msx226.
3. Kudryavtseva E.A., Voronina E.N., Lifshits G.I., Krapivina N.A., Tsvetovskaya G.A., Filipenko M.L. Otsutstviye vliyani-ya polimorfnykh lokusov genov INSIG2, FTO, GNB3 na stepen' vyrazhennosti ozhireniya u bol'nykh metabolicheskim sindromom // Vestnik Novosibirskogo gosudarstvennogo universiteta. Seriya: Biologiya, klinicheskaya meditsina. - 2010. - №8. T.3- S. 32-39.
4. Babenko V.N., Babenko R.O., Gamieldien G., Markel A.L. FTO haplotyping underlines high obesity risk for European populations. BMC Medical Genomics. 2019;12(2):46. DOI: 10.1186/s12920-019-0491-x
5. Chen J.J., Li Y.M., Zou W.Y., Fu J.L. Relationships between CETP genetic polymorphisms and Alzheimer's disease risk: a meta-analysis. DNA Cell Biol. 2014;33(11):807-815. DOI: 10.1089/dna.2013.2265.
6. Park S.L., Cheng I., Pendergrass S.A., Kucharska-Newton A.M., Lim U., Ambite J.L., Caberto C.P., Monroe K.R., Schumacher F., Hindorff L.A., Oetjens M.T., Wilson S., Goodloe R.J., Love S.A., Henderson B.E., Kolonel L.N., Haiman C.A., Crawford D.C., North K.E., Heiss G., Ritchie M.D., Wilkens L.R., Le Marchand L. Association of the FTO Obesity Risk Variant rs8050136With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations. American Journal of Epidemiology. 2013;178(5):780-790. DOI: 10.1093/aje/kwt028.
7. Suplotova L.A., Vakhromeeva K.A., Belchikova L.N., Nosikov V.V. Poisk assotsiatsiy polimorfnykh geneticheskikh markerov s sakharnym diabetom 2 tipa v russkoy populyatsii // Meditsinskaya nauka i obrazovaniye Urala. - 2014. - №4. - S. 51-57
8. Yang Y., Liu B., Xia W., Yan J., Liu H.Y., Hu L., Liu S.M. FTO Genotype and Type 2 Diabetes Mellitus: Spatial Analysis and Meta-Analysis of 62 Case-Control Studies from Different Regions. Genes. 2017;8(70). DOI:10.3390/genes8020070.
9. The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012;491(7422):56-65. DOI: 10.1038/nature11632.
10. Tabikhanova L.E., Osipova L.P., Churkina T.V., Voronina Ye.N., Filipenko M.L. Polimorfizm genov CYP1A1 i CYP2D6 v populyatsiyakh buryat, teleutov i u russkikh Vostochnoy Sibiri // Vavilovskiy zhurnal genetiki i selektsii. - 2018. - №22. T.2. - S. 205211. DOI: 10.18699/VJ18.348 ИФ- 0,510(2016)
УДК 61. 612.17+159.9.07 DOI: 10.24411/9999-025A-2019-10051 FUNCTIONAL INDICATORS OF CARDIOVASCULAR SYSTEM OF TUVAN STUDENTS WITH
DIFFERENT LEVEL OF ALERT Larisa K. Buduk-ool Tuvan State University, Kyzyl, Russia, [email protected]
To determine the level of trait anxiety and reactive anxiety at the Tuvan students of the first course. Noted the predominance of low RT moderate LT. Girls have a higher level of LT than boys. Recorded blood pressure, heart rate, determined by the minute volume of blood, stroke volume, cardiac index and stroke index, adaptive capacity. Discovered the deterioration of the adaptation, increased blood pressure, the minute volume of blood and the stroke volume, the predominance of the patients with hyperkinetic type of blood circulation in accordance with the increase of trait anxiety. The girls revealed higher functional performance of cardiovascular system compared with boys regardless of the level of anxiety.
Keywords: anxiety, cardiovascular system, adaptation, students.
Currently, there is a decrease in the level of health and physical activity of students [1 3], in connection with this, the number of students with various deviations in their health [2 1] is growing, including with an increase in psychoemotional stress and stress. Anxiety is an important sign that can indicate poor adaptation, the presence of emotional and behavioral signs of stress. The urgency of the problem lies in the early detection of
the restructuring of the system of regulation of the functions of the heart and blood vessels [3 2] associated with increased anxiety. It is widely known that indicators of the cardiovascular system can be used in the diagnosis of various body conditions, especially those associated with psychoemotional stress.
The study involved Tuvan first-year students of Tuvan State University in the amount of 125 people. The level of personal and reactive anxiety was determined by the C. D. Spielberger self-rating scale. We recorded the main indicators of the cardiovascular system - blood pressure, heart rate, using traditional calculation methods to determine the minute volume of blood, stroke volume of blood, heart index, stroke index, adaptive potential.
Statistical processing of the obtained data was performed in the program Statistica 6.0. The significance of differences was evaluated by student t-test. Differences were considered significant at p <0.05.
In the individual distribution of students by levels of anxiety, there is a predominance of people with low reactive and moderate personal anxiety. Moreover, students with a high level of personal anxiety turned out to be more than young men.
Some authors point to the relationship between changes in the functional state of the cardiovascular system with anxiety and stress [4, 5]. The indicators of blood pressure and heart rate in all the studied groups correspond to the age-gender norm. Heart rate between groups with different anxiety does not differ, and in identical groups for anxiety in girls, heart rate is higher, systolic blood pressure is lower than in boys.
In the group of young men there is a decrease in systolic blood pressure and an increase in diastolic pressure from high-anxiety to low-anxiety. In students of the compared groups by systolic blood pressure, differences were identified as tendencies, and diastolic increases with a decrease in personal anxiety.
The values of minute, shock volumes, shock index and cardiac index in students decrease with a decrease in personal anxiety. In low-anxiety girls, minute blood volume is formed due to lower stroke volume and higher heart rate, and in high-anxiety girls - higher stroke volume and lower heart rate, which is considered the most effective way to regulate cardiac activity.
30% of anxious young men have a hyperkinetic type of blood circulation, and girls have 28.6% more. The predominance of highly anxious girls with a hyperkinetic type of hemodynamics indicates the presence of signs of tension in the adaptive systems of the body.
The state of adaptation of the cardiovascular system is clearly reflected in the values of the adaptive potential. Young men have more people with adaptation stress (60.2%), and girls have more people with satisfactory adaptation (57.8%), which indicates higher functional capabilities of the body in girls. Among people with high personal anxiety there are more students with stress adaptation than among low-anxiety regardless of gender, which indicates the worst adaptation of people with psycho-emotional stress.
Thus, an increase in personal anxiety is associated with poor adaptation, increased blood pressure, minute and stroke volumes, and a hyperkinetic type of blood circulation. Girls have higher abilities of the cardiovascular system in comparison with boys, regardless of the level of anxiety.
Bibliography
1. Novak ES The health of students as a social problem / E.S. Novak // Bulletin of VolSU. - 2001. - Ser. 7. Issue 1. - S.
125-133.
2. Baevsky P.M. Health problems and norms: the point of view of the physiologist / P.M. Bayevsky // Clinical medicine. -2000. -T. 78. No. 4. - S. 59-64.
3. Baevsky R.M. Guidelines for the analysis of HRV using various electrocardiographic systems / R.M. Baevsky // Vestn. arrhythmology. - 2002. - No. 24. - S. 65-86.
4. Pavlenkovich S.S. Psychophysiological features and indicators of the functional state of the body of students of the faculty of physical education in the process of adaptation to study at the university: author. dis. ... cand. biol. Sciences: 03.03.01 / S.S. Pavlenkovich. - Astrakhan: ASU, 2013 - 23 p.
5. Tkacheva V.I. Vegetative response of the cardiovascular system to emotional stress / V.I. Tkacheva, E.Yu. Nadezhkina, O.S. Filimonova // International Student Scientific Bulletin. - 2015. - No. 2.- P.121-122.
