CC BY
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UDQ 618.2-089.163
M.T. Hamdamova, N.O. Giyasova
FERROKINETICAL INDEX IN BLOOD SERUM OF WOMEN WHO BEAR EXTENDED PERIOD COPPER-BEARING INTRAUTERINE DEVICE33
Bukhara state medical institute, Uzbekistan
In recent days, in field of Obstetricians and Gynecologists is available large arsenal of contraceptive which enables to preserve the reproductive health of women. Exploring ferrokinetic parameters (serum ferritin and transferrin), the copper content and form of transport - cereloplazmin serum can judge the latent forms of iron deficiency that develops after prolonged wearing of an intrauterine device (IUD) in women [1,2,3].
Materials and methods. All women using copper IUDs T-shaped Cu T380A (study group) were assigned depending on the duration of wearing the Navy: 1 -year (n=150); 2 to 3 years (n=150); 3 to 5 years (n=150). The control group (n=40) have joined the women do not apply copper IUDs. All subjects were representative of age, living conditions, the number of pregnancies and births, permanent residence.
Results. In the first stage of the research was carried out to study and assess the relative variability in transferrin and ferritin (ferrokinetic figures) women to apply copper-containing IUD, depending on the length of wear. Investigations were carried out every 6 months. The content of transferrin in serum initially (after the insertion of the IUD) was higher - 4,7±0,3 g/l in comparison with normal (3,7±0,05 g/l, p<0.05) and timeI tended to increase. As serum ferritin observed the opposite picture - the original figure was 37,8±2,3 pmol / l against 108,4±1,7 pmol normal (P <0.001). The correlation analysis between the level of transferring and ferritinin the serum of women shows that between these indicators there is a close inverse correlation. In early studies (baseline), this relationship is weak, negative (p=-0,3), but with increasing time of wearing the IUD it is amplified and over 6 months p = -0,5 (medium, negative correlation). Later (after 12 and 18 months), this relationship becomes strong, negative-, respectively, p=-0,7. In other periods of observation revealed a
33 М.Т. Хамдамова, Н.О. Гиясова Феррокинетические показатели сыворотки крови женщин, длительно носящих медьсодержащие внутриматочные спирали.
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negative relationship only intensified, reaching p=-0,8 (24 and 30 months). The most powerful, negative correlation is observed 36 months after insertion of the IUD, reaching p=-0,9. Strengthening the close, the negative correlation among the compared parameters indicates a clear relationship among the two women with IUDs. This fact proves the existence of a consistent relationship between these parameters that must be considered when choosing a method of contraception in this group of women and the time of wear. Thus, the detected correlation relationship between transferrin and serum ferritin in women, which increases with time. The close, the negative relationship between them indicates the development of iron deficiency in women is associated with prolonged wear IUD. The data obtained can be used as an additional diagnostic and prognostic criterion for clinical and laboratory criteria of iron deficiency in women wearing IUDs. Apparently, development of an imbalance between the transport and the standby forms serum iron determines the formation of more stable bonds in the regulation of iron metabolism in women with prolonged use of IUDs. The next stage of research was to study the content of copper and its transport form - ceruloplasmin in serum of women with IUDs. It is found that initially (after inserting the IUD) in women copper content in the serum was significantly reduced by 1.3-fold (P<0.001) relative to standard values (respectively 65,6±3,1 mg/dl vs. 83,7±2,4 mg/dL). But, with the lapse of time (6 months later) there is a gradual increase in this parameter, which is 30 months comes to normal values, and after 36 months, 1.7 times higher than the permissible level - P<0.001 (Fig. 2). The same trend as we have observed, and the level of ceruloplasmin, with the only difference that the original content of this parameter was increased with respect to the norm (P<0.05) and gradually continued to grow, reaching to the last observation interval (36 months) to a maximum value- 747,2±11,3 pmol/L (P<0.001). Correlation analysis between the copper content and form of transport - ceruloplasmin shows that between these parameters have a direct, positive correlation, that is an increase of one indicator is closely linked to an increase in other settings. Initially determined weak, direct, positive relationship between the compared parameters (p=0,2) is the same weak, a direct link is maintained and after 6 and 12 months of wearing the IUD (respectively, p=0,3). Only from the 18th month revealed the relationship is strengthened and reaches p=0,5 (average, direct, positive relationship). Eventually (after 24 months), this relationship is enhanced reaches p=0,6, but after 30 months of wearing the IUD this relationship is weakened and reduced to p=0,4. This coincides with the
normalization of the copper content in the blood serum of women in the period of observation. But after 36 months of correlation between these indices increased sharply and there is a strong, direct, positive correlation (p=0,7). This fact indicates a lack of related laws between copper and ceruloplasmin serum of women with IUDs within 22.5 years. Main abrupt changes observed after 3 years of wearing the IUD, therefore, the presence of strong, direct, positive correlation between the compared parameters indicates a negative prognostic sign of wearing the IUD 3 years.
Conclusions. An inverse correlation relationship between transferrin and ferritin serum from women with IUDs, which increases with increasing duration of wearing the IUD. The presence of the close, the negative correlation relationship between transferrin and ferritin serum indicates the formation and development of iron deficiency in women associated with extended wear IUD.
References
1. JK Jabbarov, Malikova GB Iron deficiency anemia in obstetrics and gynecology // Guidelines. - Tashkent, 2011. - 27 p.
2. Kuznetsova IV Intrauterine contraception // Gynecology. - Moscow, 2008. -Vol.10. - №2. - S.32-37.
3. Saidkariev BK Advantages of the Navy - as a reliable method of contraception // Bulletin GP doctor. - Samarkand, 2009 - Part II. - №3. - S.334-335.
УДК 615.036, 618.173
Р.Х.Хафизьянова, М.К.Мерзахмедова, Г.Н.Алеева
ИЗМЕНЕНИЕ ЛИЧНОСТНОЙ И РЕАКТИВНОЙ ТРЕВОЖНОСТИ У ЖЕНЩИН С КЛИМАКТЕРИЧЕСКИМ СИНДРОМОМ В ПОСТМЕНОПАУЗЕ ПРИ ФАРМАКОТЕРАПИ34
Казанский государственный медицинский университет, Казань, rofija_kh@mail.ru
Введение. Женщины, страдающие климактерическим синдромом (КС), часто испытывают чувство тревоги, страха и беспокойства. Настоящая работа по-
34 R.Kh.Khafizianova, M.K.Merzahmedova, G.N.Aleeva Pharmacotherapy change personal and reactive anxiety in women with climacteric syndrome in postmenopause.
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