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104. Traditional Chinese Exercise
Science has proven that regular exercise—at least 30 minutes most days of the week— increases immune function. Doing Traditional Chinese Exercise Exercise gets the blood moving quicker through the body, which also moves antibodies through the body faster than normal. This exposes potential threats to the immune system much faster, allowing the antibodies to remove them before the bacteria or viruses can become an illness.
Tai Ji Quan: Tai Ji Quan is an internalChinese martial art practiced for both its defense training and its health benefits. When you practice Tai Ji Quan, blood flows to the limbs and circulation is improved. Also, the flux of Qi around the body has been proven to strengthen the immune system against disease.A study indicates that Tai Chi practiced three times per week may boost people resistence to viruses by 50%. This study was regarding the shingles virus in particular but the researchers believe Tai Chi may have a powerful effect in raising resistence to other types of infection as well.
The Five-animal Exercise: It consists of five groups of actions imitating the movement of the tiger, deer, bear, ape and bird. It is a bionic exercise. Regular practice of the Five-animal Exercise can limber up the joints in the waist and limbs, strengthen the waist, and nourish the viscera, thus achieving the purpose of improving the immune system.
Qigong: Qi Gong is an ancient breathing exercise for internal strengthening. Qigong teaches inner strength, increases flexibility, and boosts our immune system. Practicing Qigong reduces stress, stores up energy, increases body awareness, and improves balance and coordination.
Chinese Medicine considers that the immune system (named "Zheng Qi" in Traditional Chinese Medicine) is strongly associated with the function of the internal organs. If these organs are well-balanced they will support the immune system (Zheng Qi) and strengthen its function, which will prevent you from being easily affected by external pathogenic factors. "The Yellow Emperor's Internal Canon of Medicine" said: Keep healthy, do not be evil.
Three New Lignan Glycosides from the Root Barks of Sambucus williamsii
Hance
Bing-You Yang, Hua Han , Liu Yang, Hai Jiang, Qiu-Hong Wang and Hai-Xue Kuang *
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China
Abstract: Three new lignanglycosides,named williamsoside E (1), williamsoside F (2) and williamsoside G (3) were isolated from the root barks of Sambucus williamsii Hance. Their structures were elucidated on the basis of extensive spectroscopic analysis (1D, 2D-NMR and HRESIMS) and chemical studies.
Keywords: Sambucus williamsii Hance; root barks; lignan glycosides
Introduction
Sambucus williamsii Hance is a deciduous shrubs or small tree wildly distributing in China[1] andhas been used for centuries for treatment of inflammation[2] and bone fractures and joint diseases[3].The chemical composition of S. williamsii has been extensively studied. The triterpenoids, flavonoids, lignans and the iridoids were reported[4,5].In our present work,we investigatedthe 50% ethanol eluate fraction from a macroporous resin of the root barks of S. williamsii. Our extraction and separation method can greatly enrich fractions in lignan compounds so trace lignans can be isolated. In this paper, we present the isolation and structural
characterization of the three new lignan glycosides on the basis of the interpretation of spectral data, including 1D, 2D NMR and HRESIMS data. Materials and methods
General:IR spectra were recorded on a Shimadzu FTIR-8400S spectrometer. NMR spectra were recorded on a Bruker DPX 400 NMR instrument (at 400 MHz for 1H-NMR and 100 MHz for 13C-NMR). Chemical shifts are given as 5 values with reference to tetramethylsilane (TMS) used as internal standard, and coupling constants are given in Hz. HRESIMS were carried out on Waters Xevo QTOF mass spectrometer. Preparative HPLC (Waters, Delta 600-2487) was performed on a Hypersil-ODS II (10^ m, 20 x 300 mm, Yilite, Dalian, China).
Plant Material:The root barks of S. williansii were collected in August 2008 from the Fangzheng district, Heilongjiang Province, China, and identified by the author Zhen-Yue Wang. A voucher specimen (20080079) has been deposited at Heilongjiang University of Chinese Medicine, Harbin, China.
Extraction and Isolation: The dried root barks (5.0 kg) were extracted with 95% EtOH (2xl0L) for 2h. The EtOH extracts was concentrated under reduced pressure and fractioned by AB-8 macroporous resin column (8x60cm) with H2O, 50% and 95% EtOH-H2O to give three fractions(H2O fraction, 50% EtOH-H2O fraction, 95% EtOH-H2O fraction).The 50% EtOH-H2O fraction (52.0 g) was repeatedly column chromatographed on silicagel with a gradient of CHCl3/MeOH (15:1—>1:1) solvents as eluents to afford 10 fractions: Fr.1-10. Fr.3 (16 g) continues silica gel chromatography elution with CHCl3/MeOH (10:1 to 2:1) to afford a number of subfractions A1-A4. Compounds 1 (20.1 mg) was obtained by Prep. HPLC chromatography of the sub-fraction A2 (5 g) elutionwith MeOH/H2O (2:7). A4 (10 g)was separated on ODS-A column with MeOH/H2O (1:4 to 1:0) for elution, to produce five sub-fractions (B1-B5). Thesub-fraction B2 (2 g) was purified by Prep. HPLC with MeOH/H2O (3:10) to afford 2 (12.3 mg) and 3 (11.4 mg). Conclusions
As a part of our chemical investigation on S. williamsii, three new lignan glycosides, (7R,8R)-3-methoxyl-9'-O-P-D-xylopyranosyl-4':7,5':8-diepoxyneolignan-4, 9'-diol(williamsoside E, 1), (7R,8S)-4,9-dihydroxyl-3,3'-dimethoxyl-9'-O-P-D- apiofuranosyl-(1-6)-P-D-glucopyranosyl-7,8-dihydrobenzofuran (williamsoside F, 2) and (2,3-trans-7'', 8"-erythro)-7-P-D-glucopyranosyl-dihydrobuddlenol B (williamso- side G, 3). The discovery of compounds 1, 2and3is a further addition to the diverse lignan glycoside compounds.
References
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