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15Cobalt (Co) - importance for the body and health, where it contains
Anna Shelestun , nutritionist, nutritionist
Eliseeva Tatyana, editor-in-chief of the EdaPlus.info project
E-mail: [email protected], [email protected]
Abstract. The article discusses the main properties of cobalt ( Co ) and its effect on the human body. A systematic review of modern specialized literature and relevant scientific data was carried out. The best natural sources of cobalt are indicated . The use of the mineral in various types of medicine and the effectiveness of its use in various diseases are considered. The potentially adverse effects of cobalt on the human body under certain medical conditions and diseases are analyzed separately.
Key words: cobalt , Co , cobalt, beneficial properties, contraindications, sources
Cobalt is an essential trace mineral and a component of vitamin B12. It is necessary for the formation of red blood cells, enzymatic reactions and the formation of nerve sheaths. The mineral strengthens the immune system, stimulates the activity of white blood cells to prevent infections. What foods are rich in trace elements and what are its benefits? Research and findings of scientists will surprise you.
Cobalt in the body: role and function
The component is needed in microdoses and no more than 2 mg is stored in the body of an adult. The main reserves are concentrated in the liver, but were also found in other organs of the gastrointestinal tract, kidneys. It is also part of the lymph nodes, hair. [one]
The mineral is part of vitamin B12. The latter performs several important tasks, including the creation of red blood cells. It performs the same functions as zinc and manganese and can replace them in some biochemical reactions. Cobalt is also part of the biotin-dependent Krebs cycle, the process the body uses to break down sugar and turn it into energy. [2, 3]
cobalt in food
The trace element is widely distributed in the environment. Its good food sources of cobalt are:
• fish;
• nuts;
• cereals;
Journal.edaplus.info - Журнал здорового питания и диетологии • green leafy vegetables - broccoli, spinach, etc.
Cobalt is added to some beers as a stabilizer. Fans of such a drink have an increased risk of developing cobalt intoxication, which can lead to cardiomyopathy, heart failure.
Ground vegetables contain the mineral in small amounts. As the soil becomes more scarce, its levels decrease. This does not apply to soil near mining and smelting facilities, where concentrations of the compound are very high, with negative health effects.
Cobalt in Foods - Plant and Animal Sources
The trace element is mainly found in animal proteins. The concentration in vegetables depends on the amount in the soil in which they were grown.
15 products of animal and vegetable origin, the content of cobalt
No. Product Cobalt content [4] , mg/kg
one Cheese 0.18
2 Chocolate 0.05
3 Crustaceans and molluscs 0.046
four Dried fruits and nuts 0.041
5 by-products 0.033
6 Butter 0.018
7 Rice 0.01
eight Fruit 0.009
9 Meat 0.008
ten Fish 0.007
eleven Bread 0.006
12 Vegetables (except potatoes) 0.006
13 Eggs 0.005
fourteen Bird and game 0.002
fifteen Milk 0.001
Products with a natural mineral help the body accumulate vitamins A, B3, C. [5] Daily requirement for cobalt
The recommended daily allowance for a micronutrient has not yet been established and is currently determined by vitamin B12 requirements. For example, for most adults, it is desirable to consume 2.4 mcg of vitamin B12 daily, which corresponds to 0.1 mcg of the mineral.
To determine your micronutrient needs, it's worth talking to your doctor, dietitian, or nutritionist about it. It is especially important to carefully monitor its blood levels for athletes, people with anorexia or bulimia.
Nutritionists believe that the daily requirement does not exceed 0.1-2.4 micrograms per day. However, many adults consume much more of it - an average of 4 to 8 mcg per day. While maintaining vitamin B 12 in the body at the proper level, there is no need to take the mineral additionally. If your supplement contains 1.4 mg or less, it is unlikely to cause any harm. A dose of more than 30 mg is considered lethal. [6, 7]
5 health benefits of cobalt
1. Essential for Vitamin B12
The micronutrient plays the most important role for cobalamin. Vitamin B12 is not synthesized in the body, but only comes from outside. Many vegans and vegetarians do not get enough of it, so they may
need cobalt supplements. [eight]
2. Protects Against Anemia and Maintains Healthy Blood
Cobalt can play a vital role in the absorption of iron - making it available for the formation of hemoglobin. Supplements with the component also help in the treatment of anemia when other methods are useless. [9]
3. Used to treat certain types of cancer
Medical cobalt-60 is used throughout the world to fight cancer and in radiation therapy to treat complex brain diseases. Radiocobalt allows doctors to deliver higher doses of radiation to tumors while limiting damage to surrounding healthy tissues and organs. For many brain cancers, this treatment remains one of the most accurate and advanced forms of radiation therapy available. [10, 11, 12]
4. Protects the nervous system
Cobalt is known for its ability to repair myelin sheaths, the layer that covers nerve cells and supports neurons. The trace element protects them from damage by free radicals. [13]
5. Heals wounds
Cobalt accelerates the healing of the skin after severe burns and injuries. It has even been shown to be beneficial in diabetic wounds where insufficient new blood vessel formation prevents healing. Nanofiber scaffolds solve this problem and help cells accumulate collagen and eliminate inflammation.
[14, 15]
Interaction of cobalt with minerals and vitamins
• Cobalt is closely related to vitamin B12, scientifically referred to as cobalamin. The name itself suggests a connection with the mineral. The functioning of many organs and systems depends on the coordinated work of these substances.
• Cobalt goes well with ascorbic acid. With its participation, the absorption of vitamin C is significantly increased.
Application in medicine
Cobalt-60 is used in the healthcare industry to treat cancer and sterilize sutures, gloves, syringes and other medical equipment. Gamma sterilization guarantees the complete sterility of goods and saves on their production. This is especially true for implantable orthotics and heart valves, as metals and polymers are difficult to machine.
Cobalt-60 is used to sterilize insects that spread diseases such as the Zika virus and dengue fever. The method was first used on insects in the 1950s to prevent them from reproducing and taking root in the environment. Today, with the help of high-tech development, various carriers of infections in warm climates are neutralized. [16]
Cobalt in scientific research
• Some implants contain metal and release metal particles such as cobalt into the body. The compound may cause local or systemic toxicity including metallosis, hypersensitivity, benign tumour, cardiomyopathy, hypothyroidism and neurological disorders. Annual follow-up of implanted patients is recommended to monitor the potential toxicity of metal hip prostheses. The concentration of the mineral in the blood should not exceed 7 mcg / l. [17]
• Cobalt has special physical and chemical properties that can be used in drug development. Mineral complexes cause various biological effects - they suppress proteins, change the activity of drugs. [eighteen]
• The metal has a pronounced allergenic potential. Negative effects are associated with very large doses. Occupational health risk factors include asthma, interstitial lung disease, and alveolitis. In animal experiments, ingestion of cobalt led to reproductive changes, while injections with it led to cancer. [19, 20]
• Polyurethane dressing for wounds with the addition of cobalt nitrate fibers has the best physical and chemical parameters, parameters of compatibility with blood. Compatibility tests have shown longer clotting times and less toxicity. [21]
• The introduction of cobalt chloride to athletes is a type of doping, which consists in increasing the oxygen capacity of the blood. The trace element stimulates erythropoiesis - one of the processes of hematopoiesis, which consists in the production of red blood cells. It also helps tissues and cells adapt to low oxygen levels. The advantage of such additives is that they are not prohibited and cannot be detected by anti-doping tests, but they are potentially hazardous to
health. [22]
Side Effects of Cobalt Use: Toxicity and Interactions
The International Agency for Research on Cancer classifies cobalt and its compounds as "possibly carcinogenic". This classification is based on the extreme intake of the substance by the animals during the study. There is no evidence of human carcinogenicity yet.
Since cobalt is a key part of vitamin B12, people with a rare eye condition such as Leber's syndrome should not take it without a doctor's approval. In these patients, some forms of vitamin B12 can cause vision loss. Pregnant and breastfeeding women should also not take supplements without a doctor's permission.
Poisoning is possible when large doses of an element that is of inorganic origin are ingested. Simply put, microdoses obtained from food are not capable of leading to an overdose. [23, 24]
Journal.edaplus.info - Журнал здорового питания и диетологии Cobalt deficiency - deficiency symptoms, consequences
If there is a deficiency of cobalt in the body, then there is a deficiency of B12 (and vice versa). The following symptoms may indicate a deficiency:
• numbness, weakness, tingling in the limbs;
• headache;
• nausea, poor appetite;
• bleeding gums, pale lips and tongue;
• memory problems, confusion.
Vegetarians are most at risk of deficiency of the component - it is not enough in plant foods. Symptoms of excess cobalt
The trace element is toxic at doses of 20-30 mg/day. Excess is indicated by various symptoms:
• high production of red blood cells, thick blood;
• dysfunction and enlargement of the thyroid gland;
• violation of the activity of cells in the bone marrow;
• problems with the absorption of iodine;
• diseases of the respiratory system and heart.
Excess cobalt helps to remove sesame seeds, vegetables and fruits with pectin, as well as decoctions of oatmeal, rose hips.
Interaction with medications
There are no known food or drug interactions with cobalt. But the mineral is the core of vitamin B12 and is important for the formation of red blood cells, the functioning of the nervous system and DNA synthesis. Radioactive CO-60 also has many uses, one of which is radiation therapy.
Expert comment
Tatyana Eliseeva, nutritionist, nutritionist
Remember, the overall diet determines the risk of various diseases and protection against them. Instead of focusing on individual nutrients, it is better to eat a diet that is rich in all the essential nutrients for good health.
Literature
1. Alexandersson, R. (1988). Blood and urinary concentrations as estimators of cobalt exposure. Archives of Environmental Health: An International Journal, 43(4), 299-303. DOI: 10.1080/00039896.1988.10545953
2. Barceloux, DG, & Barceloux, D. (1999). Cobalt. Journal of Toxicology: Clinical Toxicology, 37(2), 201-216. DOI: 10.1081/clt-100102420
3. Yamada, K. (2013). Cobalt: its role in health and disease. Interrelations between essential metal ions and human diseases, 295-320. DOI: 10.1007/978-94-007-7500-8_9
4. Cobalt in Food, https://selfrelianceuniversity.com/library/cobalt-in-food/
5. Determination of cobalt in food samples, https://www.researchgate.net/publication/291595743_Determination_of_cobalt_in_food_sampl es
6. Finley, BL, Unice, KM, Kerger, BD, Otani, JM, Paustenbach, DJ, Galbraith, DA, & Tvermoes, BE (2013). 31-day study of cobalt(II) chloride ingestion in humans: pharmacokinetics and clinical effects. Journal of Toxicology and Environmental Health, Part A, 76(21), 1210-1224. DOI: 10.1080/15287394.2013.848391
7. Fischer, LA, Johansen, JD, Voelund, A., Lidén, C., Julander, A., Midander, K., ... & Thyssen, JP (2016). Elicitation threshold of cobalt chloride: analysis of patch test dose-response studies. Contact Dermatitis, 74(2), 105-109. DOI: 10.1111/code.12499
8. Osman, D., Cooke, A., Young, TR, Deery, E., Robinson, NJ, & Warren, MJ (2021). The requirement for cobalt in vitamin B12: A paradigm for protein metalation. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1868(1), 118896. DOI:
10.1016/j .bbamcr.2020.118896
9. Cobalt in Anaemia, doi : 10.1111/j.0954-6820.1956.tb14312.x
10. Igarashi, T., Satoh, T., Ono, S., Iwashita, K., Hosokawa, M., Ueno, K., & Kitagawa, H. (1984). Effect of steroidal sex hormones on the sex-related differences in the hepatic activities of gamma-glutamyltranspeptidase, glutathione S-transferase and glutathione peroxidase in rats. Research communications in chemical pathology and pharmacology, 45(2), 225-232.
11. Balakrishnan, PB, Silvestri, N., Fernandez-Cabada, T., Marinaro, F., Fernandes, S., Fiorito, S., ... & Pellegrino, T. (2020). Exploiting unique alignment of cobalt ferrite nanoparticles, mild hyperthermia, and controlled intrinsic cobalt toxicity for cancer therapy. Advanced Materials, 32(45), 2003712. DOI: 10.1002/adma.202003712
12. JC, K. (1958). Cobalt-60 teletherapy. The Journal of the Indiana State Medical Association, 51(2), 185-188. PMID: 13502574
13. The Myelin Sheath, https://www.ncbi.nlm.nih.gov/books/NBK27954/
14. Klasson, M., Lindberg, M., Westberg, H., Bryngelsson, I.L., Tuerxun, K., Persson, A., & Särndahl, E. (2021). Dermal exposure to cobalt studied in vitro in keratinocytes-effects of cobalt exposure on inflammasome activated cytokines, and mRNA response. Biomarkers, 26(8), 674-684. DOI: 10.1080/1354750X.2021.1975823
15. Cobalt-based metal-organic framework as a dual cooperative controllable release system for accelerating diabetic wound healing, https://doi.org/10.1007/s12274-020-2846-1
16. Ley-Chávez, E., Martínez-Pardo, ME, Roman, R., & Canchola-Martínez, E. (2003). Application of biological dressings from radiosterilized amnios with cobalt 60 and serologic studies on the handling of burns in pediatric patients. Annals of Transplantation, 8(4), 46-49. PMID: 15171007
17. Mistretta, V., Kurth, W., & Charlier, C. (2016). Are the cobalt hip prosthesis dangerous?. Medecine Sciences: M/S, 32(8-9), 732-738. DOI: 10.1051/medsci/20163208021
18. Heffern, MC, Yamamoto, N., Holbrook, RJ, Eckermann, AL, & Meade, TJ (2013). Cobalt derivatives as promising therapeutic agents. Current opinion in chemical biology, 17(2), 189196. doi: 10.1016/j.cbpa.2012.11.019
19. Domingo, JL (1989). Cobalt in the environment and its toxicological implications. Reviews of environmental contamination and toxicology, 105-132. doi: 10.1007/978-1-4613-8850-0_3
20. Walters, GI, Robertson, AS, Moore, VC, & Burge, PS (2014). Cobalt asthma in metalworkers from an automotive engine valve manufacturer. Occupational Medicine, 64(5), 358-364. DOI: 10.1093/occmed/kqu043
21. Jaganathan, S.K., & Mani, MP (2019). Electrospinning synthesis and assessment of physicochemical properties and biocompatibility of cobalt nitrate fibers for wound healing applications. Anais da Academia Brasileira de Ciências, 91. DOI: 10.1590/00013765201920180237
22. Lippi, G., Franchini, M., & Guidi, G.C. (2005). Cobalt chloride administration in athletes: a new perspective in blood doping?. British journal of sports medicine, 39(11), 872-873. DOI: 10.1136/bjsm.2005.019232
23. Brock, T., & Stopford, W. (2003). Bioaccessibility of metals in human health risk assessment: evaluating risk from exposure to cobalt compounds. Journal of Environmental Monitoring: JEM, 5(4), 71N-76N. DOI: 10.1039/b307520f
24. Lauwerys, R., & Lison, D. (1994). Health risks associated with cobalt exposure—an overview. Science of the Total Environment, 150(1-3), 1-6. DOI : 10.1016/0048-9697(94)90125-2
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Received 24.05.2022
Cobalt (Co) - importance for the body and health, where it contains
Shelestun Anna, nutritionist
Eliseeva Tatyana, editor-in-chief of the EdaPlus.info project
E-mail: [email protected], [email protected]
