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13Molybdenum (Mo) - value for the body and health, which contains
Eliseeva Tatyana, editor-in-chief of the EdaPlus.info project E-mail: [email protected]
Abstract. The article discusses the main properties of molybdenum ( Mo ) and its effect on the human body. A systematic review of modern specialized literature and relevant scientific data was carried out. The best natural sources of molybdenum are indicated . The use of the mineral in various types of medicine and the effectiveness of its use in various diseases are considered. The potentially adverse effects of molybdenum on the human body under certain medical conditions and diseases are analyzed separately.
Key words: molybdenum , Mo , molybdenum, useful properties, contraindications, sources
Molybdenum is a useful mineral that you have hardly heard of. It is needed by the body in tiny amounts, but this is enough to participate in many vital processes. Without it, toxins accumulate in the body, amino acids are not absorbed, DNA is not processed. In this article, we break down why it's so important to health and tell you everything you need to know about the little-known trace element.
Molybdenum in the body: role and function
The substance is absorbed into the blood from the gastrointestinal tract (25-80%), and then transferred to the organs. The ability of the body to store it depends on the level of intake, the amount of copper and sulfates in the diet. The body stores a certain amount of the mineral in the form of molybdopterin in the liver, kidneys, adrenal glands, and bones. Its level is difficult to measure, since the presence in the blood and urine does not show the real situation - an excess of the mineral is excreted in the urine.
[one]
The trace element enters plant food from the soil and water with which it is irrigated. It enters the body of animals through plants, so the content of the compound in meat and offal depends on the diet. [2]
Experiments have shown that the element is poorly absorbed by humans from soy and other products. But this does not lead to its deficiency, since the micronutrient is present in other foods of plant and animal origin. [3, 4]
Molybdenum Foods to Add to Your Diet
There is not enough data on the presence of a microelement in plants, because its concentration depends on the quality of the soil on which they were grown. Although the quantity is variable, the richest sources still include offal, legumes, and grains. There are few minerals in fruits and vegetables.
15 Medium Foods Containing Molybdenum
No. Product |g per
one soy flour 314
2 Pea yellow 250
3 oats 180
four Green pea 130
5 String beans, asparagus 60
6 Whole grain flour 58.5
7 Rice 29
eight Bread 21
9 Cheese eleven
ten A pineapple 9
eleven Eggs 9
12 Banana eight
13 Potato 7
fourteen Chicken meat 5
fifteen Garlic 3
The concentration of the mineral in unfiltered water usually does not exceed 10 |ig/l, although it can reach 68-200 jxg/l in mining sites.
How much molybdenum does the body need - daily rate
The required amount depends on age and is calculated in micrograms. Average daily recommended doses of molybdenum intake [8]
Life period Age Men, women (mcg)
babies 0-6 months 2 babies 7-12 months 3
Journal.edaplus.info - Журнал здорового питания и диетологии Children 1-3 years 17 Children 4-8 years 22 Children 9-13 years old 34 Teenagers 14-18 years old 43 adults 19+ 45
For pregnant and lactating women, the daily requirement increases to 50 micrograms. Most people get this amount of the compound from food. For example, women in the US average 76 mcg/day and men 109 mcg/day. These figures are well above the recommended dietary allowance for adults. [9]
Information on the consumption of the mineral in other countries varies, but also usually exceeds the doses recommended by nutritionists. Daily upper limits depend on age. For example, for children 1-3 years of age, the maximum safe daily "serving" is 300 micrograms, for teenagers - 1700 micrograms, and for adults - 2000 micrograms. [ten]
5 Health Benefits of Molybdenum for Kids and Adults
1. Acts as a Cofactor for Four Enzymes
The element is necessary for enzymes that are involved in redox reactions, the conversion of sulfites, the breakdown and elimination of toxins. Molybdenum activates enzymes such as sulfite oxidase, aldehyde oxidase, xanthine oxidase, mitochondrial amidoxime (mARC). The role of the mineral in the destruction of sulfites, which come from food products, is especially important. If they accumulate in the body and are not excreted in a timely manner, allergies, skin problems begin to develop, and the digestive tract is disturbed. [11, 12, 13]
2. Protects against cancer, sclerosis and other diseases
The trace element removes excess copper from the body. This can play a huge role in the treatment of dangerous chronic diseases. Scientists consider it as a remedy for the treatment of hereditary Westphal-Wilson disease, oncology. [14, 15, 16, 17, 18]
3. Protects cells from damage
The body naturally produces free radicals that are harmful to health. They reduce cellular function and lead to the complete destruction of cells. Antioxidants counter this process and prevent the accumulation of cells in aging, cancer, and other chronic diseases. Molybdenum is required to activate the antioxidant functions of some enzymes. [19]
4. Eases Metabolic Diseases
The chemical element is responsible for a healthy metabolism - it starts chain reactions to produce energy. Therefore, foods with a mineral must be in the diet of every person.
5. Prevents tooth decay
The trace element is found in tooth enamel, so scientists decided to test its benefits on animals. Enamel treated with molybdenum fluoride showed accelerated cavity healing due to rapid mineral regeneration. [20, 21]
Interaction with vitamins and trace elements
Molybdenum supplements at a dosage of 500 mcg / day can provoke a deficiency of certain metals -the component displaces copper from body tissues. It also contains the enzyme xanthine oxidase, which promotes the mobilization of iron from reserves in the liver. [22]
Molybdenum in medicine
Food supplements contain molybdenum alone or together with other minerals. However, there is currently little evidence to support Mo. Such complexes may be needed for rare diseases and at certain stages of life (pregnancy, recovery from injuries, etc.). If you think you are not getting enough of a mineral from food, discuss this with your doctor or nutritionist, rather than taking supplements on your own.
It should be noted that the decay product of Mo-99, Tc-99m, is recognized as a working isotope in nuclear medicine for diagnostic imaging. It is used to detect diseases and to study the structure and function of organs. [23, 24]
Molybdenum in scientific research
• Scientists have found that esophageal cancer is associated with nutrition - the highest incidence has been recorded in countries and areas where there is a shortage of food. This primarily concerns China, Africa, the Middle East. In these regions, in addition to malnutrition, there is a lack of molybdenum and other substances in the soil. This contributes to the accumulation of nitrates and nitrites in plants, which convert them into nitrosamines - known carcinogens of the
esophagus. [25]
• Previous studies have estimated the average daily dietary intake of molybdenum at about 300400 mcg/day. To do this, the average food baskets of Americans were collected, their content was analyzed. However, new evidence suggests that the average intake is much lower - ranging from 120 to 240 mcg / day - and depends on age, gender, income. [26]
• Molybdenum deficiency due to long-term intravenous nutrition can provoke amino acid intolerance. During one study, a patient experienced hypersensitivity to L-methionine. Symptoms disappeared when the L-amino acid solutions were discontinued. The abnormalities indicated that a metabolic defect developed during the conversion of sulfite to sulfate. Supplementation with 300mcg/day of ammonium molybdate normalized uric acid production and solved the problem. [27]
Contraindications and risks associated with taking molybdenum
Molybdenum supplements are not approved by the FDA for medical use, although the potential for toxicity is low. The rules for admission are set by the manufacturers themselves, but this does not guarantee the safety or effectiveness of dietary supplements.
Molybdenum deficiency - deficiency symptoms
Deficiency of the element is rare, since it is found in many foods and is needed by the body in scanty amounts. People usually do not take it in the form of dietary supplements. The reason for this can only be diseases that do not allow the body to use the compound. Molybdenum deficiency leads to seizures,
57
Journal.edaplus.info - Журнал здорового питания и диетологии cancer of the esophagus, brain damage, death within a few days of birth, and developmental delay. [28,
29, 30]
Excess molybdenum: symptoms, toxicity
Molybdenum from food and drink does not cause any harm. But taking it in large quantities does not give any advantages. Little is known about toxic effects in humans as research is limited. However, in animals, very high levels have been associated with diarrhea, kidney failure, growth retardation, and infertility.
People exposed to high concentrations of the substance (consumption 10-15 mg/day, industrial exposure) develop side effects:
• decreased bone mineral density; [31, 32, 33]
• accumulation of uric acid, development of gout;
• reproductive problems - a decrease in testosterone, sperm quality, fertility. [34, 35, 36] Joint pain can also develop due to high levels of uric acid. [37, 38]
Interactions with drugs: when should you pay special attention to the intake of molybdenum?
The mineral does not interact with any drugs, does not interfere with their absorption. But when it comes to its consumption in the form of a supplement in large doses, you should definitely inform your doctor about this when prescribing any medication.
Expert comment
Tatyana Eliseeva, nutritionist, nutritionist
Molybdenum is a little-known but important trace element that can be obtained from legumes, grains, and offal. You don't need to supplement it as long as you follow a healthy diet. Studies show that even with a healthy diet, the average daily intake often exceeds the needs. Therefore, you should not worry about molybdenum, but about getting other vitamins and minerals.
Literature
1. Turnlund, JR, Keyes, WR, & Peiffer, GL (1995). Molybdenum absorption, excretion, and retention studied with stable isotopes in young men at five intakes of dietary molybdenum. The American journal of clinical nutrition, 62(4), 790-796. DOI: 10.1093/ajcn/62.4.790
2. Bittner, F. (2014). Molybdenum metabolism in plants and crosstalk to iron. Frontiers in plant science, 5, 28. doi: 10.3389/fpls.2014.00028
3. Sardesai, V.M. (1993). Molybdenum: an essential trace element. Nutrition in clinical practice, 8(6), 277-281. DOI: 10.1177/0115426593008006277
4. Oya, K., Hirota, K., Sato, H., Hirashima, T., & Hara, T. (1976). Studies of gastric functions during 10 years following vagotomy, fixation of the anterior wall and pyloroplasty. Nihon Heikatsukin Gakkai Zasshi, 12(4), 302-303. PMID: 1035772
5. Molybdenum Fact Sheet for Health Professionals, https://ods.od.nih.gov/factsheets/Molybdenum-HealthProfessional/
6. Seifert, M., Dorn, W., Müller, R., Holzinger, S., & Anke, M. (2009). The biological and toxicological importance of molybdenum in the environment and in the nutrition of plants, animals and man: Part III. Molybdenum content of the food. Acta Alimentaria, 38(4), 471-481. DOI: 10.1556/AAlim.38.2009.4.7
7. Molybdenum, Mo (^g), https://fdc.nal.usda.gov/fdc-app.html#/?component=1102
8. Molybdenum - fact sheet for consumers, https://ods.od.nih.gov/factsheets/Molybdenum-Consumer/
9. Pennington, JA, & Jones, JW (1987). Molybdenum, nickel, cobalt, vanadium, and strontium in total diets. Journal of the American Dietetic Association, 87(12), 1644-1650. PMID: 3680822
10. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, https://www.ncbi.nlm.nih.gov/books /NBK222301/
11. Vally, H., & Misso, NL (2012). Adverse reactions to the sulphite additives. Gastroenterology and hepatology from bed to bench, 5(1), 16. PMID: 24834193
12. Alfaro, JF, & Jones, JP (2008). Studies on the mechanism of aldehyde oxidase and xanthine oxidase. The Journal of organic chemistry, 73(23), 9469-9472. doi:10.1021/jo801053u
13. Kitamura, S., Sugihara, K., & Ohta, S. (2006). Drug-metabolizing ability of molybdenum hydroxylases. Drug metabolism and pharmacokinetics, 21(2), 83-98. DOI: 10.2133/dmpk.21.83
14. Gartner, EM, Griffith, KA, Pan, Q., Brewer, GJ, Henja, GF, Merajver, SD, & Zalupski, MM (2009). A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer. Investigational new drugs, 27(2), 159-165. DOI: 10.1007/s10637-008-9165-9
15. Brewer, GJ, Askari, F., Dick, RB, Sitterly, J., Fink, JK, Carlson, M., ... & Lorincz, MT (2009). Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine. Translational Research, 154(2), 70-77. DOI: 10.1016/j.trsl.2009.05.002
16. Redman, BG, Esper, P., Pan, Q., Dunn, RL, Hussain, HK, Chenevert, T., ... & Merajver, SD (2003). Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer. Clinical Cancer Research, 9(5), 1666-1672. PMID: 12738719
17. Jain, S., Cohen, J., Ward, MM, Kornhauser, N., Chuang, E., Cigler, T., ... & Vahdat, LT (2013). Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse. Annals of oncology, 24(6), 1491-1498. DOI: 10.1093/annonc/mds654
18. Wei, H., Zhang, WJ, McMillen, TS, LeBoeuf, RC, & Frei, B. (2012). Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice. Atherosclerosis, 223(2), 306-313. DOI: 10.1016/j.atherosclerosis.2012.06.013
19. Ni, D., Jiang, D., Kutyreff, CJ, Lai, J., Yan, Y., Barnhart, T.E., ... & Cai, W. (2018). Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice. Nature communications, 9(1), 1-11. doi:10.1038/s41467-018-07890-8
20. Ghadimi, E., Eimar, H., Marelli, B., Nazhat, S.N., Asgharian, M., Vali, H., & Tamimi, F. (2013). Trace elements can influence the physical properties of tooth enamel. Springer Plus, 2(1), 1-12. doi: 10.1186/2193-1801-2-499
21. Kambara, M., Uemura, M., Noshi, H., Miyake, T., & Konishi, K. (1989). Increased remineralization of subsurface enamel lesions with molybdenum treatment. Journal of Osaka Dental University, 23(1), 57-62. PMID: 2640940
22. Smith, BSW, & Wright, H. (1975). Copper: molybdenum interaction: effect of dietary molybdenum on the binding of copper to plasma proteins in sheep. Journal of Comparative Pathology, 85(2), 299-305. DOI: 10.1016/0021-9975(75)90072-9
23. Molybdenum-99/Technetium-99m Production and Use, https://www.ncbi.nlm.nih.gov/books/NBK215133/
24. Hasan, S., & Prelas, M.A. (2020). Molybdenum-99 production pathways and the sorbents for 99Mo/99mTc generator systems using (n, y) 99Mo: a review. S.N. Applied Sciences, 2(11), 128. https://link.springer.com/article/10.1007/s42452-020-03524-1
25. Torres-Aguilera, M., & Troche, JMR (2018). Achalasia and esophageal cancer: risks and links. Clinical and experimental gastroenterology, 11, 309. doi: 10.2147/CEG.S141642
26. Tsongas, TA, Meglen, RR, Walravens, PA, & Chappell, WR (1980). Molybdenum in the diet: an estimate of average daily intake in the United States. The American Journal of Clinical Nutrition, 33(5), 1103-1107. DOI: 10.1093/ajcn/33.5.1103
27. Abumrad, N.N., Schneider, A.J., Steel, D., & Rogers, L. (1981). Amino acid intolerance during continued total parenteral nutrition reversed by molybdate therapy. The American journal of clinical nutrition, 34(11), 2551-2559. DOI: 10.1093/ajcn/34.11.2551
28. Blot, WJ, Li, JY, Taylor, P.R., Guo, W., Dawsey, S., Wang, GQ, ... & Li, B. (1993). Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. JNCI: Journal of the National Cancer Institute, 85(18), 1483-1491. DOI: 10.1093/jnci/85.18.1483
29. Nouri, M., Chalian, H., Bahman, A., MOLA, HH, AHMADI, FM, Fakheri, H., & SOROUSH, A. (2008). Nail molybdenum and zinc contents in populations with low and moderate incidence of esophageal cancer. PMID: 18588371
30. Ray, S.S., Das, D., Ghosh, T., & Ghosh, A.K. (2012). The levels of zinc and molybdenum in hair and food grain in areas of high and low incidence of esophageal cancer: a comparative study. Global Journal of Health Science, 4(4), 168. DOI: 10.5539/ gjhs.v 4n4p168
31. Lewis, RC, Johns, LE, & Meeker, JD (2016). Exploratory analysis of the potential relationship between urinary molybdenum and bone mineral density among adult men and women from NHANES 2007-2010. Chemosphere, 164, 677-682. DOI: 10.1016/j.chemosphere.2016.08.142
32. Parry, N., Phillippo, M., Reid, MD, McGaw, BA, Flint, DJ, & Loveridge, N. (1993). Molybdenum-induced changes in the epiphyseal growth plate. Calcified tissue international, 53(3), 180-186. DOI: 10.1007/BF01321835
33. Liao, Y., Cao, H., Xia, B., Xiao, Q., Liu, P., Hu, G., & Zhang, C. (2017). Changes in trace element contents and morphology in bones of duck exposed to molybdenum or/and cadmium. Biological trace element research, 175(2), 449-457. DOI: 10.1007/s12011-016-0778-0
34. Meeker, JD, Rossano, MG, Protas, B., Diamond, MP, Puscheck, E., Daly, D., ... & Wirth, JJ (2008). Cadmium, lead, and other metals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicant. Environmental health perspectives, 116(11), 1473-1479. doi:10.1289/ehp.11490
35. Meeker, JD, Rossano, MG, Protas, B., Padmanahban, V., Diamond, MP, Puscheck, E., ... & Wirth, JJ (2010). Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum. Fertility and sterility, 93(1), 130-140. doi: 10.1016/j.fertnstert.2008.09.044
36. Jeter, M. A., & Davis, G. K. (1954). The effect of dietary molybdenum upon growth, hemoglobin, reproduction and lactation of rats. The Journal of nutrition, 54(2), 215-220. DOI: 10.1093/jn/54.2.215
37. Vyskocil, A., & Viau, C. (1999). Assessment of molybdenum toxicity in humans. Journal of applied toxicology, 19(3), 185-192. DOI: 10.1002/(sici)1099-1263(199905/06)19:3< 185:: aid-jat555>3.0.co;2-z
38. Berislav, M. (1999). A case report of acute human molybdenum toxicity from a dietary molybdenum supplement-A new member of the" lucor metallicum "family. Arhiv za higijenu rada i toksikologiju, 50(3), 289-297. PMID: 10649845
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Received 13.05.2022
Molybdenum (Mo) - value for the body and health, which contains
Eliseeva Tatyana, editor-in-chief of the EdaPlus.info project
E-mail: [email protected]
