Cellular reactivity of organism of children with scoliosis aged 7 to 10 Текст научной статьи по специальности «Клиническая медицина»

DOI 10.29254/2077-4214-2018-1-1-142-118-121 UDC 616-092.18:616.711-007.5-053.5 Dychko O. A.

CELLULAR REACTIVITY OF ORGANISM OF CHILDREN WITH SCOLIOSIS AGED 7 TO 10

SHEE «Donbas State Pedagogical University» (Sloviansk)

v.v.dichko@ukr.net

Publication relation to planned scientific research projects. The paper is a fragment of the research work «Study of the adaptive reactions of the organism that are developed under the influence of various factors of nature and society», the number of state registration 0115U003314.

Introduction. The natural reactivity of a human organism includes, except for all other characteristics, natural resistance and reactivity of organism cells [2,3,4]. This mechanism is due to chemical and biological barriers, normal microflora of all tartar shells, enzyme systems of cells, which destroy and neutralize foreign agents and participate in protective reactions. The resistance and activity are provided with the factors and corresponding reactions of nervous, endocrine and other systems [2,4,5,7].

Cellular adaptive changes, which take place with defects of organism development of different levels of complexity, are a basis for survival of an organism in constantly changing external environment [3,5,7]. In different life periods and in different situations significant variations of expressing cellular reactivity occur (active, depressed, irreactivity), they are physiological reactions of adaptation (fittings), but not evidence of the development of any diseases [2,3,4,7].

Cellular reactivity changes according to the complexity and the period of the disease in extremal situations and on other occasions.

The goal of the research paper is to study the cellular reactivity of organism of children with scoliosis aged 7 to 10 depending on their sex.

Object and methods of the research. The base for the research were: specialized comprehensive boarding school for children with scoliosis in Oleksiievo-Druzhkivka and comprehensive school № 17 in Sloviansk, Donetsk region.

Fifteen children aged 7 to 15 with scoliosis (9 boys and 6 girls) took part in the research. There were 22 practically healthy children of the same age (12 boys and 10 girls) in the control group.

The cellular reactivity of the organism of the children with scoliosis was determined according to the values of 5 indexes of intoxication by B. A. Rais and Ya. Ya. Kalf-Kalif [6], the nuclear index of the endotoxicosis degree and the hematological index of intoxication by V S. Va-syliev [1].

The research was conducted according to generally accepted bioethical standards, in accordance with the relevant principles of the Helsinki Declaration of Human Rights, the Council of Europe Convention on Human Rights and Biomedicine and relevant laws of Ukraine.

All parents gave their written consent of their children's participation in the research.

The results of the research and their consideration. The results of studying cellular reactivity of organism of children with scoliosis aged 7 to 10 are presented in Table.

Cellular reactivity of practically healthy children aged 7 to 10 depends on the sex and on the type of indicators that characterizes cellular reactivity. The cellular reactivity of the boys of this age is lower than 27,49% in comparison with indicators of the girls of this age. The indicator of intoxication of practically healthy boys tends to decrease by 28,74% and leukocyte index of intoxication by Ya. Ya. Kalf-Kalif tends to increase by 27,94%.

So the cellular reactivity of the organism of practically healthy children aged 7 to 10 depends on the sex and on the type of indicators that characterizes cellular reactivity. On most indicators practically healthy girls have higher level of the cellular reactivity of the organism in comparison with healthy boys.

The cellular reactivity of organism of children with scoliosis aged 7 to 10 have the first stage of disorder of cellular reactivity in comparison with practically healthy children. These disorders have reactive and positive character. Boys aged 7 to 10 with scoliosis have reduced hematological indicators of intoxication by V. S. Vasyliev by 22,77% in comparison with such indicators of girls with scoliosis of the same age.

The indicator of intoxication of boys with scoliosis tends to decrease by 22,06%, nuclear index of the endotoxicosis degree - by 23,26% and leukocyte index of intoxication by Ya. Ya. Kalf-Kalif - by 23,75%.

All the above-mentioned facts prove the positive changes of the cellular reactivity of organism of children with scoliosis aged 7 to 10. The one of boys with scoliosis is lower than the one of the girls with scoliosis.

It is important that the cellular reactivity of the boys with scoliosis aged 7 to 10 is lower than the one of practically healthy boys of the same age on all the indexes: hematological index of intoxication by V S. Vasyliev by 30,76%, (p <0,001), leukocyte index of intoxication by B. A. Rais by 11,67%, leukocyte index of intoxication by Ya. Ya. Kalf-Kalif by 8,75%, (p <0,001), the index of intoxication by 27,94% and nuclear index of the endotoxicosis degree by 18,60%.

The cellular reactivity of the girls with scoliosis aged 7 to 10 is lower than the indicators of practically healthy girls of the same age who have higher hematological index of intoxication by V S. Vasyliev by 35,78%, leukocyte index of intoxication by B. A. Rais by 10,87% and index of intoxication by 34,94%. At the same time, leukocyte index of intoxication by Ya. Ya. Kalf-Kalif of girls

Table.

Cellular reactivity of organism of children with scoliosis aged 7 to 10

Indexes Practically healthy children Children with scoliosis P1 P2

Boys (n=12) Girls (n=10) P Boys (n= 9) Girls (n = 6)

Indexes DDCR Indexes DDCR P

Index of intoxication 0,087+0,008 0,112+0,011 >0,05 0,068+0,007 -I 0,083+0,008 -I >0,05 >0,05 >0,05

Hematological index of intoxication by V. S. Vasyliev 341,21+3,97 435,02+4,29 <0,001 260,95+3,18 -I 320,38+3,71 -I <0,001 <0,001 <0,001

Nuclear index of the endotoxicosis degree 0,051+0,005 0,052+0,005 >0,05 0,043+0,004 -I 0,053+0,005 +I >0,05 >0,05 >0,05

Leukocyte index of intoxication by B. A. Rais 2,01+0,02 2,04+0,02 >0,05 1,80+0,02 -I 1,84+0,01 -I >0,05 <0,01 <0,01

Leukocyte index of intoxication by Ya. Ya. Kalf-Kalif 0,87+0,09 0,68+0,07 >0,05 0,80+0,07 -I 0,99+0,09 +II >0,05 >0,05 <0,05

Note: DDCR - degree of disorder of cellular reactivity.

with scoliosis aged 7 to 10 is higher by 45,59% in comparison with the indexes of practically healthy girls.

Conclusion. Comparing above-mentioned indexes, it is necessary to note that cellular reactivity of organism of both boys and girls with scoliosis aged 7 to 10 is lower than the one of practically healthy children of the same age, as well as cellular reactivity of an organism on index of intoxication, leukocyte index of intoxication by B. A. Rais, hematological index of intoxication by V S. Vasyliev is reduced, the cellular reactivity of boys is also lower on nuclear index of the endotoxicosis degree and leukocyte index of intoxication by Ya. Ya. Kalf-Kalif. The girls with scoliosis aged 7 to 10 have higher cellular re-

activity of organism than boys with scoliosis. Thus, cellular reactivity of the organism of children with scoliosis has sex differences at the age of 7 to 10 and depends on an individual indicator that characterizes the degree of cellular reactivity of organism of both boys and girls and requires rehabilitation process and means for improving cellular reactivity of children with scoliosis.

Prospects of further research. The content of the paper is the cause for studying the influence of the processes and means aimed at improving the cellular reactivity, at adaptation processes and correction of disorders so the rehabilitation method requires specially selected physical exercises.

References

1. Vasilev V, Komar V. Kriterii otsenki tyazhesti bolezni i vyzdorovliniya pri skarlatine. Zdravookhranenie Belorussii. 1983;2:38-40. [in Russiаn].

2. Garkavi L, Kvanina Ya, Ukolova M. Adaptatsionnye reaktsii i rezistentnost organizma. Rostov-on-Don: Izd-vo Rostovskogo universiteta; 1997. 119 s. [in Russiаn].

3. Gorizontov P. Gomeostaz. Moskva: Medizina; 1981. 500 s. [in Russiаn].

4. Gorisontov P, Belousova O, Fedotova M. Stress i sistema krovi. Moskva: Medizina; 1983. 240 s. [in Russiаn].

5. Dychko V, Vasylevskyi V. Reaktyvna vidpovid neitrofilnykh hranulotsytiv peryferiinoi krovi ditei molodshoho shkilnoho viku 7-10 rokiv z patolohiieiu zoru. Ukrainskyi naukovo-praktychnyi zhurnal. 2017;1:167-74. [in Ukrainian].

6. Kalf-Kalif Ya. O leykozytarnom indekse intoksikatsii i ego prakticheskom znachenii. Vrachebnoe delo. 1941;1:31-5. [in Russiаn].

7. Sydorchuk I, Sydorchuk L, Levytska S. Reaktyvna vidpovid neitrofilnykh hranulotsytiv peryferychnoi krovi khvorykh na hostryi bronkhit. Bukovynskyi medychnyi visnyk. 2015;2(74):172-6. [in Ukrainian].

КЛ1ТИННА РЕАКТИВНЮТЬ ОРГАН1ЗМУ Д1ТЕЙ З1 СКОЛ1ОЗОМ В1КОМ 7-10 РОК1В Дичко О. А.

Резюме. Клггины адаптации змлни при дефектах розвитку оргаызму pi3Horo ступеня тяжкост е основою виживання оргаызму в постмно мшливому зовншньому середовищг У pi3Hi перюди життя та в шших випад-ках вщбуваються ютоты варiацií враженост клггинно! реактивност (активна, пригычена, ареактивнють), це е фiзiологiчними реак^ями адаптацп (пристосування), а не свщченням формування будь-яких захворювань.

Метою роботи було вивчити кттинну реактивнють оргаызму дтей 3i сколюзом у вЦ 7-10 роюв у залеж-ност вщ статг

Об'ект i методи дослiдження. Базами для доотдження виступили: спецiалiзована загальноосвтя са-наторна школа-iнтернат для дiтей зi сколiозом м. Олексiево-Дружкiвка та загальноосвтя школа № 17 м. Слов'янська Донецько! областi.

Дослiдження проведено у 15 дггей вiком 7-10 роюв зi сколiозом (9 хлопчикiв i 6 дiвчаток). У якостi контрольно! групи аналопчы дослiдження були проведен у 22 практично здорових однолггках (12 хлопчикiв i 10 дiвчаток).

У дтей 3i сколiозом визначали клiтинну реактивнють оргаызму за значенням 5-ти шдекЫв iнтоксикацiI, лейкоцитарних iндексiв iнтоксикацiI за Б. А. Райсом i Я. Я. Кальф-Калiфою, ядерного iндексу ступеня ендо-токсикозу i гематологiчному показнику iнтоксикацiI за В. С. Васильевим.

За результатами дослiдження встановили, що клiтинна реактивнiсть органiзму дiтей зi сколiозом у вiцi 7-10 роюв у порiвняннi з практично здоровими д^ьми мають першу ступiнь порушень клiтинноI реактивностi. Цi порушення носять реактивний i позитивний характер. Хлопчики у вц 7-10 рокiв зi сколiозом мають зниже-ний гематолопчний показник iнтоксикацiI за В. С. Васильевим на 22,77% в порiвняннi з такими показниками у дiвчаток цього вку зi сколiозом.

У хлопчиюв зi сколiозом е тенден^я до зменшення показника iнтоксикацiI на 22,06%, ядерного шдек-су ступеня ендотоксикозу - на 23,26% i лейкоцитарного шдексу iнтоксикацiI за Я. Я. Кальф-Калiфою - на 23,75%. Зазначене вище свiдчить про позитивы вщмшност клiтинноI реактивностi органiзму дтей у вiцi 7-10 рокiв зi сколiозом. У хлопчикiв зi сколюзом вона нижче, нiж у дiвчаток зi сколiозом.

Важливим е те, що у хлопчиюв зi сколюзом у вМ 7-10 рокiв кгмтинна реактивнiсть органiзму нижче, нiж у практично здорових хлопчиюв цього ж вку за вЫма показниками: за гематолопчним показником штоксика-L^iT за В. С. Васильевим на 30,76%, (p <0,001), по лейкоцитарному шдексу штоксикаци за Б. А. Райсом - на 11,67%, по лейкоцитарному шдексу штоксикаци за Я. Я. Кальф-Калiфою - на 8,75% (p <0,001), за показником штоксикаци на 27,94% i за ядерним шдексом ступеня ендотоксикозу - на 18,60%.

Клггинна реактивнiсть органiзму дiвчаток зi сколiозом у вiцi 7-10 роюв нижче таких показникiв у практично здорових дiвчаток, в останых вище гематологiчний показник iнтоксикацiT за В. С. Васильевим на 35,78%, лейкоцитарний шдекс штоксикаци за Б. А. Рейсом - на 10,87% i показник штоксикаци - на 34,94%. Тим часом, у дiвчаток зi сколюзом у вц 7-10 роюв лейкоцитарний шдекс iнтоксикацiT за Я. Я. Кальф-Калiфою вище на 45,59% в порiвняннi з такими показниками у практично здорових дiвчаток.

Висновки. Порiвнюючи перерахованi показники слщ зазначити, що, клiтинна реактивнiсть оргаызму хлопчикiв и дiвчаток зi сколюзом у вМ 7-10 рокiв нижч^ у практично здорових дiтей цього в^, також зни-жена кттинна реактивнiсть органiзму за iндексом штоксикаци, лейкоцитарному шдексу штоксикаци за Б. А. Райсом, гематолопчному показнику штоксикаци за В. С. Васильевим, а у хлопчиюв i по ядерному шдексу ступеня ендотоксикозу i лейкоцитарному шдексу штоксикаци по Я. Я. Кальф-Калiфою. Дiвчата зi сколюзом у вМ 7-10 роюв мають вищу клггинну реактивнiсть органiзму, чим хлопчики зi сколiозом. Тобто клiтинна реактивнють оргаызму дiтей зi сколюзом мае статевi вiдмiнностi у вц 7-10 рокiв i вона залежить вщ шдивщуаль-ного показника, який характеризуе ступiнь клiтинноT реактивностi оргаызму дiвчаток i хлопчикiв i потребуе проведення реабттацмних заходiв i засобiв для покращення клiтинноT реактивностi дтей iз сколiозом.

Перспективи подальшихдосл'!джень. Матерiали роботи е пiдставою для вивчення впливу заходiв i засо-бiв направлених на покращення кттинно'| реактивностi органiзму, на адаптацiйнi процеси та корекцю порушень тому повинен бути метод реабттаци зi спецiально пiдiбраними вправами фiзичного виховання.

K^40Bi слова: дiти, сколiоз, клiтинна реактивнiсть.

КЛЕТОЧНАЯ РЕАКТИВНОСТЬ ОРГАНИЗМА ДЕТЕЙ СО СКОЛИОЗОМ В ВОЗРАСТЕ 7-10 ЛЕТ

Дычко Е. А.

Резюме. В работе представлены результаты изучения клеточной реактивности организма детей со сколиозом в возрасте 7-10 лет и практически здоровых сверстников. Позволило нам установить, что клеточная реактивность организма детей со сколиозом по сравнению с практически здоровыми детьми имеют первую степень нарушения клеточной реактивности, существенно снижена клеточная реактивность организма по индексу интоксикации, лейкоцитарному индексу интоксикации по Б. А. Райсу, гематологическому показателю интоксикации по В. С. Васильеву, и по лейкоцитарному индексу интоксикации по Я. Я. Кальф-Калифа и ядерному индексу степени эндотоксикоза. Эти нарушения носят реактивный и позитивный характер, и зависят от индивидуального показателя.

Ключевые слова: дети, сколиоз, клеточная реактивность.

CELLULAR REACTIVITY OF ORGANISM OF CHILDREN WITH SCOLIOSIS AGED 7 TO 10

Dychko O. A.

Abstract. Cellular adaptive changes, which take place with defects of organism development of different levels of complexity, are a basis for survival of an organism in constantly changing external environment. In different life periods and in different situations significant variations of expressing cellular reactivity occur (active, depressed, irreactivity), they are physiological reactions of adaptation (fittings), but not evidence of the development of any diseases.

The goal of the research paper is to study the cellular reactivity of organism of children with scoliosis aged 7 to 10 depending on their sex.

Object and methods of the research. The base for the research were: specialized comprehensive boarding school for children with scoliosis in Oleksiievo-Druzhkivka and comprehensive school № 17 in Sloviansk, Donetsk region.

Fifteen children aged 7 to 15 with scoliosis (9 boys and 6 girls) took part in the research. There were 22 practically healthy children of the same age (12 boys and 10 girls) in the control group.

The cellular reactivity of the organism of the children with scoliosis was determined according to the values of 5 indexes of intoxication by B. A. Rais and Ya. Ya. Kalf-Kalif, the nuclear index of the endotoxicosis degree and the hematological index of intoxication by V S. Vasyliev.

The results of the research and their consideration. The results of the study found that cellular reactivity of organism of children with scoliosis aged 7 to 10 have the first stage of disorder of cellular reactivity in comparison with practically healthy children. These disorders have reactive and positive character. Boys aged 7 to 10 with scoliosis have reduced hematological indicators of intoxication by V. S. Vasyliev by 22,77% in comparison with such indicators of girls with scoliosis of the same age.

The indicator of intoxication of boys with scoliosis tends to decrease by 22,06%, nuclear index of the endotoxicosis degree - by 23,26% and leukocyte index of intoxication by Ya. Ya. Kalf-Kalif - by 23,75%.

All the above-mentioned facts prove the positive changes of the cellular reactivity of organism of children with scoliosis aged 7 to 10. The one of boys with scoliosis is lower than the one of the girls with scoliosis.

It is important that the cellular reactivity of the boys with scoliosis aged 7 to 10 is lower than the one of practically healthy boys of the same age on all the indexes: hematological index of intoxication by V. S. Vasyliev by 30,76%, (p <0,001), leukocyte index of intoxication by B. A. Rais by 11,67%, leukocyte index of intoxication by Ya. Ya. Kalf-Kalif by 8,75%, (p <0,001), the index of intoxication by 27,94% and nuclear index of the endotoxicosis degree by 18,60%.

The cellular reactivity of the girls with scoliosis aged 7 to 10 is lower than the indicators of practically healthy girls of the same age who have higher hematological index of intoxication by V S. Vasyliev by 35,78%, leukocyte index of intoxication by B. A. Rais by 10,87% and index of intoxication by 34,94%. At the same time, leukocyte index of intoxication by Ya. Ya. Kalf-Kalif of girls with scoliosis aged 7 to 10 is higher by 45,59% in comparison with the indexes of practically healthy girls.

Conclusion. Comparing above-mentioned indexes, it is necessary to note that cellular reactivity of organism of both boys and girls with scoliosis aged 7 to 10 is lower than the one of practically healthy children of the same age, as well as cellular reactivity of an organism on index of intoxication, leukocyte index of intoxication by B. A. Rais, hematological index of intoxication by V. S. Vasyliev is reduced, the cellular reactivity of boys is also lower on nuclear index of the endotoxicosis degree and leukocyte index of intoxication by Ya. Ya. Kalf-Kalif. The girls with scoliosis aged 7 to 10 have higher cellular reactivity of organism than boys with scoliosis. Thus, cellular reactivity of the organism of children with scoliosis has sex differences at the age of 7 to 10 and depends on an individual indicator that characterizes the degree of cellular reactivity of organism of both boys and girls and requires rehabilitation process and means for improving cellular reactivity of children with scoliosis.

Prospects of further research. The content of the paper is the cause for studying the influence of the processes and means aimed at improving the cellular reactivity, at adaptation processes and correction of disorders so the rehabilitation method requires specially selected physical exercises.

Key words: children, scoliosis, cellular reactivity.

Рецензент - проф. Похилько В. I.

Стаття надшшла 27.01.2018 року

DOI 10.29254/2077-4214-2018-1-1-142-121-124 УДК 616.12-008.46-036.12-07 Карпенко Ю. И., Ханафи Мохамед

НАТРИЙУРЕТИЧЕСКИЙ ПЕПТИД КАК МАРКЕР ПРОГНОЗА У ПАЦИЕНТОВ С ЖЕЛУДОЧКОВОЙ АСИНХРОНИЕЙ

Одесский национальный медицинский университет (г. Одесса)

mohamedhanafi22@yahoo.com

Связь публикации с плановыми научно-исследовательскими работами. Исследование является фрагментом НИР кафедры внутренней медицины № 1 с курсом сердечно-сосудистой патологии на тему «Усовершенствование и оценка эффективности интервенционного лечения тахиаритмий»(№ государственной регистрации 011411000773).

Вступление. Согласно современным представлениям ХСН - это мультисистемное заболевание, при котором первичное нарушение функции сердца вызывает целый ряд гемодинамических, нервных и гормональных реакций, направленных на поддер-

жание кровообращения в соответствии с потребностями организма [10]. Многими авторами указано на доминирующую роль дисфункции сердца в инициации различных структурно-функциональных и нейрогуморальных реакций, лежащих в основе патогенеза СН [6,9]. Разнообразие данных реакций определяет интерес клиницистов к поиску высокоинформативных маркеров прогноза у пациентов с СН, в том числе натрийуретических пептидов. Повышение уровня предсердного натрийуретического пептида (тип А) у больных ХСН рассматривается как один из важнейших компенсаторных механизмов и