Бессимптомная тяжелая митральная недостаточность на фоне синдрома недифференцированной дисплазии соединительной ткани. Клинический случай своевременной диагностики и успешного лечения

Мартьянова Юлия Борисовна; Чернышова Елена Николаевна; Кондратьев Дмитрий Анатольевич; Лялюкова Елена Александровна

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ISSN: 2311-1623 (Print)

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doi: 10.24412/2311-1623-2022-36-50-56

Asymptomatic severe mitral regurgitation in patient with undifferentiated connective

tissue dysplasia. Clinical case of timely diagnosis and successful treatment.

Martyanova Yu. B.1, Chernysheva E. N.2, Kondratyev D. A.1, Lyalyukova E. A.3

1 Federal Center for Cardiovascular Surgery of the Ministry of Health of Russia, Astrakhan, Russia.

2 Astrakhan State Medical University of the Ministry of Health of Russia, Astrakhan, Russia.

3 State Medical University of the Ministry of Health of Russia, Omsk, Russia.

AUTHORS

Yulia B. Martyanova, M.D., cardiologist of the Department of Cardiac Surgery No. 1 of the Federal Center for Cardiovascular

Surgery of the Ministry of Health of Russia, Astrakhan, Russia.

Elena N. Chernysheva, M.D., Ph.D., docent, head of the Department of Cardiology of the Astrakhan State Medical University

of the Ministry of Health of Russia, Astrakhan, Russia.

Dmitry A. Kondratyev, M.D., Ph.D., head of the Department of Cardiac Surgery No. 1 of the Federal Center for Cardiovascular

Surgery of the Ministry of Health of Russia, Astrakhan, Russia.

Elena A. Lyalyukova, M.D., Ph.D., docent, professor of the Omsk State Medical University of the Ministry of Health of Russia,

Omsk, Russia.

Abstract

The spectrum of mitral valve (MV) pathology in patients

with connective tissue dysplasia (CTD) include conditions

from myxomatous degeneration with excess tissue of the

valve leaflets and subvalvular apparatus, which is more

common among young patients, to fibroelastic deficiency

of the MV leaflets that is usually diagnosed in older age

groups. Mitral regurgitation (MR) in patients with dysplasia

belongs to the category of primary MR that can progress

and lead to surgical treatment.

It is known that surgical intervention on MV in patients

with connective tissue dysplasia (CTD) is recommended

in cases of symptomatic severe MR. In asymptomatic severe

MR with such pathophysiological consequences as

left ventricular systolic dysfunction, pulmonary hypertension,

atrial fibrillation, surgical treatment is also indicated.

iНе можете найти то, что вам нужно? Попробуйте сервис подбора литературы.

The question of surgical treatment of asymptomatic

severe MI without the mentioned above criteria remains

controversial.

Using the clinical example of long-term observation of

the asymptomatic severe MR we present step-by-step

algorithm for patients with severe primary MI considering

the latest clinical guidelines on valvular heart disease

of 2021.

Keywords: mitral valve, mitral regurgitation, mitral valve

repair, mitral valve replacement, mitral valve dysplasia.

Conflict of interest: none declared

Received: 25.09.2022

Accepted: 24.11.2022

For citation: Martyanova Y. B., Chernyshova E. N., Kondratyev

D. A., Lyalyukova E. A. Asymptomatic severe mitral

insufficiency with the background of undifferentiated

connective tissue dysplasia syndrome. Clinical case of

timely diagnosis and successful treatment. International

Journal of Heart and Vascular Diseases. 2022; 10(36):

50�56. doi: 10.24412/2311-1623-2022-36-50-56

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