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7. Podkamenev V. V. Hirurgicheskie bolezni detskogo vozrasta. Medicina, 2005.
8. Shamsiev A.M. i dr. Hirurgicheskoe lechenie septikopiemicheskoj formy ostrogo gematogennogo osteomielita u detej // Vestnik hirurgii im. I.I. Grekova, 2010. T. 169. № 6. S. 51-53.
9. Shamsiev A.M., Yusupov Sh.A., YUldashev B.A. Vliyanie ehkologicheskih faktorov na chastotu hirurgicheskih zabolevanij u detej. / Problemy opustynivaniya v Central'noj Azii i ih regional'noe strategicheskoe reshenie // Tezisy dokladov. Samarkand, 2003. S. 86-87.
10. Shamsiev A.M., Muhammadieva L.A., Yusupov Sh.A. Perekisnoe okislenie lipidov i antioksidantnaya zashchita u detej s hronicheskim bronhitom // Mirovaya medicina: sovremennye tendencii i faktory razvitiya, 2017. S. 50.
A DIFFERENTIATED APPROACH IN THE SURGERY OF LIVER ECHINOCOCCOSIS
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Shamsiyev A.M. , Shamsiyev J.A. , Kurbaniyazov Z.B. , Rakhmanov K.E.4, Davlatov S.S.5
1Shamsiyev Azamat Muxitdinovich - Professor, DEPARTMENT OF PEDIATRIC SURGERY; 2Shamsiyev Jamshid Azamatovich - Professor, Head of the Department, DEPARTMENT OF PEDIATRIC SURGERY POSTGRADUATE, MEDICAL FACULTY; 3Kurbaniyazov Zafar Babajanovich - PhD, Associate Professor, Head of the Department; 4Rakhmanov Kosim Erdanovich - Competitor Research; 5Davlatov Salim Sulaymonovich - Senior Teacher, DEPARTMENT OF SURGICAL DISEASES № 1, SAMARKAND STATE MEDICAL INSTITUTE, SAMARKAND, REPUBLIC OF UZBEKISTAN
Abstract: the work is based on the experience of surgical treatment of 427 patients with echinococcosis of the liver of various locations operated in the 2nd clinic of SamSMI from 2003 to 2015. In the years 2003-2006. We operated 154 (36.1%) patients. These patients made up a control group. The comparison group included 134 (31.4%) patients operated in 20072010. The main group included 139 (32.5%) patients operated in 2011-2015. In comparison with 2003-2006. The incidence of postoperative complications decreased almost 5-fold - from 18.4% to 4.0%. Relapses of echinococcosis in the long term after surgery appeared in 12.9% of patients, and in the group of persons operated in 2003-2006, this indicator reached 28.2%. In subsequent years, against the background of intra- and postoperative prophylaxis of the disease, the number of relapses in the comparison group was reduced to 8.8%, and in the main group was reduced to zero. Among the main germicides, 80-100% glycerol, heated to 70 °C, does not cause destructive changes in the adjacent parenchyma, the brightest and quickest scolexic effect. In the surgery of liver echinococcosis, preference should be given to the topical mini-access, the possibilities of which can be significantly expanded by intraoperative ultrasound and video endoscopic assisting.
Keywords: liver echinococcosis, surgical treatment, relapse prevention.
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Introduction. "Scientific achievements of recent years have radically changed the approaches to diagnosis and choice of the method of treatment of patients with echinococcosis [1, 4]. Currently, echinococcosis surgery includes traditional, video endoscopic and transcutaneous minimally invasive surgery" [1,6]. This thesis of the Resolution of the XXII International Congress of the Association of Hepatology Surgeons of the CIS countries held in September 2015 in Tashkent dictates a significant number of works devoted to the surgical treatment of echinococcosis. Despite this, to date, it has not been possible to make significant progress in the prevention of recurrence of the disease. Among surgeons there is no common opinion in determining the concept, causes, form and nature of relapse, there is no consensus on intraoperative antiparasitic treatment of the fibrous capsule wall, insufficient attention is paid to the role of residual cysts [2, 3 5]. The issues of choosing the optimal tactics of surgical treatment, reducing its traumatism, conducting postoperative rehabilitation and dispensary observation of patients with echinococcosis have not been resolved, which certainly confirms the relevance of this study.
Materials and methods. The work is based on the experience of surgical treatment of 427 patients with echinococcosis of the liver of various locations operated in the 2nd clinic of SAMI from 2003 to 2015. In the years 2003-2006. We operated 154 (36.1%) patients in whom treatment of the residual cavity was carried out with 2-5% formalin solution. These patients made up a control group. The comparison group included 134 (31.4%) patients operated in 2007-2010, in which 80-100% glycerin heated to 70°C was used to treat the residual cavity. The main group included 139 (32.5%) patients operated in 2011-2015, in which the residual cavity in uncomplicated echinococcosis was treated with hot glycerol, and in case of complicated echinococcosis it was treated with hot glycerin in combination with low-frequency ultrasound. The tactics of treatment of the patients of the main group differed from that in the control group and the comparison group in that the choice of the optimal surgical access to the cyst was carried out in a differentiated manner, and the access itself was not very traumatic. In addition, the main group was chemotherapy in full volume. Albendazole was used in a dose of 10-12 mg / kg / day, recommended by WHO (1983). Preparations were prescribed by intermittent courses (1 month of treatment and 15 days - break).
Of the total number (564) of identified cysts of the liver, 62.9% were located on the diaphragmatic, 26.2% on the visceral surface of the organ, 8.3% - intraparenchymally. In the surgery of liver echinococcosis since 2011, we began to widely apply "topical mini-access", carried out as much as possible over the projection of the identified cyst. This incision was used in 98 (70.5%) patients in the main group.
Subclavian and median mini-accesses, if necessary, can be expanded to either side depending on the intraoperative finding. An important help in expanding the radicality of the operation with the use of topical mini-access is the use of intraoperative ultrasound, which was performed by 39 (39.8%) patients with a positive result in 20.5% of cases. Increasing the angle of operation with a topical mini-access is facilitated by the use of the possibilities of fibroendoscopic techniques for a thorough revision of the residual cavity, which allows you to examine the pockets, chambers and folds of the fibrous capsule difficult to access for immediate imaging, to identify and remove residual germ cells and fragments of the cuticular Shell. Fibroendoscopic assisting was performed in 23 (23.5%) of 98 patients, mainly in individuals with daughter cysts.
The absolute majority of our echinococcectomy (99.5%) had an organ-preserving character, and only 0.5% of cases had to resort to resection of the left lobe of the liver. At the same time, 430 (76.2%) of the residual cavities were treated by the type of closed echinococcectomy, and only 131 (23.3%) of the cavity of the fibrous capsules were sealed with a semi-closed drainage method.
When large cysts with a diameter greater than 4-5 cm were eliminated, we tried to apply immersion sutures in the modification of the clinic. In more than half of the cases (55.3%), the elimination of the parasite lairs was carried out according to the method modified in our clinic. The proposed technique is most conveniently used for the localization of cysts on the
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visceral surface of the liver. This method is well established as an organ-saving operation for giant cysts that occupy the entire fraction.
Results. Improvements in the choice of tactics for the surgical treatment of liver echinococcosis could not but affect the immediate results of management of this category of patients. So, in comparison with 2003-2006. The incidence of postoperative complications decreased almost 5-fold - from 18.4% to 4.0%. Much less began to occur complications such as suppuration of the residual cavity (8 times), suppuration of the laparotomic wound (2 times), formation of bile fistula (3 times), there were no subdiaphragmatic abscesses.
Long-term results of liver echinococcectomy were studied in the period from 1 to 14 years in 369 (86.4%) of 427 operated patients. At the same time, the fate of 299 (81.0%) patients was traced in terms of more than 3 years.
Relapses of echinococcosis in the long term after surgery appeared in 12.9% of patients, and in the group of persons operated in 2003-2006, this indicator reached 28.2%. In subsequent years, against the background of intra- and postoperative prophylaxis of the disease, the number of relapses in the comparison group was reduced to 8.8%, and in the main group was reduced to zero.
As a rule, the recurrence of the disease is diagnosed within 3-7 years, only in 12 (9.1%) of patients from the control group the re-development of the parasite was detected 7-14 years after the initial operation, with the diameter of the cysts not exceeding 6 cm, -5 cm, which indicated more likely a reinvisation, rather than a true relapse. In the study of gastric secretion in 10 of 12 patients, a hypoacid condition was detected in 9 of them, and only one patient had normocidal acidity of gastric juice. The revealed regularity of the timing of the development of relapse of echinococcosis determines the minimum (mandatory) period of postoperative dispensary observation: the examination should be carried out for 7 years, and subsequently persons with a hyperacid and normocidal status can be withdrawn from the observation.
Those relapses of echinococcosis, which originated in the same organ fraction, were conditionally associated with defects in the antiparasitic treatment of the residual cavity of the parasite. Such relapses were observed in 40.4% of patients. An analysis was made of the relationship of localization of recurrent cysts to the site of primary lesion in 30 patients with repeated echinococcosis of the liver. In this case, the localization of a recurrent cyst in only 26.7% of patients coincided with the segmental localization of the primary cyst, which made it possible to exclude the absolute dominance of the role of the fibrous capsule in the genesis of the recurrent course of the disease. The likelihood of recurrence is probably related to the fact that the primary liver damage could initially be multiple, and the development of only one parasitic cyst is associated with its dominance, which competitively suppresses the growth of other cysts.
Conclusions. 1. Hypoacid state of gastric juice is a significant risk factor for echinococcosis - in 90% of cases it is associated with a decreased acid-forming function of the stomach. 2. Among the main germicides, 80-100% glycerol, heated to 70 °C, does not cause destructive changes in the adjacent parenchyma, the brightest and quickest scolexic effect. 3. In the surgery of liver echinococcosis, preference should be given to the topical mini-access, the possibilities of which can be significantly expanded by intraoperative ultrasound and video endoscopic assisting. Reducing the traumatic nature of the intervention, preserving the anatomical integrity of the affected organ, reducing the frequency of iatrogenic is facilitated by the proposed method of suturing the residual cavities of the liver. 4. The use of the proposed complex helps reduce the frequency of postoperative complications from 18.4 to 4.0% with liver echinococcosis, reduce the duration of surgical intervention, and shorten the duration of inpatient treatment by half. 5. In 90.9% of cases, relapse of echinococcosis is diagnosed within 3-7 years after the operation. Only due to intraoperative treatment of the residual cavity with glycerol heated to 70 °C it is possible to reduce the frequency of recurrence of echinococcosis from 28.2 to 8.8%, and the use of hot glycerin in combination with postoperative chemotherapy allows the cases of relapse to be reduced to zero.
References
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PREVENTION AND PHARMACOTHERAPY OF LIVER ECHINOCOCCOSIS
12 3
Shamsiyev A.M. , Shamsiyev J.A. , Kurbaniyazov Z.B. , Rakhmanov K.E.4, Davlatov S.S.5
1Shamsiyev Azamat Mukhitdinovich - Professor, DEPARTMENT OF PEDIATRIC SURGERY;
2Shamsiyev Jamshid Azamatovich - Professor, Head of the Department, DEPARTMENT OF PEDIATRIC SURGERY POSTGRADUATE, MEDICAL FACULTY; 3Kurbaniyazov Zafar Babajanovich - PhD, Associate Professor, Head of the Department;
4Rakhmanov Kosim Erdanovich - Competitor Research; 5Davlatov Salim Sulaymonovich - Senior Teacher, DEPARTMENT OF SURGICAL DISEASES № 1, SAMARKAND STATE MEDICAL INSTITUTE, SAMARKAND, REPUBLIC OF UZBEKISTAN
Abstract: the results of treatment with albendazole in 15 patients and prevention in 124 patients with liver echinococcosis were analyzed. With the isolated use of albendazole for therapeutic purposes, 11 (73.3%) patients received positive results. It was established that from the moment of introduction of chemotherapy into the complex of postoperative rehabilitation the frequency of relapses decreased from 8.6 to 0.5%. The incidence of local recurrence of liver echinococcosis was 26.6%. The significant frequency of recurrences of echinococcosis in segments remote from the primary focus (43.4%) and even the defeat of another liver fraction (20%) casts doubt on the role of the fibrous capsule of the primary cyst as the main disease relapse factor.
Keywords: echinococcosis of the liver, surgical treatment, prevention, chemotherapy.
Relevance of the research problem. The adult echinococcosis chain develops in the intestines of dogs and other dog animals, and herbivores and humans are intermediate hosts where the larval form of metacestode develops in different organs. After the eggs are swallowed by the intermediate host, the oncosphere (also called exacanth larva) is released
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