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Электронный научно-образовательный ВЕСТНИК
«Здоровье и образование в XXI веке» №4 2013 том 15
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Halberg Franz *, Cor^lissen Germaine *, Delmore Patrick *, Otsuka Kuniaki Katinas George S.*, Bakken Earl E.*, Chibisov Sergei M. • (presenter), Kharlitskaya Elena V.^ Agarwal R.K.
*Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA, фDepartment of Medicine, Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan, •Department of Pathological Physiology, People's Friendship University of Russia, Moscow, Russia
VASCULAR SELF-MONITORING FOR SCIENCE AND HEALTH: SUBTRACTION ("REMOVE") APPROACH ASSESSING PUTATIVE PHYSIOLOGICAL SOLAR WIND EFFECTS
Aim. We demonstrate the detection of blood pressure (BP) resonance with the solar wind (SW) as a dividend in science from selfmonitoring one's circulation for self-help in health care.
Background. After detecting, by automatic ambulatory monitoring, systolic (S) and diastolic (D) BP and heart rate (HR) monitoring, an elevated BP and/or BP overswinging (dubbed CHAT, short for circadian hyper-amplitude-tension), on several occasions by merely changing the timing of medication (e.g., of diltiazem HCl 240 mg daily for a 75-year-old man from 08:00 to 00:00), we lowered the BP MESOR (P=0.017) and eliminated the excessive swing (P=0.029), which carries a risk higher than that associated with an elevated BP (figure on p. 41 of reference 1). Here, we examine any signature in BP of the speed of ionized particles blowing by satellites, dubbed the SW (2), which shows (intermittent) oscillations in its speed (SWS), i.a., with a period, , of about 15 months (1.3 years) but none with a of precisely 12
Vs—U
months. Such trans- (= beyond) -years are also found in deaths from myocardial infarctions that show a yearly pattern, as a component in a spectrum and a much smaller spectral peak at a transyear (longer than 1 year) component in over 29 years of data in Minnesota. In the same state, more limited data on sudden cardiac death (SCD), have accumulated since this diagnosis was separated from that of myocardial infarction by the tenth revision of the International Classification of Diseases (ICD10), which established it as code I46.1. These SCD in Minnesota show no calendar-year and only a transyear pattern (3-5).
Methods. FH was a 72-year-old man at the start of measurements of his S and DBP and HR, first at 15-minute and thereafter at 30-minute intervals, with gaps, with a Colin ABPM-630 monitor and thereafter with an A&D TM-2421 for a total of nearly 16 (rounded) ensuing years. Figure 1 shows 4 gliding spectral windows (for method, see 6, 7). Shading indicates amplitude, A, at the corresponding
Электронный научно-образовательный ВЕСТНИК
«Здоровье и образование в XXI веке» №4 2013 том 15
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(ordinate) at the midpoint of an 8-year interval, given on the abscissa; the darker the shading the greater the amplitude. In white areas, no oscillation is detected. Separately analyzed in each window are 8-year overlapping intervals of data pushed through the available series in
1-month increments. Graphs (not shown) of the N of data per 8-year interval and of the N per month in the records of SWS and of FH revealed only a major abrupt change for SWS in 1994 and no special feature at times E and E' marked in rows 1 and 2 of Figure 1, but subtly affecting all rows of physiological data.
Results. Oscillations reported before us by physicists (2), confirmed and extended to biology by us (3), are a band darkest around a 1.3-year trial period during more than the first half of the record; in the upper row of the graph; eventually the band in the SW splits and thereafter is no longer detected (this loss of the ~1.3-year component is also validated by 3 separate spectra for separate consecutive 5-year data spans, not shown). In the second row of the graph, SBP, also with a broad-band component beyond a 1- year length, undergoes a seemingly abrupt change with a delay of more than a year after the change in SW. A precise 1-yearly component is found neither in SW nor in SBP or in the last two rows for DBP and HR. There are other components, such as a prominent about 2-year component in SBP and SW and components shorter than (on the near side = cis) of a year, i.e., cisyears, and a broad half-yearly component that in SBP, like the transyear of this variable, loses half of its width
abruptly, with a lag after the abrupt change in the SW seen in the top row of the graph. That some trans- and cisyears persist in SBP when they are no longer detected in the SW supports a degree of endogenicity of transyears and cisyears, while other components, lost with a lag after the cessation of an ~1.3-year transyear in SW, are in keeping with a prior driving of part of the SBP spectrum by the SW. Furthermore, peaks in global spectral windows of SBP and SW, shown elsewhere (8), were tested for overlapping vs. nonoverlapping 95% confidence intervals (CI) of their periods (when their amplitudes did not overlap zero). Some of these CIs of s overlapped, in keeping with the driving of SBP by SW; others did not overlap, in keeping with endogenicity.
Discussion. While chance can never be ruled out, the spectral peaks are significant below the 5% level. The relevance of these findings to mechanisms of disease stems from beats among transyearly components (9) that could lead to exacerbations of disease or death, as underlined by the finding only of a transyear and no calendar-yearly component in sudden cardiac deaths in Minnesota (3-5). That the harsh seasons can be less important than the concurrent unseen SW is shown by the disappearance of some SBP components with a lag after their disappearance from the SW, as seen in Figure 1. Persisting aspects in SBP suggest in turn a putative evolutionary signature (documented by some nonoverlapping 95% confidence intervals of s in SW and SBP, not shown). The forecast of changes in space weather is pertinent for the
Электронный научно-образовательный ВЕСТНИК
«Здоровье и образование в XXI веке»
№4 2013 том 15
care of patients with myocardial infarctions and may relate to sudden cardiac deaths, notably in Minnesota. The—associations—shown—in
Ш
5=0
Figure 1 point to blood pressure as a possible receptor of SW effects, yet the pineal and hypothalamus have also been documented to be involved in mediating effects of environmental magnetism (2).
Conclusion. There is no trace of a signature of the seasons; in the systolic blood pressure of an elderly man, living in Minnesota with a mid-continental climate of alternating cold winters and hot summers; instead there are, among others, rhythms with a period statistically significantly longer than a calendar year (transyears) that are built into the organism, yet may resonate with the solar wind.
1. Halberg F et al. Resolution from a meeting
of the International Society for Research on Civilization Diseases and the Environment (New SIRMCE Confederation), Brussels, Belgium, March 17-18, 1995: Fairy tale or reality ? Medtronic Chronobiology Seminar #8, April 1995, 12 pp. text, 18 figures. URL
http://www.msi.umn.edu/~halberg/
2. Richardson JD et al. Solar wind oscillations with a 1.3-year period. Geophys Res Lett 1994; 21: 1559-1560.
3. Halberg F et al. Chronoastrobiology:
proposal, nine conferences,
heliogeomagnetics, transyears, near-weeks, near- decades, phylogenetic and ontogenetic memories. Biomed Pharmacother 2004; 58 (Suppl 1): S150-S187.
4. Halberg F et al. Theodor Hellbrugge: 85
years of age -- Ad multos transannos, sanos, fortunatos et beatos. J Circadian -Rhythms 2005; 3.
10
pp.
http://www.jcircadianrhythms.com/content/3
/1/2
5. Halberg F et al. Incidence of sudden cardiac death, myocardial infarction and far-and near-transyears. Biomed Pharmacother, in press.
6. Nintcheu-Fata S et al. Software for contour maps of moving least-squares spectra. Scripta medica (Brno) 2003; 76: 279283.
7. Cornelissen G, Halberg F. Chronomedicine. In: Armitage P, Colton T, editors. Encyclopedia of Biostatistics, 2nd ed. Chichester, UK: John Wiley & Sons Ltd; 2005. p. 796-812.
8. Halberg F et al. Chronoastrobiology: Vernadsky's future science ? Benefits from spectra of circadians and promise of a new transdisciplinary spectrum of near-matching cycles in and around us. Proceedings, III International Conference, Civilization diseases in—the—spirit—of V.I. Vernadsky, People's Friendship University of Russia, Moscow, Oct. 10-12, 2005, p. 425.
9. Cornelissen G et al. Multiple resonances among time structures, chronomes, around and in us. Is an about 1.3-year periodicity in solar wind built into the human cardiovascular chronome? Human Physiology 2004; 30 (2): 8692.
Figure 1. Time courses of human elderly systolic and diastolic blood pressure and heart rate, SBP, DBP and HR (rows
Электронный научно-образовательный ВЕСТНИК
«Здоровье и образование в XXI веке» №4 2013 том 15
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2-4, respectively) and of an environmental periodicity (in the speed of the solar wind [SW] -- particles streaming by satellites [top]). During a nearly 16-year span we see only consistent components differing from precisely 1 year in all variables, probably an effect of advancing age (1). While post hoc ergo propter hoc reasoning can never be ruled out, an abrupt change on top is followed in the second row particularly, with a lag of about one transyear, by the disappearance of some components, a finding suggesting that as a first demonstration, some of FH's cis- and transyear components were driven by the solar wind since they disappeared with a lag following the subtraction of the same components from the solar wind spectrum. The altered persistence of other spectral components in SBP suggests an evolutionary acquisition of solar transyear oscillations that may reflect solar dynamics for the past billions of years. © Halberg.
HUMAN SYSTOLIC (S) BLOOD PRESSURE (BP) SELECTIVELY RESONATES WITH SOLAR WIND SPEED (SWS) (TOP 2 SECTIONS) NO OBVIOUS RESONANCE WITH DIASTOLIC BP (DBP) OR HEART RATE (HR) (BOTTOM 2 SECTIONS)
(Uo)
5=3
Aeolian Rhythms* in gliding spectra of SWS
and SBP change in frequency (smoothly [A] or
abruptly [B,C,D], bifurcating
[D,F] and rejoining [G]); they also change in
amplitude (B) (up to disappearing [C,E] and
reappearing)
* FH, man, 72 years (y) of age at start of automatic halt-hourly around the clock measurements for -16 y (N= 2418 daily averages, total ~ 55000). Gliding spectra computed with interval = 8 y, resolution low in time but high in frequency; increment = 1 month, trial periods from 2.5 to 0.4 y, with harmonic increment = 0.05. Darker shading corresponds to larger amplitude. When several of these broad bands disappear in the SWS, at E, parts of the bands in SBP also disappear, with a lag (delay) at E', while other parts persist. These components are presumably built into the human circulation over billions of years, as persistence without corresponding components in SWS shows, but can be driven in part by the solar wind, as their disappearence after loss of corresponding components in SWS suggests. "Aeolian" derived from Aeolus, Greek God of winds, who packed the winds up and then let them loose and had them change.
