CC BY
12
Вестник Ка^НМУ №1-2019
Table 3 - The content of samples of Ibuprofen gel to determine the taste according to the method A. I.Tentzova
---__Modek№L ContentT% ------ 1 2 3
Aspartame (NutraSweet Company) 20,0 - -
Sorbitol (Roquette Freres) - 0,3
С Сотрп-Zucker® G (Südzucker AG) Brand sugar - - 15,0
It was chosen the 1st model gel due to the questionnaire.
__Index_^ Tasty remnant taste description of general taste
ModeT№ -- the left taste
Digital index
1 92 74 70 85
2 64 87 42 52
3 71 81 41 52
Thus, aspartame was taken instead of ibuprofen gel as a flavoring organoleptic properties. Since aspartame has a numeric index of 20.0, it has a higher taste hiding property than other flavors. Conclusion:
The compositions of oral gels containing an unpleasant odor and bitter taste (ibuprofen-gel in the composition of acrylic acid a)
and medicinal and additional things that have an unpleasant taste after use (cellulose-based glycine gel) were studied. It was found that it is necessary to add aspartame for ibuprofen gel (SES index 160.0 - 200.0), and secondly, mannitol (SES index 0.5-0.7). Changing the taste of the drugs through these ingredients will have a positive effect on patients.
REFERENCES
1 M.N. Anurova E.O. Bakhrushina N.V. Pyatigorskaya O.M. Yambikova Principles of correction of oral gels with synthetic substances // Pharmacy and pharmacology. - 2015. - №4 (11). - C. 15-19.
К.К. Шекеева
С.Ж. Асфендияров атындагы К,азац ¥лттыцмедицинаyHueepcumemi
КОРРИГЕНТТЕРМЕН ДЭР1Л1К ЗАТТАРДЬЩ ДЭМ1Н 6ЗГЕРТУ ПРИНЦИПТЕР1
ty^h: Ма;алада дэршердщ дэмш тузету ушш тэттiлендiрriштердi тацдау бойынша тэжiрибелiк зерттеулер сипатталган. Курамында ащы дэмь колданганнан кешн жагымсыз дэмi калатын заттары бар препараттардыц органолептикалык; касиеттерш жа;сарту мумкшдИ керсетыген.
ty^hîï сездер: корригент, дэм коррекциясы, тэттiлендiрriш, глицин, ибупрофен, пероральд гель
К.К. Шекеева
Казахский Национальный медицинский университет имени С.Д. Асфендиярова
ПРИНЦИПЫ КОРРЕКЦИИ ЛЕКАРСТВЕННЫХ СРЕДСТВ С ПОМОЩЬЮ КОРРИГЕНТОВ
Резюме: В работе описаны практические исследования по выбору корригентов для коррекции вкуса лекарственных средств. Показана возможность улучшения органолептических свойств препаратов с горьким вкусом и с неприятным послевкусием. Ключевые слова: корригент, коррекция вкуса, подсластитель, глицин, ибупрофен, пероральный гель.
UDC 616.316-002-073-076-085.
K.K. Shekeyeva
Asfendiyarov Kazakh National medical university
THE RESEARCH OF THE PROPERTIES OF STRENGTHENING THE POLYVINILPYRROLIDONE COMPOUNDS, USED IN OPHTHALMOLOGICAL FLUIDS
The article investigated the thickening properties of polyvinylpyrrolidone formulations in eye drops. In the course of research, it was found that kollidon is widely used in pharmaceutical production due to the different properties of soluble and insoluble grades of the group. It also performs the action as a solubilizer, stabilizer and fusion. One of the auxiliary substances used as a thickener in ophthalmic solutions was selected various grades of Kollidon (17, 25, 30, 90 and VA 64) for the study. The condensation property of this drug was determined by calculating various indicators (density, pH value, kinematic and dynamic viscosity, transparency) and by demonstrating the dependence of these parameters on the label and the concentration of the drug. From the studied brands, Kollidon 90 showed the highest concentration result. Keywords: polyvinylpyrrolidone, collidone, ophthalmic solution, thickener.
According to the statistics of the World Health Organization for the remaining 246 million suffer from the eye diseases such as
2017, about 285 million people worldwide suffer from eye human cataracts, glaucoma, conjunctivitis, etc. These
diseases. About 39 million of them have stopped looking, while ophthalmologic diseases can be cured with the help of drug
Vestnik KazNMU №1-2019
therapy, surgical and laser correction, using modern technologies. In the initial stages of eye diseases, various medications are used. At the subsequent stages can be treated with different eye drops.
The reason why eye drops cannot show the desired result to this time, and the lack of viscosity is a drawback. That is, when the viscosity of the ophthalmic solution is low, its streamlining increases. As a result, after dripping into the eyes, they come out again, without a therapeutic effect. For the effects of the drug, you must re-enter it in large quantities. This property, of course causes the consumer dissatisfaction.
Today, as a result of many experimental studies, there are several ways to solve this problem. One of them is to create a system with high viscosity, which will interact with eye tissues in a short time, and create an array of physical, chemical, biopharmaceutical properties and data thickeners used in ophthalmic solutions.
Purpose of the study:
The study of the thickening properties of the group of polyvinylpyrrolidone used in ophthalmic solutions. Materials and research methods:
In this study, water-soluble grades of polyvinylpyrrolidone are
used: Kollidon 25, Kollidon 30, Kollidon 90, Kollidon VA 64.
Viscosity, pH, density and transparency were detected.
Model samples were obtained by dissolving the calculated
amount of polyvinylpyrrolidone in distilled water using a
magnetic stirrer.
Tools used in the research:
• A viscometer made of a glass capillary "VTZh-2" with a capillary diameter of 1.31 mm was used to determine the viscosity.
• Laboratory ionomer "I-160" was used equipped with a glass electrode and a thermocompressor to measure the pH value.
• Arometer was used to determine density.
Table 1 - The table shows the model and concentration of the solution of polyvinylpyrrolidone:
Taken mark, [%) Models' numbers
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
1-3 Kollidon 17 10 - - - - - - - - - - - - - -
Kollidon 17 - 20 - - - - - - - - - - - - -
Kollidon 17 - - 25 - - - - - - - - - - - -
4-6 Kollidon 25 - - - 10 - - - - - - - - - - -
Kollidon 25 - - - - 15 - - - - - - - - - -
Kollidon 25 - - - - - 20 - - - - - - - - -
7-9 Kollidon 30 - - - - - - 15 - - - - - - - -
Kollidon 30 - - - - - - - 20 - - - - - - -
K0.tt.ttMfl0H 30 - - - - - - - - 25 - - - - - -
10-12 Kollidon VA64 - - - - - - - - - 10 - - - - -
Kollidon VA64 - - - - - - - - - - 15 - - - -
Kollidon VA64 - - - - - - - - - - - 25 - - -
13-15 Kollidon 90 - - - - - - - - - - - - 2.5 - -
Kollidon 90 - - - - - - - - - - - - - 5 -
Kollidon 90 - - - - - - - - - - - - - - 6.5
Results and their analysis.
Determination of viscosity: according to NSS, the optimal kinematic viscosity of the eye drops is 5-15 cSt, as well as other sources of information cannot exceed the period of 15-30 cSt of viscosity. According to other sources, the viscosity of an aqueous solution of Kollidon increases in accordance with the increase in molecular weight and does not depend on the pH of the solvent. Determination of pH value: pH values determined during sample examination:
The results show a weaker environment. Therefore, samples require a buffer solution to prepare an ophthalmic solution. Definition of transparency: the study was conducted by comparing the reference solution. As a result, all samples were transparent.
Determination of density: the density of the sample varies slightly [from 1.012 to 1.079 g/cm3).
Table 2 - Values of 15 samples under the study by density, viscosity, pH and transparency
Model № Density, g/sm3 Kinematic viscosity, sSt Dynamic viscosity, sPz pH value Transparency
1 1.012 2.23 2.57 4.13 Yellow
2 1.071 7.03 7.53 4.20 Yellow
3 1.093 7.78 8.50 4.21 Yellow
4 1.017 3.73 3.79 3.52 Light yellow
5 1.027 6.53 6.70 3.65 Light yellow
6 1.040 12.77 13.29 3.67 Light yellow
7 1.026 8.55 8.78 3.71 Light yellow
8 1.037 14.36 14.89 3.73 Light yellow
9 1.047 50.61 52.99 3.74 Light yellow
10 1.016 3.91 3.97 4.02 Light yellow
11 1.026 7.36 7.55 3.96 Light yellow
12 1.031 23.41 24.14 3.74 Light yellow
13 1.053 6.33 6.67 4.18 Colorless
Вестник Кж^НМУ №1-2019
14 1.062 16.01 17.00 4.42 Colorles
15 1.079 30.02 32.39 4.31 Colorles
ть^ыздыц = 1.062 г/см3
Kollidon 90
Kinematic viscosity = 16.01 сСт
Р Dynamic
pH =4.42 viscosity =
17.00 сПз
Diagram 1 - Indicators of Kollidon 90, denoting optimal thickening results for ophthalmic solution
The table shows the physico-chemical properties of soluble in collagen brands obtained during the study. Received brand Kollidon (17, 25, 30, 90 and VA 64) (Manufacturing company BASF, Germany). Aqueous solutions of Kollidon are colorless, transparent, indicate a weak pH value (3.52-4.42), the kinematic viscosity is concentrated and ranges from 2.23 to 50.61 sSt, and the density varies from 1.012 to 1.079 g/sm3. Among the few samples that can be used as the most capable of preparing ophthalmic solution, sample 14 is the most suitable (Kollidon 90). Since this sample can be a thickening factor even at low concentrations. The diagram shows the values obtained in the study of the brand Kollidon 90.
Conclusion. Polyvinylpyrrolidone is an organic substance that is included in the composition of additional substances, resulting from the polarization of vinylpyrrolidone. Nowadays, it is widely used in the pharmaceutical industry. Soluble brands are found in solubilizers and stabilizers. And soluble brands are used as a density binder, a solubilizer and a stabilizer. The models were selected that can be used as the thickeners for the preparation of ophthalmic solution: models 8, 9, 12, 14. From them, the sample 14 is the most effective (Kollidon 90 (5%)). This sample can show the desired concentrated effect even at low concentrations.
REFERENCES
1 Georgievsky V.P., Konaev F.A. Technology and standardization of drugs. - Kharkov: 2000. - 784 p.
2 E.A. Yegorova Glaucoma // National leadership. - 2013. - №2. - P. 41-46.
3 Egoshina Yu.A., Kiselueva L.A. 2009. Modern excipients in tablet production // Successes of modern science. - 2009. - №10. - P. 11-14.
4 Zhilyakova E.T., Baskakova A.V., Novikova M.Yu. Development of technological methods to increase the solubility of acyclovir // Basic research. - 2013. - №4. - P. 91-96.
К.К. Шекеева
С.Ж. Асфендияров атындагы К,азац ¥лттыцмедицинаyHueepcumemi
ОФТАЛЬМОЛОГИЯЛЬЩ ЕР1Т1НД1ЛЕРДЕ ЦОЛДАНЫЛАТЫН ПОЛИВИНИЛПИРРОЛИДОН ТУЫНДЫЛАРЫНЬЩ КОЮЛАТЦЫШТЬЩ ЦАСИЕТГН ЗЕРТТЕУ
ty^h: Ма;алада поливинилпирролидон туындыларыныц кезге арналган тамшылардагы коюландыргыштык; к;асиеттерi зерттелдь Зерттеу жумыстары барысында, коллидон тобыныц еритш жэне ерiмейтiн маркаларыныц эртYрлi ;асиеттершщ ар;асында фармацевтикалы; ендiрiсте кецшен ;олданылатыны аны;талды. Жэне де ол солюбилизатор, стабилизатор жэне бiрiктiрушiлер ;ызметш ат;арады. Зерттеу Yшiн офтальмологиялы; ертндыерде ;оюландыргыш ретшде ;олданылатын кемекшi заттардыц бiрi Коллидонныц эртYрлi маркалары (17, 25, 30, 90 жэне VA 64) тацдалып алынды. Осы дэрыж заттыц ;оюландыргышты; ;асиет эртYрлi керсеткiштерiн (тыгыздыгын, рН мэнш, кинематикалы; жэне динамикалы; тут;ырлыгын, мелдiрлiгiн) есептеу ар;ылы жэне осы керсеткштердщ дэрiлiк заттыц маркасы мен концентрациясына тэуелдiлiгiн керсету ар;ылы аны;талды. Зерттелген маркалар шшен ец жогаргы ;оюландыргыш ;асиет керсеткен Коллидон 90 болды. ТYЙiндi сездер: поливинилпирролидон, коллидон, офтальмологиялы; ерiтiндi, ;оюландаргыш.
К.К. Шекеева
Казахский Национальный медицинский университет имени С.Д. Асфендиярова
ИЗУЧЕНИЕ ПРОИЗВОДНЫХ ПОЛИВИНИЛПИРРОЛИДОНА КАК ЗАГУСТИТЕЛИ В ОФТАЛЬМОЛОГИЧЕСКИХ РАСТВОРАХ
Резюме: В статье представлена характеристика загустителей в офтальмологических растворах группы поливинилпирролидона. Выявлено, что их растворимые и нерастворимые марки широко применяются в различных отраслях фармацевтической промышленности. И он также является солюбилизатором и стабилизатором. Для исследования были выбраны различные марки Коллидона(17,25,30,90 и VA), который используется в качестве загустителя в офтальмологических растворах. Сгущающую способность этого препарата определяли путем расчета различных параметров (плотность, значение рН, кинематическая и динамическая вязкость и прозрачность) и указывали зависимость этих параметров от степени и концентрации лекарственного средства. Из изученных марок показал самые высокие загущающие свойства - Коллидон 90. Ключевые слова: поливинилпирролидон, коллидон, офтальмологические растворы, загустители
