CC BY
40
Shamova Maria,
Ph.D., South Ural State University, the NGO "Artlife"
E-mail: [email protected] Mukhametova Julia, a graduate student, South Ural State University E-mail: [email protected] Avstrievskih Alexander, Doctor of Technical Sciences, Professor Director General of the NGO "ArtLife" E-mail: [email protected]
THE PROCESS OF DEVELOPING AN INNOVATIVE FORM OF FOOD ADDITIVE
Abstract: The article considers the development of the technology of the new innovative form of the food additive in the form of the biologically active substance (BAA) produced at the enterprises of the company ArtLife. The dietary supplement uses an active natural substance - polyprenol, obtained by their needles of fir trees. Also, the structure of the active substance of polyprenol, its formula and functional properties are considered.
The technological process is considered, which includes the following main stages: Preparation of raw materials; Preparation of a mixture for encapsulation; Preparation of gelatin solution; Encapsulation and drying;
Evaluation of the appearance of the intermediate product; Packing and packing.
The established technological parameters that are one of the factors shaping the quality and safety of the produced products, along with the formulation composition and the management system, are described.
Organoleptic, physico-chemical, sanitary-hygienic and sanitary-toxicological studies in the production and storage process were conducted, which allowed to determine the regulated quality indicators, terms and modes of sale.
Keywords: Polyprenol, medicine, pharmaceutics, biologically active additive, dietary supplements, nutrients, functional properties, health, nutrition.
The use of natural biologically active substances Polyprenols are the most important group of
and their complexes in the correction of nutrition natural bioregulators released from plant raw mate-
and health is a priority in today's Nutrition. Particu- rials, in particular, greens of Siberian fir and other
lar attention in recent years, is given Polyprenols coniferous plants. Polyprenols are the main secret
[1-4]. of biologically active substances contained in the
above objects of nature. For a person polyprenols are the only source of vital molecules - dolichol, responsible for many physiological processes in the body. In Russia, polyprenols are included in the list of essential components for the human body, along with vitamins, minerals and other micronutrients.
Polyprenols are natural long-chain isoprenoid alcohols of general formula H- (C5H8) n-OH, where n is the number of isoprene units. Any pre-nol with more than 4 isoprene units is polyprenol. Polyprenols occupy key positions in the metabolism, acting as natural bioregulators. Dolicholi, which are found in all living organisms, including humans, are their derivatives - 2,3 - dihydropyl-enols. Polyprenols and dolichols have a similar chemical structure, since dolicholes are derivatives of polyprenols and differ from them by a single saturated isoprene unit.
Polyprenols are chemical compounds from the group of biopolymers produced in the human liver. These substances are extremely important for the normal functioning of the body, since they are responsible for the processes of interaction between cells and participate in the dolichlorophosphate cycle, during which glycoproteins are formed - receptors, growth hormones, plasma proteins, enzymes and immunoglobulins. Polyprenols restore the structure of the cell and control the process of creating proteins. The lack or lack of polyprenols in the body can lead to the appearance of various diseases. The pharmacological transformation of polyprenols takes place in the liver, where they are metabolized into dolicholes.
Polyprenols are prepared from wood greens coniferous trees botanical family pine (pine, spruce, fir, and others.) By extraction of dried and ground raw materials, followed by purification of the desired product. Contained in the needles of trees, as well as other plants, in the form of acetates - natural mixtures of oligomers (izoprenolov). Content polyprenols in the needles is 0.5-1.5% of the dry weight.
From a chemical standpoint are acyclic terpene alcohols having from 6 to 40 units izoprenodnyh: coniferous trees and the human body - from 10 to 20.
Once in the body through the digestive tract vegetable polyprenols metabolized in the liver dolichols, which also belong to the group, and polyiso-prenes have a structural similarity to polyprenols (different one saturated isoprene). Dolichols play a crucial role in the functioning doliholfosfatnogo cycle (DFTS) - defining link in the chain of biosynthesis of glycoproteins and glyukoaminoglyukanov in the cell membranes. The process of glycosylation of membrane proteins occupies a key position in ensuring the vital activity of cells. With dolichols there is a connection glyukoaminoglyukanov and glycoproteins.
It is noted that the emergence of many pathological processes, including diseases of the nervous system associated with impaired development and DFTS dolichols deficit function that determines the relevance of the development of new forms of highly specialized products using polyprenols has scientific and practical importance [5-10].
A new manufacturing technology encapsulated forms of biologically active additives (BAA) "Oleo-pren Neuro".
The technological process includes the following basic steps.
• Preparation of raw materials. Carry out pre-grinding hammer mill glycine MM10, sifted through the SGS-30 vibrating screen with a mesh size of 0.4 mm;
• Preparation of the encapsulation mixture. The components of the formulation are dosed into the reactor-homogenizer in a certain order: refined sunflower oil; antioxidant Grindoks 109; Memree Plus-30h; polyprenols mixture of75% tocopherol acetate 98%; aerosil (stirred and gomogeneziruyut); glycine (mixed and gomogeneziruyut).
Check compliance with name, number and a series of raw materials routing. Lumps and foreign
matter must be absent. The shelf life of the mixture -no more than 24 hours in a dark place, filled up to the top container;
• Preparation of gelatin solution. Set the parameters in the software mixer Melter MGP: water jacket temperature - 850C; purified water - according to the boot map; speed rpm mixer - 35 rev / min. Charged suspended components in the following order: purified water, glycerin, gelatin.
At least the auxiliary components are added -preservatives and pigments. Preparation time - 2.5 hours per 210 kg of finished gelatin solution. After completing the gelation solution is discharged through a filter (pore size 0.2 mm) in the storage tank, assert 4 hours at a temperature of600 C and fed to the capsule manufacturing site. Shelflife prepared gelatin is not more than 24 hours;
• Encapsulation and final drying. Soft gelatin capsules are prepared from a solution of a mixture of gelatin and capsule for encapsulating machine SGM1010. Capsules finally dried 30-60 hours in the drying tunnels to cease falling capsules weight;
Table 1.- Regulated indicators of qualU
• Evaluation of the appearance of the precursor. Assess visually average sample is taken and transferred to the production laboratory for testing for compliance with the stated performance requirements of technical documentation. On the container, a label is placed with the name of the precursor, quality, batch number, manufacturing date, operator's signature;
• Packaging and packaging. Implemented in accordance with the technical documentation for the manufactured product. Samples of the finished product (3 pack) are transmitted to the collection of arbitration samples.
All stages of the process are recorded in the route-accompanying sheet.
The established process parameters are one of the factors shaping the quality and safety of products, along with prescription composition and management system.
Carried out the organoleptic, physico-chemical, sanitary-hygienic and sanitary-toxicological studies in the process of production and storage, allowing to determine the regulated quality indicators (Table 1), the terms and modes of implementation.
lietary supplements "Oleopren Neuro".
Parameter Contents characteristics
The appearance of soft gelatin capsules
Color capsule contents from yellow to orange, It allowed the precipitate inside the capsule
Taste and smell of the contents of the capsule specific
The average weight of the capsule, mg 790 (OT 711 go 869)
Vitamin E content in one capsule, mg 3,75 (OT 2,6 go 4,9)
The content of polyprenols in one capsule, mg, not less than 5,0
Contents atsetonrastvorimyh substances (phosphatidylserine and phosphatidic acid) in 1 capsule, mg, not less than 14,5
The developed product is a highly effective natural complex of biologically active substances directed action on the nervous system, having vzaimnopo-tentsiruyuschimi farmokodinamicheskimi properties obespechivayuschmim prolongation effect after the end of dietetics. Performance and functional ori-
entation BAA "Oleopren Neuro" confirmed by the results of clinical trials in patients.
Displaying hygienic welfare of the product for 27 months after storage (based on the results of microbiological, sanitary-hygienic and sanitary-toxicological tests) possible to determine the shelf life - 2
years at a temperature no higher than 250 °C in a terprises of the NGO "ArtLife" certificated under the
dry, dark place. requirements of the international standards of ISO
Developed and approved technical documenta- 9000, 22000 and GMP regulations, which ensures
tion. BAA "Oleopren Neuro" is produced at the en- the stability of quality and safety of products.
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