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2о
SJIF 2023 = 6.131 / ASI Factor = 1.7
3(11), November, 2023
THE MORPHOLOGICAL FEATURES OF THE STRUCTURE OF THE BRAIN OF NEWBORN, BORN AND DEAD AT DIFFERENT PERIODS OF PREGNANCY IN THE ATELECTATIC FORM OF PNEUMOPATHY
In the morphological and morphometric study of the brain structures of newborns who died from the atelectatic form of pneumopathy, it was found that the ratio of vascular and perivascular spaces at 22-25 weeks was 4.28±0.18 ¡im, at 26-28 weeks - 4.61±0 .18 ¡m, 4.68±0.19 ¡m in the period of 29-31 weeks, 5.0±0.23 ¡m in the period of 32-36 weeks. Children born with this disease, who lived and died at different times, had cerebral vessels and the mutual ratio of the perivascular space was 3.82 ± 0.12 microns in terms of 1-5 days, 3.8 ± 0.2 microns in terms of 6-10 days, 3.79±0.2 im in terms of 11-15 days, 16 - 20 days. In daily children, it was 3.86±0.2 Im, and in the period of 21-25 days - 3.92±0.19 ¡m, and in children who lived for 25 days or more, this figure was 3.94±0, 15 ¡m.
Keywords. Atelectasis, pneumopathy, cranial, morphological changes.
ПНЕВМОПАТИЯНИНГ АТЕЛЕКТАТИК ШАКЛИ БИЛАН ЭРТА ТУГИЛГАН ЧАЦАЛОЦЛАР БОШ МИЯ ТУЗИЛМАЛАРИДАГИ МОРФОЛОГИК УЗГАРИШЛАРНИНГ ТУГИЛГАН МУДДАТЛАРИГА
ХОС ЖИХДТЛАРИ
Жуманов Зиядулла, Амонова Гулафзал, Ортитов Бобомурод
Самарканд давлат тиббиёт университети
АННОТАЦИЯ
Пневмопатиянинг ателектатик шаклидан вафот этган янги тузилган чацалоцлар бош мия тузилмалари морфологик ва морфометрик текширилганда 22-25 уафталик муддатларда цон томир ва периваскуляр бушлицнинг узаро нисбати 4,28±0,18 мкм ни, 26-28 уафталик муддатларда эса 4,61±0,18 мкм ни, 29-31 уафталик даврида 4,68±0,19 мкм ни, 32-36 уафталик даврида 5,0±0,23 мкм эканлиги аницланган булса, ушбу касаллик билан тузилиб турли муддатларда яшаб вафот этган чацалоцлар бош миясидаги цон томир ва
Jumanov Ziyadulla, Amonova Gulafzal, Ortikov Bobomurod
Samarkand State Medical University
ABSTRACT
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SJIF 2023 = 6.131 / ASI Factor = 1.7
3(11), November, 2023
периваскуляр бушлицнинг узаро нисбати 1-5 кунлик муддатда 3,82±0,12 мкм ни, 6-10 кунлик даврда 3,8±0,2 мкм ни, 11-15 кунлик даврда 3,79±0,2 мкм ни, 16-20 кунлик чацалоцларда 3,86±0,2 мкм ни, 21-25 кунлик даврида эса 3,92±0,19 мкм ни ташкил этган булса, 25 кун ва ундан ортиц яшаган чацалоцларда бу курсаткич 3,94±0,15 мкм га тенг эканлиги аницланди.
Kalit so'zlar. Atelektaziya, pnevmopatiya, kranial, morfologik o'zgarishlar.
МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ СТРУКТУРЫ ГОЛОВНОГО МОЗГА НОВОРОЖДЕННЫХ, РОДИВШИХСЯ И УМЕРШИХ НА РАЗНЫХ СРОКАХ БЕРЕМЕННОСТИ ПРИ АТЕЛЕКТАТИЧЕСКОЙ
ФОРМЕ ПНЕВМОПАТИИ
Жуманов Зиядулла, Амонова Гулафзал, Орти^в Бобомурод
Самаркандский государственный медицинский университет
АННОТАЦИЯ
При морфологическом и морфометрическом исследовании структур головного мозга новорожденных, умерших от ателектатической формы пневмопатии, установлено, что соотношение сосудистого и периваскулярного пространств в 22-25 недель составило 4,28±0,18 мкм, в 26-28 недель -4,61±0,18 мкм, 4,68± 0,19 мкм в сроке 29-31 нед., 5,0±0,23 мкм в сроке 32-36 нед. У детей, родившихся с этим заболеванием, живших и умерших в разные сроки, были сосуды головного мозга и взаимное отношение периваскулярного пространства составило 3,82±0,12 мкм в сроки 1-5 суток, 3,8±0,2 мкм в сроки 6-10 суток, 3,79±0,2 мкм в сроки 11-15 суток, 16 - в 20-сутки. У суточных детей он составил 3,86±0,2 мкм, а в период 21-25 дней - 3,92±0,19 мкм, а у детей, проживших 25 дней и более, этот показатель составил 3,94±0,15 мкм.
Ключевые слова. Ателектаз, пневмопатия, краниальные, морфологические изменения.
Currently, the proportion of this disease in the total amount of newborns is 612%. In 25-80% of babies born without maturation in the early neonatal period, it is noted that respiratory disorders lead to a aggravation of their general condition and negative consequences [2, 3].
Among the morphological manifestations of pneumopathy in the territory of the CIS states, the presence of hyaline membranes has been found to be aspiration of amniotic fluid into the respiratory tract, diffuse atelectasis and massive blood
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SJIF 2023 = 6.131 / ASI Factor = 1.7
transfusions into lung tissue. In the literature, the respiratory disorder syndrome is classified into two types, with the first type including hyaline membranes. This type accounts for 50-70% of neonatal deaths in the United States due to unattainable births. The second type includes aspiration syndrome, diffuse atelectasis, and massive blood transfusions into lung tissue. Pneumopathy has been classified into nosological forms such as primary pulmonary atelectasis, hyaline membranes, massive blood transfusion into the lungs, and aspiration syndrome. These forms are defined as noninfective pathological processes in the lungs [1, 4].
The purpose of the study. the atelectatic form of pneumopathy consists in detecting morphological and morphometric changes in cranial structures in infant mortality.
Research material and methods. In the Department of pathological anatomy of the multidisciplinary clinic of Samarkand State Medical University, a study was carried out using macroscopic, microscopic, morphometric, microphotography and statistical research methods of the cranial structures of 281 infants (1st group of 138 newborns, 2nd group of 143 living and deceased infants) who underwent pathologoanatomic examination.
Discussion of the results obtained. The results of the study show that neonatal cranial structures that have died from the atelectatic form of pneumopathy have been shown by morphological and morphometric examinations to have a vascular -perivascular space interventional ratio of 4.28±0.18 ^m at 22-25 weeks, 4.61±0.18 ^m at 26-28 weeks, 4.68±0.19 ^m at 29-31 weeks, 5.0±0.23 ^m at 32-36 weeks we can see that he did [5,7] (listed in Table 1).
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22-25 weeks old 26-28 weeks old 29-31 weeks old 32-36 weeks old ■ Vascular structure blood vessel ■ Vascular structure PVC a Vascular structure blood vessel+PVC
Table l.The ratio of areas occupied by cranial blood vessels and PVC(%)
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SJIF 2023 = 6.131 / ASI Factor = 1.7
Analysis of changes in cranial structures in infants born and died at various times with the atelectatic form of pneumopathy shows that the ratio of vascular to perivascular space is 3.82±0.12 ^m in 1-5 days, 3.8±0.2 ^m in 6-10 days, 3.79±0.2 ^m in 11-15 days, 3.86±0.2 ^m in 16-20 days bats, and 3.92 ^m in 21-25 days while±0.19 ^m was found in infants who lived 25 days or more, the rate was found to be 3.94±0.15 ^m [5.6.8] (shown in Table 2).
Table 2
The ratio of vascular and PVC occupied areas in the vascular structure of the
brain (%)
Lived Vascular structure
duration Blood vessel PVC Blood vessel + PVC
1-5 days 2,39±0,1 1,43±0,11 3,82±0,12
6-10 days 2,42±0,1 1,38±0,1 3,8±0,2
11-15 days 2,46±0,1 1,33±0,1 3,79±0,2
16-20 days 2,59±0,1 1,27±0,1 3,86±0,2
21-25 days 2,78±0,11 1,14±0,08 3,92±0,19
From 25 days 2,88±0,09 1,06±0,06 3,94±0,15
CONCLUSION.
At different periods of pregnancy, the morphometric indicators of cranial cortex neurons of babies born and died with the atelectatic form of pneumopathy varied, morphologically, changes in the ischemic type and the glial reaction manifested more strongly in the late periods of childbirth. Ischemic changes were more common in neurons compared to blood vessels.
The atelectatic form of pneumopathy can use the perineuronal and perivascular cavity expansion ratio in the cranial hemisphere cortex and longitudinal brain as a criterion for assessing the birth rate of tanatogenesis at different times, as their dimensions increase in parallel. The dynamics of destructive disorders in the head and longitudinal brain neurons and blood vessels are additional criteria for assessing the length.
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SJIF 2023 = 6.131 / ASI Factor = 1.7
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