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ТaбиFи emмдеpдi зерттеу ¥лтты; гылыми оpтaлыFы, АКШ тa биологиялы; зеpтхaнa бaзaсындa журпзшдь
3AEBHETTEP TI3IMI
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2 Ganapaty S. et al. Rare prenylatedisoflavones from Tephrosiacalophylla // Natural product communications. - 2014. - V. 9., №7. - C. 937940.
3 Tanaka H. et al.Three New Constituents from the Roots of Erythrinavariegata and Their Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus / / Chemistry & biodiversity. - 2011. - V. 8.,№3. - P. 476-482.
4 Krishnaveni M. Medicinal Plants-A Boon for HIV/AIDS // Journal of Pharmacy Research. - 2012. - Vol.3., №5. - P. 58-69.
С.Е. Момбеков1'2, У.М. Датхаев2 Е.К. Оразбеков1'2
1Национальный центр по исследованию натуральных продуктов, Университет Миссисиппи, Оксфорд, США 2Казахский национальный медицинский университет С.Д. Асфендиярова, Алматы, Казахстан
АНТИБАКТЕРИАЛЬНЫЕ СВОЙСТВА КОМПОНЕНТА ОРОБОЛВЫДЕЛЕННЫЙ ИЗ ПЛОДОВ МАСШНААиНАЭТ1АСА
ПРОИЗРСТАЮЩИЙ В КАЗАХСТАНЕ
Резюме: Были изучены биологические активности экстрактов полученные из плодов Мас1ига аигапйаса (Ъ.) произрастающий в Казахстане, с целью повышения биологической активности экстракт был разделен на фракции. Этилацетатная фракция метанольного экстракта методом вакумно-жидкостной хроматографии разделили на несколько субфракции, через колончатую хроматографию выделили один из основных действующих компонентов Оробол с антибактериальным эффектом. Выделенный намиОробол был изучен фармакологический, на вторичном эксперименте значение антибактериального эффекта показало с1С5означением 4,68мкг/мл.
Ключевые слова: Оробол, Мас!ига аигапйаса, ВЭЖХ, ЯМР
S.E. Mombekov12, U.M. Datkhayev2, Y.K. Orazbekov12
1National Center for Natural Products Research, School of Pharmacy, The University of Mississippi,
University, MS 38677, USA 2Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
ANTIBACTERIAL PROPERTIES OF THE COMPONENT OROBALL ISOLATED FROM THE FRUITS OF MACLURAAURANTIACA GROWING IN KAZAKHSTAN
Resume: Biological activity of extracts obtained from Macluraaurantiaca (L.) fruits grown in Kazakhstan was studied, with the purpose of increasing biological activity, the extract was divided into fractions. The ethyl acetate fraction of the methanol extract was separated by several sub-fractions using a liquid-liquid chromatography method, one of the main active ingredients Orobol with antibacterial effect was isolated through column chromatography. The Oroball isolated by us was studied pharmacologically, in a secondary experiment the value of antibacterial effect showed cIC50 to be 4.68 |ig / ml. Keywords: Orobol, Macluraaurantiaca, HPLC, NMR
THE MAIN APPROACHES TO IMPLEMENTATION OF PHARMACEUTICAL TRACK AND TRACE SYSTEM OF MEDICAL PRODUCTS IN THE
REPUBLIC OF KAZAKHSTAN
U.M. Datkhayev, K.S. Zhakipbekov, E.A. Serikbayeva, D.B. Dadanbekova, M.A. Berdibekov
Department of organization and management and economics of pharmacy and clinical pharmacy
In recent yearsone of the main problem of the global pharmaceutical market is the falsification of medicines. The variety of assortment of medicinal preparations and implementation of the pharmaceutical via the Internet pharmacies are kind of the beginning of this problem.The best way to combat counterfeiting of falsification is a pharmaceutical track and trace system. In this article, we reviewed the main approaches to implementation of pharmaceutical track and trace system of medical products in the Republic of Kazakhstan, its advantages and relevance. During the study we used review of literature. Moreover, we have identified the relevance of the subject for further research .Taking everything into account, we realized that the pharmaceutical track and trace system aimed at protecting the health of the people of the Republic of Kazakhstan from counterfeit medicines, moreover we will be able to provide the population with safe, quality and original products. Keywords:pharmaceutical track and trace system, counterfeiting and original products, Republic of Kazakhstan, the state program, european medicines verification system.
УДК 615.15:614.23/.014.47(574)
Introduction. According to experts, nowadays falsification of the pharmaceutical production takes 12% of the general pharmaceutical drug population. Just so you know, falsification is going to be dangerous not only for life and health, also for financial situation of people. All counterfeiting pharmaceutical products which will go to the pharmacy, hospital and other medical institutions are able to harm public health. Due to this reason, we need a special system which would track medical products from the manufacturer to the consumer in pharmacy. Many countries are thinking about a system that would not only monitor the logistics supply chain of products, but also the originality, the safety of the drug for use. In addition, this type of system for track-and-trace medical products is one of the best ways of struggle against the shadow market, which is already full with counterfeiting drugs [1].
The relevance of the study. Currently, one of the main problems of the pharmaceutical worldis the falsification. Now we are able to find counterfeiting medicines not only at shadow market, also we could find out them at ordinary pharmaceutical market. The most important outcome of this problem its damage for patient's life, moreover it can be the main cause of death. Start from this problem, many world associations of medical products start to offer a special medical system of pharmaceutical market. First steps or initiatives we are about to see in policy of World Health Organization's program, which is called "Health -2020".The first country which is impelemnted the system was our neighborhood country Turkey. In addition, the United States of America and Europe are going to enter this pharmaceutical track andtrace system in 2023 and 2019 [2].
The best way to start the tracking of medical products is by serialization. With the help of serialization of pharmaceuticals, we can provide the population of Kazakhstan with qualitative and safe medical products.It is also worth mentioning that the system not only certifies the originality of the drug, but it wouldn't affect its price.As a result, in the Republic of Kazakhstan domestic and foreign products market will be protected from falsification, and will be delivered to the final consumer in its original form. Therefore, after the introduction of this system in the Republic of Kazakhstan, we will provide the population with affordable, safe, quality medical products.
Currently, in our country this system is one of the measures for the implementation of the state program of the Ministry of health for 2016 - 2019 years "Densaulyk"[3].The system for tracking medical products is not only pharmaceutical control which keeps watch over the health of people, but also a complex of measures to combat the smuggling of drugs, illegal selling of drugs, to
prevent fraud with a bar code,and help for rational using of medicines.
All participants of the pharmaceutical market will get benefit from the implementation of the system.In this case, the state will receive the latest information about using drugs,and they will use this information to prepare the budget plan in years to come. Moreover, the received information about side effects and information about the monitoring of drug safety will be further used for the monitoring of prices of medical products. Besides, with the new system people are able to get full information the expiry date of the medication, side effects, information about the manufacturer (in which factory, in which country was released this drug), if a series of the drug had some problems on what basis this drug were admitted to the pharmacy or to the clinic.Hence, domestic producers can increase the volume of their productions, and health organizations can plan their necessary needs. As a result, the population will have high-quality, safe, authentic products.
The aim of the study.To study the main approaches to implementation of pharmaceutical track and trace system of medical products in the Republic of Kazakhstan. Research methods. During the study were used systematic, comparative and other methods of analysis. Informational materials which is used in the study is data published in print, as well as the materials specialized periodicals. The study materials. The first country which successfully implemented the system in full is our neighboring country Turkey.In the period 2010-2012, the system was fully implemented in the country.At the moment, Europe is planning to organize a system on two levels. The first level is a National database that will have every country in Europe. The second one is going to consist of the information that will be sendform the National database to European and all of them will create anEuropean database.So it's going to be National Verification Medicines System and European Verification Medicines System. In Europe, pharmaceutical track and trace system of medical products will be implemented fully in 2019.In the United States of America the part connected with legalization of the system is much heavier than in Europe. In America there are 50 different States, the laws of each one can be different from another one and different in general. That is what is legal in one State is not legal in another State.American pharmaceutical community in the process of implementing pharmaceutical track and trace system of medical products in the period 2013-2023.The first who introduced the law about the system was the former President of the United States Barack Obama[4,5]. (Figure 1).
Pharmacy
Figure 1 - European medicines verification system (EMVS)
The main principle of the system is encoded in the barcode.The name of marking is Data Matrix, it contains a special unique, randomized serial number. The code contains information about the shelf life, side effects and data about the manufacturer. Every
drug is required to be serialized. The main advantage isif there will be problems with the series, it willaccompanied with information on the basis of which the preparation of this series were admitted to the pharmacy or medical facility. (Figure 2).
Figure 2 - Life cycle of pharmaceutical track-and-trace system
Just so you know, in our country this system is one of the measures for the implementation of the state program of the Ministry of health for 2016 - 2019 years "Densaulyk". The government is going to introduce the program in several stages.The first phase was prepared the concept of the system and the information side of system. In a second step, in 2017 in the framework of the purchase of medicines Single Distributor will track and trace medical products.. In 2018 GVFMC (the guaranteed volume of free medical care) included in the controlled drugs and medical products on the pharmaceutical market of the Republic of Kazakhstan. On the conclusion step in 2019, everything will be tracked and traced in pharmaceutical market of the RK.
System in the Republic of Kazakhstan is being implemented by the organization of LLP (Limited Liability Partnership)"SK-pharmacy".A Memorandum about the system has been signed between LLP "SK-pharmacy" and the Agency of medicines and medical products of Turkey. According to international experts pharmaceutical track-and-trace system of Turkey which is known as ITS is the best one [7].
Additionally, the system isn't capable of protecting the health of the population and their finances, but it will help keeps the brand name of pharmaceutical companies. As the company whose
products were implicated in the falsification, can loses its credibility of consumers. Now the use of drugs for the pharmaceutical company, as it is for drug the public about fake slippery. There are two pharmaceutical companies involved in the pilot project of introduction track and tracesystem of medical products in the Republic of Kazakhstan. They are: JSC "Nobel Almaty pharmaceutical factory" and "Abdi Ibrahim global farm" [8].
Currently, these famous companies like Siemens and Bosch are producing special equipment for pharmaceutical companies that can apply a Data Matrix barcode on medicines. Conclusion.Taking everything into account, implement pharmaceutical track and trace system of medical products in the Republic of Kazakhstan will bring several advantages. First of all, we will develop together with the global pharmaceutical market, keeping up with the study and implementation of new technologies. Secondly, all products of domestic and foreign manufacturer in the pharmaceutical market of our country are about to be original.Thirdly, we will ensure the people of Kazakhstan with safe, high quality, original products that will not require additional financial costs. Last but not least, is the fact that the system will help in the fight against fraud counterfeiting of medical products.
REFERENCES
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3 Казахстан Республикасыныц денсаульщ сак;тау саласын дамытудыц 2016-2019 жылдарга арналган «Денсаулык» мемлекеттш багдарламасы. Астана. - 2015
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У.М. Датхаев, К.С. Жакипбеков, Э.А. Серикбаева, Д.Б. Даданбекова, М.А. Берд1беков
Фармацияны уйымдастыру жэне басцару жэне экономикасы жэне клиникалыц фармация кафедрасы
КАЗАХСТАН РЕСПУБЛИКАСЫНДА МЕДИЦИНАЛЬЩ 0НШДЕРД1 КАДАFАЛАУ ЖУЙЕСШ ЕНПЗУДЩ НЕГ1ЗГ1 ТЭС1ЛДЕМЕЛЕР1
ТYЙiн: Дуниежузшш фармацевтикалы; нарыщтагы соцгы жылдардагы негiзгi мэселелердiц бiрi бул дэрШк заттардыц фальсификациясы болып табылады. Фармацевтикалы; 0нiмдердiц ассортиментiнiц кец болуы, галамтор желiсiндегi дэрiханалар ар;ылы дэрiлiк заттардыц босатылуы, осы мэселенiц бастамасына алып келедi. Фальсификациямен куресу амалдарыныц бiрi болып медициналы; 0нiмдердi ;адагалау жуйей болды. Осы ма;алада Казахстан Республикасында медициналы; 0нiмдердi ;адагалау ЖYЙесiн енпзудщ негiзгi тэсiлдемелерi, оныц арты;шылык;тары мен езектШп K0рсеiлген. Зерттеу барысында эдебиет K0здерiне шолулы; талдау жасалынды.Так;ырыптыц 0зектШпн аныщтап, келекшекте зерттеуге тура келетшше к0з жеткiздiк. Нэтижесiнде медициналы; 0шмдерд ;адагалау ЖYЙесiнiц Казахстан Республикасыныц азаматтарыныц денсаулык;тарын жалган дэрiлiк 0нiмдерден ;оргауга багытталганына K0зiмiздi жеткiздiк, ягни ж\гоенщ ар;асында ;аушйз, сапалы, TYПнуск;алы медициналы; 0нiмдермен халы;ты ;амтамасыз ете аламыз.
ТYЙiндi свздер: Медициналы; 0нiмдердi ;адагалау ЖYЙесi, фальсификация, TYПнуск;алы препараттар, Казахстан Республикасы, мемлекеттiк багдарлама,европалы; тексеру ЖYЙесi.
У.М. Датхаев, К.С. Жакипбеков, Э.А. Серикбаева, Д.Б. Даданбекова, М.А. Берд1беков
Кафедра организации,управления и экономики фармации и клинической фармации
ОСНОВНЫЕ ПОДХОДЫ К ВНЕДРЕНИЮ СИСТЕМЫ ОТСЛЕЖИВАНИЯ МЕДИЦИНСКОЙ ПРОДУКЦИИ В РЕСПУБЛИКЕ КАЗАХСТАН
Резюме: В последние годы в мировом фармацевтическом рынке одной главных проблем является фальсификация лекарственных средств. Многообразие ассортимента лекарственных препаратов, а так же реализация лекарственых средств через интернет аптеки являются своего рода началом фальсификации. Одним из методом борьбы с фальсификацией лекарственных средств является система отслеживания медицинскоЙ продукции. В данноЙ статье нами рассмотрены основные подходы к внедрению системы отслеживания медицинской продукции в Республике Казахстан, ее преимущества и актуальность. При проведении исследования нами использован обзорный анализ литературных источников. Так же нами была выявлена актуальность данной темы для дальнейшего исследования. В итоге мы пришли к заключению, что система отслеживания медицинской продукции направлена на защиту здоровья народа Республики Казахстан от фальсифицированных лекарственных средств, то есть что с помощью системы мы сможем обеспечить население безопасной, качественней и оригинальной продукцией.
Ключевые слова: Система отслеживания медицинской продукции, фальсификация, оригинальные препараты, Республика Казахстан, государственная программа, европейская система проверки.
