CC BY
479th multidisciplinary international
Conference of Biological Psychiatry
«Stress and Behavior»
Proceedings of the 9th International Multidisciplinary Conference «Stress and behavior» Saint-Petersburg, Russia, 16-19 May 2005 Editor: Allan V. Kalueff, PhD
CONFERENCE ABSTRACTS 1. PSYCHOPHARMACOLOGY
THE BLOCKADE OF AMYGDALOID CORTICOLIBERIN RECEPTORS BY ASTESSIN DIMINISHES THE REINFORCING EFFECTS OF AMPHETAMINE, MORPHINE AND LEU-ENKEPHALINE BUT NOT ETHAMINAL-NATRIUM ON SELF-STIMULATION IN RATS
P.D. Shabanov, A.A. Lebedev, E.E. Voevodin, V.F. Streltsov
Department of Pharmacology, Military Medical Academy, St. Petersburg, Russia
Amphetamine (1 mg/kg), morphine (1 mg/kg) and ethaminal-natrium (5 mg/kg) activated, but astressin (1 pg/pl), a nonselective antagonist of corticoliberin receptors, administered intraamygdaloidally, depressed self-stimulation reaction of lateral hypothalamus in rats. The blockade of extrahypothalamic (in the central nucleus of amygdala) corticoliberin receptors by means of astressin changed the effects of different narcogens on self-stimulation reaction. On that background, amphetamine did not activate self-stimulation, ethaminal-natrium supported the significant psychoactivative effect, but morphine changed its stimulating effect on depressant one. Leu-enkephaline possessed the stable depresssant effect, strengthening the action of astressin. Perhaps, the strengthening of depressant action of leu-enkephaline on self-stimulation by means of astressin is associated with temporary excluding of activative influence of the central nucleus of amygdala on hypothalamus. Supported by RFBR grant № 04-04-49672.
Psychopharmacol. Biol. Narcol. 2005. Vol. 5, N 2. P. 890-891
Psyhopharmacology & biological narcology
ISSN 1606-8181
