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9Suhuang Zhike capsule combined with Montelukast, sodium treat 30 cases clinical observation of children cough variant asthma
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WangYoupeng LiYe
1.Chinese medicine graduate student in grade 2010,which belongs to Graduate student college of Heilongjianguniversity of Chinese medicine ;2. The second hospital belongs to Heilongjianguniversity of Chinese medicine ,Harbin city, Heilongjiangprovince of China.
Abstract: Objective To observe the therapeutic effect of Suhuang Zhike Capsule [capsule of Zisuye(Folium Perillae) and Mahuang(Herba Ephedrae) for cough] for children's cough variant asthma. Methods 62 children(6-14 years old) wth CVA were randomized into trearment group and control group with 31cases in each. The treatment group was given Montelukast Sodium tablet and Suhuang Zhike Capsule complete ,and 30 cases were completed. The control group was given Montelukast Sodium tablet and starch capsule.The treatment course lasted for 14 days.The total effective rates and the relief rates of single symptom ,such as cough, pharyngeal itching, rapid breathing and expectoration were observed in both groups after the treatment. Results The total effect rate of the treatment group and the control group was 90% and 64.52% respectively. The differences between groups were statistically significant (P<0.05).The relief rates of single symptom in the treatment group were superior to those in the control group (P<0.05). Conclusion Suhuang zhike capsule is effective for children's CVA and could be spplied as a clinical medicine,
key words: Suhuang Zhike capsule; Children's cough variant asthma; Clinical observation
Cough variant asthma (CVA)[1] is a special type of asthma, cough is the only or the main clinical manifestations, no obvious wheezing and shortness of breath, but there is hyperresponsiveness(BHR) . The treatment of Suhuang Zhike capsule has great effect on adult cough variant asthma ,which great effect is related to reducing BHR and improveing bronchial sensitive state [2]' Till now, there is no objective basis provided for treating children CVA ,therefore, this study is intended to observe clinical curative effect of Suhuang Zhike capsules treating children CVA .
1. Materials and methods
1.1 Diagnostic criteria
1.1.1 Modern medicine[3]: (1). Coughing lasts at least 4 weeks and seriously in the early morning or at night, mainly performs a dry cough; (2) There is no signs of infection or antibiotic treatment is invalid for a long time; (3.) Anti-asthmatic drugs are effective on Diagnostic treatment ; (4) Ruling out other causes of chronic cough; (5) Bronchial provocation test is positive and (or) the daily variation rate of PEF (continuous monitoring for 1 ~ 2 weeks)is more then 20% or higher;( 6.) Individual or level1 or 2 relatives atopic have disease history, or allergen test positive.
Item 1 ~ 4 are basic conditions for diagnosis.
1.1.2 TCM diagnostic criteria: Refer to asthma diagnostic criteria in Pediatrics of traditional Chinese medicine[4] as rhe asthma diagnostic of Children CVA : cough,sputum less or no phlegm and hard to cough up, which apparently at night or in the morning.
1.2 Includion and Exclusion criteria
1.2.1 Includion criteria: (1)Accord with the modern medicine and TCM diagnostic criteria of children CVA ;(2)Ages between 6 and 14 years old;(3)Parents or other statutory guardians agree.
1.2.2 Exclusion criteria: (1)Fever, pharyngitis; (2) Chronic obstructive pulmonary disease, lung cancer, tuberculosis etc.; (3) High blood pressure, heart disease and and some serious primary diseases; (4) Having taked some other drugs for research or taked some relevant Chinese medicine for treating ; (5)The allergies to this known Composition of TCM.
1.2.3 Cases of lossor and excluding standard: Haveing quited or did not complete the whole treatment who is affect the efficacy or safety decision as a loss. Included cases did not meet the inclusion criteria or failured to follow the drug testing scheme should be excluded.
1.3 General information: All the 62 Cases comed from Pediatric clinics,which is belongs to the second hospital of Heilongjiang University of Chinese medicine ,Feb 2011 to Jul 2011.62 cases were devided into two groups,each 31cases.31 cases in the treatment group were adopted with foundation treatment and cooperate with Suhuang zhike capsule , and 30 cases completed. 31 cases in the control group were adopted with foundation treatment and cooperate with starch capsule ,and 31 cases completed. The treatment course lasted for 14 days. There were 18 boys and 12 girls whose average age was (9.63±2.16) years old and the average course of the disease was (2.13±0.82) months in the treatment group,and 16 boys and 15 girls whose average age was (11.20±3,77) years old and the average courses of the disease was (2.19±0.79) months in the control group.
2. Methods
2.1 Treatmen
Foundation treatment:Given Montelukast Sodium tablet (Trade name: Singulair, Hangzhou MSD pharmaceutical co., LTD., approved by J20070070. 5 mg each). 5 mg/t/d.
Treatment group:the foundation treatment combined with Suhuang Zhike Capcule [ The Yangtze river pharmaceutical group, Beijing Haiyan pharmaceutical co.,LTD.,approved by Z20103075.Composition: Ephedra, Perilla frutescens)(L and S), Eriobotrya japonica, Pheretima aspergillum, Cryptotympana pustulata Fabricius, Peucedanum praeruptorum Dunn, Schisandra chinensis(Turcz) Baill, Arctium lappa L. 0.45 g each, equivalent to 4.44 g of herbs.] Take method: 6 -9 years old, 2 pills each time and 3 times a day,9 -14 years old, 3 pills each time, and 3 times a day.
Control group:the foundation treatment combined with starch capsule (The second hospital pharmaceutical factory in HeilongjiangUniversity of traditional Chinese medicine provided experiment preparations. Main composition: starch. 0.45 g each.)
Two groups both lasted for 14 days. Ban to take other cough medicine during the treatment.
2.2 Observation indexes and methods
2.2.1 Safety testing: including general physical examination and adverse reactions during the period of treatment , blood routine, urine routine, stool routine, liver(ALT), kidney (Cr, BUN).
2.2.2 Efficacy indicators: make a record related signs and symptoms before and after treatment , including cough, throat itching, wheeze, cough up phlegm.
2.3 Curative effect judgement standard
CVA curative effect judgment standard [6]: Clinical cure: completely relieve cough symptoms, primary symptom score of 0; Obvious effective : primary symptom score degraded two levels at the same time; Effective: primary symptom score degraded one level at the same time, or a primary symptom degraded two levels, a primary symptom degraded one level; Invalid: cough relief was not obvious or cough more seriously.
2.4 Statistical methods
Using SPSS16.0 statistical software for statistical analysis. Measurement data using t test; Count data useing x test and Fisher test.
3.Results
3.1 The two groups' comparison of cough curative effect
The total effective rate of the treatment group and the control group was 90% and 64.52% respectively. The differences between groups were sataistically significant (P<0.05).The relief rates of single symptom in the treatment group were superior to those in the control group (P<0.05).
3.2 The curative effect comparison of single TCM symptoms
The rates of single TCM of two groups were back to normal as table 1,showed that the treatment group were better then the control group(P<0.05).
Table 1 The rates of single TCM symptoms were back to normal after treatment
Group Cases Cough Throat itching Rapid breathing Expectoration
Treatment 30 53.33(16/30) 37.04(10/27) 78.26(18/23) 70.83(17/24)
Control 31 22.58(7/31) 19.23(5/26) 52.38(11/21) 53.85(14/26)
3.3 Safety analysis
General physical examination showed that the blood routine, stool routine, urine routine, liver and kidney were all normal in these two groups. 4.Discussion
CVA is a special type of asthma.Children with CVA who was not controled well would become CA. Children with CVA should be treated earlier which could reduce the burden of family and improved the quality of patients' life.
The treatment principle of CVA was the same with asthma [5]which was taking ICS or Montelukast Sodium tablet.Both of these had a quick effect ,but a rapid recurrence after stopped taking or dose reduction.The TCM treatment principle was to keep the balance of Yin and Yang.TCM could reduce the symptoms gradually, shorten the timing, reduce the number of disease recurrence and drug dependen,the prognosis is also good.
In this study, the results showed that Suhuang Zhike capsule had a good effect on treating children CVA, which was convenient for children to take and compliance was good,could be spplied as a clinical medicine.
References
[1]The respiratory disease branch of Chinese medical association of asthma group. The diagnosis and treatment of coughing guide[J]. Chinese tuberculosis and respiratory journal, 2009, 32 (6) : 409.
[2] ZhangYanping, MiaoQing, ChaoYan, etc. The randomized controlled multicenter clinical study of Suhuang Zhike capsule treated cough variant asthma[J].Journal of traditional Chinese medicine, 2008,49 (6) : 504 ~ 506.
[3]The branch of academy of pediatrics and Chinese medical association respiratory group "the Chinese journal of pediatrics editorial board". Diagnosis standard of children asthma[J]. Chinese journal of pediatrics, 2008 46-48 (10) : 746.
[4] Xu Rongqian, Wang Junhong, Wang Sumei, etc. Journal of pediatrics of traditional Chinese medicine [M]. Beijing: Chinese press of traditional Chinese medicine, 2010:93 ~ 95.
[5] The cooperation of Chinese pediatric asthma . Routine diagnostic criteria and treatment of children asthma [J]. Chinese journal of pediatrics, 1993, 31 (4) : 222.
Clinical observation on 60 cases of fasciitis of back muscles with the electroacupuncture by the point-through-point of back method
WANG Chun-xia, WANG Dong-Yan, FENG Li-Yuan, WU Di
Second Affiliated Hospital of HeilongjiangUniversity of Traditional Chinese Medicine, Harbin, China
[Abstract] Objective:To observe therapeutic effect of fasciitis of back muscles with the electroacupuncture by the point-through-point of back method in the treatment. Methods: 60 cases of fasciitis of back muscles were randomly divided into two groups.The treatment group were treated with the electroacupuncture by the point-through-point of back method and the control group were treated with simple acupuncture. After treatment of 30 days, the therapeutic effect was assessed with visual analogue scales(VAS). Results The total effective rate was 96.7% in the treatment group and 76.7% in the control group. The treatment group in improvement pain was better than the control group and with scores significantly decreased (P<0.01). Conclusion the
