CC BY
4DOI 10.24412/CL-37135-2023-1-37-37
STUDY OF OSMOTIC AND CROSS-LINKING DEFORMATIONS IN BIOLOGICAL TISSUES BY OPTICAL COHERENCE ELASTOGRAPHY
YULIA ALEXANDROVSKAYA1, EKATERINA KASIANENKO2, OLGA BAUM2, ALEXANDER SOVETSKY1, ALEXANDER MATVEEV1, TATIANA SHMIGOL3, PAVEL KARAVAIKIN3,4, VADIM NEGREBETSKY3, VLADIMIR ZAITSEV1
1A.V. Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences, Russia
2 a
Institute of Photon Technologies, Federal Scientific Research Center "Crystallography and Photonics", Russian Academy of Sciences,, Russia N.I. Pirogov National Research Medical University, Ministry of Health of Russia,Russia 4Central Clinical Hospital with Polyclinic, Russia
ABSTRACT
New insights into the diffusion-associated deformations of biological tissues studied by optical coherent elastography (OCE) are discussed in this study. Possible applications of the strain analysis to the diagnostics of early degradation of biological tissues, such as gradual proteoglycan depletion in cartilage, are proposed. It is shown that using the emerging OCE technique enabling quantitative visualization of spatially-resolved strain dynamics [1,2] the osmotically-induced deformations can be distinguished from the ones caused by the formation of collagen cross-links. Various chemical agents, such as organic alcohols, omnipaque, inorganic salts and glutaraldehyde, are considered in terms of their activity in inducing osmotic and cross-linking deformations in tissues and polyacrylamide gels (tissue phantoms) [3].
ACKNOWLEDGEMENTS
The study was supported by the Russian Science Foundation grant No. 22-12-00295
REFERENCES
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[2] Yu. Alexandrovskaya, O. Baum, V. Zaitsev, A. Sovetsky, A. Matveyev, L. Matveev, K. Larin, E. Sobol, V. Tuchin, Optical and mechanical properties of the cartilage during optical clearing, In book Tissue optical clearing: new prospects in optical imaging, CRC Press (Dan Zhu, Elina Genina, and Valery Tuchin Eds.), 2021, Boca Raton, Florida, United States.
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