CC BY
14
КЛИНИЧЕСКАЯ МЕДИЦИНА
© КОЛЛЕКТИВ АВТОРОВ, 2016 УДК 616.5-006-07
G. A. Gyurka, S. Costinas, B. Costinas
STRUCTURAL COMPARATIVE ISSUES BETWEEN NORMAL SKIN AND SURROUNDING SKIN FROM REMOVED MELANOCYTIC NEVI
Faculty of Medicine of Transilvania University of Bra§ov (Romania)
Environmental factors play an important role in preserving the integrity of the skin. The changes can occur to components and ultrastructure of the skin due to genetic factors, predisposing environmental factors, and favored by the emergence of skin pathology. In this context, the present study refers to the normal structural appearance of the skin and presents comparative, characteristic appearances of melanocytic nevi. Such reviews are important since the pathology of melanocytic nevi is occurring at an increased frequency.
Keywords: skin, melanocytic nevi, structure
The skin, as an organ, acts as the barrier between the external environment and the body [8, 10]. Various risk factors from the environment can produce, in certain circumstances, changes in skin structure and are associated with various skin diseases. In the context of environmental risk factors impacting upon the structure of the skin, these include pollutants, temperature changes, climatic variations, hormonal factors and, not least, exposure to ultraviolet radiation without adequate protection [11, 15].
Given these risk factors, there are numerous external forces that can cause skin changes [7]. As well as associated pathologies, there are numerous studies that show how biomolecular mechanisms and pathophysiology are connected to changes to the skin, giving rise to dermatologi-cal disorders [3, 14]. For these reasons, this study looks at, in addition to polluting factors, eating. This is a factor that can affect the functionality of organs, although the effect is generally viewed as tegumental [3, 5]. Similarly, changes that occur in the skin layers, producing alterations in niveliul down to six layers, cause changes to subcomponents and ultrastructural type [1, 2]. The changes occur in the dermis and epidermis are linked to alternations to subcomponents.
The study outlined in this paper is useful for examining skin pathology idea, particularly with the medical examination of children. Children are the most commonly affected segment of the population. After this age group, as children become older, this condition is often followed by a degree of disability in relation to impaired tegumentuilui. Older people have a high vulnerability to disease. Among the different dermatological disorders that affect the skin, melanocytic nevi are considered the most common pathology [14]. In context, melanocytic nevi can be found at an early age, those from childhood to old age [9, 13].
The frequency spread of melanocytic nevi in the body segments is strictly interdependent
with individual phenotype, with predisposing genetic factors and exposure to harmful factors directed towards the skin, such as exposure to ultraviolet radiation, are deemed to have a minor role [5]. From this perspective, what appear as benign melanocytic nevi may degenerate and become malignant [15]. Such changes to the skin can be demonstrated successfully on experimental animal models [6].
MATERIAL AND METHODS
This study demonstrates the structural aspects of normal skin together with nevi aspects of skin pigmentation. Being a structural study, data is presented in comparison with normal skin images and images with different skin structures with melanocytic nevi. The image analysis was performed on permanent microscopic preparations carried out in different laboratories. Observations were performed using a Nikon microscope with magnifying lenses of different powers: x 20 for overview and x40 for structural details.
RESULTS AND DISCUSSION
Outlined in this section are the structural aspects of the normal epidermis. Figure 1 shows the layered tissue type malpighian with keratini-zation and its subjacent area, represented by connective tissue (fig. 1).
The purpose of the study is to present comparative structural issues related to the normal epidermis and melanocytic nevi. To show this, selected segments of the body were chosen, where melanocytic nevi occur adjacent to hair. In addition to the typical appearance of melanocytic nevi in the dome around the hair follicles, there are sebaceous glands and sweat glands additionally associated with hair.
Next picture captures the sebaceous gland. The embodiment shown is similar in melanocytic nevi in areas of glandular epithelium and in which are present the histological structures. In the context of the above image, figure 2 shows the sebaceous gland type alvelolar adjacent pilot folli-
Figure 1 - H&E Staining x20
Figure 2 - H&E Staining x20
Figure 3 - H&E Staining x20
Figure 4 - H&E Staining x40
Figure 5 - H&E Staining x40
Figure 6 - H&E Staining x40
cles, present both in normal cases and in areas where they were excised melanocytic nevi adjacent hair (fig. 2).
Figure 3 displays sweat glands, sebaceous glands present in the vicinity and which are found both in normal cases and in areas where the skin of melanocytic nevi were removed (fig. 3).
Since the parts were excised for examination of skin areas, the next image shows subcutaneous fat (fig. 4).
The next picture represents a small part of a microscopic field from microscopic preparations taken after the excision of a melanocytic nevus. Observe the hair and its adjacent portion of the sebaceous gland (fig. 5).
The following picture shows the appearance of sweat glands taken by a microscopic preparation. Here where a close-up is shown of a melanocytic nevus (fig. 6).
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CONCLUSIONS
Given the many risk factors, as presented in the introduction of this material, and the resultant changes in level of skin to skin diseases with both benign and malignant potential, this study provides useful information for those tasked with undertaking medical examinations. Those interested in this scientific field can examine the pictures to visualize the normal structural melanocytic nevi and to add to the body of knowledge in relation to dermatological pathology.
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Received 20.01.16.
Г. A. Гюрка, С. Костинас, Б. Костинас
СТРУКТУРНЫЙ СРАВНИТЕЛЬНЫЙ АНАЛИЗ ЗДОРОВОЙ КОЖИ И КОЖИ, ОКРУЖАЮЩЕЙ УЧАСТОК УДАЛЕННОГО МЕЛАНОЦИТАРНОГО НЕВУСА
Факультет медицины университета Трансильвании Брашов (Румыния)
Экологические факторы играют важную роль в сохранении целостности кожных покровов. Изменения могут произойти в компонентах и ультраструктуре кожи из-за генетических факторов, а также факторов окружающей среды, и могут обусловить возникновение патологии кожи. В этом контексте в настоящем исследовании изучен структурный вид здоровой кожи в сравнении с характеристиками меланоцитарного невуса. Такие исследования имеют важное значение, так как в настоящее время регистрируется увеличение уровня заболеваемости меланоцитарным невусом.
Ключевые слова: кожа, меланоцитарный невус, структура
Г. A. Гюрка, С. Костинас, Б. Костинас
САУ ТЕР1 МЕН АЛЫСТАТЫЛFАН МЕЛАНОЦИТАРЛЫ НЕВУСТЫЩ БЭЛ1П KОРШАFАН ТЕР1НЩ К^РЫЛЫМДЬЩ САЛЫСТЫРМАЛЫ ТАЛДАУЫ
Трансильвания Брашов (Румыния) университеты.ц медицина факультет
Экологиялык факторлар тер1 кабаттарыныц тутасты^ын сактауда мацызды роль аткарады. Генетикалык факторлардыц, коршаFан орта факторларыныц эсер1нен тер1 компоненттер1 мен ультракурылымында езгер1стер орын алуы мYмкiн жэне салдарынан тер1 патологиясы орын алуы ыктимал. Бул туррыда осы зерттеуде сау тер1н1ц меланоцитарлы невустыц сипаттамасымен салыстырудаFы курылымдык тур1 зерделендк Мундай зерттеулердщ мацызы зор, себеб1 каз1рп уакытта меланоцитарлы невуспен ауыру децгей1н1к артуы т1ркелуде. Клт сездер: тер1, меланоцитарлы невус, курылым
