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the children (14%) demonstrated a moderate severity of chronic catarrhal gingivitis.
Conclusion. Clinical observations during the period of the study detected a positive dynamics in the treatment of patients in the 1st and 2nd groups. Gingival condition in children of both groups improved which is evidenced by the data of index evaluation.
The toothpaste with a sorption action Dentalen and oral rinse Dentalen strong containing nanosorbent demonstrate better properties, although the means of the trade mark PRESIDENT (toothpaste PresiDent Exclusive and rinse PresiDent Profi) possess better antibacterial and anti-inflammatory action.
References.
1. Grudianov A.I. Periodontal diseases. - M., Mia, 2009.
2. Kuriakina N.V. Periodontal diseases // Moscow - Medical book. - N.Nowgorod. - 2007. - p.292.
3. Kuznetsov E.V. Microbial flora of the oral cavity and its role in the development of pathological processes / E.V. Kuznetsov, V.N. Tsarev // Therapeutic dentistry: Educational manual. - M.: Medpress-inform. - 2003. - P.178-212
4. Zorina O.A. Microbiocenosis of the oral cavity within the norm and in case of inflammatory perio-dontal diseases / O.A. Zorina, A.A. Kulakov, A.I. Grudianov // Stomatology, 2011,1. - p. 73-78.
5. Therapeutic stomatology // Textbook: in 3 parts, edited by G.M. Barer. - Moscow. - GEOTAR -Media. - 2008. - P.2. - Periodontal diseases. - 224 p.
6. Mashchenko I.S. Inflammatory and dystrophic periodontal diseases: educational text book. - Dnepropetrovsk: ART-PRES, 2003. - 244 p.
Kitsak T.C.
assatant of the Children's Dental Surgery department, Higher State Educational Establishment of Ukraine
«Bukovinian State Medical University» Кцак Тетяна Степатвна асистент кафедри хiрyргiчноï та дитячо'1' стоматологИ' ВДНЗД "Буковинський державний медичний yHiверситет "
STATE OF DENTAL MORBIDITY RATEAMONG PASSENGER CAR ATTENDANTS OF CHERNIVTSI RAILROAD CENTRE OF LVIV RAILROAD СТОМАТОЛОГ1ЧНА ПАТОЛОГ1Я У ПРОВ1ДНИК1В ПАСАЖИРСЬКИХ ВАГОН1В ЧЕРН1ВЕЦЬКОГО ВУЗЛА ЛЬВIВСЬКОÏ ЗАЛ1ЗНИЦ1
Summary: 3661 railroad men are employed by Chernivtsi railroad centre of Lviv railroad, of which the car attendants constitute the largest part- 484 (13,2%). While carrying out their professional duties the passenger car attendants are constantly under the influence of a number of harmful factors: abrupt changes in working temperature range, noise and vibration, dust content, enhanced level of air microbial contamination inside the cars, disturbance of sleep and rest schedule, physiological and neuro-emotional tension.
Key words: dental disease, harmful factors, neuro-emotional stress.
Анотащя: На Чершвецькому вузлi Львiвськоï залiзницi працюе 3661 залiзничник, з них провщники складають найб№шу частку - 484 (13,2%). Провщники знаходяться шд впливом низки шшдливих чин-нишв: pi3Ki змши температурного режиму, шум та вiбрацiя, запиленють, тдвищений piBem мiкробноï за-брудненосп повггря вагошв, порушення режиму сну та вщпочинку, нервово-емоцшш навантаження.
Ключовi слова: хвороби зубiв, шкiдливi фактори, нервово-емоцшш навантаження.
The increase of dental morbidity rateamong people whose professional activity is connected with chronic exposure of their organs to occupational hazards is associated with the increase of chronic concomitant physical diseases, changes in antioxidant-prooxi-dant system of mouth cavity tissues, microbial equilibrium, and toxic hypoxia. Various harmful factors of the working environment influence the employees in the process of their working career that is why the working conditions are considerably determined by the presence of industrial hazards. The occupational hazards are determined as working environment conditions which in case of irrational organization of work affect the employees' health and their working ability.
Depending on the nature of the occupational hazards origin they are divided into: hazards associated with labour process which are caused by the irrational labour organization (excessive tension of the nervous system, tension of visual organs, hearing organs, great labour intensity, etc.); hazards associated with the occupational process created by the technical deficiencies
of the operating machinery (industrial dust, noise, vibration, hazardous chemicals, radiation). In Ukraine, on the average 7,5-8 thousand professional diseases are registered annually, which itself shows the complexity and ambiguity of the estimates to use these indicators for making conclusions and taking organizational and administrative decisions.
The research worksaimed at identifyingthe forming patterns of health of the passenger car attendants under the influence of occupational factors for the purpose of scientific justification of low-cost and effective health improvement are of great importancesince prolonged exposure of the organism to harmful factors worsens health and results incontraction of various diseases that adversely affects the performance of official duties by the employees.
The aim of the research. To examine the state of dental hard tissues, to assess the intensity and peculiarities of clinical manifestations of both carious proces-sand noncariousaffectsof dental hard tissues among the passenger car attendants of Chernivtsi station.
Wschodnioeuropejskie Czasopismo Naukowe (East European Scientific Journal) #3(19), 2017
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Materials and research methods
To solve the tasks we have examined 52 people, including 30 passenger car attendants of Chernivtsi station (treatment group) and 22 employees not exposed to harmful factors (experimental group). All patients were divided into four age groups and examined according to recommendations of World Health Organization on dental examination. Teeth assessment was conducted according to CFE (caries, filled, extracted) index. We have conducted the research of dental disease among passenger car attendants in four age groups - groupl- 19-24 years old, group II- 25-34 years old, group III- 35-44 years old and group IV- 45 years old and older. The treatment group was formed in each age category consisting of employees directly involved in the occupational process, and the control group including employees not involved into the production cycle. 52 people were examined altogether.
In the process of examining the dental hard tissues and the quality of their treatment we, except the total 30
25
<u 20 re
lu 15
10 5 0
CFE index, have conducted a detailed analysis of its components, namely we have taken into account the number of teeth with uncomplicated and complicated caries concerning the C-caries index. The teeth with complicated caries, in their turn, were divided into those which can be treated and those subject to extraction.
F (filling) index components includedthe number of fillings that required replacement, including: broken fillings and restoration; fillings and restoration on aproximalsurfaces with poor contact points and overhanging edges.
The crownworks were allocated into a particular group, singling out the unsatisfactory ones (mainly including the absence of the contact points and presence of overhanging edges) from their total number.
"E" component included the absent teeth during examination.
The results of the examination were subjected to statistical analysis.
19-24 (2,1)
25-34 (7,5)
35-44 (10,2) 45 and older (20,4)
Age group
□ CFE (E) DCFE (C)
Research results and their consideration. We
have investigated the state of dental health of the passenger car attendants depending on their age and length of service. The prevalence of caries among the car at-tendantsis 100% throughout all age groups. The intensity of teeth affection is 20 teeth in the treatment group in the age of 19-24 years old, reaching almost 26 teeth per one examined person in the age of 45 years old and older. The growth rate of affected teeth is not great, but stable - about two affected teeth in each age group. CFE index is almost 20% less in the control group throughout all age groups and the growth of affected teeth is half less than in the control group.
The number of teeth affected by caries (C) within CFEstructure in the treatment group increases from 2,5 (12,50%) in the age of 19 - 24 years old to 6,42 (26,52%) in the third age group (35 - 44 years old) and in the fourth age group (45 years old and older) reduces to 4,77 (18,37%). This decrease is happening due to the increase in the number of extracted teeth. In the treatment group "C" component of CFE index is stable
within four affected teeth in all age groups except young employees where it is 2,4 affected teeth.
The number of filled teeth in the treatment group is reduced by half from 15,0 in the first age group to 7,52 in the fourth group. In the experimental group "F" component of CFE index is stable throughout all age groups and is within 12-13 fillings per one examined person.
The intensity indicator for odontoclasis is caused by the number of extracted teeth. In the treatment group the proportion of extracted teeth (E) according to CFEindexin the first age group is 12,30% and increases to 40,37% in the fourth age group (52,67%), i.e.it is more than four times bigger. The number of extracted teeth in the control group is 2,5 times less.
The number of extracted teeth in the treatment group significantly exceeds the number of treated teeth with age. One extracted tooth at a young age corresponds to six treated teeth, and one extracted tooth corresponds to only 0,5treated one in the fourth age group. In the control group throughout all age groups (except
u
46 Wschodnioeuropejskie Czasopismo Naukowe (East European Scientific Journal)#3(19), 2017 H3kl
group I where one extracted tooth corresponds to 13 treated ones) one extracted tooth corresponds to three -four treated teeth.
Conclusion.The treatment and control groups in the process of their examination were diagnosticated having complicated caries that indicates insufficient level of oral cavity sanation. However, this index in the treatment group is bigger than the analogous one in the control groups throughout I, II, III age groups by 3,90; 5,18; 2,63 times (p <0.05) respectively, and in group IV the number of teeth with complicated caries 0,28 times exceeds such number in the treatment group (p> 0.05) compared to the control one.The complicated caries in the control group is gradually developing till 34 (p> 0.05), and in the third age group (till 44) it abruptly increases by three in comparison with the first age group. Further, with age increasingit remains at the same level (p> 0.05). The development dynamics of the complicated caries in the treatment group looks differently-firstlyincrease of the number of teeth with complicated caries is diagnosed with double speed at the age till 34 (p <0.05), then the number of the affected teeth is approximately at the same level from 34 to 44 (p> 0.05), after 44 sharp decrease of the affected teeth by 2,5 times is diagnosed (p <0.05). We have conducted analysis of the state of the teeth to be treated and extracted in order to assess the complexity of the teeth affection by complicated dental caries.
As the research results show, the number of teeth with complicated caries to be treated in the first age group both throughout the treatment and control groups is the same and 1,75 times approximatelyexceeds the number of teeth to be extracted. In the second age group the number of teeth to be treatedand extracted in the treatment group is almost the same and throughout the control group the number of teeth to be treatedtwice exceeds the number of teeth subject to extraction. In the fourth age group the percentage of teeth to be treated both in the treatment and control groups is 10-15% less than of teeth to be extracted.
This indicates approximately the same lack of dental care request by the examined people, as well as insufficient quality of treatment.
Slight increase in the number of filled teeth in the treatment group is observed throughout the first to the third age groups (from 0,66 to 1,66), with following decrease in the IV group to 1,6. The treatment group showed such increase only in the second group to 3,33, and the third and fourth age groups showed almost double decrease in the number of filled teeth.
In addition, the quality of the fillings is rather lowas at the age of 19-24 the control group showed that 17,37% of fillings require their replacement, and this figure reaches 57,64% in the treatment group. At the age from 25 to 34, the number of low quality fillings further increases by 17,33%in the treatment group, and by 18,27% in the control group. The older age group showed the increase in the number of low-quality fillings in both groups up to 50%, and their total number is reduced.
The extent of dental health service among the total number of the examined people is very low, almost
50% of initial carious affection is not treated. The quality of the fillings is "unsatisfactory". The combination of these two indicators shows the complete lack of routine dental treatment. The treatment is only carried out at 30% rate of the required extent upon the appeal for such treatment. In our opinion, such a situation arose due to the absence of clinical examination of the employees of the enterprises with hazardous production factors.
The analysis of the number of extracted teeth, on the one hand, characterizes the quality and scope of dental care rendered to the patients. On the other hand it characterizes fast progress of pathological processes in the hard tissues of the tooth and parodentiumresult-ing in their complete loss.
With age, the treatment group is characterised with significant increase of the number of extracted teeth and the dynamics of this growth is much faster than in the control group.
Thus, the increase of the extracted teeth in the treatment group is almost twice higher than in the control group (p <0.05), and proportion of the extracted teeth within CFE in the treatment group is one and a half times higher than in the control group.
The degree of caries expansion among the passenger car attendants is 100% in all age groups, the number affected teeth with caries depending on the length of service and age ranges from 20,0 to 25,97. Only half of teeth affected by cariesistreated. Depending on the age from 12% to 53% of teeth are extracted.
Lack of prevention programs at high caries affection of teeth and its complications, high prevalence of diseases of paradontresults in the increase of the need for therapeutic, surgical and orthopedic treatment.In this respect the treatment exclusively upon appeal is conducted.
We recommend restoringthe programs ofdental diseases prevention that would include dental education of the employees, learning the rules of sensible nutrition, learning the rules of the mouth cavityhygienic care, secondary prevention (planned oral cavity sana-tion), dispensary observation.
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National *Kozovyi R., Vakalyuk I., Yatsyshyn R.
Ivano-Frankivsk Medical University, Ivano-Frankivsk, Ukraine
FREQUENCY OF POLYMORPHIC VARIANTS OF THE GSTT1 AND GSTM1 GENES AMONG LONG LIVERS WITH ARTERIAL HYPERTENSION AND OSTEOARTHRITIS RESIDING IN THE
CARPATHIAN REGION
Abstract
Objectives: The objective of the research was to study the relationships between the frequency of polymorphic variants of the GSTT1 and GSTM1 genes among long livers with arterial hypertension and osteoarthritis residing in the Carpathian region.
Methods: Molecular genetic testing of genes of phase II biotransformation of xenobiotics was performed in 166 long livers residing in Ivano-Frankivsk region. To compare the results, the patients were divided into four groups: Group I included 53 long livers with stage II arterial hypertension and stage II osteoarthritis; Group II comprised 41 long livers with stage II arterial hypertension without osteoarthritis; Group III included 34 long livers with stage II osteoarthritis without arterial hypertension; Group IV comprised 38 apparently healthy long livers (without any diagnosed disease).
Results: The analysis of the obtained data has revealed that the frequency of the functionally inactive GSTT1 and GSTM1 alleles among the all long livers of Ivano-Frankivsk region was 24.70% and 46.99%, respectively. In long livers of four comparison groups, the functionally active GSTT1 and GSTM1 alleles predominated. There were no statistically significant differences between patients with arterial hypertension and osteoarthritis and healthy long livers with the GSTM1 +/GSTT1+, GSTM1 +/GSTT1 -, GSTM1 -/GSTT1 +, GSTM1-/GSTT1 -genotypes. When studying the peculiarities of the onset and clinical course of arterial hypertension and osteoarthritis in long livers, we have revealed that in 76% of cases, clinical manifestations of the disease were detected in senile patients (over 75 years of age). A relatively slow worsening of symptoms was observed; the transition from the first to the second stage continued for 10-20 years.
Keywords
Polymorphic variants of genes, GSTM1, GSTT1, long livers
Introduction.
The development of pathological conditions depends on individual hereditary traits determining different sensitivity to the same exogenous factors. The xe-nobiotic detoxification system plays the key role in the response of a particular person to environmental exposure. Therefore, the study of individual peculiarities of the detoxification system functioning being relevant
and necessary under conditions of modern anthropogenic load is essential when determining the individual risk of developing pathological processes [1, 2]. There are typically three stages involved in the system of xe-nobiotic transformation, namely the activation of xeno-biotics (phase I), the detoxification of xenobiotics (phase II) and the elimination of xenobiotics from the body (phase III). Phase I - the activation of xenobiotics or metabolic transformation - involves the attachment
