CC BY
5
UDK 004.02:004.5:004.9
Bokiyev M. assistant
of Andijan State Medical Institute Mamazulunov N. assistant
of Andijan State Medical Institute
SOME BIOLOGICAL ACTIVE PRODUCTS OF METALLOCENES
Annotation: The article provides information about ferrocene and its derivatives containing iron, as well as biologically active substances containing ferrocene
Keywords: ferrocene, cyclopentadiene, ferrostimulants, siacrine, bioglue, ferrocerone
Kili and Poson synthesized in 1951 a specific compound of cyclopentadiene, disiclopentadienyltemyl, often called ferrocene. It can be obtained from a magnesium compound of cyclopentadiene and iron (II) chloride (I), cyclopentadiene with heated Fe (II) and iron (II) chloride (III) in the presence of Na, freshly cracked cyclopentadiene (IV) [1].
Ferrocene is a complex organic compound containing iron (Fe), a metalloorganic substance with a sandwich structure.
In 1952, as a result of X-ray structural analysis, E. Fisher in Germany, G. Wilkinson in England and R. Woodward in the United States proposed to name dicyclopentadienyltemir "Ferrocene" and also its structural formula. According to this structure, the Fe atom is located between two symmetrical cyclopentadienyl (C5H5) rings [2].
Ferrocene can even be obtained from some amine bases (diethylamine) by deprotonation (V), iron from pentacarbonyl (VI), and other metallocenes (VII)
Several scientists, including the German scientist W. Schlyogl, the American scientist R. Woodward, the Russian A. N. Nesmeyanov, N. S. Kochetkova, contributed to the development of ferrocene chemistry with their
FeCl2 4H2O + 2C5H6 IV
2 C5H5- MgBr I
[3].
students. These scientists have found that ferrocene can easily enter into reactions such as exchange and aggregation, just like aromatic hydrocarbons [2-4].
A.N. Nesmyanov studied in detail the ability of ferrocene to react with aryldiazonium, and showed that the reaction can form ferrocene compounds with different structures [5].
Lutle et al proposed the arylation reactions of ferrocene in the presence of sulfuric acid [6].
As a result of the research, aryl derivatives containing halides, nitro and carboxyl, alkyl, acetyl, cyanide groups were synthesized, isolated and their structure was studied.
The purely isolated metallocene derivatives can be summarized as follows:
R= OCl, OCH3, OC2H5, o COOCH3, p- COOC2H5, m- COOC2H5, O-CH2OH, m=COOH o=CH3, p=CN
The arylation reaction of ferrocene was studied in detail by A. Kasahara and others, and the reaction of the following structure was carried out. As a result, dialysic arylaldehyde salts and other derivatives of ferrocene were synthesized, and their structure was studied by IR, NMR, and MASS spectra [7].
Fe r^CHO
^CHO
Through these reactions, the ferrocene, represented by metallocenes, exhibits aromatic properties by easily exchanging its hydrogen for other functional groups according to the environment. An example of this is ferroquine, which is widely used in the treatment of anemia:
In the scientific laboratory "Commodity Chemistry" of Andijan State University biostimulators "Ferrostimulators", "MAXIX", "MAKSIT", "ADUMAX", "Ferbek-P" and "Ferbek-PD" were synthesized and put into practice. These biostimulants not only accelerate the growth of the plant, but also have a positive effect on seed germination and overall development of the plant, and increase productivity by 3-4 s / s.
One of the medicinal properties of ferrocene compounds is that they can treat several diseases at the same time. For example, ferrocene-containing substances such as ferrocerone, askin, siacrine AP-1, siacrine AndMos [8, 9]. In particular, ferrocerone has been shown to be effective in the treatment of severe anemia, as well as in the treatment of anemia. Or the sodium salt of p-ferrocenylphenol has been proven to cure not only anemia but also colds. Its main features have been proven to be significantly superior to existing analogues in the world, as well as its ability to treat radiation sickness, one of the most serious problems of our time. pia-ferrocenylphenol-based siacrine bioelements were obtained. These bioelements differ from their cyanacrine-based analogues in several respects. The glue does not stick to the hands of surgeons and medical devices. The rate of transition to the working position is 1.5-2 times faster, which prevents the formation of various pus on the operated surface. Accelerates tissue to a normal life cycle. It is obvious that the physiological activity of ferrocene and its derivatives, their low cost, allows them to benefit greatly from their widespread use in the national economy. Based on the above, it can be concluded that ferrocene-based many of the new chemicals obtained show high biological activity. The main reason why ferrocene derivatives exhibit such positive properties can be explained by the fact that its structural structure is close to that of the gem, which is the most active compound in the cells of living organisms.
It is known from the biochemical literature that heme-containing enzymes are actively involved in the metabolic process in all living organisms. In particular, the cytochrome system is one of the key enzymes in the final stages of the redox process in the cell, the final product of metabolism - the formation of water and carbon dioxide. That is, without this cytochrome system, the metabolic process in cells and tissues will not end. This means that ferrocene-based drugs are involved in cellular metabolism and may be involved in the regulation of certain processes in living organisms.
References:
1. Kealy T.J, Pauson P.L - Nature, 1951, Vol. 168, r.1039
2. Nesmeyanov A.N., Perevalova E.G., Golovnya R.V., Shilovtseva L.S. - About alkylferrocenax and fer-rotsenilamine - DAN USSR, 97, 459-461 (1954)
3. Jump up to: a b Wilkinson, G. (1956). "Ferrocene". Organic Syntheses. 36:31 doi: 10.15227 / orgsyn.036.0031 .; Collective Volume, 4, p. 473
4. Nesmeyanov A.N., Perevalova E.G., Golovnya R.V., Shilovtseva L.S. - About alkylferrocenax and fer-rotsenilamine - DAN SSSR, t. 102 № 3, 535- 538 (1955)
5. Nesmeyanov A.N. - "Substitutions in the ferrocenenuc - leus" Proc. Royal Soc. (London), 246, 495 (1955).
6. Little W. F., Lynn K. N., Williams R.- Novel Side Reaction Accompanying the Arylation of Ferrozene. An Example of Free Radical Sudstation. J. did., Vol. 30055 (1963)
7. Askarov IR, Khojimatov MM, Kirgizov Sh.M., Otakhonov QQ - "Synthesis of some aromatic compounds of metallocenes" Scientific Bulletin, (AUL) №2, 42,43-p (2014).
8. Abdulloyev O.Sh. Iron-containing biostimulants, their classification and certification: dis. .. chemistry f. fals. Doc (PhD): 02.00.09 // Abdulloyev O.Sh. -Andijon, 2018. - P. 123.
9. Askarov I.R., Kyrgyzov SH.M. Ferrocene and its prospects in agriculture. // Problems and prospects of classification and certification of goods on the basis of chemical composition. Scientific-practical conf. materials. - Tashkent, 2013. - P. 327-331.1
