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1SOME ASPECTS OF COMBINED TREATMENT OF GLIAL BRAIN TUMORS
Husanov Z.T.
Husanov Zafar Tashmurodovich - Assistant of the Neurosurgery, DEPARTMENT OF NEUROSURGERY, SAMARKAND STATE MEDICAL UNIVERSITY, SAMARKAND, REPUBLIC OF UZBEKISTAN
Abstract: the article analyzes the results of combined treatment ofpatients with intracerebral tumors of the cerebral
hemispheres with surgical intervention and chemotherapy and radiotherapy.
Key words: glioma, relapse, chemotherapy, radiotherapy, intracerebral, neurooncology
Every year, brain tumors are diagnosed on average with a frequency of 21 cases per 100,000 population [1-5,711, 15]. Primary brain tumors are the fourth leading cause of tumor death among men aged 15 to 54 years and women aged 15 to 34 years and are the second most common cause of death among tumors in children under 15 years of age, and this mortality is mainly due to malignant tumors. brain [3-9]. Treatment of patients with malignant intracerebral tumors is one of the most difficult problems in neurooncology and clinical radiology. The development of combined treatment methods for glial tumors and substantiation of the role of the radiation component in their treatment is of great importance in increasing the duration and quality of life of patients [12, 13, 14].
The aim of the work was to study the long-term results of complex treatment of patients with recurrent glial tumors of the brain, operated on in the neurosurgical department of the 1st clinic of the Samara State Medical Institute.
Materials and research methods. The study included 75 patients with intracerebral tumors of the cerebral hemispheres (ICBMT) who were treated in the neurosurgical department of the 1st clinic of the Samarkand Medical Institute in the period from 2012 to 2021. All patients were subjected to surgical intervention.
All patients with tumors of the cerebral hemispheres were divided into 10 groups depending on the location of the neoplasm, namely, in 22 (29.3%) patients, the tumors were localized in the temporal lobe, in 13 (17.3%) - in the frontal lobe, in 9 (12%) - in the parietal lobe, in 8 (10.7%) - in the frontotemporal lobes, in 6 (8%) patients - in the fronto-parietal and parietal-occipital lobes, in 5 (6.7%) ) - in the temporo-parietal lobes, as well as 2 (2.7%) patients in the fronto-parietal-temporal, temporo-occipital and parieto-temporo-occipital lobes of the brain.
The analysis of the results of surgical interventions was carried out on the basis of intraoperative observations, protocols of operations, and the dynamics of the neurological status of patients after surgery.
Surgical removal of the tumor was performed in all 75 patients (68 primary operations and 7 after tumor recurrence).
In a comparative assessment of clinical and neurological symptoms of patients with glial tumors in the pre- and postoperative periods, significant changes were noted. Comparative assessment of the main neurological symptoms of glial tumors, which included speech and movement disorders, epileptic convulsions, dysfunctions of the cranial nerves, and meningeal symptoms.
Death was observed in 8 (10.6%) patients, 2 of them died in the early postoperative period due to respiratory and cardiovascular failure. The remaining 6 patients died in the late postoperative period after 12.8±1.47 m onths.
Thus, it can be concluded that the complex treatment of patients with IOBP with surgical intervention and chemoradiotherapy contributes to the prolongation of the median life expectancy of patients, and also improves their quality of life.
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