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20SILICON NANOMATERIALS FOR BIOSENSING AND BIOIMAGING
YAO HE
1Laboratory of Nanoscale Biochemical Analysis, Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou 215123, China
yaohe@suda.edu.cn
Abstract
During the past decades, silicon nanotechnology for biological and biomedical applications has been extensively studied due to the favorable biocompatibility of silicon. Notably, silicon nanohybrids featuring unique electronic/optical/mechanical properties have been widely employed for constructing biosensing platforms with excellent sensitivity, good specificity, adaptable reproducibility, and multiplexing capabilities [1-4]. In addition, it is worth mentioning that the silicon nanohybrids can be explored for setting up surface-enhanced Raman scattering (SERS) big data, allowing artificial intelligence (AI)-based DNA discrimination in label-free manners [5]. On the other hand, proof-of-concept studies have opened up promising avenues for developing fluorescent silicon nanoprobes-based bioimaging techniques. Of particular significance, silicon-based nanoprobes feature strong fluorescence, robust photostability, and negligible toxicity. Those attractive merits have triggered extensive exploration of functionalized silicon nanomaterials as potentially ideal biological fluorescent probes, showing high promise for in vitro and in vivo bioimaging analysis [6-10].
References
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