Научная статья на тему 'RISK FACTORS FOR THE DEVELOPMENT OF NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCTION IN WOMEN OF VARIOUS GROUPS'

RISK FACTORS FOR THE DEVELOPMENT OF NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCTION IN WOMEN OF VARIOUS GROUPS Текст научной статьи по специальности «Клиническая медицина»

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Ключевые слова
FEMALE / RISK FACTORS / KABUL

Аннотация научной статьи по клинической медицине, автор научной работы — Akhtar Mohammad Totakhail, Ihsanuddin Ihsan, Karibayev K.R., Akhenbekova A.Zh.

Background: There was higher cardiovascular mortality reported, women accounted for 47.3 % of IHD patients.However, data on non ST Elevated Myocardial Infarction (NSTEMI) in females, particularly the risk factors expression in different groups are scarce in our country. Objectives: This study was conducted to determine the prevalence of risk factors of NSTEMI in females, its occurrence at various groups such as pre and postmenopausal, socioeconomic state rural and urban, various age groups. Materials and methods: Retrospective cross sectional study data collected from 234 females out of 477 NSTEMI patientsfrom 3 tertiary hospitals in Kabul. medical files of patients attended hospitals from January 1st to December 31st, 2020. For analysis SPSS (version 26, SPSS, Inc., Chicago, IL, USA) was used The significant level considered 0.05; Chi - square (x2) test for analyze categorical data, and numeric data was analyzed by t test, mean and SD. Results: The current study looked into most prevalent risk factors36 (75.0%) of premenopausal and 108 (58.1%) postmenopausal patients had hypertension (P=0.032); furthermore, 27 (56.3%) of anemia were premenopausal (P<0.001). physical inactivity was more prevalent75 (56.0 %) in old age (P<0.001).There was a family history in 20 (76.9%) of the young age group(P<0.001).Family history more in good economy patients (P=0.003), Smoking is more prevalent in patients with good socioeconomic status.(P=0.001).DM was in 24 (61.5%) of fair economy patients (P=0.041).Overweight and obesity occurrence is more common in urban78 (50.6 %)(P=0.001), CKD more common in rural 13 (16.3 %)(P<0.001). Conclusion: The most prevalent risk factors were Hypertension and anemia in premenopausal in physical inactivity in old age, and diabetes mellitus in fair socioeconomics, family history of IHD in young age, smoking in people of good socioeconomic, overweight and obesity I urban residents, CKD more prevalent in rural.

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Текст научной работы на тему «RISK FACTORS FOR THE DEVELOPMENT OF NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCTION IN WOMEN OF VARIOUS GROUPS»

Received: 30 June 2021 / Accepted: 06 December 2021 / Published online: 30 December 2021 DOI 10.34689/SH.2021.23.6.011 УДК 616.127-005.8

RISK FACTORS FOR THE DEVELOPMENT OF NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCTION IN WOMEN OF VARIOUS GROUPS Akhtar Mohammad Totakhail1, Ihsanuddin Ihsan1, Kairat R. Karibayev2, Aida Zh. Akhenbekova3 4

1 Paktia university, Medical faculty, Department of Internal Medicine, Paktia, Afghanistan;

2 Cardiocenter Central Clinic Hospital Almaty, Almaty, Republic of Kazakhstan;

3 Al-Farabi Kazakh National University, Faculty of Medicine and Healthcare, Higher School of Medicine, Almaty, Republic of Kazakhstan;

4 NJSC "Kazakh National Medical University named after S. D. Asfendiyarov", Almaty c., Republic of Kazakhstan.

Abstract

Background; There was higher cardiovascular mortality reported, women accounted for 47.3 % of IHD patients.However, data on non ST Elevated Myocardial Infarction (NSTEMI) in females, particularly the risk factors expression in different groups are scarce in our country.

Objectives: This study was conducted to determine the prevalence of risk factors of NSTEMI in females, its occurrence at various groups such as pre and postmenopausal, socioeconomic state rural and urban, various age groups.

Materials and methods: Retrospective cross sectional study data collected from 234 females out of 477 NSTEMI patientsfrom 3 tertiary hospitals in Kabul. medical files of patients attended hospitals from January 1st to December 31st, 2020. For analysis SPSS (version 26, SPSS, Inc., Chicago, IL, USA) was used The significant level considered 0.05;Chi-square (x2) test for analyze categorical data, and numeric data was analyzed by t test, mean and SD.

Results: The current study looked into most prevalent risk factors36 (75.0%) of premenopausal and 108 (58.1%) postmenopausal patients had hypertension (P=0.032); furthermore, 27 (56.3%) of anemia were premenopausal (P<0.001). physical inactivity was more prevalent75 (56.0 %) in old age (P<0.001).There was a family history in 20 (76.9%) of the young age group(P<0.001).Family history more in good economy patients (P=0.003), Smoking is more prevalent in patients with good socioeconomic status.(P=0.001).DM was in 24 (61.5%) of fair economy patients (P=0.041).0verweight and obesity occurrence is more common in urban78 (50.6 %)(P=0.001), CKD more common in rural 13 (16.3 %)(P<0.001).

Conclusion: The most prevalent risk factors were Hypertension and anemia in premenopausal in physical inactivity in old age, and diabetes mellitus in fair socioeconomics, family history of IHD in young age, smoking in people of good socioeconomic, overweight and obesity I urban residents, CKD more prevalent in rural. Keywords: NSTEMI, Female, Risk factors, Kabul.

Резюме

ФАКТОРЫ РИСКА РАЗВИТИЯ ИНФАРКТА МИОКАРДА БЕЗ ПОДЪЕМА СЕГМЕНТА ST У ЖЕНЩИН РАЗЛИЧНЫХ ГРУПП

Ахтар Мохаммад Тотахаил1, Ихсануддин Ихсан1, Кайрат Р. Карибаев2, Аида Ж. Ахенбекова34

1 Университет Пактия, Медицинский факультет, Кафедра внутренних болезней, г. Пактия, Афганистан;

2 Кардиологический Центр Центральной клинической больницы Алматы, г. Алматы, Республика Казахстан;

3 Казахский Национальный университет им. Аль-Фараби, Факультет медицины и здравоохранения, Высшая школа медицины, г. Алматы, Республика Казахстан;

4 НАО «Казахский Национальный медицинский университет им. С.Д. Асфендиярова», г. Алматы, Республика Казахстан.

Введение: Сообщалось о более высокой сердечно-сосудистой смертности, составляющей у женщин 47,3% пациентов с ИБС. Однако в нашей стране недостаточно данных об инфаркте миокарда без элевации ST (NSTEMI) у женщин, особенно о проявлении факторов риска в различных группах.

Цель: Это исследование было проведено с целью определения распространенности факторов риска NSTEMI у женщин, его частоте в различных группах, как до- и в постменопаузе, по социально-экономическому состоянию, сельских и городских районов, в различных возрастных группах.

Материалы и методы: Были анализированы данные ретроспективного перекрестного исследования, включающие 234 женщины из 477 пациентов NSTEMI из 3-х больниц в Кабуле, медицинские карты пациентов, посещавших больницы с 1 января по 31 декабря 2020 года. Для анализа SPSS (версия 26, SPSS, Inc., Чикаго,

Иллинойс, США) использовался уровень значимости 0,05; критерий Хи-квадрат (x2) для анализа категориальных данных, а числовые данные анализировались с помощью t-критерия, среднего и SD.

Результаты: В текущем исследовании изучались наиболее распространенные факторы риска: у 36 (75,0%) пациенток в пре-менопаузе, и у 108 (58,1%) пациенток в постменопаузе была гипертония (Р=0,032); кроме того, у 27 (56,3%) анемия была в пре-менопаузе (Р<0,001). в пожилом возрасте гиподинамия была более распространена у 75 (56,0 %) человек (Р<0,001). У 20 (76,9%) представителей молодой возрастной группы имелся семейный анамнез (Р<0,001). Семейный анамнез чаще у пациентов с хорошим экономическим статусом (Р=0,003), курение чаще встречается у пациентов с хорошим социально-экономическим статусом (Р=0,001). СД был у 24 (61,5%) пациентов с хрошим экономическим статусом (Р=0,041). Избыточный вес и ожирение чаще встречаются у пациентов из города 78 (50,6%) (Р=0,001), ХБП чаще встречается у пациентов из сельских регионов 13 (16,3%) (Р<0,001).

Выводы: Наиболее распространенными факторами риска NSTEMI были гипертония и анемия в пре-менопаузе, гиподинамия в пожилом возрасте и сахарный диабет при благополучной социально-экономической ситуации, семейный анамнез ИБС в молодом возрасте, курение у людей с хорошим социально-экономическим положением, избыточный вес и ожирение у городских жителей, ХБП чаще встречается в сельской местности.

Ключевые слова: NSTEMI, женщина, факторы риска, Кабул.

Туйшдеме

ST СЕГМЕНТ1Н К9ТЕРМЕСТЕН МИОКАРД ИНФАРКТ1СШ1Н ДАМУ КАУ1П ФАКТОРЛАРЫ ЭР ТYРЛI ТОПТАГЫ ЭЙЕЛДЕРДЕ

Ахтар Мохаммад Тотахаил1, Ихсануддин Ихсан1, Кайрат Р. Карибаев2, Аида Ж. Ахенбекова3

1 Пактия университет! Медицина факультетшщ шм аурулар кафедрасы, Пактия к-, Ауганстан;

2 Кардиологиялык орталык, Алматы Орталык клиникалык ауруханасы, Алматы к-, Казакстан Республикасы;

3 Эл-Фараби атындыгы Казак ¥лтык университетi, Медицина Жогары Мектебi, Медицина жэне денсаулык сактау факультету Алматы к-, Казакстан Республикасы;

4 КЕАК «С-Д- Асфендияров атындагы Казак улттык медицина университет», Алматы к-, Казакстан Республикасы.

Kipicne: ЖYрек-кан тамырлары ©лiмiнiк жогарылыгы туралы хабарланды, эйелдер ЖИА-мен ауыратын наукастардыч 47,3%-ын курады. Алайда, бiздiк елiмiзде эйелдерде (NSTEMI) дечгейУч жогарылау ынсыз миокард инфаркш туралы, 8сiресе эр тYрлi топтардагы кауiп факторларыныч к©рiнiсi туралы м8лiметтер жеткiлiксiз.

Максаты: бул зерттеу эйелдерде NSTEMI кауiп факторларыныч таралуын, оныч менопаузадан бурын жэне одан кейЫп топтарда кездесуiн, ауылдык жэне калалык аудандардыч элеуметш-экономикалык жавдайын, эр тYрлi жас топтарын аныктау максатында жYргiзiлдi.

Материалдар жэне эдicтepi: Кабулдагы 3 Yшiншi аурухананыч NSTEMI 477 пациентУч 234 8йелiнен жиналган ретроспективтi кросс-зерттеу деректерк 2020 жылдыч 1 качтарынан 31 желтоксанына дейiн ауруханаларга келген пациенттердщ медициналык карталары. SPSS талдау Yшiн (26 нуска, SPSS, Inc., Чикаго, Иллинойс, А^Ш) 0,05 мачыздылык дечгей колданылды; категориялык деректердi талдау Yшiн Хи-квадрат ©лшемi (x2), ал сандык деректер t-критерий, орташа жэне SD аркылы талданды.

Нэтижелер: агымдагы зерттеуде менопаузага дейiнгi 36 (75,0%) наукаста жэне постменопаузадан кейiнгi 108 (58,1%) наукаста гипертония (P=0,032) жи кездесетiн кауiп факторлары зерттелдi; сонымен катар, 27 (56,3%) менопауза алдындагы анемия (p<0,001) болды. Егде жаста гиподинамия 75 (56,0 %) адамда жи кездеседi (p<0,001). Жастоптыч 20 (76,9%) ©кУнде отбасылык анамнез болды (Р<0,001). Отбасы тарихы жаксы экономикалык жавдайы бар наукастарда жиi кездеседi (P=0,003), темекi шегу жаксы элеуметш-экономикалык жавдайы бар наукастарда жиi кездеседк (Р=0,001). SD 8дiл экономикасы бар елдердщ 24 (61,5%) пациентiнде болды (Р=0,041). Артык салмак пен семiздiк калалык 78 (50,6%) (Р=0,001), ауылдык жерлерде жиi кездеседi 13 (16,3 %) (р<0,001).

Корытынды: еч к©п таралган кауiп факторлары гипертония жэне менопаузадагы анемия, егде жастагы физикалык белсендiлiк жэне 8дiл 8леуметтiк-экономикалык жавдайдагы кант диабетi, жас кезiндегi ЖЖА отбасылык тарихы, элеуметш-экономикалык жавдайы жаксы адамдарда темею шегу, артык салмак жэне семiздiк.

TYÜiHdi свздер: NSTEMI, эйел, к,ау'т факторлары, Кабул.

Bibliographic citation:

Akhtar Mohammad Totakhail, Ihsanuddin Ihsan, Karibayev K.R., Akhenbekova A.Zh. Risk factors for the development of non-ST segment elevation myocardial infarction in women of various groups // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 6, pp. 97-102. doi 10.34689/SH.2021.23.6.011

Ахтар Мохаммад Тотахаил, Ихсануддин Ихсан, Карибаев К.Р., Ахенбекова А.Ж. Факторы риска развития инфаркта миокарда без подъема сегмента ST у женщин различных групп // Наука и Здравоохранение. 2021. 6(Т.23). С. 97-102. doi 10.34689/SH.2021.23.6.011

Akhtar Mohammad Totakhail, Ihsanuddin Ihsan, Karibayev K.R., Akhenbekova A.Ж. ST сегментЫ к©терместен миокард инфарктюУ ч даму каут факторлары эр тYрлi топтагы эйелдерде // Гылым жэне Денсаулык сактау. 2021. 6 (Т.23). Б. 97-102. doi 10.34689/SH.2021.23.6.011

Introduction

IHD affects about 126 million individuals (1,655 per 100,000), or 1.72 % of the global population; nine million people have died as a result of the disease. Men were more likely than women to be troubled, and the onset was most typically in the fourth decade [1]. In a current Indian study, 28.45% of ischemic heart disease patients reported premenopausal, while 71.55 % were postmenopausal; the most common risk factors among postmenopausal women included hypertension and dyslipidemia [2]. 24.7 % of patients had STEMI, 32.1 % NSTEMI/UA, and 43.2 % had stable angina; females were more likely to have NSTEMI/UA than other types of IHD, with women suffering from STEMI, NSTEMI/UA, and stable angina in percentages of 21 percent, 31.3 percent, and 24 percent, respectively [3]. According to a recent study in Sri Lanka, 37.7% of patients with acute coronary syndrome had unstable angina, 36.7 percent NSTEMI, and 25.7 percent STEMI; 35.5 percent of overall NSTEMI patients were female, whereas 16.9% of STEMI patients and 43.4 percent of unstable angina patients were female [4] Yet even with this, males and females have approximately simillar rates of NSTEMI [5,6]. According to a study conducted, hypertension was the most common risk factor in 67 percent of female patients, preceded by smoking (52%), hyperlipidemia (35%), and obesity, diabetes, and positive family load (33%, 24%, and 24%, respectively [7].

Heart disease caused for 17.9% of all female deaths in Afghanistan, according to the Afghanistan Mortality Survey 2020 [8]. The Prevalence of coronary artery disease and its risk factors among outpatients in northern Afghanistan in Andkhoy city found that 47.3 % of women had IHD and that hypertension and physical inactivity were the leading risk factors for acute coronary syndromes. However, it did not look into sex-related differences in Ischemic heart disease types, hospital mortality due to NSTEMI, or risk factors in different age groups[9]

In order to determine the prevalence of risk factors of female patients who suffered from NSTEMI; This allows us to determine the prevalence of disease risk factors in in pre-and post-menopausal women, as well as other groups, to identify risk factors and further to evaluate across different groups; This kind of study has never been reported from Kabul Afghanistan. Therefore, the present study entitled -Risk factors for the development of NSTEMI in women of various groups. And undertaken by us. Collaboration is motivated by the identification of the incidence of NSTEMI in females. This study also represents risk factors in many

terms that help us understand and plan for the health and social care systems of that community. And to figure out what has gone unreported in the healthcare system that needs to be solved.

Methodology

Data was acquired from medical files of NSTEMI patients who attended Ibnisina, Jamoriat, and Amiri complex from January 1 to December 31, 2020 in this retrospective cross sectional study. These are the capital's tertiary hospitals, and the bulk of patients come for major medical treatments, especially cardiovascular disorders. According to our findings, out of 477 NSTEMI, 234/477 (49.0%) were female. Cluster sampling was used to choose these individuals.

Patients with ambiguous diagnoses, incomplete reports, or incomplete medical records were excluded from the study.

To compile information, with respect to Afghanistan laws and regulations, and committed to the values mentioned in the Helsinki Declaration, informed consent was acquired from ministry of public health and hospital authorities.

Myocardial necrosis was characterized by NSTEMI as the outcome of myocardial ischemia, which was associated with myocardial infarction and clinical signs and symptoms. One of the conditions listed below must be met in order to make a diagnosis;

1. In the presence of myocardial ischemia, as well as indicators of it, the levels of cardiac biomarkers (especially troponin) rise or decline.

2. Symptoms of ischemia;

3. ECG show new (ST change or new presence of left bundle branch block.);

4. ECG show pathological Q waves;

5. On echocardiogram, there is a loss of cardiac contractility and a new beginning of regional wall motion abnormalities[10].

Aim. Our study aimed to assess the prevalence of NSTEMI risk factors in female among different groups, like age, premenopausal and post-menopausal, rural urban.

Research tools

The checklist for Study was used as a tool to identify and determine prevalence of NSTEMI risk factorsin women during 2020. Variables described and diagnosed according to related hospital procedure based on accepted valid guidelines. Patients ages, and diagnosis of some other diseases as risk factors was confirmed as per hospital records. The Checklist included questions about variables on demographics and common risk factors (Table 1).

Table 1.

Prevalence of NSTEMI in female during 2020; A Study From Kabul Afghanistan._

Variable Premenopausal N=48 (20.5%) Postmenopausal N=186 (79.5%) P value

Total N-234

Age mean (SD) 57.55 (14) 38.27 (6.6) 62.53 (12) <0.001

Address Rural % 80 (34.2) 12 (25%) 68 (36.6%) 0.132

Urban % 154 (65.8%) 36 (75.0%) 118 (63.4%)

Family History % 69 (30.5%) 30 (62.5%) 39 (21%) <0.001

Hypertension % 144 (61.50%) 36 (75%) 108 (58.1%) 0.032

Systolic BP % 129 (21) 135.94 127.27 0.012

Diastolic BP % 80 (11) 84.27 79.54 0.014

Overweight or Obesity % 100 (42.70%) 20 (41.7%) 80 (43.0%) 0.867

BMI mean (SD) 25.35 (4.74) 24.70 (4.85) 25.52 (4.71) 0.289

COPD % 27 (11.5%) 3 (6.3%) 24 (12.9%) 0.198

Past History % 84 (35.90%) 12 (25%) 72 (38.7%) 0.078

Socioeconomic State Poor % 189 (80.8%) 39 (81.3%) 150 (80.6%) 0.147

Fair % 39 (16.7%) 6 (12.5%) 33 (17.7%)

Good % 6 (2.6%) 3 (6.3%) 3 (1.6%)

Smoking % 7 (3.0%) 2 (4.2%) 5 (2.7%) 0.592

Physical Inactivity % 141 (60.30%) 12 (25.0%) 129 (69.4%) <0.001

Dyslipidemia % 93 (39.70%) 18 (37.5%) 75 (40.3%) 0.722

Anemia % 81 (35.60%) 27 (56.3%) 54 (29.0%) <0.001

Hb mean (SD) 12.9 (1.73) 12.33 (2.01) 13.06 (1.62) 0.009

Diabetes Mellitus % 102 (43.60%) 21 (43.8%) 81 (43.5%) 0.98

Glucose mean (SD) 119 (63) 118.56 (46) 119.52 (67) 0.926

CKD % 17 (7.30%) 6 (12.5%) 11 (5.9%) 0.117

Creatinine mean (SD) 1.09 (0.75) 1.22 (0.65) 1.07 (0.78) 0.230*

Statistical analysis

Data was extracted from medical records and entered into a computer spread sheet. Prevalence of NSTEMI risk factors was calculated as a percentage of female having defined NSTEMI clinical diagnosis. The analysis of data was performed by the SPSS (version 26, SPSS, Inc., Chicago, IL, USA) software package. The significant level in this study was considered 0.05. The chi-square (x2) test was used to assess categorical data, and the t test was utilized to evaluate mean and SD of numeric data.

Result

Premenopausal 48 (20.5%) and Postmenopausal 186 (79.5%) women were observed in this study. Their mean ages were 38.27 (6.6) and 62.53 (12) respectively (P<0.001). Hypertensionwas the most frequent risk factor;

present in 144 (61.5%) of the patients with a mean of 129 ± 21 (Mean ±SD) systolic pressure and 80 ±12 diastolic pressures. Physical inactivity was its second in 141 (60.3%) and DM was the third with 102 (43.6%) patients. The mean level of fasting blood glucose was 119 ±63. subsequently in order Overweight and obesity in 100 (42.7%) patients; the mean BMI found 25.38 ±4.5, Prior history of IHD had 84 (35.9%), Dyslipidemia and anemia were in 93 (39.7%) and 81 (34.6%) patients. The mean hemoglobin level in all of these patients was 12.9± 1.7 Family history of Ischemic heart diseases and Chronic kidney diseases were 69 (29.5%) and 17 (7.3%). The mean creatinine level reported 1.09 ±0.74 (Mean ±SD). About 7 (3%) of the patients said they were smokers (Table 2)

Table 2.

Structure of risk factors of myocardial infarction without ST segment elevationin in female during 2020 year from Kabul Afghanistan._

Age Groups P value

Risk Factors Young Age Middle age Old Age

Frequency % Frequency % Frequency %

Hypertension 20 76.9% 82 61.2% 42 56.8% 0.1 90

Physical Inactivity 4 15.4% 75 56.0% 62 83.8% <0.001

Diabetes Mellitus 13 50.0% 50 37.3% 39 52.7% 0.079

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overweight or Obesity 6 23.1% 67 50.0% 27 36.5% .017*

Past History 7 26.9% 47 35.1% 30 40.5% 0.440

Dyslipidemia 8 30.8% 59 44.0% 26 35.1% 0.278

Anemia 13 50.0% 41 30.6% 27 36.5% 0.150

Family History 20 76.9% 41 30.6% 8 10.8% <0.001

COPD 0 0.0% 16 11.9% 11 14.9% 0.122

CRF 3 11.5% 10 7.5% 4 5.4% 0.579

Smoking 1 3.8% 5 3.7% 1 1.4% 0.605

Family history as a risk factor was present in 63 (33.3%) poor, 3 (7.7%) in fair and 3 (50.0%) in good socioeconomic patients. Which that this risk factor more prevalent in good economy patients (P=0.003)

When risk factors were compared, we discovered that 36 (75.0%) of premenopausal patients and 108 (58.1%) postmenopausal patients had hypertension (P=0.032); furthermore, 27 (56.3%) and 54 (29.0%) had Anemia, anemia more in premenopausal (P<0.001).

In the young age group, 4 (15.4 %); the middle age group, 75 (56.0 %); and in the old age group, 62 (83.8 %) patients were physically inactive. Physical inactivity was more prevalent in old age (P<0.001).There was a family

history in 20 (76.9%) of the middle age group, 41 (30.6%) of the middle age, and 8 (10.8%) of the old age groups. Family history of IHD more prevalent in young age patients (P<0.001).

Our study observed that poor patients were 2 (1.1%), fair 4 (10.3% and good economy patients 1 (16.7%) Smoking. It explored that this risk factor is more prevalent in patients with good socioeconomic status (P=0.001).

Aspect of DM we revealed that poor patients were 75 (39,7%), fair 24 (61,5% and good economy patients 3 (50.0%) diabetic. It explored that this risk factor is more prevalent in patients with fair socioeconomic status (P=0.041).

Table 3.

Risk factors for myocardial infarction without st segment elevation women in different socio-economic groups from Kabul Afghanistan._

Socioeconomic State N=234

Risk factors Poor Fair Good P value

Frequency Percent Frequency Percent Frequency Percent

Hypertension 114 60.3% 24 61.5% 6 100.0% 0.144

Physical Inactivity 111 58.7% 24 61.5% 6 100.0% 0.124

Diabetes Mellitus 75 39.7% 24 61.5% 3 50.0% 0.041

Overweight or Obesity 79 41.8% 18 46.2% 3 50.0% 0.826

Past History 72 38.1% 9 23.1% 3 50.0% 0.157

Dyslipidemia 72 38.1% 18 46.2% 3 50.0% 0.564

Anemia 69 36.5% 9 23.1% 3 50.0% 0.200

Family History 63 33.3% 3 7.7% 3 50.0% 0.003

COPD 18 9.5% 9 23.1% 0 0.0% 0.036

CKD 16 8.5% 1 2.6% 0 0.0% 0.341

Smoking 2 1.1% 4 10.3% 1 16.7% 0.001

Overweight and obesity occurrence in rural and urban patients were 22 (27.5) and 78 (50.6 %), respectively which show Overweight and obesity higher in urban patients

Discussion

Premenopausal women were more likely than postmenopausal women to have hypertension, a family history of IHD, and anemia. 75 percent vs. 58.10 percent, 63 percent vs. 21 percent, and 56 percent vs. 29 percent were the percentages, respectively.

Hypertension is the most common risk factor, affecting 61.5 % of women. Several investigations came up with similar findings.[5,7], This percentage, however, was lower than in others research[6,11].In research undertaken in Germany and the United States, this trend has been much more prevalent. [12,13].The second factor was revealed to be physical inactivity, which is more likely to affect rural residents. In the Sri Lankan study, this risk factor was less prominent than in ours[14].According to our findings, Diabetes affected 43.6 percent of individuals. This rate of occurrence was higher than that found in several research[6,7,11-13,15]. Our DM findings were lower than those of a study included in the review[5,13,16,17].By comparing obesity and BMI to a study, a similar result was achieved[5,18].Our smoking findings were nearly identical to those of Indian researchers[5,19];We accounted for half of the findings of the Polish study by smoking[13].However, only about a tenth of the research carried in Bosnia and Herzegovina and Sweden was reported[7,11].The significant inequalities in data reflect Afghan society's

(P=0.001), and CKD rates were 13 (16.3 %) and 4 %, respectively (2.6 %). Which show that CKD was higher in rural patients (P<0.001).

customs and traditions. Women are less likely to smoke and are discouraged from doing so in public places.

Premenopausal women had greater blood pressure, although diabetes was the same in both groups. [20].Premenopausal and postmenopausal women suffered from dyslipidemia and obesity in similar ways. However, it was discovered in a study that it was more common among postmenopausal women. [20].

Conclusion:

We discovered that premenopausal patients had a higher prevalence of hypertension as a risk factor (P=0.032); furthermore, Anemia were also more common in premenopausal (P<0.001).

Physical inactivity was more prevalent in old age (P<0.001), Family history of IHD in young age patients (P<0.001). Family history risk factor more frequent in good economy patients (P=0.003), Smoking has been investigated as a risk factor that is higher in patients with a good socioeconomic status (P=0.001). Patients with a moderate socioeconomic background are more likely to develop diabetes(P=0.041).

Patients in uban areas are more likely to be overweight or obese. (P=0.001), Rural patients had a greater rate of CKD. (P<0.001).

Figure 1 Risk factor difference between rural and urban residents.

Conflict of interest: The authors declare that they do not have any competing interests.

Contribution of the authors: All authors have made an equal contribution to the writing of the article.

Akhtar Mohammad Totakhail, Ihsanuddin Ihsan - data collection, analysis and interpretation of results;

Kairat R. Karibayev, Aida Zh. Akhenbekova - methodological and scientific management of the study

Funding: There is no financial support and sponsorship.

Information about the publication: The results of this study have not been previously published in other journals and are not awaiting review by other publishers.

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Coresponding Author

Ibrahimi Ikramullah - Lecturer at Department of Internal Medicine of Medical Faculty of Nangarhar University, Nangarhar Afghanistan, Nangarhar Afghanistan Email: ikr.ibrahimi@gmail.com Phone: +93777165716

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