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13maturation and calcification of bone matrix; promote collagen synthesis and deposition of calcium salts; improve quality of callus; accelerate fracture healing. References
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Research the effect of Sambueus glycosides tablet on the analgesic, antiinflammatory and promote the bone fracture healing
Ya-wen HE, Liu YANG, Hai JIANG, Qiu-hong WANG, Bing-you YANG, Hai-xue KUANG* Heilongjiang University of Chinese Medicine, Harbin, China
Abstracts:ObjectiveTo study the Sambucus total glycosides tablets analgesiaanti-inflammatory effects and its effects on fracture healing. Methodsanti-inflammatory effects by ear swelling in mice and rat foot swelling experiments; Analgesic action by mouse hot plate method; New Zealand white rabbit fracture modelthrough the light microscope and electron microscope observation of each degree of fracture healing.Results the total glycosides Sambucus piece of high, medium and low dose group to inhibit ear swelling in mice and rat foot swelling significantly inhibitory effect (P < 0.05).Sambucus total glycosides tablets of high, medium and low dose group in 1h can increase pain threshold of mice (P < 0.05). Sambucus total glycosides tablets of high dose group, medium and promote the role of bone tissue and osteoblasts to form. Conclusion Sambucustotal glycosides tablet has good resistance to acute inflammation and analgesic effect, and can promote the fracture healing.
Key words:Sambucus total glycosides tablets; Anti-inflammatory; Analgesia; Fracture healing
Diseases related with pain and inflammations are the most important symptoms for bringing the patient to physician[1]. Large number of clinical observations suggest thatSambucuswilliamsiiHance treatment of fractures has a characteristics of short duration, rapid
recovery and high efficacy.However, there are few studies on thethe analgesic, anti-inflammatory and promote the bone fracture healingeffects. Materials and methods
The anti-inflammatory effects of the Sambucus glycosides tablet,using xylene smear both sides ofear and in mouse, using fresh eggalbumin-induced pedal oedemain rats[4].
The analgesic effects against thermallynociceptive pain in mouseusing capillary amplifying device[2-4].
Fractures were made in the left tibiae of male New Zealand White rabbits weighing approximately 2.5 kg. The operations were performed under sterile conditions. Therabbits were anesthetized with Sodium pentobarbital. The fractures weremade using the technique of Incomplete fracture. Sambucus glycosides tablet were administered (each group at 220, 110 and 60 mg/kg doses) and traumatic pill (280 mg/kg doses)orally to adult Rabbits having a drill hole injury (2 mm) in the radial. Vehicle distilled waterwas given to the control group. After continuous administration 36 days, euthanized and tibiae bones collected,through the light microscope and electron microscope observation of each degree of fracture healing[5-7]. Results and discussion
By examining the xylene-induced mouse ear swelling test showed thatSambucusglycosides tablet of high, medium and low dose group significantly inhibited mouse ear swelling, respectively
0.98.1.28.1.31.P < 0.05).Rats foot swelling significantly inhibitory effect (P < 0.05).Description Sambucus glycosides tablets has anti-inflammatory effects
Sambucus glycosides tablets of high, medium dose group in 1h can increase pain threshold of mice,their pain threshold values were 58.7,47.2 (P < 0.05). DescriptionSambucus glycosides tablets has analgesic effect.
Sambucus glycosides tablets of high dose group, medium and promote the role of bone tissue and osteoblasts to form. Conclusion
The findings of this experimental animal studyindicate that Sambucusglycosides tablet possesses analgesic, anti-inflammatory properties and can promotion of bone tissue and osteoblastsformation. References
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