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13RECENT ADVANCES IN OPTICAL IMAGING FOR PHOTODYNAMIC THERAPY
BUHONG LI
Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, 350117, P. R. China.
*E-mail: bhli@fjnu.edu.cn
Abstract
Photodynamic therapy (PDT) is a clinically-approved, minimally-invasive therapeutic procedure that utilizes photosensitizer to generate cytotoxic reactive singlet oxygen for the treatment of a wide variety of malignant and nonmalignant conditions. For PDT applications, the robust and comprehensive individualized dosimetry is essential for achieving satisfactory outcomes but remains a challenge, particularly for clinical translation. The main dosimetric parameters for predicting the PDT efficacy include the delivered light dose, the administrated photosensitizer distribution and concentration, the tissue oxygen concentration, the amount of singlet oxygen generation and the resulting biological responses. In this talk, the emerging optical imaging techniques that in use or under development for monitoring dosimetric parameters during PDT treatment were be presented. In particular, laserspeckle imaging, laser Doppler imaging, optical coherence tomography and singlet oxygen luminescence imagingwill be highlighted. In addition, the future challenges in developing real-time and non-invasive optical techniques for monitoring PDT dosimetric parameters will be discussed.
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