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0Central Asian Journal of
Education and Innovation
PROPERTIES OF THE LIVER DURING PREGNANCY IN EXPERIMENTAL CHRONIC RENAL FAILURE Rakhmonkulova Nargiza Gofurovna Nuriddinova Saodat Fazliddinovna
Abu Ali ibn Sina renamed Bukhara State Medical Institute, Bukhara Regional Perinatal Center, Uzbekistan. Department of Obstetrics and Gynecology N2 4th year student of the Faculty of Medicine of Turkey, Bukhara State Medical Institute named after Abu Ali ibn Sino https://doi.org/10.5281/zenodo.11396318
ARTICLE INFO
ABSTRACT
Qabul qilindi: 20-May 2024 yil Ma'qullandi: 25- May 2024 yil Nashr qilindi: 30- May 2024 yil
KEY WORDS
Liver morphometric indicators, liver pathologies, experimental chronic kidney failure.
The treatment of liver pathologies in chronic renal failure observed during pregnancy worldwide and the prevention of their consequences remain a medical and social problem.Despite the development of methods of prevention and diagnosis, treatment of liver diseases, mortality rates continue to occupy a leading position.In our country, special attention is currently being paid to improving the social protection and health care system of the population, improving the quality of diagnosis, treatment and prevention of chronic liver diseases.
In some cases, based on morphological changes in internal organs, methods of differential diagnosis of the immediate cause of complications have been developed, each of which can have several consequences for the body at once, which can lead to death. The installation of such experiments is unthinkable without knowledge of the morphological and morphometric parameters of laboratory animals, which is an important part of the model experiment and remains poorly understood to this day.
Introduction. Studying the normative morphological and morphometric indicators of the liver of fetal white-breed rats in the laboratory, determining the anatomical parameters of the liver in the fetus its experimental reactive changes after chronic kidney failure, comparing the fetal - dependent histo-topographic characteristics of the liver of white-breed rats with indicators of healthy rats in experimental chronic kidney failure; an experimental study of the comparative classification of morphometric changes in the liver of fetal rats after correction with juicer water in chronic kidney failure was carried out.
The tasks of the study consist of those in the well: 1. Study of normative morphological and morphometric indicators of the liver of fetal white-breed rats;
2.Study of the anatomical parameters of the liver of white-breed rats in the fetus and its reactive changes after experimental chronic kidney failure;
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3. Comparison of fetal -dependent histo-topographic characteristics of the liver of white-breed rats with indicators of healthy rats in experimental chronic kidney failure;
4.Comparative classification of morphometric changes in the liver of fetal rats after correction with juicer waters in experimental chronic kidney failure.
I will give us an example of what was done before the experiment.Direct injection of embryonic cells provides a quick tool for epithelial differentiation and tubulogenesis to develop the necessary stages, including the compound complex and the assembly of the basal membrane. In addition, grafting techniques have been studied that allow the study of embryonic renal vascularization and the effects of endothelial cells on differentiating embryonic cells. (Steenhard, Brooke M -2021).
There has been a study of a significant correlation between high consumption of fatty foods in white rats and structural changes in the kidney, such as decreased glomeruli number density, deformities, significant expansion of renal vessels and tubules, glomerular necrosis and atrophy, and thickening of the basal membrane.(Muhammed eyup Altunkaynak, Elvan Ozbek, Berrin Zuhal Altunkaynak, Ismail San, Deniz Unal and Bunyami Unal-2020). The purpose of the scientific work: to study the post-chronic renal failure changes in morphological and morphometric indicators of the liver of fetal rats without a white breed Results from the experiment:
Morphological structure of liver tissue. Paint G-E. EU 10x10 ok.
1. Deformation of the central venous wall (sclerotic changes) and narrowing of the cavity .
2. Perenchymatous protein (hydropic and hyaline droplet ) dystrophy in hepatocytes. hepatocytes-the nucleus is painted with a reduced basafil in the center, the cytoplasm of which is occupied by vacuoles (droplets) of different sizes).
3. Elastic-fibrosis tissue and polymorphic cell inflammatory infiltrate in the Portal tract.
4. The cavity of the Sinusoid cavity and perisinusoid area (Disse ) is enlarged swelling.
Morphological structure of liver tissue. Paint G-E. EU 10x10 ok.
1. Deformation of the wall of the vein and artery of the hepatic triad (sclerotic changes) and narrowing of the cavity ,around inflammatory infiltrate.
2. Perenchymatous protein (hydropic and hyaline droplet ) dystrophy in hepatocytes. hepatocytes-the nucleus is painted with a reduced basafil in the center, the cytoplasm of which is occupied by vacuoles (droplets) of different sizes).
3. Elastic-fibrosis tissue and polymorphic cell inflammatory infiltrate in the Portal tract.
4. The cavity of the Sinusoid cavity and perisinusoid area (Disse ) is enlarged swelling. Conclusion. Chronic kidney failure" chronic glomerulonephritis " is a consequence of all
glomerulopathies : acute glomerulosclerosis , membranous and membranous-proliferative glomerulonephritis. In this case , the kidneys are symmetrically defined by the fact that they do not budge, the surface remains granular. In our experiment , the following changes were detected when the expressive chronic deficiency in white-breed rats was deciphered and microscopic examination of the changes in it was carried out.Shrinkage of the size of the glomeruli , sclerotic (in dimensions)changes, the onset of hyalinosis , enlarged cavity, infiltration. It is determined that narrowing of the Afferent and efferent arterioles, disruption of blood circulation between them, leads to secondary damage to the balls.The shmulyansky-Bauman capsule is thickened.Ischemic processes have been found to cause focussed cariolysis, carioresis, in the nucleus of the distal and proximal curved-bugrian epithelium, protein ( hydropic and hyaline droplet ) dystrophy in the cytoplasm , swelling in interstitial-intermediate tissue, fibrosis causing thickening of tissue. It was found that the wall of the middle and small-caliber arteries thickened , and narrowing of the blood flow path led to secondary hypertension and atrophy of the renal parenchyma. Rats in the same group studied the anatomical and morphological changes that occur in the liver during pregnancy. When the liver is macroscopic , the size is enlarged , the surface is smooth, the capsule is reminiscent of tense nutmeg. When examined microscopically: deformation of the central venous wall
(sclerotic changes) , fullness and narrowing of the cavity (in dimensions), inflammatory infiltrate around. Perenchymatous protein (hydropic and hyaline droplet ) dystrophy in hepatocytes. hepatocytes-the nucleus is painted with a reduced basaphil in the center, the cytoplasm of which is occupied by vacuoles (droplets) of different sizes. We can see that the uneven fat(drops) of hepatocytes located at the edges of the liver fragments press - fatty dystrophy has developed.The cavity of the Sinusoid cavity and perisinusoid area (Disse ) is enlarged ,swelling.metabolism is evident in the fact that processes are slow, while the numerical increase in bi-nuclear hepatocytes is evident in the decompensation process.
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